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UniProtKB - P67870 (CSK2B_HUMAN)

Entry version 185 (29 Sep 2021)
Sequence version 1 (11 Oct 2004)
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Protein

Casein kinase II subunit beta

Gene

CSNK2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610).

Participates in Wnt signaling (By similarity).

By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi109Zinc1
Metal bindingi114Zinc1
Metal bindingi137Zinc1
Metal bindingi140Zinc1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P67870

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1483191, Synthesis of PC
R-HSA-201688, WNT mediated activation of DVL
R-HSA-2514853, Condensation of Prometaphase Chromosomes
R-HSA-445144, Signal transduction by L1
R-HSA-6798695, Neutrophil degranulation
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8932339, ROS sensing by NFE2L2
R-HSA-8934903, Receptor Mediated Mitophagy
R-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8948751, Regulation of PTEN stability and activity

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P67870

SIGNOR Signaling Network Open Resource

More...SIGNORi		P67870

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P67870, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Alternative name(s):
Phosvitin
Protein G5a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSNK2B
Synonyms:CK2N, G5A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2460, CSNK2B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		115441, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P67870

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000204435

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Poirier-Bienvenu neurodevelopmental syndrome (POBINDS)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant neurodevelopmental disorder characterized by onset of seizures in infancy, developmental delay, impaired intellectual development, and poor or absent speech.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0836505 – 215Missing in POBINDS; associated in cis with C-86. 1 PublicationAdd BLAST211
Natural variantiVAR_08365186R → C in POBINDS; unknown pathological significance; associated in cis with 5-E--R-215 del. 1 Publication1
Natural variantiVAR_083652111R → P in POBINDS. 1 Publication1
Natural variantiVAR_083653137C → F in POBINDS. 1 Publication1
Natural variantiVAR_083654137C → G in POBINDS. 1 Publication1
Natural variantiVAR_083655187L → R in POBINDS. 1 Publication1

Keywords - Diseasei

Disease variant, Epilepsy, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		1460

MalaCards human disease database

More...MalaCardsi		CSNK2B
MIMi618732, phenotype

Open Targets

More...OpenTargetsi		ENSG00000204435

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		178469, Autosomal dominant non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26960

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P67870, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2358

Drug and drug target database

More...DrugBanki		DB00171, ATP
DB04216, Quercetin

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CSNK2B

Domain mapping of disease mutations (DMDM)

More...DMDMi		54037520

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000682362 – 215Casein kinase II subunit betaAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei2Phosphoserine; by autocatalysis1 Publication1
Modified residuei3Phosphoserine; by autocatalysis1 Publication1
Modified residuei8PhosphoserineCombined sources1
Modified residuei37PhosphothreonineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei212N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by alpha subunit.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P67870

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P67870

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P67870

MaxQB - The MaxQuant DataBase

More...MaxQBi		P67870

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P67870

PeptideAtlas

More...PeptideAtlasi		P67870

PRoteomics IDEntifications database

More...PRIDEi		P67870

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57524

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P67870, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P67870

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P67870

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P67870

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P67870

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204435, Expressed in right testis and 113 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P67870, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P67870, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204435, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Casein kinase II/CK2 is a tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions.

Interacts with DYNLT2 (By similarity).

Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation.

Interacts with MUSK; mediates phosphorylation of MUSK by CK2.

Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.

