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UniProtKB - P67870 (CSK2B_HUMAN)

Protein

Casein kinase II subunit beta

Gene

CSNK2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi109Zinc1
Metal bindingi114Zinc1
Metal bindingi137Zinc1
Metal bindingi140Zinc1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1483191 Synthesis of PC
R-HSA-201688 WNT mediated activation of DVL
R-HSA-2514853 Condensation of Prometaphase Chromosomes
R-HSA-445144 Signal transduction by L1
R-HSA-6798695 Neutrophil degranulation
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8934903 Receptor Mediated Mitophagy
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8948751 Regulation of PTEN stability and activity

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P67870

SIGNOR Signaling Network Open Resource

More...SIGNORi		P67870

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P67870 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Alternative name(s):
Phosvitin
Protein G5a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSNK2B
Synonyms:CK2N, G5A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000204435.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:2460 CSNK2B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		115441 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P67870

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1460

MalaCards human disease database

More...MalaCardsi		CSNK2B

Open Targets

More...OpenTargetsi		ENSG00000204435

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		178469 Autosomal dominant non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26960

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2358

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...DMDMi		54037520

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000682362 – 215Casein kinase II subunit betaAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei2Phosphoserine; by autocatalysis1 Publication1
Modified residuei3Phosphoserine; by autocatalysis1 Publication1
Modified residuei8PhosphoserineCombined sources1
Modified residuei37PhosphothreonineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei212N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by alpha subunit.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P67870

MaxQB - The MaxQuant DataBase

More...MaxQBi		P67870

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P67870

PeptideAtlas

More...PeptideAtlasi		P67870

PRoteomics IDEntifications database

More...PRIDEi		P67870

ProteomicsDB human proteome resource

More...ProteomicsDBi		57524

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P67870

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P67870

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204435 Expressed in 86 organ(s), highest expression level in right testis

CleanEx database of gene expression profiles

More...CleanExi		HS_CSNK2B

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P67870 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P67870 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB004349
CAB013087
CAB016059
HPA005944

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107843, 326 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P67870

Database of interacting proteins

More...DIPi		DIP-131N

Protein interaction database and analysis system

More...IntActi		P67870, 219 interactors

Molecular INTeraction database

More...MINTi		P67870

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365025

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P67870

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P67870

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P67870

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P67870

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni188 – 193Interaction with alpha subunitBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 64Asp/Glu-rich (acidic)10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the casein kinase 2 subunit beta family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3092 Eukaryota
COG5041 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003781

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000039270

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG051131

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P67870

KEGG Orthology (KO)

More...KOi		K03115

Database for complete collections of gene phylogenies

More...PhylomeDBi		P67870

TreeFam database of animal gene trees

More...TreeFami		TF314462

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1820.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016149 Casein_kin_II_reg-sub_N
IPR035991 Casein_kinase_II_beta_like
IPR000704 Casein_kinase_II_reg-sub

The PANTHER Classification System

More...PANTHERi		PTHR11740 PTHR11740, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01214 CK_II_beta, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00472 CASNKINASEII

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01085 CK_II_beta, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57798 SSF57798, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01101 CK2_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P67870-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL 
        60         70         80         90        100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK 
       110        120        130        140        150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR 
       160        170        180        190        200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ 
       210 
LQAASNFKSP VKTIR
Length:215
Mass (Da):24,942
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE465B1E699B0E0EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SRQ6Q5SRQ6_HUMAN
Casein kinase II subunit beta
CSNK2B hCG_43725
234Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SRQ3Q5SRQ3_HUMAN
Casein kinase II subunit beta
CSNK2B CSNK2B-LY6G5B-1181
228Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
N0E644N0E644_HUMAN
Casein kinase II subunit beta
CSNK2B CSNK2B-LY6G5B-562
161Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM58A0A0G2JM58_HUMAN
Casein kinase II subunit beta
CSNK2B
161Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
N0E472N0E472_HUMAN
Casein kinase II subunit beta
CSNK2B CSNK2B-LY6G5B--991
304Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM12A0A0G2JM12_HUMAN
Casein kinase II subunit beta
CSNK2B
304Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6P8H0Y6P8_HUMAN
Uncharacterized protein
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti194P → A in AAA52123 (PubMed:2513884).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X16937 mRNA Translation: CAA34811.1
X16312 mRNA Translation: CAA34379.1
M30448 mRNA Translation: AAA52123.1
X57152 Genomic DNA Translation: CAA40442.1
AY113186 mRNA Translation: AAM50092.1
CR541699 mRNA Translation: CAG46500.1
AF129756 Genomic DNA Translation: AAD18081.1
BA000025 Genomic DNA Translation: BAB63386.1
DQ314868 Genomic DNA Translation: ABC40727.1
AK311860 mRNA Translation: BAG34801.1
AL662899 Genomic DNA No translation available.
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR753842 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03473.1
BC112017 mRNA Translation: AAI12018.1
BC112019 mRNA Translation: AAI12020.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4712.1

