CSNK2B

Functionⁱ

Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.By similarity2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	109	Zinc	1
Metal bindingⁱ	114	Zinc	1
Metal bindingⁱ	137	Zinc	1
Metal bindingⁱ	140	Zinc	1

GO - Molecular functionⁱ

chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 25519132
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
metal ion binding Source: UniProtKB-KW
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11984006
protein kinase regulator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein serine/threonine kinase activity
Source: CAFA
Inferred from direct assayⁱ
- 15723517
ribonucleoprotein complex binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signaling receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19233263
- 19592636
transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 19324893

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adiponectin-activated signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 19233263
cellular protein-containing complex assembly
Source: BHF-UCL
Non-traceable author statementⁱ
- 19324893
endothelial tube morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19592636
liver regeneration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of blood vessel endothelial cell migration
Source: BHF-UCL
Inferred from direct assayⁱ
- 19592636
negative regulation of cell proliferation
Source: BHF-UCL
Traceable author statementⁱ
- 19324893
neutrophil degranulation Source: Reactome
peptidyl-threonine phosphorylation
Source: CAFA
Inferred from direct assayⁱ
- 15723517
positive regulation of activin receptor signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19592636
positive regulation of pathway-restricted SMAD protein phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 19592636
regulation of DNA binding
Source: BHF-UCL
Non-traceable author statementⁱ
- 19324893
regulation of signal transduction by p53 class mediator Source: Reactome
response to testosterone
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signal transduction
Source: UniProtKB
Traceable author statementⁱ
- 2513884
Wnt signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Wnt signaling pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1483191 Synthesis of PC R-HSA-201688 WNT mediated activation of DVL R-HSA-2514853 Condensation of Prometaphase Chromosomes R-HSA-445144 Signal transduction by L1 R-HSA-6798695 Neutrophil degranulation R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-8934903 Receptor Mediated Mitophagy R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8948751 Regulation of PTEN stability and activity
SignaLinkⁱ	P67870
SIGNORⁱ	P67870

Protein family/group databases

MoonDBⁱ	P67870 Predicted

MoonDBⁱ

P67870 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Casein kinase II subunit beta Short name: CK II beta Alternative name(s): Phosvitin Protein G5a
Gene namesⁱ	Name:CSNK2B Synonyms:CK2N, G5A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000204435.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2460 CSNK2B
MIMⁱ	115441 gene
neXtProtⁱ	NX_P67870

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1460
MalaCards human disease database More...MalaCardsⁱ	CSNK2B
Open Targets More...OpenTargetsⁱ	ENSG00000204435
Orphanetⁱ	178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBⁱ	PA26960

Chemistry databases

ChEMBLⁱ	CHEMBL2358

ChEMBLⁱ

CHEMBL2358

Polymorphism and mutation databases

DMDMⁱ	54037520

DMDMⁱ

54037520

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000068236	2 – 215	Casein kinase II subunit betaAdd BLAST		214

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	2	Phosphoserine; by autocatalysis1 Publication	1
Modified residueⁱ	3	Phosphoserine; by autocatalysis1 Publication	1
Modified residueⁱ	8	PhosphoserineCombined sources	1
Modified residueⁱ	37	PhosphothreonineCombined sources	1
Modified residueⁱ	69	PhosphoserineCombined sources	1
Modified residueⁱ	209	PhosphoserineCombined sources	1
Modified residueⁱ	212	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	212	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Post-translational modificationⁱ

Phosphorylated by alpha subunit.2 Publications

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P67870
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P67870
PaxDbⁱ	P67870
PeptideAtlas More...PeptideAtlasⁱ	P67870
PRIDEⁱ	P67870
ProteomicsDBⁱ	57524

PTM databases

iPTMnetⁱ	P67870
PhosphoSitePlusⁱ	P67870

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000204435 Expressed in 86 organ(s), highest expression level in right testis
CleanExⁱ	HS_CSNK2B
ExpressionAtlasⁱ	P67870 baseline and differential
Genevisibleⁱ	P67870 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004349 CAB013087 CAB016059 HPA005944