By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P67870
With#Exp.IntAct
BANP - isoform 2 [Q8N9N5-2]3EBI-348169,EBI-11524452
CACNA1A [O00555]2EBI-348169,EBI-766279
CBX4 - isoform 2 [O00257-3]2EBI-348169,EBI-4392727
CSNK2A1 [P68400]26EBI-348169,EBI-347804
CSNK2A2 [P19784]13EBI-348169,EBI-347451
itself7EBI-348169,EBI-348169
CST1 [P01037]3EBI-348169,EBI-1056240
FAM86C1P - isoform 2 [Q9NVL1-2]3EBI-348169,EBI-12845222
GLIS2 [Q9BZE0]3EBI-348169,EBI-7251368
hCG_2003792 [A0A024R5S0]3EBI-348169,EBI-10188461
HOXB5 [P09067]3EBI-348169,EBI-3893317
INO80B [Q9C086]3EBI-348169,EBI-715611
MGC50722 [Q8IVT4]3EBI-348169,EBI-14086479
NGDN [Q8NEJ9]3EBI-348169,EBI-9995414
NRF1 - isoform 4 [Q16656-4]3EBI-348169,EBI-11742836
NTAQ1 [Q96HA8]3EBI-348169,EBI-741158
PACS1 [Q6VY07]3EBI-348169,EBI-2555014
PIMREG [Q9BSJ6]3EBI-348169,EBI-2568609
PTTG2 - isoform 2 [Q9NZH5-2]3EBI-348169,EBI-17630019
RBM39 [Q14498]3EBI-348169,EBI-395290
RNF2 [Q99496]2EBI-348169,EBI-722416
RPS6KA3 [P51812]3EBI-348169,EBI-1046616
SELI [Q8WU57]3EBI-348169,EBI-751012
SIRT1 [Q96EB6]5EBI-348169,EBI-1802965
TFAP2D [Q7Z6R9]3EBI-348169,EBI-11952651
TLX3 [O43711]3EBI-348169,EBI-3939165
TRIM54 [Q9BYV2]3EBI-348169,EBI-2130429
TWF1 [Q12792]3EBI-348169,EBI-1056675
WWOX - isoform 5 [Q9NZC7-5]3EBI-348169,EBI-12040603
ZNF19 [P17023]3EBI-348169,EBI-12884200
ZNF410 - isoform 3 [Q86VK4-3]3EBI-348169,EBI-11741890
Arntl [Q9WTL8] from Mus musculus.4EBI-348169,EBI-644534
Clip1 [Q9JK25] from Rattus norvegicus.2EBI-348169,EBI-908338
Clock [O08785] from Mus musculus.2EBI-348169,EBI-79859
Cry1 [P97784] from Mus musculus.2EBI-348169,EBI-1266607

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107843, 408 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2428, Casein kinase II complex, CSNK2A2 variant
CPX-2437, Casein kinase II complex, CSNK2A1-CNSK2A2 variant
CPX-914, Casein kinase II complex, CSNK2A1 variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P67870

Database of interacting proteins

More...DIPi		DIP-131N

Protein interaction database and analysis system

More...IntActi		P67870, 254 interactors

Molecular INTeraction database

More...MINTi		P67870

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365042

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P67870

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P67870, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P67870

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P67870

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni188 – 193Interaction with alpha subunitBy similarity6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the casein kinase 2 subunit beta family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3092, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003781

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034027_3_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P67870

Database of Orthologous Groups

More...OrthoDBi		1335521at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P67870

TreeFam database of animal gene trees

More...TreeFami		TF314462

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1820.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016149, Casein_kin_II_reg-sub_N
IPR035991, Casein_kinase_II_beta-like
IPR000704, Casein_kinase_II_reg-sub

The PANTHER Classification System

More...PANTHERi		PTHR11740, PTHR11740, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01214, CK_II_beta, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00472, CASNKINASEII

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01085, CK_II_beta, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57798, SSF57798, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01101, CK2_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

P67870-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL 
        60         70         80         90        100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK 
       110        120        130        140        150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR 
       160        170        180        190        200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ 
       210 
LQAASNFKSP VKTIR
Length:215
Mass (Da):24,942
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE465B1E699B0E0EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SRQ3Q5SRQ3_HUMAN
Casein kinase II subunit beta
CSNK2B CSNK2B-LY6G5B-1181
228Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SRQ6Q5SRQ6_HUMAN
Casein kinase II subunit beta
CSNK2B hCG_43725
234Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
N0E644N0E644_HUMAN
Casein kinase II subunit beta
CSNK2B CSNK2B-LY6G5B-562
161Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM58A0A0G2JM58_HUMAN
Casein kinase II subunit beta
CSNK2B
161Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V500A0A7I2V500_HUMAN
Casein kinase II subunit beta
CSNK2B
98Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2YQ78A0A7I2YQ78_HUMAN
Casein kinase II subunit beta
CSNK2B
231Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2YQQ2A0A7I2YQQ2_HUMAN
Casein kinase II subunit beta
CSNK2B
164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
N0E472N0E472_HUMAN
Casein kinase II subunit beta
CSNK2B CSNK2B-LY6G5B--991
304Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM12A0A0G2JM12_HUMAN
Casein kinase II subunit beta
CSNK2B
304Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6P8H0Y6P8_HUMAN
Uncharacterized protein
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti194P → A in AAA52123 (PubMed:2513884).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0836505 – 215Missing in POBINDS; associated in cis with C-86. 1 PublicationAdd BLAST211
Natural variantiVAR_08365186R → C in POBINDS; unknown pathological significance; associated in cis with 5-E--R-215 del. 1 Publication1
Natural variantiVAR_083652111R → P in POBINDS. 1 Publication1
Natural variantiVAR_083653137C → F in POBINDS. 1 Publication1
Natural variantiVAR_083654137C → G in POBINDS. 1 Publication1
Natural variantiVAR_083655187L → R in POBINDS. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X16937 mRNA Translation: CAA34811.1
X16312 mRNA Translation: CAA34379.1
M30448 mRNA Translation: AAA52123.1
X57152 Genomic DNA Translation: CAA40442.1
AY113186 mRNA Translation: AAM50092.1
CR541699 mRNA Translation: CAG46500.1
AF129756 Genomic DNA Translation: AAD18081.1
BA000025 Genomic DNA Translation: BAB63386.1
DQ314868 Genomic DNA Translation: ABC40727.1
AK311860 mRNA Translation: BAG34801.1
AL662899 Genomic DNA No translation available.
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR753842 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03473.1
BC112017 mRNA Translation: AAI12018.1
BC112019 mRNA Translation: AAI12020.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4712.1

Protein sequence database of the Protein Information Resource

More...PIRi		A39459

NCBI Reference Sequences

More...RefSeqi		NP_001269314.1, NM_001282385.1
NP_001311.3, NM_001320.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000375865; ENSP00000365025; ENSG00000204435
ENST00000375866; ENSP00000365026; ENSG00000204435
ENST00000375882; ENSP00000365042; ENSG00000204435
ENST00000383427; ENSP00000372919; ENSG00000206406
ENST00000383433; ENSP00000372925; ENSG00000206406
ENST00000400110; ENSP00000382980; ENSG00000206406
ENST00000412802; ENSP00000413469; ENSG00000224774
ENST00000418230; ENSP00000411322; ENSG00000228875
ENST00000422567; ENSP00000407018; ENSG00000224398
ENST00000429633; ENSP00000409510; ENSG00000230700
ENST00000431476; ENSP00000394855; ENSG00000224398
ENST00000436169; ENSP00000412520; ENSG00000224398
ENST00000443673; ENSP00000400188; ENSG00000230700
ENST00000448596; ENSP00000391038; ENSG00000232960
ENST00000451917; ENSP00000415303; ENSG00000224774
ENST00000452985; ENSP00000415237; ENSG00000228875
ENST00000453234; ENSP00000395275; ENSG00000224774
ENST00000454382; ENSP00000390900; ENSG00000232960
ENST00000454511; ENSP00000393756; ENSG00000232960
ENST00000455161; ENSP00000407379; ENSG00000230700
ENST00000458330; ENSP00000410802; ENSG00000228875

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1460

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1460

UCSC genome browser

More...UCSCi		uc003nvr.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16937 mRNA Translation: CAA34811.1
X16312 mRNA Translation: CAA34379.1
M30448 mRNA Translation: AAA52123.1
X57152 Genomic DNA Translation: CAA40442.1
AY113186 mRNA Translation: AAM50092.1
CR541699 mRNA Translation: CAG46500.1
AF129756 Genomic DNA Translation: AAD18081.1
BA000025 Genomic DNA Translation: BAB63386.1
DQ314868 Genomic DNA Translation: ABC40727.1
AK311860 mRNA Translation: BAG34801.1
AL662899 Genomic DNA No translation available.
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR753842 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03473.1
BC112017 mRNA Translation: AAI12018.1
BC112019 mRNA Translation: AAI12020.1
CCDSiCCDS4712.1
PIRiA39459
RefSeqiNP_001269314.1, NM_001282385.1
NP_001311.3, NM_001320.6

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DS5X-ray3.16E/F/G/H181-203[»]
1JWHX-ray3.10C/D1-215[»]
1QF8X-ray1.74A/B1-182[»]
3EEDX-ray2.80A/B1-193[»]
4DGLX-ray3.00A/B1-215[»]
4MD7X-ray3.10A/B/C/D1-215[»]
4MD8X-ray3.30A/B/C/D1-215[»]
4MD9X-ray3.50A/B/C/D/I/J/N/O1-215[»]
4NH1X-ray3.30C/D1-215[»]
6Q38X-ray1.74C186-193[»]
SMRiP67870
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107843, 408 interactors
ComplexPortaliCPX-2428, Casein kinase II complex, CSNK2A2 variant
CPX-2437, Casein kinase II complex, CSNK2A1-CNSK2A2 variant
CPX-914, Casein kinase II complex, CSNK2A1 variant
CORUMiP67870
DIPiDIP-131N
IntActiP67870, 254 interactors
MINTiP67870
STRINGi9606.ENSP00000365042

Chemistry databases

BindingDBiP67870
ChEMBLiCHEMBL2358
DrugBankiDB00171, ATP
DB04216, Quercetin

Protein family/group databases

MoonDBiP67870, Predicted

PTM databases

GlyGeniP67870, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP67870
MetOSiteiP67870
PhosphoSitePlusiP67870
SwissPalmiP67870

