Casein kinase II subunit beta

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "An AUTS2-polycomb complex activates gene expression in the CNS."
    Gao Z., Lee P., Stafford J.M., von Schimmelmann M., Schaefer A., Reinberg D.
    Nature 516:349-354(2014) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins."
    Kusk M., Ahmed R., Thomsen B., Bendixen C., Issinger O.G., Boldyreff B.
    Mol Cell Biochem 191:51-58(1999) [PubMed] [Europe PMC] [Abstract]
  • "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region."
    Lehner B., Semple J.I., Brown S.E., Counsell D., Campbell R.D., Sanderson C.M.
    Genomics 83:153-167(2004) [PubMed] [Europe PMC] [Abstract]
  • "Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells."
    Vandamme J., Volkel P., Rosnoblet C., Le Faou P., Angrand P.O.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  • "Toward an understanding of the protein interaction network of the human liver."
    Wang J., Huo K., Ma L., Tang L., Li D., Huang X., Yuan Y., Li C., Wang W., Guan W., Chen H., Jin C., Wei J., Zhang W., Yang Y., Liu Q., Zhou Y., Zhang C.

    , Wu Z., Xu W., Zhang Y., Liu T., Yu D., Zhang Y., Chen L., Zhu D., Zhong X., Kang L., Gan X., Yu X., Ma Q., Yan J., Zhou L., Liu Z., Zhu Y., Zhou T., He F., Yang X.
    Mol Syst Biol 7:536-536(2011) [PubMed] [Europe PMC] [Abstract]
  • "Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions."
    Wallach T., Schellenberg K., Maier B., Kalathur R.K., Porras P., Wanker E.E., Futschik M.E., Kramer A.
    PLoS Genet 9:e1003398-e1003398(2013) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• protein domain specific binding Source: UniProtKBInferred from physical interactionⁱ
  • "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins."
    Tchernev V.T., Mansfield T.A., Giot L., Kumar A.M., Nandabalan K., Li Y., Mishra V.S., Detter J.C., Rothberg J.M., Wallace M.R., Southwick F.S., Kingsmore S.F.
    Mol. Med. 8:56-64(2002) [PubMed] [Europe PMC] [Abstract]
• protein kinase regulator activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein serine/threonine kinase activity Source: CAFAInferred from direct assayⁱ
  • "Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1."
    Abbott K.L., Archambault J., Xiao H., Nguyen B.D., Roeder R.G., Greenblatt J., Omichinski J.G., Legault P.
    Biochemistry 44:2716-2731(2005) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling."
    Heiker J.T., Wottawah C.M., Juhl C., Kosel D., Morl K., Beck-Sickinger A.G.
    Cell Signal 21:936-942(2009) [PubMed] [Europe PMC] [Abstract]
  • "Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling."
    Lee N.Y., Haney J.C., Sogani J., Blobe G.C.
    FASEB J 23:3712-3721(2009) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding."
    Soufi A., Noy P., Buckle M., Sawasdichai A., Gaston K., Jayaraman P.S.
    Nucleic Acids Res 37:3288-3300(2009) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adiponectin-activated signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling."
    Heiker J.T., Wottawah C.M., Juhl C., Kosel D., Morl K., Beck-Sickinger A.G.
    Cell Signal 21:936-942(2009) [PubMed] [Europe PMC] [Abstract]
• cellular protein-containing complex assembly Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding."
    Soufi A., Noy P., Buckle M., Sawasdichai A., Gaston K., Jayaraman P.S.
    Nucleic Acids Res 37:3288-3300(2009) [PubMed] [Europe PMC] [Abstract]
• endothelial tube morphogenesis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling."
    Lee N.Y., Haney J.C., Sogani J., Blobe G.C.
    FASEB J 23:3712-3721(2009) [PubMed] [Europe PMC] [Abstract]
• macroautophagy Source: Reactome
• negative regulation of blood vessel endothelial cell migration Source: BHF-UCLInferred from direct assayⁱ
  • "Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling."
    Lee N.Y., Haney J.C., Sogani J., Blobe G.C.
    FASEB J 23:3712-3721(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding."
    Soufi A., Noy P., Buckle M., Sawasdichai A., Gaston K., Jayaraman P.S.
    Nucleic Acids Res 37:3288-3300(2009) [PubMed] [Europe PMC] [Abstract]
• neutrophil degranulation Source: Reactome
• peptidyl-threonine phosphorylation Source: CAFAInferred from direct assayⁱ
  • "Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1."
    Abbott K.L., Archambault J., Xiao H., Nguyen B.D., Roeder R.G., Greenblatt J., Omichinski J.G., Legault P.
    Biochemistry 44:2716-2731(2005) [PubMed] [Europe PMC] [Abstract]
• phosphatidylcholine biosynthetic process Source: Reactome
• positive regulation of activin receptor signaling pathway Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling."
    Lee N.Y., Haney J.C., Sogani J., Blobe G.C.
    FASEB J 23:3712-3721(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • "Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling."
    Lee N.Y., Haney J.C., Sogani J., Blobe G.C.
    FASEB J 23:3712-3721(2009) [PubMed] [Europe PMC] [Abstract]
• protein folding Source: Reactome
• regulation of DNA binding Source: BHF-UCLNon-traceable author statementⁱ
  • "CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding."
    Soufi A., Noy P., Buckle M., Sawasdichai A., Gaston K., Jayaraman P.S.
    Nucleic Acids Res 37:3288-3300(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of signal transduction by p53 class mediator Source: Reactome
• signal transduction Source: UniProtKBTraceable author statementⁱ
  • Ref.3

