UBE2L3

Functionⁱ

Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.7 Publications

Caution

PubMed:10760570 reported that UBE2L1, UBE2L2 and UBE2L4 are most likely pseudogenes and the only expressed member of this subfamily seems to be UBE2L3.Curated

Catalytic activityⁱ

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation1 Publication

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	86	Glycyl thioester intermediatePROSITE-ProRule annotation		1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
enzyme binding
Source: UniProtKB
Traceable author statementⁱ
- 8563171
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
transcription coactivator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15367689
ubiquitin conjugating enzyme activity
Source: MGI
Inferred from direct assayⁱ
- 20061386
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11278816
- 21532592
ubiquitin-protein transferase activator activity
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 12628165
ubiquitin-protein transferase activity
Source: UniProtKB
Inferred from direct assayⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle phase transition
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18946090
cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18946090
cellular protein modification process
Source: UniProtKB
Traceable author statementⁱ
- 8576257
cellular response to glucocorticoid stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 17003263
cellular response to steroid hormone stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15367689
positive regulation of protein targeting to mitochondrion
Source: ParkinsonsUK-UCL
Inferred from high throughput mutant phenotypeⁱ
- 24270810
positive regulation of protein ubiquitination
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 12628165
positive regulation of ubiquitin-protein transferase activity
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 12628165
protein K11-linked ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 20061386
protein polyubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 10888878
- 14765125
protein ubiquitination
Source: UniProtKB
Inferred from direct assayⁱ
- 21532592
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 17003263
ubiquitin-dependent protein catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Transcription, Transcription regulation, Ubl conjugation pathway
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.3.2.B6 2681
Reactomeⁱ	R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	P68036
UniPathwayⁱ	UPA00143

Protein family/group databases

MoonDBⁱ	P68036 Predicted

MoonDBⁱ

P68036 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ubiquitin-conjugating enzyme E2 L3 (EC:2.3.2.231 Publication) Alternative name(s): E2 ubiquitin-conjugating enzyme L3 L-UBC UbcH7 Ubiquitin carrier protein L3 Ubiquitin-conjugating enzyme E2-F1 Ubiquitin-protein ligase L3
Gene namesⁱ	Name:UBE2L3 Synonyms:UBCE7, UBCH7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185651.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12488 UBE2L3
MIMⁱ	603721 gene
neXtProtⁱ	NX_P68036

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	9	K → E: Marked decrease in autoubiquitination. 1 Publication	1
Mutagenesisⁱ	63	F → A: Decrease in autoubiquitination. 1 Publication	1
Mutagenesisⁱ	86	C → S: Loss of catalytic activity. Prevents ubiquitin-dependent proteasomal degradation of UBE2L3. 2 Publications	1
Mutagenesisⁱ	88	P → D: Does not convert into a lysine reactive E2; when associated with D-119. 1 Publication	1
Mutagenesisⁱ	93	E → R: Decrease in autoubiquitination. 1 Publication	1
Mutagenesisⁱ	96	K → E: Decrease in autoubiquitination. 1 Publication	1
Mutagenesisⁱ	100	K → E: Decrease in autoubiquitination. 1 Publication	1
Mutagenesisⁱ	119	H → D: Does not convert into a lysine reactive E2; when associated with D-88. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7332
Open Targets More...OpenTargetsⁱ	ENSG00000185651
Orphanetⁱ	536 NON RARE IN EUROPE: Systemic lupus erythematosus
PharmGKBⁱ	PA37137

Polymorphism and mutation databases

BioMutaⁱ	UBE2L3
DMDMⁱ	54039805

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000082476	1 – 154	Ubiquitin-conjugating enzyme E2 L3Add BLAST		154

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	131	N6-acetyllysineCombined sources		1

Post-translational modificationⁱ

Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to ubiquitin-dependent proteasomal degradation. Autoubiquitinated in vitro (PubMed:22496338).2 Publications

Keywords - PTMⁱ

Acetylation, Ubl conjugation

Proteomic databases

EPDⁱ	P68036
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P68036
PaxDbⁱ	P68036
PeptideAtlas More...PeptideAtlasⁱ	P68036
PRIDEⁱ	P68036
ProteomicsDBⁱ	57528
TopDownProteomicsⁱ	P68036-1 [P68036-1] P68036-2 [P68036-2]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P51966
UCD-2DPAGEⁱ	P68036

PTM databases

iPTMnetⁱ	P68036
PhosphoSitePlusⁱ	P68036
SwissPalmⁱ	P68036

Expressionⁱ

Tissue specificityⁱ

Ubiquitous, with highest expression in testis.

