Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase class 1 (fda), Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175Proton acceptorBy similarity1
Active sitei212Schiff-base intermediate with dihydroxyacetone-PBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1 (EC:4.1.2.13)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolase
Gene namesi
Name:fda
Ordered Locus Names:SAV2606
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002169042 – 296Fructose-bisphosphate aldolase class 1Add BLAST295

Proteomic databases

PaxDbiP67472
PRIDEiP67472

2D gel databases

World-2DPAGEi0002:P67472

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV2606

Structurei

3D structure databases

ProteinModelPortaliP67472
SMRiP67472
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105WYW Bacteria
COG3588 LUCA
HOGENOMiHOG000073502
KOiK01623
OMAiVFGTKER

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00729 FBP_aldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000741 FBA_I
IPR023014 FBA_I_Gram+-type
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P67472-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKEQLEKMK NGKGFIAALD QSGGSTPKAL KEYGVNEDQY SNEDEMFQLV
60 70 80 90 100
HDMRTRVVTS PSFSPDKILG AILFEQTMDR EVEGKYTADY LADKGVVPFL
110 120 130 140 150
KVDKGLAEEQ NGVQLMKPID NLDSLLDRAN ERHIFGTKMR SNILELNEQG
160 170 180 190 200
IKDVVEQQFE VAKQIIAKGL VPIIEPEVNI NAKDKAEIEK VLKAELKKGL
210 220 230 240 250
DSLNADQLVM LKLTIPTEPN LYKELAEHPN VVRVVVLSGG YSREKANELL
260 270 280 290
KDNDELIASF SRALASDLRA DQSKEEFDKA LGDAVESIYD ASVNKN
Length:296
Mass (Da):33,042
Last modified:January 23, 2007 - v2
Checksum:iD63B1A3C7646725B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB58768.1
RefSeqiWP_001031409.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB58768; BAB58768; SAV2606
KEGGisav:SAV2606

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB58768.1
RefSeqiWP_001031409.1, NC_002758.2

3D structure databases

ProteinModelPortaliP67472
SMRiP67472
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV2606

2D gel databases

World-2DPAGEi0002:P67472

Proteomic databases

PaxDbiP67472
PRIDEiP67472

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58768; BAB58768; SAV2606
KEGGisav:SAV2606

Phylogenomic databases

eggNOGiENOG4105WYW Bacteria
COG3588 LUCA
HOGENOMiHOG000073502
KOiK01623
OMAiVFGTKER

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00729 FBP_aldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000741 FBA_I
IPR023014 FBA_I_Gram+-type
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALF1_STAAM
AccessioniPrimary (citable) accession number: P67472
Secondary accession number(s): Q99R31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again