HPAⁱ

CAB004349
CAB013087
CAB016059
HPA005944

Interactionⁱ

Subunit structureⁱ

Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.By similarity7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		7	EBI-348169,EBI-348169
Arntl	Q9WTL8	4	EBI-348169,EBI-644534	From Mus musculus.
CACNA1A	O00555	2	EBI-348169,EBI-766279
CBX4	O00257-3	2	EBI-348169,EBI-4392727
Clip1	Q9JK25	2	EBI-348169,EBI-908338	From Rattus norvegicus.
Clock	O08785	2	EBI-348169,EBI-79859	From Mus musculus.
Cry1	P97784	2	EBI-348169,EBI-1266607	From Mus musculus.
CSNK2A1	P68400	22	EBI-348169,EBI-347804
CSNK2A2	P19784	10	EBI-348169,EBI-347451
PACS1	Q6VY07	3	EBI-348169,EBI-2555014
RNF2	Q99496	2	EBI-348169,EBI-722416
SIRT1	Q96EB6	5	EBI-348169,EBI-1802965

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107843, 325 interactors
CORUMⁱ	P67870
Database of interacting proteins More...DIPⁱ	DIP-131N
IntActⁱ	P67870, 219 interactors
Molecular INTeraction database More...MINTⁱ	P67870
STRINGⁱ	9606.ENSP00000365025

Chemistry databases

BindingDBⁱ

P67870

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	9 – 15	Combined sources	7
Turnⁱ	17 – 20	Combined sources	4
Helixⁱ	27 – 31	Combined sources	5
Helixⁱ	33 – 36	Combined sources	4
Helixⁱ	39 – 41	Combined sources	3
Beta strandⁱ	43 – 45	Combined sources	3
Helixⁱ	46 – 53	Combined sources	8
Beta strandⁱ	59 – 61	Combined sources	3
Helixⁱ	67 – 87	Combined sources	21
Helixⁱ	91 – 102	Combined sources	12
Turnⁱ	103 – 106	Combined sources	4
Helixⁱ	112 – 114	Combined sources	3
Beta strandⁱ	120 – 122	Combined sources	3
Beta strandⁱ	134 – 136	Combined sources	3
Turnⁱ	138 – 140	Combined sources	3
Beta strandⁱ	142 – 144	Combined sources	3
Helixⁱ	149 – 151	Combined sources	3
Beta strandⁱ	152 – 155	Combined sources	4
Helixⁱ	156 – 158	Combined sources	3
Turnⁱ	159 – 162	Combined sources	4
Helixⁱ	163 – 170	Combined sources	8
Helixⁱ	172 – 174	Combined sources	3
Beta strandⁱ	187 – 189	Combined sources	3
Beta strandⁱ	190 – 192	Combined sources	3
Helixⁱ	195 – 198	Combined sources	4
Turnⁱ	199 – 201	Combined sources	3
Helixⁱ	202 – 205	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P67870
SMRⁱ	P67870
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P67870

EvolutionaryTraceⁱ

P67870

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	188 – 193	Interaction with alpha subunitBy similarity		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	55 – 64	Asp/Glu-rich (acidic)		10

Sequence similaritiesⁱ

Belongs to the casein kinase 2 subunit beta family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3092 Eukaryota COG5041 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003781
HOGENOMⁱ	HOG000039270
HOVERGENⁱ	HBG051131
InParanoidⁱ	P67870
KEGG Orthology (KO) More...KOⁱ	K03115
PhylomeDBⁱ	P67870
TreeFamⁱ	TF314462

Family and domain databases

Gene3Dⁱ	1.10.1820.10, 1 hit
InterProⁱ	View protein in InterPro IPR016149 Casein_kin_II_reg-sub_N IPR035991 Casein_kinase_II_beta_like IPR000704 Casein_kinase_II_reg-sub
PANTHERⁱ	PTHR11740 PTHR11740, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01214 CK_II_beta, 1 hit
PRINTSⁱ	PR00472 CASNKINASEII
SMARTⁱ	View protein in SMART SM01085 CK_II_beta, 1 hit
SUPFAMⁱ	SSF57798 SSF57798, 1 hit
PROSITEⁱ	View protein in PROSITE PS01101 CK2_BETA, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show all Align All

P67870-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL 
        60         70         80         90        100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK 
       110        120        130        140        150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR 
       160        170        180        190        200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ 
       210 
LQAASNFKSP VKTIR