Gene expression databases

Bgeeⁱ	ENSG00000185651 Expressed in 226 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_UBE2L3
ExpressionAtlasⁱ	P68036 baseline and differential
Genevisibleⁱ	P68036 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045609 HPA062415

HPAⁱ

HPA045609
HPA062415

Interactionⁱ

Subunit structureⁱ

Interacts with PRKN; involved in ubiquitination and degradation of misfolded proteins. Interacts with UBE3A; used by the papilloma virus HPV-16 E6 protein to ubiquitinate p53/TP53. Interacts with CCNB1IP1, CBL, ZAP70, RNF19A, RNF19B and RNF144B. Interacts with ARIH1. Interacts with ARIH2 (via RING-type 1). Interacts with NCOA1; they functionally interact to regulate progesterone receptor transcriptional activity. May interact with NR3C1. Interacts with NDFIP1 (via N-terminus); the interaction mediates recruitment of UBE2L3 to ITCH and causes MAP3K7 ubiquitination (PubMed:25632008).13 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ARIH1	Q9Y4X5	5	EBI-711173,EBI-2514233
ARIH2	O95376	12	EBI-711173,EBI-711158
MID1	O15344	3	EBI-711173,EBI-2340316
ospG	Q99PZ6	4	EBI-15556257,EBI-9316527	From Shigella flexneri.
RBCK1	Q9BYM8	3	EBI-711173,EBI-2340624
RNF144A	P50876	3	EBI-711173,EBI-2340657
RNF19B	Q6ZMZ0	2	EBI-711173,EBI-2466594
sopA	Q8ZNR3	2	EBI-15556257,EBI-15674008	From Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Traceable author statementⁱ
- 8563171
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11278816
- 21532592

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113180, 143 interactors
CORUMⁱ	P68036
Database of interacting proteins More...DIPⁱ	DIP-6124N
IntActⁱ	P68036, 33 interactors
Molecular INTeraction database More...MINTⁱ	P68036
STRINGⁱ	9606.ENSP00000344259

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	1 – 17	Combined sources	17
Beta strandⁱ	20 – 27	Combined sources	8
Turnⁱ	29 – 31	Combined sources	3
Beta strandⁱ	34 – 39	Combined sources	6
Turnⁱ	44 – 48	Combined sources	5
Beta strandⁱ	49 – 56	Combined sources	8
Turnⁱ	59 – 62	Combined sources	4
Beta strandⁱ	67 – 72	Combined sources	6
Beta strandⁱ	77 – 79	Combined sources	3
Beta strandⁱ	83 – 85	Combined sources	3
Helixⁱ	88 – 90	Combined sources	3
Turnⁱ	92 – 94	Combined sources	3
Helixⁱ	101 – 113	Combined sources	13
Beta strandⁱ	117 – 119	Combined sources	3
Helixⁱ	123 – 131	Combined sources	9
Helixⁱ	133 – 147	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	P68036
SMRⁱ	P68036
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P68036

EvolutionaryTraceⁱ

P68036

Family & Domainsⁱ

Domainⁱ

In contrast to other ubiquitin-conjugating enzymes E2, residues essential for lysine reactivity are absent: Pro and a His residues are present instead of an Asp and an Asp residues in positions 88 and 119, respectively.1 Publication

Sequence similaritiesⁱ

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0422 Eukaryota COG5078 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143990
HOGENOMⁱ	HOG000233455
HOVERGENⁱ	HBG063308
InParanoidⁱ	P68036
KEGG Orthology (KO) More...KOⁱ	K04552
OMAⁱ	RFTIDIT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QDO
PhylomeDBⁱ	P68036
TreeFamⁱ	TF313043

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00195 UBCc, 1 hit
Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR023313 UBQ-conjugating_AS IPR016135 UBQ-conjugating_enzyme/RWD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS00183 UBIQUITIN_CONJUGAT_1, 1 hit PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P68036-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA 
        60         70         80         90        100
FRIEINFPAE YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK 
       110        120        130        140        150
TDQVIQSLIA LVNDPQPEHP LRADLAEEYS KDRKKFCKNA EEFTKKYGEK 

RPVD

Length:154

Mass (Da):17,862

Last modified:October 11, 2004 - v1

Checksum:ⁱF5A30243BE3C9985

GO

Isoform 2 (identifier: P68036-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
10-41: Missing.

