Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prohibitin

Gene

Phb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA synthesis

Enzyme and pathway databases

ReactomeiR-MMU-5673000 RAF activation
R-MMU-8949664 Processing of SMDT1

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin
Alternative name(s):
B-cell receptor-associated protein 32
Short name:
BAP 32
Gene namesi
Name:Phb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97572 Phb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3751656

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002138792 – 272ProhibitinAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei91PhosphothreonineBy similarity1
Modified residuei128N6-acetyllysineCombined sources1
Modified residuei186N6-acetyllysineCombined sources1
Modified residuei202N6-acetyllysine; alternateCombined sources1
Modified residuei202N6-succinyllysine; alternateCombined sources1
Modified residuei249PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP67778
MaxQBiP67778
PaxDbiP67778
PeptideAtlasiP67778
PRIDEiP67778
TopDownProteomicsiP67778

2D gel databases

REPRODUCTION-2DPAGEiIPI00133440
P67778
SWISS-2DPAGEiP67778

PTM databases

iPTMnetiP67778
PhosphoSitePlusiP67778
SwissPalmiP67778

Expressioni

Tissue specificityi

Widely expressed in different tissues.1 Publication

Developmental stagei

Throughout gestation, highly expressed in brown fat, heart, liver, developing renal tubules and neurons, and detected at lower levels in tissues such as lung and exocrine pancreas.1 Publication

Gene expression databases

BgeeiENSMUSG00000038845 Expressed in 290 organ(s), highest expression level in heart
CleanExiMM_PHB
ExpressionAtlasiP67778 baseline and differential
GenevisibleiP67778 MM

Interactioni

Subunit structurei

Interacts with PHB2. Interacts with STOML2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Rab32Q9CZE34EBI-298507,EBI-11566047

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202141, 4 interactors
CORUMiP67778
IntActiP67778, 15 interactors
MINTiP67778
STRINGi10090.ENSMUSP00000119603

Structurei

3D structure databases

ProteinModelPortaliP67778
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili177 – 211Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the prohibitin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3083 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000074770
HOGENOMiHOG000205692
HOVERGENiHBG004457
InParanoidiP67778
KOiK17080
OMAiRTRIRDN
OrthoDBiEOG091G0IHW
TreeFamiTF300095

Family and domain databases

CDDicd03401 SPFH_prohibitin, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR000163 Prohibitin
PANTHERiPTHR23222 PTHR23222, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00679 PROHIBITIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P67778-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAKVFESIG KFGLALAVAG GVVNSALYNV DAGHRAVIFD RFRGVQDIVV
60 70 80 90 100
GEGTHFLIPW VQKPIIFDCR SRPRNVPVIT GSKDLQNVNI TLRILFRPVA
110 120 130 140 150
SQLPRIYTSI GEDYDERVLP SITTEILKSV VARFDAGELI TQRELVSRQV
160 170 180 190 200
SDDLTERAAT FGLILDDVSL THLTFGKEFT EAVEAKQVAQ QEAERARFVV
210 220 230 240 250
EKAEQQKKAA IISAEGDSKA AELIANSLAT AGDGLIELRK LEAAEDIAYQ
260 270
LSRSRNITYL PAGQSVLLQL PQ
Length:272
Mass (Da):29,820
Last modified:October 11, 2004 - v1
Checksum:i6B26073E169C2FFC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SQG5Q5SQG5_MOUSE
Prohibitin
Phb
207Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti255R → W in BAE29988 (PubMed:16141072).Curated1
Sequence conflicti255R → W in BAE30089 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78682 mRNA Translation: CAA55349.1
AK002714 mRNA Translation: BAB22305.1
AK010619 mRNA Translation: BAB27067.1
AK150956 mRNA Translation: BAE29988.1
AK151073 mRNA Translation: BAE30089.1
AK168248 mRNA Translation: BAE40198.1
AK168656 mRNA Translation: BAE40512.1
AL732490 Genomic DNA No translation available.
BC083354 mRNA Translation: AAH83354.1
BC089034 mRNA Translation: AAH89034.1
CCDSiCCDS25280.1
RefSeqiNP_032857.1, NM_008831.4
UniGeneiMm.263862

Genome annotation databases

EnsembliENSMUST00000125172; ENSMUSP00000119603; ENSMUSG00000038845
GeneIDi18673
KEGGimmu:18673
UCSCiuc007lan.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78682 mRNA Translation: CAA55349.1
AK002714 mRNA Translation: BAB22305.1
AK010619 mRNA Translation: BAB27067.1
AK150956 mRNA Translation: BAE29988.1
AK151073 mRNA Translation: BAE30089.1
AK168248 mRNA Translation: BAE40198.1
AK168656 mRNA Translation: BAE40512.1
AL732490 Genomic DNA No translation available.
BC083354 mRNA Translation: AAH83354.1
BC089034 mRNA Translation: AAH89034.1
CCDSiCCDS25280.1
RefSeqiNP_032857.1, NM_008831.4
UniGeneiMm.263862

3D structure databases

ProteinModelPortaliP67778
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202141, 4 interactors
CORUMiP67778
IntActiP67778, 15 interactors
MINTiP67778
STRINGi10090.ENSMUSP00000119603

Chemistry databases

ChEMBLiCHEMBL3751656

PTM databases

iPTMnetiP67778
PhosphoSitePlusiP67778
SwissPalmiP67778

2D gel databases

REPRODUCTION-2DPAGEiIPI00133440
P67778
SWISS-2DPAGEiP67778

Proteomic databases

EPDiP67778
MaxQBiP67778
PaxDbiP67778
PeptideAtlasiP67778
PRIDEiP67778
TopDownProteomicsiP67778

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000125172; ENSMUSP00000119603; ENSMUSG00000038845
GeneIDi18673
KEGGimmu:18673
UCSCiuc007lan.2 mouse

Organism-specific databases

CTDi5245
MGIiMGI:97572 Phb

Phylogenomic databases

eggNOGiKOG3083 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000074770
HOGENOMiHOG000205692
HOVERGENiHBG004457
InParanoidiP67778
KOiK17080
OMAiRTRIRDN
OrthoDBiEOG091G0IHW
TreeFamiTF300095

Enzyme and pathway databases

ReactomeiR-MMU-5673000 RAF activation
R-MMU-8949664 Processing of SMDT1

Miscellaneous databases

PROiPR:P67778
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038845 Expressed in 290 organ(s), highest expression level in heart
CleanExiMM_PHB
ExpressionAtlasiP67778 baseline and differential
GenevisibleiP67778 MM

Family and domain databases

CDDicd03401 SPFH_prohibitin, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR000163 Prohibitin
PANTHERiPTHR23222 PTHR23222, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00679 PROHIBITIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHB_MOUSE
AccessioniPrimary (citable) accession number: P67778
Secondary accession number(s): P24142, Q3UB75, Q5SQG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again