Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pro-opiomelanocortin

Gene

POMC

Organism
Balaenoptera borealis (Sei whale) (Pollack whale)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Precursor protein for pituitary hormones that regulate stress and environmental adaptation.
Corticotropin: Stimulates the adrenal glands to release cortisol.
Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.

GO - Molecular functioni

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 3 chains:
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Alternative name(s):
Melanotropin alpha
Gene namesi
Name:POMC
OrganismiBalaenoptera borealis (Sei whale) (Pollack whale)
Taxonomic identifieri9768 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaMysticetiBalaenopteridaeBalaenoptera

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000249371 – 39CorticotropinAdd BLAST39
PeptideiPRO_00000249381 – 13Melanocyte-stimulating hormone alphaAdd BLAST13
PeptideiPRO_000002493919 – 39Corticotropin-like intermediary peptideAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylserineBy similarity1
Modified residuei13Valine amideBy similarity1
Modified residuei31PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PRIDEiP68000

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP68000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the POMC family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013531 Mcrtin_ACTH_cent
IPR001941 PMOC
PfamiView protein in Pfam
PF00976 ACTH_domain, 1 hit
PRINTSiPR00383 MELANOCORTIN
SMARTiView protein in SMART
SM01363 ACTH_domain, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P68000-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
SYSMEHFRWG KPVGKKRRPV KVYPNGAEDE SAEAFPLEF
Length:39
Mass (Da):4,541
Last modified:July 21, 1986 - v1
Checksum:i461FD46C28945A6E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei391

Sequence databases

PIRiPN0127

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiPN0127

3D structure databases

SMRiP68000
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP68000

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR013531 Mcrtin_ACTH_cent
IPR001941 PMOC
PfamiView protein in Pfam
PF00976 ACTH_domain, 1 hit
PRINTSiPR00383 MELANOCORTIN
SMARTiView protein in SMART
SM01363 ACTH_domain, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOLI_BALBO
AccessioniPrimary (citable) accession number: P68000
Secondary accession number(s): P01195
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 25, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again