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Protein

Casein kinase II subunit beta

Gene

CSNK2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi109Zinc1
Metal bindingi114Zinc1
Metal bindingi137Zinc1
Metal bindingi140Zinc1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1483191 Synthesis of PC
R-HSA-201688 WNT mediated activation of DVL
R-HSA-2514853 Condensation of Prometaphase Chromosomes
R-HSA-445144 Signal transduction by L1
R-HSA-6798695 Neutrophil degranulation
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8934903 Receptor Mediated Mitophagy
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8948751 Regulation of PTEN stability and activity
SignaLinkiP67870
SIGNORiP67870

Protein family/group databases

MoonDBiP67870 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Alternative name(s):
Phosvitin
Protein G5a
Gene namesi
Name:CSNK2B
Synonyms:CK2N, G5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204435.13
HGNCiHGNC:2460 CSNK2B
MIMi115441 gene
neXtProtiNX_P67870

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi1460
MalaCardsiCSNK2B
OpenTargetsiENSG00000204435
Orphaneti178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBiPA26960

Chemistry databases

ChEMBLiCHEMBL2358

Polymorphism and mutation databases

DMDMi54037520

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000682362 – 215Casein kinase II subunit betaAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2Phosphoserine; by autocatalysis1 Publication1
Modified residuei3Phosphoserine; by autocatalysis1 Publication1
Modified residuei8PhosphoserineCombined sources1
Modified residuei37PhosphothreonineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei212N6-acetyllysine; alternateCombined sources1
Cross-linki212Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Post-translational modificationi

Phosphorylated by alpha subunit.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP67870
MaxQBiP67870
PaxDbiP67870
PeptideAtlasiP67870
PRIDEiP67870
ProteomicsDBi57524

PTM databases

iPTMnetiP67870
PhosphoSitePlusiP67870

Expressioni

Gene expression databases

BgeeiENSG00000204435 Expressed in 86 organ(s), highest expression level in right testis
CleanExiHS_CSNK2B
ExpressionAtlasiP67870 baseline and differential
GenevisibleiP67870 HS

Organism-specific databases

HPAiCAB004349
CAB013087
CAB016059
HPA005944

Interactioni

Subunit structurei

Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2. Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.By similarity7 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107843, 325 interactors
CORUMiP67870
DIPiDIP-131N
IntActiP67870, 219 interactors
MINTiP67870
STRINGi9606.ENSP00000365025

Chemistry databases

BindingDBiP67870

Structurei

Secondary structure

1215
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP67870
SMRiP67870
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP67870

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni188 – 193Interaction with alpha subunitBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 64Asp/Glu-rich (acidic)10

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3092 Eukaryota
COG5041 LUCA
GeneTreeiENSGT00390000003781
HOGENOMiHOG000039270
HOVERGENiHBG051131
InParanoidiP67870
KOiK03115
PhylomeDBiP67870
TreeFamiTF314462

Family and domain databases

Gene3Di1.10.1820.10, 1 hit
InterProiView protein in InterPro
IPR016149 Casein_kin_II_reg-sub_N
IPR035991 Casein_kinase_II_beta_like
IPR000704 Casein_kinase_II_reg-sub
PANTHERiPTHR11740 PTHR11740, 1 hit
PfamiView protein in Pfam
PF01214 CK_II_beta, 1 hit
PRINTSiPR00472 CASNKINASEII
SMARTiView protein in SMART
SM01085 CK_II_beta, 1 hit
SUPFAMiSSF57798 SSF57798, 1 hit
PROSITEiView protein in PROSITE
PS01101 CK2_BETA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P67870-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL
60 70 80 90 100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK
110 120 130 140 150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ
210
LQAASNFKSP VKTIR
Length:215
Mass (Da):24,942
Last modified:October 11, 2004 - v1
Checksum:iE465B1E699B0E0EC
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SRQ6Q5SRQ6_HUMAN
Casein kinase II subunit beta
CSNK2B hCG_43725
234Annotation score:
Q5SRQ3Q5SRQ3_HUMAN
Casein kinase II subunit beta
CSNK2B CSNK2B-LY6G5B-1181
228Annotation score:
N0E644N0E644_HUMAN
Casein kinase II subunit beta
CSNK2B CSNK2B-LY6G5B-562
161Annotation score:
A0A0G2JM58A0A0G2JM58_HUMAN
Casein kinase II subunit beta
CSNK2B
161Annotation score:
N0E472N0E472_HUMAN
Casein kinase II subunit beta
CSNK2B CSNK2B-LY6G5B--991
304Annotation score:
A0A0G2JM12A0A0G2JM12_HUMAN
Casein kinase II subunit beta
CSNK2B
304Annotation score:
H0Y6P8H0Y6P8_HUMAN
Uncharacterized protein
212Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti194P → A in AAA52123 (PubMed:2513884).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16937 mRNA Translation: CAA34811.1
X16312 mRNA Translation: CAA34379.1
M30448 mRNA Translation: AAA52123.1
X57152 Genomic DNA Translation: CAA40442.1
AY113186 mRNA Translation: AAM50092.1
CR541699 mRNA Translation: CAG46500.1
AF129756 Genomic DNA Translation: AAD18081.1
BA000025 Genomic DNA Translation: BAB63386.1
DQ314868 Genomic DNA Translation: ABC40727.1
AK311860 mRNA Translation: BAG34801.1
AL662899 Genomic DNA No translation available.
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR753842 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03473.1
BC112017 mRNA Translation: AAI12018.1
BC112019 mRNA Translation: AAI12020.1
CCDSiCCDS4712.1
PIRiA39459
RefSeqiNP_001269314.1, NM_001282385.1
NP_001311.3, NM_001320.6
UniGeneiHs.73527

