UniProtKB - P67970 (INS_CHICK)
Protein
Insulin
Gene
INS
Organism
Gallus gallus (Chicken)
Status
Functioni
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
GO - Biological processi
- cell population proliferation Source: AgBase
- gene expression Source: AgBase
- glucose metabolic process Source: UniProtKB-KW
- negative regulation of apoptotic process Source: AgBase
- neural retina development Source: AgBase
- positive regulation of gene expression Source: AgBase
Keywordsi
Molecular function | Hormone |
Biological process | Carbohydrate metabolism, Glucose metabolism |
Enzyme and pathway databases
Reactomei | R-GGA-264876, Insulin processing R-GGA-422085, Synthesis, secretion, and deacylation of Ghrelin R-GGA-6807878, COPI-mediated anterograde transport R-GGA-74713, IRS activation R-GGA-74749, Signal attenuation R-GGA-74751, Insulin receptor signalling cascade R-GGA-74752, Signaling by Insulin receptor R-GGA-77387, Insulin receptor recycling |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:INS |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: AgBase
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 1 PublicationAdd BLAST | 24 | |
PeptideiPRO_0000015790 | 25 – 54 | Insulin B chainAdd BLAST | 30 | |
PropeptideiPRO_0000015791 | 57 – 84 | C peptideAdd BLAST | 28 | |
PeptideiPRO_0000015792 | 87 – 107 | Insulin A chainAdd BLAST | 21 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 93 | Interchain (between B and A chains) | ||
Disulfide bondi | 43 ↔ 106 | Interchain (between B and A chains) | ||
Disulfide bondi | 92 ↔ 97 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondProteomic databases
PaxDbi | P67970 |
Interactioni
Subunit structurei
Heterodimer of a B chain and an A chain linked by two disulfide bonds.
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000010567 |
Family & Domainsi
Sequence similaritiesi
Belongs to the insulin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S5P5, Eukaryota |
GeneTreei | ENSGT00940000164327 |
HOGENOMi | CLU_140421_1_0_1 |
InParanoidi | P67970 |
OMAi | APPQHLC |
OrthoDBi | 1644517at2759 |
PhylomeDBi | P67970 |
TreeFami | TF332820 |
Family and domain databases
CDDi | cd04367, IlGF_insulin_like, 1 hit |
InterProi | View protein in InterPro IPR004825, Insulin IPR016179, Insulin-like IPR036438, Insulin-like_sf IPR022353, Insulin_CS IPR022352, Insulin_family |
PANTHERi | PTHR11454, PTHR11454, 1 hit |
Pfami | View protein in Pfam PF00049, Insulin, 1 hit |
PRINTSi | PR00277, INSULIN PR00276, INSULINFAMLY |
SMARTi | View protein in SMART SM00078, IlGF, 1 hit |
SUPFAMi | SSF56994, SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262, INSULIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P67970-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALWIRSLPL LALLVFSGPG TSYAAANQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
SPKARRDVEQ PLVSSPLRGE AGVLPFQQEE YEKVKRGIVE QCCHNTCSLY
QLENYCN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00416 Genomic DNA Translation: CAA23707.1 V00418 Genomic DNA Translation: CAA23708.1 X58993 mRNA Translation: CAA41738.1 AY438372 Genomic DNA Translation: AAR13049.1 |
PIRi | A90796, IPCH |
RefSeqi | NP_990553.1, NM_205222.3 |
Genome annotation databases
Ensembli | ENSGALT00000010581; ENSGALP00000010567; ENSGALG00000006552 |
GeneIDi | 396145 |
KEGGi | gga:396145 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00416 Genomic DNA Translation: CAA23707.1 V00418 Genomic DNA Translation: CAA23708.1 X58993 mRNA Translation: CAA41738.1 AY438372 Genomic DNA Translation: AAR13049.1 |
PIRi | A90796, IPCH |
RefSeqi | NP_990553.1, NM_205222.3 |
3D structure databases
SMRi | P67970 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000010567 |
Proteomic databases
PaxDbi | P67970 |
Genome annotation databases
Ensembli | ENSGALT00000010581; ENSGALP00000010567; ENSGALG00000006552 |
GeneIDi | 396145 |
KEGGi | gga:396145 |
Organism-specific databases
CTDi | 3630 |
Phylogenomic databases
eggNOGi | ENOG502S5P5, Eukaryota |
GeneTreei | ENSGT00940000164327 |
HOGENOMi | CLU_140421_1_0_1 |
InParanoidi | P67970 |
OMAi | APPQHLC |
OrthoDBi | 1644517at2759 |
PhylomeDBi | P67970 |
TreeFami | TF332820 |
Enzyme and pathway databases
Reactomei | R-GGA-264876, Insulin processing R-GGA-422085, Synthesis, secretion, and deacylation of Ghrelin R-GGA-6807878, COPI-mediated anterograde transport R-GGA-74713, IRS activation R-GGA-74749, Signal attenuation R-GGA-74751, Insulin receptor signalling cascade R-GGA-74752, Signaling by Insulin receptor R-GGA-77387, Insulin receptor recycling |
Miscellaneous databases
PROi | PR:P67970 |
Family and domain databases
CDDi | cd04367, IlGF_insulin_like, 1 hit |
InterProi | View protein in InterPro IPR004825, Insulin IPR016179, Insulin-like IPR036438, Insulin-like_sf IPR022353, Insulin_CS IPR022352, Insulin_family |
PANTHERi | PTHR11454, PTHR11454, 1 hit |
Pfami | View protein in Pfam PF00049, Insulin, 1 hit |
PRINTSi | PR00277, INSULIN PR00276, INSULINFAMLY |
SMARTi | View protein in SMART SM00078, IlGF, 1 hit |
SUPFAMi | SSF56994, SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262, INSULIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INS_CHICK | |
Accessioni | P67970Primary (citable) accession number: P67970 Secondary accession number(s): P01332, Q53YX4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | December 2, 2020 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families