Length:215

Mass (Da):24,942

Last modified:October 11, 2004 - v1

Checksum:ⁱE465B1E699B0E0EC

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5SRQ6	Q5SRQ6_HUMAN	Casein kinase II subunit beta Casein kinase II subunit beta, CK II beta	CSNK2B hCG_43725	234	Annotation score:
Q5SRQ3	Q5SRQ3_HUMAN	Casein kinase II subunit beta Casein kinase II subunit beta, CK II beta	CSNK2B CSNK2B-LY6G5B-1181	228	Annotation score:
N0E644	N0E644_HUMAN	Casein kinase II subunit beta Casein kinase II subunit beta, CK II beta	CSNK2B CSNK2B-LY6G5B-562	161	Annotation score:
A0A0G2JM58	A0A0G2JM58_HUMAN	Casein kinase II subunit beta Casein kinase II subunit beta, CK II beta	CSNK2B	161	Annotation score:
N0E472	N0E472_HUMAN	Casein kinase II subunit beta Casein kinase II subunit beta (Chimera CSNK2B-LY6G5B splicing isoform 991)	CSNK2B CSNK2B-LY6G5B--991	304	Annotation score:
A0A0G2JM12	A0A0G2JM12_HUMAN	Casein kinase II subunit beta Casein kinase II subunit beta	CSNK2B	304	Annotation score:
H0Y6P8	H0Y6P8_HUMAN	Uncharacterized protein Uncharacterized protein		212	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	194	P → A in AAA52123 (PubMed:2513884).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X16937 mRNA Translation: CAA34811.1 X16312 mRNA Translation: CAA34379.1 M30448 mRNA Translation: AAA52123.1 X57152 Genomic DNA Translation: CAA40442.1 AY113186 mRNA Translation: AAM50092.1 CR541699 mRNA Translation: CAG46500.1 AF129756 Genomic DNA Translation: AAD18081.1 BA000025 Genomic DNA Translation: BAB63386.1 DQ314868 Genomic DNA Translation: ABC40727.1 AK311860 mRNA Translation: BAG34801.1 AL662899 Genomic DNA No translation available. AL670886 Genomic DNA No translation available. AL805934 Genomic DNA No translation available. BX511262 Genomic DNA No translation available. CR354443 Genomic DNA No translation available. CR753842 Genomic DNA No translation available. CR759761 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03473.1 BC112017 mRNA Translation: AAI12018.1 BC112019 mRNA Translation: AAI12020.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4712.1
PIRⁱ	A39459
NCBI Reference Sequences More...RefSeqⁱ	NP_001269314.1, NM_001282385.1 NP_001311.3, NM_001320.6
UniGeneⁱ	Hs.73527

Genome annotation databases

Ensemblⁱ	ENST00000375865; ENSP00000365025; ENSG00000204435 ENST00000375866; ENSP00000365026; ENSG00000204435 ENST00000375882; ENSP00000365042; ENSG00000204435 ENST00000383427; ENSP00000372919; ENSG00000206406 ENST00000383433; ENSP00000372925; ENSG00000206406 ENST00000400110; ENSP00000382980; ENSG00000206406 ENST00000412802; ENSP00000413469; ENSG00000224774 ENST00000418230; ENSP00000411322; ENSG00000228875 ENST00000422567; ENSP00000407018; ENSG00000224398 ENST00000429633; ENSP00000409510; ENSG00000230700 ENST00000431476; ENSP00000394855; ENSG00000224398 ENST00000436169; ENSP00000412520; ENSG00000224398 ENST00000443673; ENSP00000400188; ENSG00000230700 ENST00000448596; ENSP00000391038; ENSG00000232960 ENST00000451917; ENSP00000415303; ENSG00000224774 ENST00000452985; ENSP00000415237; ENSG00000228875 ENST00000453234; ENSP00000395275; ENSG00000224774 ENST00000454382; ENSP00000390900; ENSG00000232960 ENST00000454511; ENSP00000393756; ENSG00000232960 ENST00000455161; ENSP00000407379; ENSG00000230700 ENST00000458330; ENSP00000410802; ENSG00000228875
GeneIDⁱ	1460
KEGGⁱ	hsa:1460
UCSC genome browser More...UCSCⁱ	uc003nvr.3 human

