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UniProtKB - P67087 (RSMI_ECOLI)

Entry version 119 (12 Aug 2020)
Sequence version 1 (11 Oct 2004)
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Protein

Ribosomal RNA small subunit methyltransferase I

Gene

rsmI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. In vitro, active on the assembled 30S subunit, but not naked 16S rRNA or 70S ribosomes.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • enzyme-directed rRNA 2'-O-methylation Source: EcoCyc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:G7641-MONOMER
ECOL316407:JW3115-MONOMER
MetaCyc:G7641-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.198, 2026

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase I (EC:2.1.1.198)
Alternative name(s):
16S rRNA 2'-O-ribose C1402 methyltransferase
rRNA (cytidine-2'-O-)-methyltransferase RsmI
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rsmI
Synonyms:yraL
Ordered Locus Names:b3146, JW3115
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002119381 – 286Ribosomal RNA small subunit methyltransferase IAdd BLAST286

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P67087

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P67087

PRoteomics IDEntifications database

More...PRIDEi		P67087

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4261593, 91 interactors

Database of interacting proteins

More...DIPi		DIP-12896N

Protein interaction database and analysis system

More...IntActi		P67087, 3 interactors

STRING: functional protein association networks

More...STRINGi		511145.b3146

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1286
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P67087

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the methyltransferase superfamily. RsmI family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0313, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_044779_4_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P67087

KEGG Orthology (KO)

More...KOi		K07056

Database for complete collections of gene phylogenies

More...PhylomeDBi		P67087

Family and domain databases

Conserved Domains Database

More...CDDi		cd11648, RsmI, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.950.10, 1 hit
3.40.1010.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01877, 16SrRNA_methyltr_I, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000878, 4pyrrol_Mease
IPR035996, 4pyrrol_Methylase_sf
IPR014777, 4pyrrole_Mease_sub1
IPR014776, 4pyrrole_Mease_sub2
IPR008189, rRNA_ssu_MeTfrase_I
IPR018063, SAM_MeTrfase_RsmI_CS

The PANTHER Classification System

More...PANTHERi		PTHR46111, PTHR46111, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00590, TP_methylase, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005917, MTase_YraL, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53790, SSF53790, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00096, TIGR00096, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01296, RSMI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P67087-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQHQSADNS QGQLYIVPTP IGNLADITQR ALEVLQAVDL IAAEDTRHTG 
        60         70         80         90        100
LLLQHFGINA RLFALHDHNE QQKAETLLAK LQEGQNIALV SDAGTPLIND 
       110        120        130        140        150
PGYHLVRTCR EAGIRVVPLP GPCAAITALS AAGLPSDRFC YEGFLPAKSK 
       160        170        180        190        200
GRRDALKAIE AEPRTLIFYE STHRLLDSLE DIVAVLGESR YVVLARELTK 
       210        220        230        240        250
TWETIHGAPV GELLAWVKED ENRRKGEMVL IVEGHKAQEE DLPADALRTL 
       260        270        280 
ALLQAELPLK KAAALAAEIH GVKKNALYKY ALEQQG
Length:286
Mass (Da):31,348
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i886EA492858FB95C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA57949.1
U00096 Genomic DNA Translation: AAC76180.1
AP009048 Genomic DNA Translation: BAE77192.1

Protein sequence database of the Protein Information Resource

More...PIRi		F65104

NCBI Reference Sequences

More...RefSeqi		NP_417615.1, NC_000913.3
WP_000809262.1, NZ_STEB01000012.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC76180; AAC76180; b3146
BAE77192; BAE77192; BAE77192

Database of genes from NCBI RefSeq genomes

More...GeneIDi		48722632
947664

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW3115
eco:b3146

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.3584

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA57949.1
U00096 Genomic DNA Translation: AAC76180.1
AP009048 Genomic DNA Translation: BAE77192.1
PIRiF65104
RefSeqiNP_417615.1, NC_000913.3
WP_000809262.1, NZ_STEB01000012.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HW4X-ray2.21A/B/C12-258[»]
SMRiP67087
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4261593, 91 interactors
DIPiDIP-12896N
IntActiP67087, 3 interactors
STRINGi511145.b3146

Proteomic databases

jPOSTiP67087
PaxDbiP67087
PRIDEiP67087

Genome annotation databases

EnsemblBacteriaiAAC76180; AAC76180; b3146
BAE77192; BAE77192; BAE77192
GeneIDi48722632
947664
KEGGiecj:JW3115
eco:b3146
PATRICifig|1411691.4.peg.3584

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB2630

Phylogenomic databases

eggNOGiCOG0313, Bacteria
HOGENOMiCLU_044779_4_0_6
InParanoidiP67087
KOiK07056
PhylomeDBiP67087

Enzyme and pathway databases

BioCyciEcoCyc:G7641-MONOMER
ECOL316407:JW3115-MONOMER
MetaCyc:G7641-MONOMER
BRENDAi2.1.1.198, 2026

Miscellaneous databases

Protein Ontology

More...PROi		PR:P67087

Family and domain databases

CDDicd11648, RsmI, 1 hit
Gene3Di3.30.950.10, 1 hit
3.40.1010.10, 1 hit
HAMAPiMF_01877, 16SrRNA_methyltr_I, 1 hit
InterProiView protein in InterPro
IPR000878, 4pyrrol_Mease
IPR035996, 4pyrrol_Methylase_sf
IPR014777, 4pyrrole_Mease_sub1
IPR014776, 4pyrrole_Mease_sub2
IPR008189, rRNA_ssu_MeTfrase_I
IPR018063, SAM_MeTrfase_RsmI_CS
PANTHERiPTHR46111, PTHR46111, 1 hit
PfamiView protein in Pfam
PF00590, TP_methylase, 1 hit
PIRSFiPIRSF005917, MTase_YraL, 1 hit
SUPFAMiSSF53790, SSF53790, 1 hit
TIGRFAMsiTIGR00096, TIGR00096, 1 hit
PROSITEiView protein in PROSITE
PS01296, RSMI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRSMI_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P67087
Secondary accession number(s): P45528, Q2M964
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: August 12, 2020
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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