UniProtKB - P67870 (CSK2B_HUMAN)
Casein kinase II subunit beta
CSNK2B
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 109 | Zinc | 1 | |
Metal bindingi | 114 | Zinc | 1 | |
Metal bindingi | 137 | Zinc | 1 | |
Metal bindingi | 140 | Zinc | 1 |
GO - Molecular functioni
- chromatin binding Source: MGI
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- protein domain specific binding Source: UniProtKB
- protein kinase regulator activity Source: GO_Central
- protein serine/threonine kinase activity Source: CAFA
- ribonucleoprotein complex binding Source: Ensembl
- signaling receptor binding Source: BHF-UCL
- transcription factor binding Source: BHF-UCL
GO - Biological processi
- adiponectin-activated signaling pathway Source: BHF-UCL
- cellular protein-containing complex assembly Source: BHF-UCL
- endothelial tube morphogenesis Source: BHF-UCL
- liver regeneration Source: Ensembl
- macroautophagy Source: Reactome
- negative regulation of blood vessel endothelial cell migration Source: BHF-UCL
- negative regulation of cell population proliferation Source: BHF-UCL
- neutrophil degranulation Source: Reactome
- peptidyl-threonine phosphorylation Source: CAFA
- phosphatidylcholine biosynthetic process Source: Reactome
- positive regulation of activin receptor signaling pathway Source: BHF-UCL
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- protein folding Source: Reactome
- regulation of DNA binding Source: BHF-UCL
- regulation of signal transduction by p53 class mediator Source: Reactome
- response to testosterone Source: Ensembl
- signal transduction Source: UniProtKB
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Wnt signaling pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P67870 |
Reactomei | R-HSA-1483191, Synthesis of PC R-HSA-201688, WNT mediated activation of DVL R-HSA-2514853, Condensation of Prometaphase Chromosomes R-HSA-445144, Signal transduction by L1 R-HSA-6798695, Neutrophil degranulation R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-8934903, Receptor Mediated Mitophagy R-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8948751, Regulation of PTEN stability and activity |
SignaLinki | P67870 |
SIGNORi | P67870 |
Protein family/group databases
MoonDBi | P67870, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Casein kinase II subunit betaShort name: CK II beta Alternative name(s): Phosvitin Protein G5a |
Gene namesi | Name:CSNK2B Synonyms:CK2N, G5A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204435.13 |
HGNCi | HGNC:2460, CSNK2B |
MIMi | 115441, gene |
neXtProti | NX_P67870 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Nucleus
- nuclear matrix Source: Ensembl
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- chromatin Source: Ensembl
- cilium Source: Ensembl
- cytoplasm Source: BHF-UCL
- ficolin-1-rich granule lumen Source: Reactome
- protein kinase CK2 complex Source: CAFA
- secretory granule lumen Source: Reactome
Pathology & Biotechi
Involvement in diseasei
Poirier-Bienvenu neurodevelopmental syndrome (POBINDS)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083650 | 5 – 215 | Missing in POBINDS; associated in cis with C-86. 1 PublicationAdd BLAST | 211 | |
Natural variantiVAR_083651 | 86 | R → C in POBINDS; unknown pathological significance; associated in cis with 5-E--R-215 del. 1 Publication | 1 | |
Natural variantiVAR_083652 | 111 | R → P in POBINDS. 1 Publication | 1 | |
Natural variantiVAR_083653 | 137 | C → F in POBINDS. 1 Publication | 1 | |
Natural variantiVAR_083654 | 137 | C → G in POBINDS. 1 Publication | 1 | |
Natural variantiVAR_083655 | 187 | L → R in POBINDS. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, Epilepsy, Mental retardationOrganism-specific databases
