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Protein

Beta-lactoglobulin-1/B

Gene
N/A
Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule.

GO - Molecular functioni

Keywordsi

Molecular functionMilk protein
Biological processTransport
LigandRetinol-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactoglobulin-1/B
Short name:
Beta-LG
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei1257 Ovi a 5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 182 PublicationsAdd BLAST18
ChainiPRO_000001791019 – 180Beta-lactoglobulin-1/BAdd BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84 ↔ 178
Disulfide bondi124 ↔ 139Alternate
Disulfide bondi124 ↔ 137

Post-translational modificationi

Alternate disulfide bonds occur in equal amounts.

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP67976

Interactioni

Subunit structurei

Under physiological conditions beta-lactoglobulin exists as an equilibrium mixture of monomeric and dimeric forms.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 33Combined sources4
Beta strandi38 – 46Combined sources9
Helixi47 – 49Combined sources3
Beta strandi60 – 66Combined sources7
Beta strandi72 – 80Combined sources9
Beta strandi83 – 93Combined sources11
Beta strandi99 – 104Combined sources6
Beta strandi107 – 115Combined sources9
Beta strandi117 – 126Combined sources10
Beta strandi128 – 130Combined sources3
Helixi131 – 133Combined sources3
Beta strandi136 – 145Combined sources10
Helixi148 – 158Combined sources11
Beta strandi165 – 168Combined sources4
Helixi171 – 174Combined sources4
Turni177 – 179Combined sources3

3D structure databases

ProteinModelPortaliP67976
SMRiP67976
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG104361

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR002447 Blactoglobulin
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01172 BLCTOGLOBULN
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67976-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCLLLALGL ALACGVQAII VTQTMKGLDI QKVAGTWHSL AMAASDISLL
60 70 80 90 100
DAQSAPLRVY VEELKPTPEG NLEILLQKWE NGECAQKKII AEKTKIPAVF
110 120 130 140 150
KIDALNENKV LVLDTDYKKY LLFCMENSAE PEQSLACQCL VRTPEVDNEA
160 170 180
LEKFDKALKA LPMHIRLAFN PTQLEGQCHV
Length:180
Mass (Da):19,921
Last modified:August 1, 1988 - v1
Checksum:iBABC82E89E757333
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti38H → Y in lactoglobulin 2=A and 3=C. 1
Natural varianti166R → Q in lactoglobulin 3=C. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04520 mRNA Translation: CAA28204.1
X12817 Genomic DNA Translation: CAA31305.1
X07004
, X07005, X07006, X07007, X07008, X07009 Genomic DNA Translation: CAA30059.1 Sequence problems.
M32236
, M32233, M32232, M32235 Genomic DNA Translation: AAA31510.1
PIRiJQ0749 LGSH
RefSeqiNP_001009366.1, NM_001009366.1
UniGeneiOar.441

Genome annotation databases

GeneIDi443385
KEGGioas:443385

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLACB_SHEEP
AccessioniPrimary (citable) accession number: P67976
Secondary accession number(s): P02757
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1988
Last modified: January 31, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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