Protein	Similar proteins		Species	Score	Length	Source
P67870	Casein kinase II subunit beta		BOVIN		215	UniRef100_P67870
Casein kinase II subunit beta		CHICK		215
Casein kinase II subunit beta		MOUSE		215
Casein kinase II subunit beta		PIG		215
Casein kinase II subunit beta		RABIT		215
+57

Protein	Similar proteins		Species	Score	Length	Source
P67870	Casein kinase II subunit beta		BOVIN		215	UniRef90_P67870
Casein kinase II subunit beta		CHICK		215
Casein kinase II subunit beta		MOUSE		215
Casein kinase II subunit beta		PIG		215
Casein kinase II subunit beta		RABIT		215
+67

Protein	Similar proteins		Species	Score	Length	Source
P67870	Casein kinase II subunit beta		BOVIN		215	UniRef50_P67870
Casein kinase II subunit beta		CHICK		215
Casein kinase II subunit beta		MOUSE		215
Casein kinase II subunit beta		PIG		215
Casein kinase II subunit beta		RABIT		215
+613

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X16937 mRNA Translation: CAA34811.1 X16312 mRNA Translation: CAA34379.1 M30448 mRNA Translation: AAA52123.1 X57152 Genomic DNA Translation: CAA40442.1 AY113186 mRNA Translation: AAM50092.1 CR541699 mRNA Translation: CAG46500.1 AF129756 Genomic DNA Translation: AAD18081.1 BA000025 Genomic DNA Translation: BAB63386.1 DQ314868 Genomic DNA Translation: ABC40727.1 AK311860 mRNA Translation: BAG34801.1 AL662899 Genomic DNA No translation available. AL670886 Genomic DNA No translation available. AL805934 Genomic DNA No translation available. BX511262 Genomic DNA No translation available. CR354443 Genomic DNA No translation available. CR753842 Genomic DNA No translation available. CR759761 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03473.1 BC112017 mRNA Translation: AAI12018.1 BC112019 mRNA Translation: AAI12020.1
CCDSⁱ	CCDS4712.1
PIRⁱ	A39459
RefSeqⁱ	NP_001269314.1, NM_001282385.1 NP_001311.3, NM_001320.6
UniGeneⁱ	Hs.73527

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1DS5	X-ray	3.16	E/F/G/H	181-203	[»]
	1JWH	X-ray	3.10	C/D	1-215	[»]
	1QF8	X-ray	1.74	A/B	1-182	[»]
	3EED	X-ray	2.80	A/B	1-193	[»]
	4DGL	X-ray	3.00	A/B	1-215	[»]
	4MD7	X-ray	3.10	A/B/C/D	1-215	[»]
	4MD8	X-ray	3.30	A/B/C/D	1-215	[»]
	4MD9	X-ray	3.50	A/B/C/D/I/J/N/O	1-215	[»]
	4NH1	X-ray	3.30	C/D	1-215	[»]
ProteinModelPortalⁱ	P67870
SMRⁱ	P67870
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107843, 325 interactors
CORUMⁱ	P67870
DIPⁱ	DIP-131N
IntActⁱ	P67870, 219 interactors
MINTⁱ	P67870
STRINGⁱ	9606.ENSP00000365025

Chemistry databases

BindingDBⁱ	P67870
ChEMBLⁱ	CHEMBL2358

Protein family/group databases

MoonDBⁱ	P67870 Predicted

MoonDBⁱ

P67870 Predicted

PTM databases

iPTMnetⁱ	P67870
PhosphoSitePlusⁱ	P67870

Polymorphism and mutation databases

DMDMⁱ	54037520

DMDMⁱ

54037520

Proteomic databases

EPDⁱ	P67870
MaxQBⁱ	P67870
PaxDbⁱ	P67870
PeptideAtlasⁱ	P67870
PRIDEⁱ	P67870
ProteomicsDBⁱ	57524

