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Protein

60S ribosomal protein L22

Gene

Rpl22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Binds to Epstein-Barr virus small RNAs and to heparin.

GO - Molecular functioni

  • heparin binding Source: MGI
  • RNA binding Source: GO_Central
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • alpha-beta T cell differentiation Source: MGI
  • cytoplasmic translation Source: GO_Central

Keywordsi

Molecular functionHeparin-binding, Ribonucleoprotein, Ribosomal protein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L22
Alternative name(s):
Heparin-binding protein HBp15
Gene namesi
Name:Rpl22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:99262 Rpl22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155021 – 12860S ribosomal protein L22Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphothreonineCombined sources1
Modified residuei66PhosphoserineBy similarity1
Modified residuei69N6-succinyllysineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP67984
PaxDbiP67984
PeptideAtlasiP67984
PRIDEiP67984

PTM databases

iPTMnetiP67984
PhosphoSitePlusiP67984
SwissPalmiP67984

Expressioni

Gene expression databases

BgeeiENSMUSG00000028936
CleanExiMM_RPL22
ExpressionAtlasiP67984 baseline and differential
GenevisibleiP67984 MM

Interactioni

Protein-protein interaction databases

BioGridi202971, 4 interactors
IntActiP67984, 6 interactors
MINTiP67984
STRINGi10090.ENSMUSP00000099480

Structurei

3D structure databases

ProteinModelPortaliP67984
SMRiP67984
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi120 – 128Asp/Glu-rich (highly acidic)9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3434 Eukaryota
ENOG4111UVJ LUCA
GeneTreeiENSGT00390000003719
HOGENOMiHOG000198396
HOVERGENiHBG004373
InParanoidiP67984
KOiK02891
OMAiYQLRFYN
OrthoDBiEOG091G0POE
PhylomeDBiP67984
TreeFamiTF313018

Family and domain databases

Gene3Di3.30.1360.210, 1 hit
InterProiView protein in InterPro
IPR002671 Ribosomal_L22e
IPR038526 Ribosomal_L22e_sf
PANTHERiPTHR10064 PTHR10064, 1 hit
PfamiView protein in Pfam
PF01776 Ribosomal_L22e, 1 hit

Sequencei

Sequence statusi: Complete.

P67984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVKKLVAK GGKKKKQVLK FTLDCTHPVE DGIMDAANFE QFLQERIKVN
60 70 80 90 100
GKAGNLGGGV VTIERSKSKI TVTSEVPFSK RYLKYLTKKY LKKNNLRDWL
110 120
RVVANSKESY ELRYFQINQD EEEEEDED
Length:128
Mass (Da):14,759
Last modified:January 23, 2007 - v2
Checksum:i3F29D8BE70DEF96C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17653 mRNA Translation: BAA04546.1
BC007139 mRNA Translation: AAH07139.1
BC021344 mRNA Translation: AAH21344.1
CCDSiCCDS18999.1
PIRiJC2119
RefSeqiNP_033105.1, NM_009079.3
UniGeneiMm.307846

Genome annotation databases

EnsembliENSMUST00000103191; ENSMUSP00000099480; ENSMUSG00000028936
ENSMUST00000139685; ENSMUSP00000118787; ENSMUSG00000028936
ENSMUST00000188151; ENSMUSP00000140276; ENSMUSG00000028936
GeneIDi19934
KEGGimmu:19934
UCSCiuc008wah.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRL22_MOUSE
AccessioniPrimary (citable) accession number: P67984
Secondary accession number(s): P41104
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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