UniProtKB - P65488 (MUTB_MYCBO)
Protein
Probable methylmalonyl-CoA mutase large subunit
Gene
mutB
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Functioni
Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates.By similarity
Catalytic activityi
- EC:5.4.99.2
Cofactori
adenosylcob(III)alaminBy similarity
: propanoyl-CoA degradation Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Probable propionyl-CoA carboxylase beta chain 6 (accD6)
- no protein annotated in this organism
- Probable methylmalonyl-CoA mutase large subunit (mutB), PROBABLE METHYLMALONYL-COA MUTASE LARGE SUBUNIT MUTB (MCM) (mutB), Methylmalonyl-CoA mutase (mutA), Probable methylmalonyl-CoA mutase small subunit (mutA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 629 | Cobalt (cobalamin axial ligand)By similarity | 1 |
GO - Molecular functioni
- cobalamin binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- methylmalonyl-CoA mutase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Isomerase |
Ligand | Cobalamin, Cobalt, Metal-binding |
Enzyme and pathway databases
BioCyci | MBOV233413:G1GT4-1586-MONOMER |
UniPathwayi | UPA00945;UER00910 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:mutB Ordered Locus Names:BQ2027_MB1530 |
Organismi | Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) |
Taxonomic identifieri | 233413 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000194271 | 1 – 750 | Probable methylmalonyl-CoA mutase large subunitAdd BLAST | 750 |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta chain.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 616 – 748 | B12-bindingPROSITE-ProRule annotationAdd BLAST | 133 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 587 – 626 | Methylmalonyl-CoA-binding siteBy similarityAdd BLAST | 40 |
Sequence similaritiesi
Belongs to the methylmalonyl-CoA mutase family.Curated
Phylogenomic databases
OMAi | GPYATMY |
Family and domain databases
InterProi | View protein in InterPro IPR006159, Acid_CoA_mut_C IPR016176, Cbl-dep_enz_cat IPR006158, Cobalamin-bd IPR036724, Cobalamin-bd_sf IPR006099, MeMalonylCoA_mutase_a/b_cat IPR006098, MMCoA_mutase_a_cat |
Pfami | View protein in Pfam PF02310, B12-binding, 1 hit PF01642, MM_CoA_mutase, 1 hit |
SUPFAMi | SSF51703, SSF51703, 1 hit SSF52242, SSF52242, 1 hit |
TIGRFAMsi | TIGR00640, acid_CoA_mut_C, 1 hit TIGR00641, acid_CoA_mut_N, 1 hit |
PROSITEi | View protein in PROSITE PS51332, B12_BINDING, 1 hit PS00544, METMALONYL_COA_MUTASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P65488-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTKTPVIGS FAGVPLHSER AAQSPTEAAV HTHVAAAAAA HGYTPEQLVW
60 70 80 90 100
HTPEGIDVTP VYIAADRAAA EAEGYPLHSF PGEPPFVRGP YPTMYVNQPW
110 120 130 140 150
TIRQYAGFST AADSNAFYRR NLAAGQKGLS VAFDLATHRG YDSDHPRVQG
160 170 180 190 200
DVGMAGVAID SILDMRQLFD GIDLSTVSVS MTMNGAVLPI LALYVVAAEE
210 220 230 240 250
QGVAPEQLAG TIQNDILKEF MVRNTYIYPP KPSMRIISDI FAYTSAKMPK
260 270 280 290 300
FNSISISGYH IQEAGATADL ELAYTLADGV DYIRAGLNAG LDIDSFAPRL
310 320 330 340 350
SFFWGIGMNF FMEVAKLRAG RLLWSELVAQ FAPKSAKSLS LRTHSQTSGW
360 370 380 390 400
SLTAQDVFNN VARTCIEAMA ATQGHTQSLH TNALDEALAL PTDFSARIAR
410 420 430 440 450
NTQLVLQQES GTTRPIDPWG GSYYVEWLTH RLARRARAHI AEVAEHGGMA
460 470 480 490 500
QAISDGIPKL RIEEAAARTQ ARIDSGQQPV VGVNKYQVPE DHEIEVLKVE
510 520 530 540 550
NSRVRAEQLA KLQRLRAGRD EPAVRAALAE LTRAAAEQGR AGADGLGNNL
560 570 580 590 600
LALAIDAARA QATVGEISEA LEKVYGRHRA EIRTISGVYR DEVGKAPNIA
610 620 630 640 650
AATELVEKFA EADGRRPRIL IAKMGQDGHD RGQKVIATAF ADIGFDVDVG
660 670 680 690 700
SLFSTPEEVA RQAADNDVHV IGVSSLAAGH LTLVPALRDA LAQVGRPDIM
710 720 730 740 750
IVVGGVIPPG DFDELYAAGA TAIFPPGTVI ADAAIDLLHR LAERLGYTLD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LT708304 Genomic DNA Translation: SIU00133.1 |
RefSeqi | NP_855182.1, NC_002945.3 WP_003407587.1, NC_002945.4 |
Genome annotation databases
EnsemblBacteriai | CDO42778; CDO42778; Mb1530 |
GeneIDi | 45425473 |
PATRICi | fig|233413.5.peg.1672 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LT708304 Genomic DNA Translation: SIU00133.1 |
RefSeqi | NP_855182.1, NC_002945.3 WP_003407587.1, NC_002945.4 |
3D structure databases
SMRi | P65488 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | CDO42778; CDO42778; Mb1530 |
GeneIDi | 45425473 |
PATRICi | fig|233413.5.peg.1672 |
Phylogenomic databases
OMAi | GPYATMY |
Enzyme and pathway databases
UniPathwayi | UPA00945;UER00910 |
BioCyci | MBOV233413:G1GT4-1586-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR006159, Acid_CoA_mut_C IPR016176, Cbl-dep_enz_cat IPR006158, Cobalamin-bd IPR036724, Cobalamin-bd_sf IPR006099, MeMalonylCoA_mutase_a/b_cat IPR006098, MMCoA_mutase_a_cat |
Pfami | View protein in Pfam PF02310, B12-binding, 1 hit PF01642, MM_CoA_mutase, 1 hit |
SUPFAMi | SSF51703, SSF51703, 1 hit SSF52242, SSF52242, 1 hit |
TIGRFAMsi | TIGR00640, acid_CoA_mut_C, 1 hit TIGR00641, acid_CoA_mut_N, 1 hit |
PROSITEi | View protein in PROSITE PS51332, B12_BINDING, 1 hit PS00544, METMALONYL_COA_MUTASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MUTB_MYCBO | |
Accessioni | P65488Primary (citable) accession number: P65488 Secondary accession number(s): A0A1R3Y0N2, P71774, X2BID6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | February 10, 2021 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families