    "Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II."
    Heller-Harrison R.A., Meisner H., Czech M.P.
    Biochemistry 28:9053-9058(1989) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• Wnt signaling pathway Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins."
    Kusk M., Ahmed R., Thomsen B., Bendixen C., Issinger O.G., Boldyreff B.
    Mol Cell Biochem 191:51-58(1999) [PubMed] [Europe PMC] [Abstract]
  • "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region."
    Lehner B., Semple J.I., Brown S.E., Counsell D., Campbell R.D., Sanderson C.M.
    Genomics 83:153-167(2004) [PubMed] [Europe PMC] [Abstract]
  • "Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells."
    Vandamme J., Volkel P., Rosnoblet C., Le Faou P., Angrand P.O.
    Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  • "Toward an understanding of the protein interaction network of the human liver."
    Wang J., Huo K., Ma L., Tang L., Li D., Huang X., Yuan Y., Li C., Wang W., Guan W., Chen H., Jin C., Wei J., Zhang W., Yang Y., Liu Q., Zhou Y., Zhang C.

    , Wu Z., Xu W., Zhang Y., Liu T., Yu D., Zhang Y., Chen L., Zhu D., Zhong X., Kang L., Gan X., Yu X., Ma Q., Yan J., Zhou L., Liu Z., Zhu Y., Zhou T., He F., Yang X.
    Mol Syst Biol 7:536-536(2011) [PubMed] [Europe PMC] [Abstract]
  • "Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions."
    Wallach T., Schellenberg K., Maier B., Kalathur R.K., Porras P., Wanker E.E., Futschik M.E., Kramer A.
    PLoS Genet 9:e1003398-e1003398(2013) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: UniProtKBInferred from physical interactionⁱ
  • "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins."
    Tchernev V.T., Mansfield T.A., Giot L., Kumar A.M., Nandabalan K., Li Y., Mishra V.S., Detter J.C., Rothberg J.M., Wallace M.R., Southwick F.S., Kingsmore S.F.
    Mol. Med. 8:56-64(2002) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling."
    Heiker J.T., Wottawah C.M., Juhl C., Kosel D., Morl K., Beck-Sickinger A.G.
    Cell Signal 21:936-942(2009) [PubMed] [Europe PMC] [Abstract]
  • "Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling."
    Lee N.Y., Haney J.C., Sogani J., Blobe G.C.
    FASEB J 23:3712-3721(2009) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding."
    Soufi A., Noy P., Buckle M., Sawasdichai A., Gaston K., Jayaraman P.S.
    Nucleic Acids Res 37:3288-3300(2009) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL 
        60         70         80         90        100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK 
       110        120        130        140        150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR 
       160        170        180        190        200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ 
       210 
LQAASNFKSP VKTIR                                       

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 6
   Human chromosome 6: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
6. SIMILARITY comments
   Index of protein domains and families