UniProtKB - P67871 (CSK2B_MOUSE)
Casein kinase II subunit beta
Csnk2b
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 109 | ZincBy similarity | 1 | |
Metal bindingi | 114 | ZincBy similarity | 1 | |
Metal bindingi | 137 | ZincBy similarity | 1 | |
Metal bindingi | 140 | ZincBy similarity | 1 |
GO - Molecular functioni
- chromatin binding Source: MGI
- identical protein binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- protein domain specific binding Source: MGI
- protein kinase regulator activity Source: GO_Central
- protein serine/threonine kinase activity Source: MGI
- ribonucleoprotein complex binding Source: MGI
- signaling receptor binding Source: MGI
- transcription factor binding Source: MGI
GO - Biological processi
- adiponectin-activated signaling pathway Source: MGI
- endothelial tube morphogenesis Source: MGI
- negative regulation of blood vessel endothelial cell migration Source: MGI
- peptidyl-threonine phosphorylation Source: MGI
- positive regulation of activin receptor signaling pathway Source: MGI
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
- postsynaptic modulation of chemical synaptic transmission Source: MGI
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Wnt signaling pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-1483191, Synthesis of PC R-MMU-201688, WNT mediated activation of DVL R-MMU-2514853, Condensation of Prometaphase Chromosomes R-MMU-445144, Signal transduction by L1 R-MMU-6798695, Neutrophil degranulation R-MMU-6804756, Regulation of TP53 Activity through Phosphorylation R-MMU-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-MMU-8934903, Receptor Mediated Mitophagy R-MMU-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-MMU-8948751, Regulation of PTEN stability and activity |
Names & Taxonomyi
Protein namesi | Recommended name: Casein kinase II subunit betaShort name: CK II beta Alternative name(s): Phosvitin |
Gene namesi | Name:Csnk2b Synonyms:Ck2n |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88548, Csnk2b |
Subcellular locationi
Nucleus
- nuclear matrix Source: MGI
- nucleus Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cell projection Source: MGI
- chromatin Source: MGI
- cilium Source: MGI
- cytoplasm Source: MGI
- glutamatergic synapse Source: MGI
- postsynapse Source: GOC
- protein kinase CK2 complex Source: MGI
- Schaffer collateral - CA1 synapse Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000068237 | 2 – 215 | Casein kinase II subunit betaAdd BLAST | 214 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 2 | Phosphoserine; by autocatalysisBy similarityCurated | 1 | |
Modified residuei | 3 | Phosphoserine; by autocatalysisBy similarity | 1 | |
Modified residuei | 8 | PhosphoserineBy similarity | 1 | |
Modified residuei | 37 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 69 | PhosphoserineBy similarity | 1 | |
Modified residuei | 209 | PhosphoserineBy similarity | 1 | |
Modified residuei | 212 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 212 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P67871 |
jPOSTi | P67871 |
MaxQBi | P67871 |
PaxDbi | P67871 |
PRIDEi | P67871 |
TopDownProteomicsi | P67871 |
PTM databases
iPTMneti | P67871 |
PhosphoSitePlusi | P67871 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024387, Expressed in spermatid and 303 other tissues |
ExpressionAtlasi | P67871, baseline and differential |
Genevisiblei | P67871, MM |
Interactioni
Subunit structurei
Casein kinase II/CK2 is a tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions.
Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation (By similarity).
Interacts with DYNLT2.
Interacts with MUSK; mediates phosphorylation of MUSK by CK2.
Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1 (By similarity).
By similarityBinary interactionsi
Hide detailsP67871
GO - Molecular functioni
- identical protein binding Source: MGI
- protein domain specific binding Source: MGI
- signaling receptor binding Source: MGI
- transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198947, 27 interactors |
CORUMi | P67871 |
DIPi | DIP-35573N |
IntActi | P67871, 15 interactors |
MINTi | P67871 |
STRINGi | 10090.ENSMUSP00000025246 |
Miscellaneous databases
RNActi | P67871, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 188 – 193 | Interaction with alpha subunitBy similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 55 – 64 | Asp/Glu-rich (acidic) | 10 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3092, Eukaryota |
GeneTreei | ENSGT00390000003781 |
InParanoidi | P67871 |
OMAi | LCQSQPL |
PhylomeDBi | P67871 |
TreeFami | TF314462 |
Family and domain databases
Gene3Di | 1.10.1820.10, 1 hit |
InterProi | View protein in InterPro IPR016149, Casein_kin_II_reg-sub_N IPR035991, Casein_kinase_II_beta-like IPR000704, Casein_kinase_II_reg-sub |
PANTHERi | PTHR11740, PTHR11740, 1 hit |
Pfami | View protein in Pfam PF01214, CK_II_beta, 1 hit |