Genome annotation databases

EnsembliENST00000375865; ENSP00000365025; ENSG00000204435
ENST00000375866; ENSP00000365026; ENSG00000204435
ENST00000375882; ENSP00000365042; ENSG00000204435
ENST00000383427; ENSP00000372919; ENSG00000206406
ENST00000383433; ENSP00000372925; ENSG00000206406
ENST00000400110; ENSP00000382980; ENSG00000206406
ENST00000412802; ENSP00000413469; ENSG00000224774
ENST00000418230; ENSP00000411322; ENSG00000228875
ENST00000422567; ENSP00000407018; ENSG00000224398
ENST00000429633; ENSP00000409510; ENSG00000230700
ENST00000431476; ENSP00000394855; ENSG00000224398
ENST00000436169; ENSP00000412520; ENSG00000224398
ENST00000443673; ENSP00000400188; ENSG00000230700
ENST00000448596; ENSP00000391038; ENSG00000232960
ENST00000451917; ENSP00000415303; ENSG00000224774
ENST00000452985; ENSP00000415237; ENSG00000228875
ENST00000453234; ENSP00000395275; ENSG00000224774
ENST00000454382; ENSP00000390900; ENSG00000232960
ENST00000454511; ENSP00000393756; ENSG00000232960
ENST00000455161; ENSP00000407379; ENSG00000230700
ENST00000458330; ENSP00000410802; ENSG00000228875
GeneIDi1460
KEGGihsa:1460
UCSCiuc003nvr.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16937 mRNA Translation: CAA34811.1
X16312 mRNA Translation: CAA34379.1
M30448 mRNA Translation: AAA52123.1
X57152 Genomic DNA Translation: CAA40442.1
AY113186 mRNA Translation: AAM50092.1
CR541699 mRNA Translation: CAG46500.1
AF129756 Genomic DNA Translation: AAD18081.1
BA000025 Genomic DNA Translation: BAB63386.1
DQ314868 Genomic DNA Translation: ABC40727.1
AK311860 mRNA Translation: BAG34801.1
AL662899 Genomic DNA No translation available.
AL670886 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR354443 Genomic DNA No translation available.
CR753842 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03473.1
BC112017 mRNA Translation: AAI12018.1
BC112019 mRNA Translation: AAI12020.1
CCDSiCCDS4712.1
PIRiA39459
RefSeqiNP_001269314.1, NM_001282385.1
NP_001311.3, NM_001320.6
UniGeneiHs.73527

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DS5X-ray3.16E/F/G/H181-203[»]
1JWHX-ray3.10C/D1-215[»]
1QF8X-ray1.74A/B1-182[»]
3EEDX-ray2.80A/B1-193[»]
4DGLX-ray3.00A/B1-215[»]
4MD7X-ray3.10A/B/C/D1-215[»]
4MD8X-ray3.30A/B/C/D1-215[»]
4MD9X-ray3.50A/B/C/D/I/J/N/O1-215[»]
4NH1X-ray3.30C/D1-215[»]
ProteinModelPortaliP67870
SMRiP67870
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107843, 325 interactors
CORUMiP67870
DIPiDIP-131N
IntActiP67870, 219 interactors
MINTiP67870
STRINGi9606.ENSP00000365025