« Hide

        10         20         30         40         50
MAASRRLMKD NPPYDKGAFR IEINFPAEYP FKPPKITFKT KIYHPNIDEK 
        60         70         80         90        100
GQVCLPVISA ENWKPATKTD QVIQSLIALV NDPQPEHPLR ADLAEEYSKD 
       110        120 
RKKFCKNAEE FTKKYGEKRP VD

Show »

Length:122

Mass (Da):14,121

Checksum:ⁱB6D14D8ABF26E365

GO

Isoform 3 (identifier: P68036-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-9: MAASRRLMK → MQVAAGTRGD...AGYRRAHGPE

« Hide

        10         20         30         40         50
MQVAAGTRGD TRLQEVALLP QLFDLLVLGQ RRARLLRQVP SALAGKDLAQ 
        60         70         80         90        100
LQAGATLAGY RRAHGPEELE EIRKCGMKNF RNIQVDEANL LTWQGLIVPD 
       110        120        130        140        150
NPPYDKGAFR IEINFPAEYP FKPPKITFKT KIYHPNIDEK GQVCLPVISA 
       160        170        180        190        200
ENWKPATKTD QVIQSLIALV NDPQPEHPLR ADLAEEYSKD RKKFCKNAEE 
       210 
FTKKYGEKRP VD

Note: No experimental confirmation available.

Show »

Length:212

Mass (Da):24,004

Checksum:ⁱFBA57DE90E19DA78

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	15	R → S in BAG61806 (PubMed:14702039).Curated	1
Sequence conflictⁱ	23	R → C in AAG17922 (Ref. 4) Curated	1
Sequence conflictⁱ	118	E → K in AAG17922 (Ref. 4) Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047342	1 – 9	MAASRRLMK → MQVAAGTRGDTRLQEVALLP QLFDLLVLGQRRARLLRQVP SALAGKDLAQLQAGATLAGY RRAHGPE in isoform 3. 1 Publication		9
Alternative sequenceⁱVSP_045152	10 – 41	Missing in isoform 2. 1 PublicationAdd BLAST		32

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S81003 mRNA Translation: AAB36017.1 X92962 mRNA Translation: CAA63538.1 AJ000519 mRNA Translation: CAA04156.1 AF300336 Genomic DNA Translation: AAG17922.1 CR456606 mRNA Translation: CAG30492.1 AK293179 mRNA Translation: BAG56722.1 AK299985 mRNA Translation: BAG61806.1 AK311761 mRNA Translation: BAG34704.1 AP000553 Genomic DNA No translation available. AP000557 Genomic DNA No translation available. AP000558 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW59459.1 BC053368 mRNA Translation: AAH53368.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13790.1 [P68036-1] CCDS58795.1 [P68036-3] CCDS58796.1 [P68036-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001243284.1, NM_001256355.1 [P68036-3] NP_001243285.1, NM_001256356.1 [P68036-2] NP_003338.1, NM_003347.3 [P68036-1]
UniGeneⁱ	Hs.108104

Genome annotation databases

Ensemblⁱ	ENST00000342192; ENSP00000344259; ENSG00000185651 [P68036-1] ENST00000458578; ENSP00000400906; ENSG00000185651 [P68036-3] ENST00000545681; ENSP00000445931; ENSG00000185651 [P68036-2]
GeneIDⁱ	7332
KEGGⁱ	hsa:7332
UCSC genome browser More...UCSCⁱ	uc002zva.2 human [P68036-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P68036	Ubiquitin-conjugating enzyme E2 L3		BOVIN		154	UniRef100_P68036
Ubiquitin-conjugating enzyme E2 L3		MOUSE		154
Uncharacterized protein (Fragment)		MICSU		157
Ubiquitin-conjugating enzyme E2L 3, isoform CRA_a		HUMAN		154
UBE2L3 isoform 1		PANTR		154
+47
P68036-2	Ubiquitin-conjugating enzyme E2 L3		MOUSE		122	UniRef100_A0A338P7E5
UBE2L3 isoform 2		PANTR		122
ubiquitin-conjugating enzyme E2 L3 isoform X2		ODORO		122
Ubiquitin conjugating enzyme E2 L3		SAIBB		122
Uncharacterized protein		PROCO		122
+20