PRINTSi | PR00472, CASNKINASEII |
SMARTi | View protein in SMART SM01085, CK_II_beta, 1 hit |
SUPFAMi | SSF57798, SSF57798, 1 hit |
PROSITEi | View protein in PROSITE PS01101, CK2_BETA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL
60 70 80 90 100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK
110 120 130 140 150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ
210
LQAASNFKSP VKTIR
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3UZX4 | G3UZX4_MOUSE | Casein kinase II subunit beta | Csnk2b | 257 | Annotation score: | ||
G3UWU5 | G3UWU5_MOUSE | Casein kinase II subunit beta | Csnk2b | 58 | Annotation score: | ||
G3UZJ5 | G3UZJ5_MOUSE | Casein kinase II subunit beta | Csnk2b | 206 | Annotation score: | ||
G3UXG7 | G3UXG7_MOUSE | Casein kinase II subunit beta | Csnk2b | 164 | Annotation score: | ||
G3UZA4 | G3UZA4_MOUSE | Casein kinase II subunit beta | Csnk2b | 122 | Annotation score: | ||
G3UXU2 | G3UXU2_MOUSE | Casein kinase II subunit beta | Csnk2b | 180 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52959 mRNA Translation: CAA37132.1 X56502 mRNA Translation: CAA39857.1 X80685 Genomic DNA Translation: CAA56700.1 AF109719 Genomic DNA Translation: AAF03911.1 AK002903 mRNA Translation: BAB22445.1 AK010730 mRNA Translation: BAB27147.1 AK012369 mRNA Translation: BAB28193.1 AK146186 mRNA Translation: BAE26962.1 AK161330 mRNA Translation: BAE36328.1 BC003775 mRNA Translation: AAH03775.1 |
CCDSi | CCDS28684.1 |
PIRi | S14724 |
RefSeqi | NP_001290374.1, NM_001303445.1 NP_034105.1, NM_009975.3 |
Genome annotation databases
Ensembli | ENSMUST00000025246; ENSMUSP00000025246; ENSMUSG00000024387 ENSMUST00000173114; ENSMUSP00000134218; ENSMUSG00000024387 |
GeneIDi | 13001 |
KEGGi | mmu:13001 |
UCSCi | uc008cfu.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52959 mRNA Translation: CAA37132.1 X56502 mRNA Translation: CAA39857.1 X80685 Genomic DNA Translation: CAA56700.1 AF109719 Genomic DNA Translation: AAF03911.1 AK002903 mRNA Translation: BAB22445.1 AK010730 mRNA Translation: BAB27147.1 AK012369 mRNA Translation: BAB28193.1 AK146186 mRNA Translation: BAE26962.1 AK161330 mRNA Translation: BAE36328.1 BC003775 mRNA Translation: AAH03775.1 |
CCDSi | CCDS28684.1 |
PIRi | S14724 |
RefSeqi | NP_001290374.1, NM_001303445.1 NP_034105.1, NM_009975.3 |
3D structure databases
SMRi | P67871 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198947, 27 interactors |
CORUMi | P67871 |
DIPi | DIP-35573N |
IntActi | P67871, 15 interactors |
MINTi | P67871 |
STRINGi | 10090.ENSMUSP00000025246 |
Chemistry databases
ChEMBLi | CHEMBL4095 |
PTM databases
iPTMneti | P67871 |
PhosphoSitePlusi | P67871 |
Proteomic databases
EPDi | P67871 |
jPOSTi | P67871 |
MaxQBi | P67871 |
PaxDbi | P67871 |
PRIDEi | P67871 |
TopDownProteomicsi | P67871 |
Protocols and materials databases
Antibodypediai | 1045, 586 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000025246; ENSMUSP00000025246; ENSMUSG00000024387 ENSMUST00000173114; ENSMUSP00000134218; ENSMUSG00000024387 |
GeneIDi | 13001 |
KEGGi | mmu:13001 |
UCSCi | uc008cfu.2, mouse |
Organism-specific databases
CTDi | 1460 |
MGIi | MGI:88548, Csnk2b |
Phylogenomic databases
eggNOGi | KOG3092, Eukaryota |
GeneTreei | ENSGT00390000003781 |
InParanoidi | P67871 |
OMAi | LCQSQPL |
PhylomeDBi | P67871 |
TreeFami | TF314462 |
Enzyme and pathway databases
Reactomei | R-MMU-1483191, Synthesis of PC R-MMU-201688, WNT mediated activation of DVL R-MMU-2514853, Condensation of Prometaphase Chromosomes R-MMU-445144, Signal transduction by L1 R-MMU-6798695, Neutrophil degranulation R-MMU-6804756, Regulation of TP53 Activity through Phosphorylation R-MMU-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-MMU-8934903, Receptor Mediated Mitophagy R-MMU-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-MMU-8948751, Regulation of PTEN stability and activity |
Miscellaneous databases
BioGRID-ORCSi | 13001, 10 hits in 17 CRISPR screens |
ChiTaRSi | Csnk2b, mouse |
PROi | PR:P67871 |
RNActi | P67871, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024387, Expressed in spermatid and 303 other tissues |
ExpressionAtlasi | P67871, baseline and differential |
Genevisiblei | P67871, MM |
Family and domain databases
Gene3Di | 1.10.1820.10, 1 hit |
InterProi | View protein in InterPro IPR016149, Casein_kin_II_reg-sub_N IPR035991, Casein_kinase_II_beta-like IPR000704, Casein_kinase_II_reg-sub |
PANTHERi | PTHR11740, PTHR11740, 1 hit |
Pfami | View protein in Pfam PF01214, CK_II_beta, 1 hit |
PRINTSi | PR00472, CASNKINASEII |
SMARTi | View protein in SMART SM01085, CK_II_beta, 1 hit |
SUPFAMi | SSF57798, SSF57798, 1 hit |
PROSITEi | View protein in PROSITE PS01101, CK2_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSK2B_MOUSE | |
Accessioni | P67871Primary (citable) accession number: P67871 Secondary accession number(s): P07312, P13862, Q3TTJ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families