Protein sequence database of the Protein Information Resource

More...PIRi		A39459

NCBI Reference Sequences

More...RefSeqi		NP_001269314.1, NM_001282385.1
NP_001311.3, NM_001320.6

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.73527

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000375865; ENSP00000365025; ENSG00000204435
ENST00000375866; ENSP00000365026; ENSG00000204435
ENST00000375882; ENSP00000365042; ENSG00000204435
ENST00000383427; ENSP00000372919; ENSG00000206406
ENST00000383433; ENSP00000372925; ENSG00000206406
ENST00000400110; ENSP00000382980; ENSG00000206406
ENST00000412802; ENSP00000413469; ENSG00000224774
ENST00000418230; ENSP00000411322; ENSG00000228875
ENST00000422567; ENSP00000407018; ENSG00000224398
ENST00000429633; ENSP00000409510; ENSG00000230700
ENST00000431476; ENSP00000394855; ENSG00000224398
ENST00000436169; ENSP00000412520; ENSG00000224398
ENST00000443673; ENSP00000400188; ENSG00000230700
ENST00000448596; ENSP00000391038; ENSG00000232960
ENST00000451917; ENSP00000415303; ENSG00000224774
ENST00000452985; ENSP00000415237; ENSG00000228875
ENST00000453234; ENSP00000395275; ENSG00000224774
ENST00000454382; ENSP00000390900; ENSG00000232960
ENST00000454511; ENSP00000393756; ENSG00000232960
ENST00000455161; ENSP00000407379; ENSG00000230700
ENST00000458330; ENSP00000410802; ENSG00000228875

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1460

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1460

UCSC genome browser

More...UCSCi		uc003nvr.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16937 mRNA Translation: CAA34811.1
X16312 mRNA Translation: CAA34379.1
M30448 mRNA Translation: AAA52123.1
X57152 Genomic DNA Translation: CAA40442.1
AY113186 mRNA Translation: AAM50092.1
CR541699 mRNA Translation: CAG46500.1
AF129756 Genomic DNA Translation: AAD18081.1
BA000025 Genomic DNA Translation: BAB63386.1
DQ314868 Genomic DNA Translation: ABC40727.1
AK311860 mRNA Translation: BAG34801.1
AL662899 Genomic DNA No translation available.
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR753842 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03473.1
BC112017 mRNA Translation: AAI12018.1
BC112019 mRNA Translation: AAI12020.1
CCDSiCCDS4712.1
PIRiA39459
RefSeqiNP_001269314.1, NM_001282385.1
NP_001311.3, NM_001320.6
UniGeneiHs.73527

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DS5X-ray3.16E/F/G/H181-203[»]
1JWHX-ray3.10C/D1-215[»]
1QF8X-ray1.74A/B1-182[»]
3EEDX-ray2.80A/B1-193[»]
4DGLX-ray3.00A/B1-215[»]
4MD7X-ray3.10A/B/C/D1-215[»]
4MD8X-ray3.30A/B/C/D1-215[»]
4MD9X-ray3.50A/B/C/D/I/J/N/O1-215[»]
4NH1X-ray3.30C/D1-215[»]
ProteinModelPortaliP67870
SMRiP67870
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107843, 326 interactors
CORUMiP67870
DIPiDIP-131N
IntActiP67870, 219 interactors
MINTiP67870
STRINGi9606.ENSP00000365025