DisGeNETi | 1460 |
MalaCardsi | CSNK2B |
MIMi | 618732, phenotype |
OpenTargetsi | ENSG00000204435 |
Orphaneti | 178469, Autosomal dominant non-syndromic intellectual disability |
PharmGKBi | PA26960 |
Miscellaneous databases
Pharosi | P67870, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2358 |
DrugBanki | DB00171, ATP DB04216, Quercetin |
Polymorphism and mutation databases
BioMutai | CSNK2B |
DMDMi | 54037520 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000068236 | 2 – 215 | Casein kinase II subunit betaAdd BLAST | 214 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 2 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 3 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 8 | PhosphoserineCombined sources | 1 | |
Modified residuei | 37 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 69 | PhosphoserineCombined sources | 1 | |
Modified residuei | 209 | PhosphoserineCombined sources | 1 | |
Modified residuei | 212 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 212 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P67870 |
jPOSTi | P67870 |
MassIVEi | P67870 |
MaxQBi | P67870 |
PaxDbi | P67870 |
PeptideAtlasi | P67870 |
PRIDEi | P67870 |
ProteomicsDBi | 57524 |
PTM databases
iPTMneti | P67870 |
MetOSitei | P67870 |
PhosphoSitePlusi | P67870 |
SwissPalmi | P67870 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204435, Expressed in right testis and 112 other tissues |
ExpressionAtlasi | P67870, baseline and differential |
Genevisiblei | P67870, HS |
Organism-specific databases
HPAi | ENSG00000204435, Low tissue specificity |
Interactioni
Subunit structurei
Casein kinase II/CK2 is a tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions.
Interacts with DYNLT2 (By similarity).
Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation.
Interacts with MUSK; mediates phosphorylation of MUSK by CK2.
Interacts with FGF1; this interaction is increased in the presence of FIBP, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.
By similarity7 PublicationsBinary interactionsi
Hide detailsP67870
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein domain specific binding Source: UniProtKB
- signaling receptor binding Source: BHF-UCL
- transcription factor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 107843, 383 interactors |
CORUMi | P67870 |
DIPi | DIP-131N |
IntActi | P67870, 247 interactors |
MINTi | P67870 |
STRINGi | 9606.ENSP00000365042 |
Chemistry databases
BindingDBi | P67870 |
Miscellaneous databases
RNActi | P67870, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P67870 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P67870 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 188 – 193 | Interaction with alpha subunitBy similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 55 – 64 | Asp/Glu-rich (acidic) | 10 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3092, Eukaryota |
GeneTreei | ENSGT00390000003781 |
HOGENOMi | CLU_034027_3_3_1 |
InParanoidi | P67870 |
OrthoDBi | 1335521at2759 |
PhylomeDBi | P67870 |
TreeFami | TF314462 |
Family and domain databases
Gene3Di | 1.10.1820.10, 1 hit |
InterProi | View protein in InterPro IPR016149, Casein_kin_II_reg-sub_N IPR035991, Casein_kinase_II_beta-like IPR000704, Casein_kinase_II_reg-sub |
PANTHERi | PTHR11740, PTHR11740, 1 hit |
Pfami | View protein in Pfam PF01214, CK_II_beta, 1 hit |
PRINTSi | PR00472, CASNKINASEII |
SMARTi | View protein in SMART SM01085, CK_II_beta, 1 hit |
SUPFAMi | SSF57798, SSF57798, 1 hit |
PROSITEi | View protein in PROSITE PS01101, CK2_BETA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL
60 70 80 90 100
DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK
110 120 130 140 150
YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR
160 170 180 190 200
HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ
210
LQAASNFKSP VKTIR
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5SRQ6 | Q5SRQ6_HUMAN | Casein kinase II subunit beta | CSNK2B hCG_43725 | 234 | Annotation score: | ||
Q5SRQ3 | Q5SRQ3_HUMAN | Casein kinase II subunit beta | CSNK2B CSNK2B-LY6G5B-1181 | 228 | Annotation score: | ||
N0E644 | N0E644_HUMAN | Casein kinase II subunit beta | CSNK2B CSNK2B-LY6G5B-562 | 161 | Annotation score: | ||
A0A0G2JM58 | A0A0G2JM58_HUMAN | Casein kinase II subunit beta | CSNK2B | 161 | Annotation score: | ||
N0E472 | N0E472_HUMAN | Casein kinase II subunit beta | CSNK2B CSNK2B-LY6G5B--991 | 304 | Annotation score: | ||
A0A0G2JM12 | A0A0G2JM12_HUMAN | Casein kinase II subunit beta | CSNK2B | 304 | Annotation score: | ||
H0Y6P8 | H0Y6P8_HUMAN | Uncharacterized protein | 212 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 194 | P → A in AAA52123 (PubMed:2513884).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083650 | 5 – 215 | Missing in POBINDS; associated in cis with C-86. 1 PublicationAdd BLAST | 211 | |
Natural variantiVAR_083651 | 86 | R → C in POBINDS; unknown pathological significance; associated in cis with 5-E--R-215 del. 1 Publication | 1 | |
Natural variantiVAR_083652 | 111 | R → P in POBINDS. 1 Publication | 1 | |
Natural variantiVAR_083653 | 137 | C → F in POBINDS. 1 Publication | 1 | |
Natural variantiVAR_083654 | 137 | C → G in POBINDS. 1 Publication | 1 | |
Natural variantiVAR_083655 | 187 | L → R in POBINDS. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X16937 mRNA Translation: CAA34811.1 X16312 mRNA Translation: CAA34379.1 M30448 mRNA Translation: AAA52123.1 X57152 Genomic DNA Translation: CAA40442.1 AY113186 mRNA Translation: AAM50092.1 CR541699 mRNA Translation: CAG46500.1 AF129756 Genomic DNA Translation: AAD18081.1 BA000025 Genomic DNA Translation: BAB63386.1 DQ314868 Genomic DNA Translation: ABC40727.1 AK311860 mRNA Translation: BAG34801.1 AL662899 Genomic DNA No translation available. AL670886 Genomic DNA No translation available. AL805934 Genomic DNA No translation available. BX511262 Genomic DNA No translation available. CR354443 Genomic DNA No translation available. CR753842 Genomic DNA No translation available. CR759761 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03473.1 BC112017 mRNA Translation: AAI12018.1 BC112019 mRNA Translation: AAI12020.1 |
CCDSi | CCDS4712.1 |
PIRi | A39459 |
RefSeqi | NP_001269314.1, NM_001282385.1 NP_001311.3, NM_001320.6 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X16937 mRNA Translation: CAA34811.1 X16312 mRNA Translation: CAA34379.1 M30448 mRNA Translation: AAA52123.1 X57152 Genomic DNA Translation: CAA40442.1 AY113186 mRNA Translation: AAM50092.1 CR541699 mRNA Translation: CAG46500.1 AF129756 Genomic DNA Translation: AAD18081.1 BA000025 Genomic DNA Translation: BAB63386.1 DQ314868 Genomic DNA Translation: ABC40727.1 AK311860 mRNA Translation: BAG34801.1 AL662899 Genomic DNA No translation available. AL670886 Genomic DNA No translation available. AL805934 Genomic DNA No translation available. BX511262 Genomic DNA No translation available. CR354443 Genomic DNA No translation available. CR753842 Genomic DNA No translation available. CR759761 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03473.1 BC112017 mRNA Translation: AAI12018.1 BC112019 mRNA Translation: AAI12020.1 |
CCDSi | CCDS4712.1 |
PIRi | A39459 |
RefSeqi | NP_001269314.1, NM_001282385.1 NP_001311.3, NM_001320.6 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DS5 | X-ray | 3.16 | E/F/G/H | 181-203 | [»] | |