Genetic variation databases

BioMutaiCSNK2B
DMDMi54037520

Proteomic databases

EPDiP67870
jPOSTiP67870
MassIVEiP67870
MaxQBiP67870
PaxDbiP67870
PeptideAtlasiP67870
PRIDEiP67870
ProteomicsDBi57524

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1045, 612 antibodies

The DNASU plasmid repository

More...DNASUi		1460

Genome annotation databases

EnsembliENST00000375865; ENSP00000365025; ENSG00000204435
ENST00000375866; ENSP00000365026; ENSG00000204435
ENST00000375882; ENSP00000365042; ENSG00000204435
ENST00000383427; ENSP00000372919; ENSG00000206406
ENST00000383433; ENSP00000372925; ENSG00000206406
ENST00000400110; ENSP00000382980; ENSG00000206406
ENST00000412802; ENSP00000413469; ENSG00000224774
ENST00000418230; ENSP00000411322; ENSG00000228875
ENST00000422567; ENSP00000407018; ENSG00000224398
ENST00000429633; ENSP00000409510; ENSG00000230700
ENST00000431476; ENSP00000394855; ENSG00000224398
ENST00000436169; ENSP00000412520; ENSG00000224398
ENST00000443673; ENSP00000400188; ENSG00000230700
ENST00000448596; ENSP00000391038; ENSG00000232960
ENST00000451917; ENSP00000415303; ENSG00000224774
ENST00000452985; ENSP00000415237; ENSG00000228875
ENST00000453234; ENSP00000395275; ENSG00000224774
ENST00000454382; ENSP00000390900; ENSG00000232960
ENST00000454511; ENSP00000393756; ENSG00000232960
ENST00000455161; ENSP00000407379; ENSG00000230700
ENST00000458330; ENSP00000410802; ENSG00000228875
GeneIDi1460
KEGGihsa:1460
UCSCiuc003nvr.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1460
DisGeNETi1460

GeneCards: human genes, protein and diseases

More...GeneCardsi		CSNK2B
HGNCiHGNC:2460, CSNK2B
HPAiENSG00000204435, Low tissue specificity
MalaCardsiCSNK2B
MIMi115441, gene
618732, phenotype
neXtProtiNX_P67870
OpenTargetsiENSG00000204435
Orphaneti178469, Autosomal dominant non-syndromic intellectual disability
PharmGKBiPA26960
VEuPathDBiHostDB:ENSG00000204435

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3092, Eukaryota
GeneTreeiENSGT00390000003781
HOGENOMiCLU_034027_3_3_1
InParanoidiP67870
OrthoDBi1335521at2759
PhylomeDBiP67870
TreeFamiTF314462

Enzyme and pathway databases

PathwayCommonsiP67870
ReactomeiR-HSA-1483191, Synthesis of PC
R-HSA-201688, WNT mediated activation of DVL
R-HSA-2514853, Condensation of Prometaphase Chromosomes
R-HSA-445144, Signal transduction by L1
R-HSA-6798695, Neutrophil degranulation
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8932339, ROS sensing by NFE2L2
R-HSA-8934903, Receptor Mediated Mitophagy
R-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8948751, Regulation of PTEN stability and activity
SignaLinkiP67870
SIGNORiP67870

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1460, 699 hits in 1041 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CSNK2B, human
EvolutionaryTraceiP67870

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CSNK2B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1460
PharosiP67870, Tbio

Protein Ontology

More...PROi		PR:P67870
RNActiP67870, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204435, Expressed in right testis and 113 other tissues
ExpressionAtlasiP67870, baseline and differential
GenevisibleiP67870, HS

Family and domain databases

Gene3Di1.10.1820.10, 1 hit
InterProiView protein in InterPro
IPR016149, Casein_kin_II_reg-sub_N
IPR035991, Casein_kinase_II_beta-like
IPR000704, Casein_kinase_II_reg-sub
PANTHERiPTHR11740, PTHR11740, 1 hit
PfamiView protein in Pfam
PF01214, CK_II_beta, 1 hit
PRINTSiPR00472, CASNKINASEII
SMARTiView protein in SMART
SM01085, CK_II_beta, 1 hit
SUPFAMiSSF57798, SSF57798, 1 hit
PROSITEiView protein in PROSITE
PS01101, CK2_BETA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSK2B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P67870
Secondary accession number(s): B0UXA9
, P07312, P13862, Q4VX47
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 29, 2021
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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