Chemistry databases

BindingDBiP67870
ChEMBLiCHEMBL2358

Protein family/group databases

MoonDBiP67870 Predicted

PTM databases

iPTMnetiP67870
PhosphoSitePlusiP67870

Polymorphism and mutation databases

DMDMi54037520

Proteomic databases

EPDiP67870
MaxQBiP67870
PaxDbiP67870
PeptideAtlasiP67870
PRIDEiP67870
ProteomicsDBi57524

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		1460
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375865; ENSP00000365025; ENSG00000204435
ENST00000375866; ENSP00000365026; ENSG00000204435
ENST00000375882; ENSP00000365042; ENSG00000204435
ENST00000383427; ENSP00000372919; ENSG00000206406
ENST00000383433; ENSP00000372925; ENSG00000206406
ENST00000400110; ENSP00000382980; ENSG00000206406
ENST00000412802; ENSP00000413469; ENSG00000224774
ENST00000418230; ENSP00000411322; ENSG00000228875
ENST00000422567; ENSP00000407018; ENSG00000224398
ENST00000429633; ENSP00000409510; ENSG00000230700
ENST00000431476; ENSP00000394855; ENSG00000224398
ENST00000436169; ENSP00000412520; ENSG00000224398
ENST00000443673; ENSP00000400188; ENSG00000230700
ENST00000448596; ENSP00000391038; ENSG00000232960
ENST00000451917; ENSP00000415303; ENSG00000224774
ENST00000452985; ENSP00000415237; ENSG00000228875
ENST00000453234; ENSP00000395275; ENSG00000224774
ENST00000454382; ENSP00000390900; ENSG00000232960
ENST00000454511; ENSP00000393756; ENSG00000232960
ENST00000455161; ENSP00000407379; ENSG00000230700
ENST00000458330; ENSP00000410802; ENSG00000228875
GeneIDi1460
KEGGihsa:1460
UCSCiuc003nvr.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1460
DisGeNETi1460
EuPathDBiHostDB:ENSG00000204435.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		CSNK2B
HGNCiHGNC:2460 CSNK2B
HPAiCAB004349
CAB013087
CAB016059
HPA005944
MalaCardsiCSNK2B
MIMi115441 gene
neXtProtiNX_P67870
OpenTargetsiENSG00000204435
Orphaneti178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBiPA26960

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3092 Eukaryota
COG5041 LUCA
GeneTreeiENSGT00390000003781
HOGENOMiHOG000039270
HOVERGENiHBG051131
InParanoidiP67870
KOiK03115
PhylomeDBiP67870
TreeFamiTF314462

Enzyme and pathway databases

ReactomeiR-HSA-1483191 Synthesis of PC
R-HSA-201688 WNT mediated activation of DVL
R-HSA-2514853 Condensation of Prometaphase Chromosomes
R-HSA-445144 Signal transduction by L1
R-HSA-6798695 Neutrophil degranulation
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8934903 Receptor Mediated Mitophagy
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8948751 Regulation of PTEN stability and activity
SignaLinkiP67870
SIGNORiP67870

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CSNK2B human
EvolutionaryTraceiP67870

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CSNK2B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1460

Protein Ontology

More...PROi		PR:P67870

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204435 Expressed in 86 organ(s), highest expression level in right testis
CleanExiHS_CSNK2B
ExpressionAtlasiP67870 baseline and differential
GenevisibleiP67870 HS

Family and domain databases

Gene3Di1.10.1820.10, 1 hit
InterProiView protein in InterPro
IPR016149 Casein_kin_II_reg-sub_N
IPR035991 Casein_kinase_II_beta_like
IPR000704 Casein_kinase_II_reg-sub
PANTHERiPTHR11740 PTHR11740, 1 hit
PfamiView protein in Pfam
PF01214 CK_II_beta, 1 hit
PRINTSiPR00472 CASNKINASEII
SMARTiView protein in SMART
SM01085 CK_II_beta, 1 hit
SUPFAMiSSF57798 SSF57798, 1 hit
PROSITEiView protein in PROSITE
PS01101 CK2_BETA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSK2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P67870
Secondary accession number(s): B0UXA9
, P07312, P13862, Q4VX47
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: December 5, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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