1JWH | X-ray | 3.10 | C/D | 1-215 | [»] | |
1QF8 | X-ray | 1.74 | A/B | 1-182 | [»] | |
3EED | X-ray | 2.80 | A/B | 1-193 | [»] | |
4DGL | X-ray | 3.00 | A/B | 1-215 | [»] | |
4MD7 | X-ray | 3.10 | A/B/C/D | 1-215 | [»] | |
4MD8 | X-ray | 3.30 | A/B/C/D | 1-215 | [»] | |
4MD9 | X-ray | 3.50 | A/B/C/D/I/J/N/O | 1-215 | [»] | |
4NH1 | X-ray | 3.30 | C/D | 1-215 | [»] | |
6Q38 | X-ray | 1.74 | C | 186-193 | [»] | |
SMRi | P67870 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107843, 383 interactors |
CORUMi | P67870 |
DIPi | DIP-131N |
IntActi | P67870, 247 interactors |
MINTi | P67870 |
STRINGi | 9606.ENSP00000365042 |
Chemistry databases
BindingDBi | P67870 |
ChEMBLi | CHEMBL2358 |
DrugBanki | DB00171, ATP DB04216, Quercetin |
Protein family/group databases
MoonDBi | P67870, Predicted |
PTM databases
iPTMneti | P67870 |
MetOSitei | P67870 |
PhosphoSitePlusi | P67870 |
SwissPalmi | P67870 |
Polymorphism and mutation databases
BioMutai | CSNK2B |
DMDMi | 54037520 |
Proteomic databases
EPDi | P67870 |
jPOSTi | P67870 |
MassIVEi | P67870 |
MaxQBi | P67870 |
PaxDbi | P67870 |
PeptideAtlasi | P67870 |
PRIDEi | P67870 |
ProteomicsDBi | 57524 |
Protocols and materials databases
Antibodypediai | 1045, 586 antibodies |
DNASUi | 1460 |
Genome annotation databases
Organism-specific databases
CTDi | 1460 |
DisGeNETi | 1460 |
EuPathDBi | HostDB:ENSG00000204435.13 |
GeneCardsi | CSNK2B |
HGNCi | HGNC:2460, CSNK2B |
HPAi | ENSG00000204435, Low tissue specificity |
MalaCardsi | CSNK2B |
MIMi | 115441, gene 618732, phenotype |
neXtProti | NX_P67870 |
OpenTargetsi | ENSG00000204435 |
Orphaneti | 178469, Autosomal dominant non-syndromic intellectual disability |
PharmGKBi | PA26960 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3092, Eukaryota |
GeneTreei | ENSGT00390000003781 |
HOGENOMi | CLU_034027_3_3_1 |
InParanoidi | P67870 |
OrthoDBi | 1335521at2759 |
PhylomeDBi | P67870 |
TreeFami | TF314462 |
Enzyme and pathway databases
PathwayCommonsi | P67870 |
Reactomei | R-HSA-1483191, Synthesis of PC R-HSA-201688, WNT mediated activation of DVL R-HSA-2514853, Condensation of Prometaphase Chromosomes R-HSA-445144, Signal transduction by L1 R-HSA-6798695, Neutrophil degranulation R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-8934903, Receptor Mediated Mitophagy R-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-HSA-8948751, Regulation of PTEN stability and activity |
SignaLinki | P67870 |
SIGNORi | P67870 |
Miscellaneous databases
BioGRID-ORCSi | 1460, 662 hits in 859 CRISPR screens |
ChiTaRSi | CSNK2B, human |
EvolutionaryTracei | P67870 |
GeneWikii | CSNK2B |
GenomeRNAii | 1460 |
Pharosi | P67870, Tbio |
PROi | PR:P67870 |
RNActi | P67870, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204435, Expressed in right testis and 112 other tissues |
ExpressionAtlasi | P67870, baseline and differential |
Genevisiblei | P67870, HS |
Family and domain databases
Gene3Di | 1.10.1820.10, 1 hit |
InterProi | View protein in InterPro IPR016149, Casein_kin_II_reg-sub_N IPR035991, Casein_kinase_II_beta-like IPR000704, Casein_kinase_II_reg-sub |
PANTHERi | PTHR11740, PTHR11740, 1 hit |
Pfami | View protein in Pfam PF01214, CK_II_beta, 1 hit |
PRINTSi | PR00472, CASNKINASEII |
SMARTi | View protein in SMART SM01085, CK_II_beta, 1 hit |
SUPFAMi | SSF57798, SSF57798, 1 hit |
PROSITEi | View protein in PROSITE PS01101, CK2_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSK2B_HUMAN | |
Accessioni | P67870Primary (citable) accession number: P67870 Secondary accession number(s): B0UXA9 Q4VX47 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | December 2, 2020 | |
This is version 181 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations