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Entry version 119 (07 Oct 2020)
Sequence version 2 (04 Dec 2007)
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Protein

Xanthine permease XanQ

Gene

xanQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specific, proton motive force-dependent high-affinity transporter for xanthine.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by CCCP and N-ethylmaleimide.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4.2 µM for xanthine1 Publication
  1. Vmax=6.36 nmol/min/mg enzyme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei31Essential for affinity and specificity1
Sitei93Essential for affinity and specificity1
Sitei272Essential for purine uptake1
Sitei304Essential for purine uptake1
Sitei430Important for purine uptake and affinity1
Sitei432Important for purine uptake and affinity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • xanthine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:YGFO-MONOMER
MetaCyc:YGFO-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.40.4.3, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Xanthine permease XanQ
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:xanQ
Synonyms:ygfO
Ordered Locus Names:b2882, JW2850
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 55PeriplasmicSequence analysis9
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 80CytoplasmicSequence analysis4
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 120PeriplasmicSequence analysisAdd BLAST19
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 151CytoplasmicSequence analysis10
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 180PeriplasmicSequence analysis8
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 210CytoplasmicSequence analysis9
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 258PeriplasmicSequence analysisAdd BLAST27
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 298CytoplasmicSequence analysisAdd BLAST19
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 342PeriplasmicSequence analysisAdd BLAST23
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364CytoplasmicSequence analysis1
Transmembranei365 – 384HelicalSequence analysisAdd BLAST20
Topological domaini385 – 425PeriplasmicSequence analysisAdd BLAST41
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21
Topological domaini447 – 466CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi31H → C or L: Decrease in activity. 1 Publication1
Mutagenesisi31H → K or R: Strong decrease in activity. 1 Publication1
Mutagenesisi31H → N: No change in activity. 1 Publication1
Mutagenesisi31H → Q: Increase of activity. 1 Publication1
Mutagenesisi93N → A: Highly active. 1 Publication1
Mutagenesisi93N → C, D or T: Strong decrease in activity. 1 Publication1
Mutagenesisi93N → Q: Loss of activity. 1 Publication1
Mutagenesisi93N → S: Increase of activity. 1 Publication1
Mutagenesisi164K → C or R: Highly active. 1 Publication1
Mutagenesisi232D → C: Decrease in activity. 1 Publication1
Mutagenesisi232D → E: Highly active. 1 Publication1
Mutagenesisi258Q → C: Decrease in activity. 1 Publication1
Mutagenesisi258Q → N: Highly active. 1 Publication1
Mutagenesisi272E → C: Loss of activity. 1 Publication1
Mutagenesisi272E → D: Strong decrease in activity. 1 Publication1
Mutagenesisi304D → C: Loss of activity. 1 Publication1
Mutagenesisi304D → E: Strong decrease in activity. 1 Publication1
Mutagenesisi385R → C: Decrease in activity. 1 Publication1
Mutagenesisi385R → K: Highly active. 1 Publication1
Mutagenesisi421P → C: Strong decrease in activity. 1 Publication1
Mutagenesisi421P → G: Highly active. 1 Publication1
Mutagenesisi423S → C: Highly active. 1 Publication1
Mutagenesisi424I → C: Highly active. 1 Publication1
Mutagenesisi425Y → C: Strong decrease in activity. 1 Publication1
Mutagenesisi427L → C: Decrease in activity. 1 Publication1
Mutagenesisi430N → T: Loss of activity. 1 Publication1
Mutagenesisi432I → A, S, T or V: Strong decrease in activity. 1 Publication1
Mutagenesisi432I → L, M, E or F: Loss of activity. 1 Publication1
Mutagenesisi432I → N or Q: Highly active. 1 Publication1
Mutagenesisi436G → C: Highly active. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001659651 – 466Xanthine permease XanQAdd BLAST466

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P67444

PRoteomics IDEntifications database

More...
PRIDEi
P67444

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4261448, 22 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2882