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1460
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000375865; ENSP00000365025; ENSG00000204435 ENST00000375866; ENSP00000365026; ENSG00000204435 ENST00000375882; ENSP00000365042; ENSG00000204435 ENST00000383427; ENSP00000372919; ENSG00000206406 ENST00000383433; ENSP00000372925; ENSG00000206406 ENST00000400110; ENSP00000382980; ENSG00000206406 ENST00000412802; ENSP00000413469; ENSG00000224774 ENST00000418230; ENSP00000411322; ENSG00000228875 ENST00000422567; ENSP00000407018; ENSG00000224398 ENST00000429633; ENSP00000409510; ENSG00000230700 ENST00000431476; ENSP00000394855; ENSG00000224398 ENST00000436169; ENSP00000412520; ENSG00000224398 ENST00000443673; ENSP00000400188; ENSG00000230700 ENST00000448596; ENSP00000391038; ENSG00000232960 ENST00000451917; ENSP00000415303; ENSG00000224774 ENST00000452985; ENSP00000415237; ENSG00000228875 ENST00000453234; ENSP00000395275; ENSG00000224774 ENST00000454382; ENSP00000390900; ENSG00000232960 ENST00000454511; ENSP00000393756; ENSG00000232960 ENST00000455161; ENSP00000407379; ENSG00000230700 ENST00000458330; ENSP00000410802; ENSG00000228875
GeneIDⁱ	1460
KEGGⁱ	hsa:1460
UCSCⁱ	uc003nvr.3 human

Organism-specific databases

CTDⁱ	1460
DisGeNETⁱ	1460
EuPathDBⁱ	HostDB:ENSG00000204435.13
GeneCardsⁱ	CSNK2B
HGNCⁱ	HGNC:2460 CSNK2B
HPAⁱ	CAB004349 CAB013087 CAB016059 HPA005944
MalaCardsⁱ	CSNK2B
MIMⁱ	115441 gene
neXtProtⁱ	NX_P67870
OpenTargetsⁱ	ENSG00000204435
Orphanetⁱ	178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBⁱ	PA26960
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3092 Eukaryota COG5041 LUCA
GeneTreeⁱ	ENSGT00390000003781
HOGENOMⁱ	HOG000039270
HOVERGENⁱ	HBG051131
InParanoidⁱ	P67870
KOⁱ	K03115
PhylomeDBⁱ	P67870
TreeFamⁱ	TF314462

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1483191 Synthesis of PC R-HSA-201688 WNT mediated activation of DVL R-HSA-2514853 Condensation of Prometaphase Chromosomes R-HSA-445144 Signal transduction by L1 R-HSA-6798695 Neutrophil degranulation R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-8934903 Receptor Mediated Mitophagy R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8948751 Regulation of PTEN stability and activity
SignaLinkⁱ	P67870
SIGNORⁱ	P67870

Miscellaneous databases

ChiTaRSⁱ	CSNK2B human
EvolutionaryTraceⁱ	P67870
GeneWikiⁱ	CSNK2B
GenomeRNAiⁱ	1460
Protein Ontology More...PROⁱ	PR:P67870
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000204435 Expressed in 86 organ(s), highest expression level in right testis
CleanExⁱ	HS_CSNK2B
ExpressionAtlasⁱ	P67870 baseline and differential
Genevisibleⁱ	P67870 HS

Family and domain databases

Gene3Dⁱ	1.10.1820.10, 1 hit
InterProⁱ	View protein in InterPro IPR016149 Casein_kin_II_reg-sub_N IPR035991 Casein_kinase_II_beta_like IPR000704 Casein_kinase_II_reg-sub
PANTHERⁱ	PTHR11740 PTHR11740, 1 hit
Pfamⁱ	View protein in Pfam PF01214 CK_II_beta, 1 hit
PRINTSⁱ	PR00472 CASNKINASEII
SMARTⁱ	View protein in SMART SM01085 CK_II_beta, 1 hit
SUPFAMⁱ	SSF57798 SSF57798, 1 hit
PROSITEⁱ	View protein in PROSITE PS01101 CK2_BETA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CSK2B_HUMAN
Accessionⁱ	P67870Primary (citable) accession number: P67870 Secondary accession number(s): B0UXA9 , P07312, P13862, Q4VX47
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
	Last sequence update:	October 11, 2004
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniProtKB - P67870 (CSK2B_HUMAN)

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Casein kinase II subunit beta

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