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UniProtKB - P68036 (UB2L3_HUMAN)

Entry version 171 (02 Dec 2020)
Sequence version 1 (11 Oct 2004)
Previous versions | rss
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Protein

Ubiquitin-conjugating enzyme E2 L3

Gene

UBE2L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.7 Publications

Caution

PubMed:10760570 reported that UBE2L1, UBE2L2 and UBE2L4 are most likely pseudogenes and the only expressed member of this subfamily seems to be UBE2L3.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation1 Publication EC:2.3.2.23

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei86Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processTranscription, Transcription regulation, Ubl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.2.B6, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P68036

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P68036

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P68036, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 L3 (EC:2.3.2.231 Publication)
Alternative name(s):
E2 ubiquitin-conjugating enzyme L3
L-UBC
UbcH7
Ubiquitin carrier protein L3
Ubiquitin-conjugating enzyme E2-F1
Ubiquitin-protein ligase L3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBE2L3
Synonyms:UBCE7, UBCH7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000185651.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:12488, UBE2L3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603721, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P68036

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi9K → E: Marked decrease in autoubiquitination. 1 Publication1
Mutagenesisi63F → A: Decrease in autoubiquitination. 1 Publication1
Mutagenesisi86C → S: Loss of catalytic activity. Prevents ubiquitin-dependent proteasomal degradation of UBE2L3. 2 Publications1
Mutagenesisi88P → D: Does not convert into a lysine reactive E2; when associated with D-119. 1 Publication1
Mutagenesisi93E → R: Decrease in autoubiquitination. 1 Publication1
Mutagenesisi96K → E: Decrease in autoubiquitination. 1 Publication1
Mutagenesisi100K → E: Decrease in autoubiquitination. 1 Publication1
Mutagenesisi119H → D: Does not convert into a lysine reactive E2; when associated with D-88. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		7332

MalaCards human disease database

More...MalaCardsi		UBE2L3

Open Targets

More...OpenTargetsi		ENSG00000185651

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		536, Systemic lupus erythematosus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37137

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P68036, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105871

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UBE2L3

Domain mapping of disease mutations (DMDM)

More...DMDMi		54039805

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000824761 – 154Ubiquitin-conjugating enzyme E2 L3Add BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei131N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to ubiquitin-dependent proteasomal degradation. Autoubiquitinated in vitro (PubMed:22496338).2 Publications

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P68036

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P68036

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P68036

MaxQB - The MaxQuant DataBase

More...MaxQBi		P68036

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P68036

PeptideAtlas

More...PeptideAtlasi		P68036

PRoteomics IDEntifications database

More...PRIDEi		P68036

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		18904
3856
57528 [P68036-1]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P68036-1 [P68036-1]
P68036-2 [P68036-2]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P51966

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P68036

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P68036

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P68036

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P68036

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous, with highest expression in testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185651, Expressed in C1 segment of cervical spinal cord and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P68036, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P68036, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185651, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRKN; involved in ubiquitination and degradation of misfolded proteins.

Interacts with UBE3A; used by the papilloma virus HPV-16 E6 protein to ubiquitinate p53/TP53.

Interacts with CCNB1IP1, CBL, ZAP70, RNF19A, RNF19B and RNF144B.

Interacts with ARIH1.

Interacts with ARIH2 (via RING-type 1).

Interacts with NCOA1; they functionally interact to regulate progesterone receptor transcriptional activity. May interact with NR3C1.

Interacts with NDFIP1 (via N-terminus); the interaction mediates recruitment of UBE2L3 to ITCH and causes MAP3K7 ubiquitination (PubMed:25632008).

13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113180, 193 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P68036

Database of interacting proteins

More...DIPi		DIP-6124N

Protein interaction database and analysis system

More...IntActi		P68036, 35 interactors

Molecular INTeraction database

More...MINTi		P68036

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000485133

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P68036, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P68036

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P68036

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P68036

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 149UBC corePROSITE-ProRule annotationAdd BLAST148

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

In contrast to other ubiquitin-conjugating enzymes E2, residues essential for lysine reactivity are absent: Pro and a His residues are present instead of an Asp and an Asp residues in positions 88 and 119, respectively.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0422, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153654

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030988_13_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P68036

Identification of Orthologs from Complete Genome Data

More...OMAi		YRRAHGP

Database of Orthologous Groups

More...OrthoDBi		1420213at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P68036

TreeFam database of animal gene trees

More...TreeFami		TF313043

Family and domain databases

Conserved Domains Database

More...CDDi		cd00195, UBCc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.110.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00592

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000608, UBQ-conjugat_E2
IPR023313, UBQ-conjugating_AS
IPR016135, UBQ-conjugating_enzyme/RWD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00179, UQ_con, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54495, SSF54495, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00183, UBC_1, 1 hit
PS50127, UBC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P68036-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA 
        60         70         80         90        100
FRIEINFPAE YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK 
       110        120        130        140        150
TDQVIQSLIA LVNDPQPEHP LRADLAEEYS KDRKKFCKNA EEFTKKYGEK 

RPVD
Length:154
Mass (Da):17,862
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5A30243BE3C9985
GO
Isoform 2 (identifier: P68036-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-41: Missing.

Show »
Length:122
Mass (Da):14,121
Checksum:iB6D14D8ABF26E365
GO
Isoform 3 (identifier: P68036-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAASRRLMK → MQVAAGTRGD...AGYRRAHGPE

Show »
Length:212
Mass (Da):24,004
Checksum:iFBA57DE90E19DA78
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15R → S in BAG61806 (PubMed:14702039).Curated1
Sequence conflicti23R → C in AAG17922 (Ref. 4) Curated1
Sequence conflicti118E → K in AAG17922 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0473421 – 9MAASRRLMK → MQVAAGTRGDTRLQEVALLP QLFDLLVLGQRRARLLRQVP SALAGKDLAQLQAGATLAGY RRAHGPE in isoform 3. 1 Publication9
Alternative sequenceiVSP_04515210 – 41Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S81003 mRNA Translation: AAB36017.1
X92962 mRNA Translation: CAA63538.1
AJ000519 mRNA Translation: CAA04156.1
AF300336 Genomic DNA Translation: AAG17922.1
CR456606 mRNA Translation: CAG30492.1
AK293179 mRNA Translation: BAG56722.1
AK299985 mRNA Translation: BAG61806.1
AK311761 mRNA Translation: BAG34704.1
AP000553 Genomic DNA No translation available.
AP000557 Genomic DNA No translation available.
AP000558 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59459.1
BC053368 mRNA Translation: AAH53368.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13790.1 [P68036-1]
CCDS58795.1 [P68036-3]
CCDS58796.1 [P68036-2]

NCBI Reference Sequences

More...RefSeqi		NP_001243284.1, NM_001256355.1 [P68036-3]
NP_001243285.1, NM_001256356.1 [P68036-2]
NP_003338.1, NM_003347.3 [P68036-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000342192; ENSP00000344259; ENSG00000185651 [P68036-1]
ENST00000458578; ENSP00000400906; ENSG00000185651 [P68036-3]
ENST00000545681; ENSP00000445931; ENSG00000185651 [P68036-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7332

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7332

UCSC genome browser

More...UCSCi		uc002zva.2, human [P68036-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81003 mRNA Translation: AAB36017.1
X92962 mRNA Translation: CAA63538.1
AJ000519 mRNA Translation: CAA04156.1
AF300336 Genomic DNA Translation: AAG17922.1
CR456606 mRNA Translation: CAG30492.1
AK293179 mRNA Translation: BAG56722.1
AK299985 mRNA Translation: BAG61806.1
AK311761 mRNA Translation: BAG34704.1
AP000553 Genomic DNA No translation available.
AP000557 Genomic DNA No translation available.
AP000558 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59459.1
BC053368 mRNA Translation: AAH53368.1
CCDSiCCDS13790.1 [P68036-1]
CCDS58795.1 [P68036-3]
CCDS58796.1 [P68036-2]
RefSeqiNP_001243284.1, NM_001256355.1 [P68036-3]
NP_001243285.1, NM_001256356.1 [P68036-2]
NP_003338.1, NM_003347.3 [P68036-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C4ZX-ray2.60D1-154[»]
1FBVX-ray2.90C1-154[»]
3SQVX-ray3.30C/D1-154[»]
3SY2X-ray3.27C/D1-154[»]
4Q5EX-ray1.87C1-154[»]
4Q5HX-ray2.00C1-154[»]
5HPTX-ray2.84C/F2-154[»]
5TTEX-ray3.50E1-154[»]
5UDHX-ray3.24C/D1-154[»]
6CP2X-ray2.90B1-154[»]
6DJWX-ray3.80C1-154[»]
6DJXX-ray4.80C1-154[»]
6N13NMR-C1-154[»]
6XXUNMR-A1-154[»]
BMRBiP68036
SMRiP68036
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113180, 193 interactors
CORUMiP68036
DIPiDIP-6124N
IntActiP68036, 35 interactors
MINTiP68036
STRINGi9606.ENSP00000485133

Chemistry databases

ChEMBLiCHEMBL4105871

Protein family/group databases

MoonDBiP68036, Predicted

PTM databases

iPTMnetiP68036
PhosphoSitePlusiP68036
SwissPalmiP68036

Polymorphism and mutation databases

BioMutaiUBE2L3
DMDMi54039805

2D gel databases

OGPiP51966
UCD-2DPAGEiP68036

Proteomic databases

EPDiP68036
jPOSTiP68036
MassIVEiP68036
MaxQBiP68036
PaxDbiP68036
PeptideAtlasiP68036
PRIDEiP68036
ProteomicsDBi18904
3856
57528 [P68036-1]
TopDownProteomicsiP68036-1 [P68036-1]
P68036-2 [P68036-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		8540, 443 antibodies

The DNASU plasmid repository

More...DNASUi		7332

Genome annotation databases

EnsembliENST00000342192; ENSP00000344259; ENSG00000185651 [P68036-1]
ENST00000458578; ENSP00000400906; ENSG00000185651 [P68036-3]
ENST00000545681; ENSP00000445931; ENSG00000185651 [P68036-2]
GeneIDi7332
KEGGihsa:7332
UCSCiuc002zva.2, human [P68036-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7332
DisGeNETi7332
EuPathDBiHostDB:ENSG00000185651.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		UBE2L3
HGNCiHGNC:12488, UBE2L3
HPAiENSG00000185651, Low tissue specificity
MalaCardsiUBE2L3
MIMi603721, gene
neXtProtiNX_P68036
OpenTargetsiENSG00000185651
Orphaneti536, Systemic lupus erythematosus
PharmGKBiPA37137

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0422, Eukaryota
GeneTreeiENSGT00940000153654
HOGENOMiCLU_030988_13_3_1
InParanoidiP68036
OMAiYRRAHGP
OrthoDBi1420213at2759
PhylomeDBiP68036
TreeFamiTF313043

Enzyme and pathway databases

UniPathwayiUPA00143
BRENDAi2.3.2.B6, 2681
PathwayCommonsiP68036
ReactomeiR-HSA-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-8866654, E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiP68036

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7332, 624 hits in 821 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UBE2L3, human
EvolutionaryTraceiP68036

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UBE2L3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7332
PharosiP68036, Tbio

Protein Ontology

More...PROi		PR:P68036
RNActiP68036, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185651, Expressed in C1 segment of cervical spinal cord and 239 other tissues
ExpressionAtlasiP68036, baseline and differential
GenevisibleiP68036, HS

Family and domain databases

CDDicd00195, UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
IDEALiIID00592
InterProiView protein in InterPro
IPR000608, UBQ-conjugat_E2
IPR023313, UBQ-conjugating_AS
IPR016135, UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179, UQ_con, 1 hit
SUPFAMiSSF54495, SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183, UBC_1, 1 hit
PS50127, UBC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUB2L3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P68036
Secondary accession number(s): B2R4A7
, B4DDG1, B4DSZ4, E7EWS7, P51966, P70653, Q9HAV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: December 2, 2020
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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