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2233, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017959_8_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P67444

KEGG Orthology (KO)

More...
KOi
K16346

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P67444

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006042, Xan_ur_permease
IPR006043, Xant/urac/vitC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00860, Xan_ur_permease, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00801, ncs2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01116, XANTH_URACIL_PERMASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P67444-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDINHAGSD LIFELEDRPP FHQALVGAIT HLLAIFVPMV TPALIVGAAL
60 70 80 90 100
QLSAETTAYL VSMAMIASGI GTWLQVNRYG IVGSGLLSIQ SVNFSFVTVM
110 120 130 140 150
IALGSSMKSD GFHEELIMSS LLGVSFVGAF LVVGSSFILP YLRRVITPTV
160 170 180 190 200
SGIVVLMIGL SLIKVGIIDF GGGFAAKSSG TFGNYEHLGV GLLVLIVVIG
210 220 230 240 250
FNCCRSPLLR MGGIAIGLCV GYIASLCLGM VDFSSMRNLP LITIPHPFKY
260 270 280 290 300
GFSFSFHQFL VVGTIYLLSV LEAVGDITAT AMVSRRPIQG EEYQSRLKGG
310 320 330 340 350
VLADGLVSVI ASAVGSLPLT TFAQNNGVIQ MTGVASRYVG RTIAVMLVIL
360 370 380 390 400
GLFPMIGGFF TTIPSAVLGG AMTLMFSMIA IAGIRIIITN GLKRRETLIV
410 420 430 440 450
ATSLGLGLGV SYDPEIFKIL PASIYVLVEN PICAGGLTAI LLNIILPGGY
460
RQENVLPGIT SAEEMD
Length:466
Mass (Da):49,108
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95EAFB06FEEE9175
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA83063 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U28375 Genomic DNA Translation: AAA83063.1 Different initiation.
U00096 Genomic DNA Translation: AAC75920.2
AP009048 Genomic DNA Translation: BAE76948.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B65072

NCBI Reference Sequences

More...
RefSeqi
NP_417358.2, NC_000913.3
WP_001280192.1, NZ_STEB01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75920; AAC75920; b2882
BAE76948; BAE76948; BAE76948

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
49583243
949075

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2850
eco:b2882

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3852

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA Translation: AAA83063.1 Different initiation.
U00096 Genomic DNA Translation: AAC75920.2
AP009048 Genomic DNA Translation: BAE76948.1
PIRiB65072
RefSeqiNP_417358.2, NC_000913.3
WP_001280192.1, NZ_STEB01000001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4261448, 22 interactors
STRINGi511145.b2882

Protein family/group databases

TCDBi2.A.40.4.3, the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family

Proteomic databases

PaxDbiP67444
PRIDEiP67444

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
949075

Genome annotation databases

EnsemblBacteriaiAAC75920; AAC75920; b2882
BAE76948; BAE76948; BAE76948
GeneIDi49583243
949075
KEGGiecj:JW2850
eco:b2882
PATRICifig|1411691.4.peg.3852

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2877

Phylogenomic databases

eggNOGiCOG2233, Bacteria
HOGENOMiCLU_017959_8_0_6
InParanoidiP67444
KOiK16346
PhylomeDBiP67444

Enzyme and pathway databases

BioCyciEcoCyc:YGFO-MONOMER
MetaCyc:YGFO-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P67444

Family and domain databases

InterProiView protein in InterPro
IPR006042, Xan_ur_permease
IPR006043, Xant/urac/vitC
PfamiView protein in Pfam
PF00860, Xan_ur_permease, 1 hit
TIGRFAMsiTIGR00801, ncs2, 1 hit
PROSITEiView protein in PROSITE
PS01116, XANTH_URACIL_PERMASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXANQ_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P67444
Secondary accession number(s): Q2M9V8, Q46815
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: December 4, 2007
Last modified: October 7, 2020
This is version 119 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
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