Protein	Similar proteins		Species	Score	Length	Source
P68036	Ubiquitin-conjugating enzyme E2 L3		BOVIN		154	UniRef90_P68036
Ubiquitin-conjugating enzyme E2 L3		MOUSE		154
Ubiquitin-conjugating enzyme E2 L5		HUMAN		154
Ubiquitin-conjugating enzyme E2 L3		PONAB		154
Uncharacterized protein (Fragment)		MICSU		157
+150
P68036-2	Uncharacterized protein		OTOGA		150	UniRef90_H0XVC6
Uncharacterized protein		ORNAN		64
Ubiquitin-conjugating enzyme E2 L3 (Fragment)		ESCRO		129
Ubiquitin-conjugating enzyme E2 L3		TUPCH		124
Ubiquitin-conjugating enzyme E2 L3 (Fragment)		ANAPL		123
+42
P68036-3	Uncharacterized protein		PROCO		211	UniRef90_P68036-3
Ubiquitin conjugating enzyme E2 L3		SAIBB		211
Uncharacterized protein		RHIRO		211
Uncharacterized protein		RHIBE		211
Uncharacterized protein		Cebus capucinus imitator		211
+11

Protein	Similar proteins		Species	Score	Length	Source
P68036	Ubiquitin-conjugating enzyme E2 L3		BOVIN		154	UniRef50_P68036
Ubiquitin-conjugating enzyme E2 L3		MOUSE		154
Ubiquitin-conjugating enzyme E2 L5		HUMAN		154
Ubiquitin-conjugating enzyme E2 L3		PONAB		154
Uncharacterized protein (Fragment)		MICSU		157
+299
P68036-2	Ubiquitin/ISG15-conjugating enzyme E2 L6	)	HUMAN		153	UniRef50_O14933
UBE2L6 isoform 2		PANTR		153
Uncharacterized protein		NOMLE		153
UBE2L6 isoform 2		PONAB		153
Ubiquitin conjugating enzyme E2 L6		GORGO		153
+254
P68036-3	Uncharacterized protein		CALJA		211	UniRef50_P68036-3
Uncharacterized protein		PAPAN		211
Uncharacterized protein		CERAT		211
Uncharacterized protein		MANLE		211
Uncharacterized protein		MACFA		211
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S81003 mRNA Translation: AAB36017.1 X92962 mRNA Translation: CAA63538.1 AJ000519 mRNA Translation: CAA04156.1 AF300336 Genomic DNA Translation: AAG17922.1 CR456606 mRNA Translation: CAG30492.1 AK293179 mRNA Translation: BAG56722.1 AK299985 mRNA Translation: BAG61806.1 AK311761 mRNA Translation: BAG34704.1 AP000553 Genomic DNA No translation available. AP000557 Genomic DNA No translation available. AP000558 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW59459.1 BC053368 mRNA Translation: AAH53368.1
CCDSⁱ	CCDS13790.1 [P68036-1] CCDS58795.1 [P68036-3] CCDS58796.1 [P68036-2]
RefSeqⁱ	NP_001243284.1, NM_001256355.1 [P68036-3] NP_001243285.1, NM_001256356.1 [P68036-2] NP_003338.1, NM_003347.3 [P68036-1]
UniGeneⁱ	Hs.108104

