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Entry version 116 (07 Apr 2021)
Sequence version 1 (11 Oct 2004)
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Protein

Uncharacterized protein YgeY

Gene

ygeY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarity, Co2+By similarityNote: Binds 2 Zn2+ or Co2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi81Cobalt or zinc 1By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei83By similarity1
Metal bindingi114Cobalt or zinc 1By similarity1
Metal bindingi114Cobalt or zinc 2By similarity1
Active sitei148Proton acceptorBy similarity1
Metal bindingi149Cobalt or zinc 2By similarity1
Metal bindingi174Cobalt or zinc 1By similarity1
Metal bindingi374Cobalt or zinc 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandCobalt, Metal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
EcoCyc:G7491-MONOMER

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M20.A08

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein YgeY
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ygeY
Ordered Locus Names:b2872, JW2840
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001853391 – 403Uncharacterized protein YgeYAdd BLAST403

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P65807

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P65807

PRoteomics IDEntifications database

More...
PRIDEi
P65807

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
4262323, 17 interactors

Protein interaction database and analysis system

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IntActi
P65807, 10 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b2872

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P65807

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M20A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
COG0624, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021802_2_1_6

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P65807

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P65807

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001261, ArgE/DapE_CS
IPR036264, Bact_exopeptidase_dim_dom
IPR002933, Peptidase_M20
IPR017706, Peptidase_M20/DapE_YgeY
IPR011650, Peptidase_M20_dimer

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07687, M20_dimer, 1 hit
PF01546, Peptidase_M20, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55031, SSF55031, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03526, selenium_YgeY, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00758, ARGE_DAPE_CPG2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P65807-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKNIPFKLI LEKAKDYQAD MTRFLRDMVA IPSESCDEKR VVHRIKEEME
60 70 80 90 100
KVGFDKVEID PMGNVLGYIG HGPRLVAMDA HIDTVGIGNI KNWDFDPYEG
110 120 130 140 150
METDELIGGR GTSDQEGGMA SMVYAGKIIK DLGLEDEYTL LVTGTVQEED
160 170 180 190 200
CDGLCWQYII EQSGIRPEFV VSTEPTDCQV YRGQRGRMEI RIDVQGVSCH
210 220 230 240 250
GSAPERGDNA IFKMGPILGE LQELSQRLGY DEFLGKGTLT VSEIFFTSPS
260 270 280 290 300
RCAVADSCAV SIDRRLTWGE TWEGALDEIR ALPAVQKANA VVSMYNYDRP
310 320 330 340 350
SWTGLVYPTE CYFPTWKVEE DHFTVKALVN AYEGLFGKAP VVDKWTFSTN
360 370 380 390 400
GVSIMGRHGI PVIGFGPGKE PEAHAPNEKT WKSHLVTCAA MYAAIPLSWL

ATE
Length:403
Mass (Da):44,804
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87937D12244038B6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U28375 Genomic DNA Translation: AAA83053.1
U00096 Genomic DNA Translation: AAC75910.1
AP009048 Genomic DNA Translation: BAE76938.1

Protein sequence database of the Protein Information Resource

More...
PIRi
H65070

NCBI Reference Sequences

More...
RefSeqi
NP_417348.1, NC_000913.3
WP_001107125.1, NZ_STEB01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75910; AAC75910; b2872
BAE76938; BAE76938; BAE76938

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947360

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2840
eco:b2872

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3862

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA Translation: AAA83053.1
U00096 Genomic DNA Translation: AAC75910.1
AP009048 Genomic DNA Translation: BAE76938.1
PIRiH65070
RefSeqiNP_417348.1, NC_000913.3
WP_001107125.1, NZ_STEB01000001.1

3D structure databases

SMRiP65807
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4262323, 17 interactors
IntActiP65807, 10 interactors
STRINGi511145.b2872

Protein family/group databases

MEROPSiM20.A08

Proteomic databases

jPOSTiP65807
PaxDbiP65807
PRIDEiP65807

Genome annotation databases

EnsemblBacteriaiAAC75910; AAC75910; b2872
BAE76938; BAE76938; BAE76938
GeneIDi947360
KEGGiecj:JW2840
eco:b2872
PATRICifig|1411691.4.peg.3862

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2867

Phylogenomic databases

eggNOGiCOG0624, Bacteria
HOGENOMiCLU_021802_2_1_6
InParanoidiP65807
PhylomeDBiP65807

Enzyme and pathway databases

BioCyciEcoCyc:G7491-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P65807

Family and domain databases

InterProiView protein in InterPro
IPR001261, ArgE/DapE_CS
IPR036264, Bact_exopeptidase_dim_dom
IPR002933, Peptidase_M20
IPR017706, Peptidase_M20/DapE_YgeY
IPR011650, Peptidase_M20_dimer
PfamiView protein in Pfam
PF07687, M20_dimer, 1 hit
PF01546, Peptidase_M20, 1 hit
SUPFAMiSSF55031, SSF55031, 1 hit
TIGRFAMsiTIGR03526, selenium_YgeY, 1 hit
PROSITEiView protein in PROSITE
PS00758, ARGE_DAPE_CPG2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYGEY_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P65807
Secondary accession number(s): Q2M9W8, Q46805
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 7, 2021
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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