Chemistry databases

BindingDBiP67870
ChEMBLiCHEMBL2358

Protein family/group databases

MoonDBiP67870 Predicted

PTM databases

iPTMnetiP67870
PhosphoSitePlusiP67870

Polymorphism and mutation databases

DMDMi54037520

Proteomic databases

EPDiP67870
MaxQBiP67870
PaxDbiP67870
PeptideAtlasiP67870
PRIDEiP67870
ProteomicsDBi57524

Protocols and materials databases

DNASUi1460
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375865; ENSP00000365025; ENSG00000204435
ENST00000375866; ENSP00000365026; ENSG00000204435
ENST00000375882; ENSP00000365042; ENSG00000204435
ENST00000383427; ENSP00000372919; ENSG00000206406
ENST00000383433; ENSP00000372925; ENSG00000206406
ENST00000400110; ENSP00000382980; ENSG00000206406
ENST00000412802; ENSP00000413469; ENSG00000224774
ENST00000418230; ENSP00000411322; ENSG00000228875
ENST00000422567; ENSP00000407018; ENSG00000224398
ENST00000429633; ENSP00000409510; ENSG00000230700
ENST00000431476; ENSP00000394855; ENSG00000224398
ENST00000436169; ENSP00000412520; ENSG00000224398
ENST00000443673; ENSP00000400188; ENSG00000230700
ENST00000448596; ENSP00000391038; ENSG00000232960
ENST00000451917; ENSP00000415303; ENSG00000224774
ENST00000452985; ENSP00000415237; ENSG00000228875
ENST00000453234; ENSP00000395275; ENSG00000224774
ENST00000454382; ENSP00000390900; ENSG00000232960
ENST00000454511; ENSP00000393756; ENSG00000232960
ENST00000455161; ENSP00000407379; ENSG00000230700
ENST00000458330; ENSP00000410802; ENSG00000228875
GeneIDi1460
KEGGihsa:1460
UCSCiuc003nvr.3 human

Organism-specific databases

CTDi1460
DisGeNETi1460
EuPathDBiHostDB:ENSG00000204435.13
GeneCardsiCSNK2B
HGNCiHGNC:2460 CSNK2B
HPAiCAB004349
CAB013087
CAB016059
HPA005944
MalaCardsiCSNK2B
MIMi115441 gene
neXtProtiNX_P67870
OpenTargetsiENSG00000204435
Orphaneti178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBiPA26960
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3092 Eukaryota
COG5041 LUCA
GeneTreeiENSGT00390000003781
HOGENOMiHOG000039270
HOVERGENiHBG051131
InParanoidiP67870
KOiK03115
PhylomeDBiP67870
TreeFamiTF314462

Enzyme and pathway databases

ReactomeiR-HSA-1483191 Synthesis of PC
R-HSA-201688 WNT mediated activation of DVL
R-HSA-2514853 Condensation of Prometaphase Chromosomes
R-HSA-445144 Signal transduction by L1
R-HSA-6798695 Neutrophil degranulation
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8934903 Receptor Mediated Mitophagy
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8948751 Regulation of PTEN stability and activity
SignaLinkiP67870
SIGNORiP67870

Miscellaneous databases

ChiTaRSiCSNK2B human
EvolutionaryTraceiP67870
GeneWikiiCSNK2B
GenomeRNAii1460
PROiPR:P67870
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204435 Expressed in 86 organ(s), highest expression level in right testis
CleanExiHS_CSNK2B
ExpressionAtlasiP67870 baseline and differential
GenevisibleiP67870 HS

Family and domain databases

Gene3Di1.10.1820.10, 1 hit
InterProiView protein in InterPro
IPR016149 Casein_kin_II_reg-sub_N
IPR035991 Casein_kinase_II_beta_like
IPR000704 Casein_kinase_II_reg-sub
PANTHERiPTHR11740 PTHR11740, 1 hit
PfamiView protein in Pfam
PF01214 CK_II_beta, 1 hit
PRINTSiPR00472 CASNKINASEII
SMARTiView protein in SMART
SM01085 CK_II_beta, 1 hit
SUPFAMiSSF57798 SSF57798, 1 hit
PROSITEiView protein in PROSITE
PS01101 CK2_BETA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSK2B_HUMAN
AccessioniPrimary (citable) accession number: P67870
Secondary accession number(s): B0UXA9
, P07312, P13862, Q4VX47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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