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1C4Z	X-ray	2.60	D	1-154	[»]
	1FBV	X-ray	2.90	C	1-154	[»]
	3SQV	X-ray	3.30	C/D	1-154	[»]
	3SY2	X-ray	3.27	C/D	1-154	[»]
	4Q5E	X-ray	1.87	C	1-154	[»]
	4Q5H	X-ray	2.00	C	1-154	[»]
	5HPT	X-ray	2.84	C/F	2-154	[»]
	5TTE	X-ray	3.50	E	1-154	[»]
	5UDH	X-ray	3.24	C/D	1-154	[»]
	6CP2	X-ray	2.90	B	1-154	[»]
	6DJW	X-ray	3.80	C	1-154	[»]
	6DJX	X-ray	4.80	C	1-154	[»]
ProteinModelPortalⁱ	P68036
SMRⁱ	P68036
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113180, 143 interactors
CORUMⁱ	P68036
DIPⁱ	DIP-6124N
IntActⁱ	P68036, 33 interactors
MINTⁱ	P68036
STRINGⁱ	9606.ENSP00000344259

Protein family/group databases

MoonDBⁱ	P68036 Predicted

MoonDBⁱ

P68036 Predicted

PTM databases

iPTMnetⁱ	P68036
PhosphoSitePlusⁱ	P68036
SwissPalmⁱ	P68036

Polymorphism and mutation databases

BioMutaⁱ	UBE2L3
DMDMⁱ	54039805

2D gel databases

OGPⁱ	P51966
UCD-2DPAGEⁱ	P68036

Proteomic databases

EPDⁱ	P68036
MaxQBⁱ	P68036
PaxDbⁱ	P68036
PeptideAtlasⁱ	P68036
PRIDEⁱ	P68036
ProteomicsDBⁱ	57528
TopDownProteomicsⁱ	P68036-1 [P68036-1] P68036-2 [P68036-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7332
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000342192; ENSP00000344259; ENSG00000185651 [P68036-1] ENST00000458578; ENSP00000400906; ENSG00000185651 [P68036-3] ENST00000545681; ENSP00000445931; ENSG00000185651 [P68036-2]
GeneIDⁱ	7332
KEGGⁱ	hsa:7332
UCSCⁱ	uc002zva.2 human [P68036-1]

Organism-specific databases

CTDⁱ	7332
DisGeNETⁱ	7332
EuPathDBⁱ	HostDB:ENSG00000185651.14
GeneCardsⁱ	UBE2L3
HGNCⁱ	HGNC:12488 UBE2L3
HPAⁱ	HPA045609 HPA062415
MIMⁱ	603721 gene
neXtProtⁱ	NX_P68036
OpenTargetsⁱ	ENSG00000185651
Orphanetⁱ	536 NON RARE IN EUROPE: Systemic lupus erythematosus
PharmGKBⁱ	PA37137
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0422 Eukaryota COG5078 LUCA
GeneTreeⁱ	ENSGT00910000143990
HOGENOMⁱ	HOG000233455
HOVERGENⁱ	HBG063308
InParanoidⁱ	P68036
KOⁱ	K04552
OMAⁱ	RFTIDIT
OrthoDBⁱ	EOG091G0QDO
PhylomeDBⁱ	P68036
TreeFamⁱ	TF313043

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
BRENDAⁱ	2.3.2.B6 2681
Reactomeⁱ	R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkⁱ	P68036

Miscellaneous databases

ChiTaRSⁱ	UBE2L3 human
EvolutionaryTraceⁱ	P68036
GeneWikiⁱ	UBE2L3
GenomeRNAiⁱ	7332
Protein Ontology More...PROⁱ	PR:P68036
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185651 Expressed in 226 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_UBE2L3
ExpressionAtlasⁱ	P68036 baseline and differential
Genevisibleⁱ	P68036 HS

Family and domain databases

CDDⁱ	cd00195 UBCc, 1 hit
Gene3Dⁱ	3.10.110.10, 1 hit
InterProⁱ	View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR023313 UBQ-conjugating_AS IPR016135 UBQ-conjugating_enzyme/RWD
Pfamⁱ	View protein in Pfam PF00179 UQ_con, 1 hit
SUPFAMⁱ	SSF54495 SSF54495, 1 hit
PROSITEⁱ	View protein in PROSITE PS00183 UBIQUITIN_CONJUGAT_1, 1 hit PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UB2L3_HUMAN
Accessionⁱ	P68036Primary (citable) accession number: P68036 Secondary accession number(s): B2R4A7 Q9HAV1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
	Last sequence update:	October 11, 2004
	Last modified:	November 7, 2018
	This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P68036 (UB2L3_HUMAN)

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Ubiquitin-conjugating enzyme E2 L3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Sites

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