UniProtKB - P65467 (MURB_STRR6)
Protein
UDP-N-acetylenolpyruvoylglucosamine reductase
Gene
murB
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Functioni
Cell wall formation.UniRule annotation
Catalytic activityi
- NADP+ + UDP-N-acetyl-α-D-muramate = H+ + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-α-D-glucosamineUniRule annotationEC:1.3.1.98UniRule annotation
Cofactori
FADUniRule annotation
: peptidoglycan biosynthesis Pathwayi
This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 173 | UniRule annotation | 1 | |
Active sitei | 223 | Proton donorUniRule annotation | 1 | |
Active sitei | 293 | UniRule annotation | 1 |
GO - Molecular functioni
- FAD binding Source: InterPro
- UDP-N-acetylmuramate dehydrogenase activity Source: UniProtKB-UniRule
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cell wall organization Source: UniProtKB-KW
- peptidoglycan biosynthetic process Source: UniProtKB-UniRule
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis |
Ligand | FAD, Flavoprotein, NADP |
Enzyme and pathway databases
BioCyci | SPNE171101:SPR1247-MONOMER |
UniPathwayi | UPA00219 |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)Alternative name(s): UDP-N-acetylmuramate dehydrogenaseUniRule annotation |
Gene namesi | Name:murBUniRule annotation Ordered Locus Names:spr1247 |
Organismi | Streptococcus pneumoniae (strain ATCC BAA-255 / R6) |
Taxonomic identifieri | 171101 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000179271 | 1 – 316 | UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST | 316 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 194 | FAD-binding PCMH-typeUniRule annotationAdd BLAST | 165 |
Sequence similaritiesi
Belongs to the MurB family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105D4A Bacteria COG0812 LUCA |
HOGENOMi | HOG000284355 |
KOi | K00075 |
OMAi | IGNAGSF |
Family and domain databases
Gene3Di | 3.30.43.10, 1 hit 3.30.465.10, 1 hit 3.90.78.10, 1 hit |
HAMAPi | MF_00037 MurB, 1 hit |
InterProi | View protein in InterPro IPR016166 FAD-bd_PCMH IPR036318 FAD-bd_PCMH-like_sf IPR016167 FAD-bd_PCMH_sub1 IPR016169 FAD-bd_PCMH_sub2 IPR003170 MurB IPR011601 MurB_C IPR036635 MurB_C_sf IPR006094 Oxid_FAD_bind_N |
PANTHERi | PTHR21071 PTHR21071, 1 hit |
Pfami | View protein in Pfam PF01565 FAD_binding_4, 1 hit PF02873 MurB_C, 1 hit |
SUPFAMi | SSF56176 SSF56176, 1 hit SSF56194 SSF56194, 1 hit |
TIGRFAMsi | TIGR00179 murB, 1 hit |
PROSITEi | View protein in PROSITE PS51387 FAD_PCMH, 1 hit |
i Sequence
Sequence statusi: Complete.
P65467-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVREKMLEI LEGIDIRFKE PLHSYSYTKV GGEADYLVFP RNRFELARVV
60 70 80 90 100
KFANQENIPW MVLGNASNII VRDGGIRGFV ILCDKLNNVS VDGYTIEAEA
110 120 130 140 150
GANLIETTRI ALRHSLTGFE FACGIPGSVG GAVFMNAGAY GGEIAHILQS
160 170 180 190 200
CKVLTKDGEI ETLSAKDLAF GYRHSAIQES GAVVLSVKFA LAPGTHQVIK
210 220 230 240 250
QEMDRLTHLR ELKQPLEYPS CGSVFKRPVG HFAGQLISEA GLKGYRIGGV
260 270 280 290 300
EVSEKHAGFM INVADGTAKD YEDLIQSVIE KVKEHSGITL EREVRILGES
310
LSVAKMYAGG FTPCKR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE007317 Genomic DNA Translation: AAL00051.1 |
PIRi | F98027 |
RefSeqi | NP_358840.1, NC_003098.1 WP_000116181.1, NC_003098.1 |
Genome annotation databases
EnsemblBacteriai | AAL00051; AAL00051; spr1247 |
GeneIDi | 934461 |
KEGGi | spr:spr1247 |
PATRICi | fig|171101.6.peg.1352 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE007317 Genomic DNA Translation: AAL00051.1 |
PIRi | F98027 |
RefSeqi | NP_358840.1, NC_003098.1 WP_000116181.1, NC_003098.1 |
3D structure databases
SMRi | P65467 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 171101.spr1247 |
Genome annotation databases
EnsemblBacteriai | AAL00051; AAL00051; spr1247 |
GeneIDi | 934461 |
KEGGi | spr:spr1247 |
PATRICi | fig|171101.6.peg.1352 |
Phylogenomic databases
eggNOGi | ENOG4105D4A Bacteria COG0812 LUCA |
HOGENOMi | HOG000284355 |
KOi | K00075 |
OMAi | IGNAGSF |
Enzyme and pathway databases
UniPathwayi | UPA00219 |
BioCyci | SPNE171101:SPR1247-MONOMER |
Family and domain databases
Gene3Di | 3.30.43.10, 1 hit 3.30.465.10, 1 hit 3.90.78.10, 1 hit |
HAMAPi | MF_00037 MurB, 1 hit |
InterProi | View protein in InterPro IPR016166 FAD-bd_PCMH IPR036318 FAD-bd_PCMH-like_sf IPR016167 FAD-bd_PCMH_sub1 IPR016169 FAD-bd_PCMH_sub2 IPR003170 MurB IPR011601 MurB_C IPR036635 MurB_C_sf IPR006094 Oxid_FAD_bind_N |
PANTHERi | PTHR21071 PTHR21071, 1 hit |
Pfami | View protein in Pfam PF01565 FAD_binding_4, 1 hit PF02873 MurB_C, 1 hit |
SUPFAMi | SSF56176 SSF56176, 1 hit SSF56194 SSF56194, 1 hit |
TIGRFAMsi | TIGR00179 murB, 1 hit |
PROSITEi | View protein in PROSITE PS51387 FAD_PCMH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MURB_STRR6 | |
Accessioni | P65467Primary (citable) accession number: P65467 Secondary accession number(s): Q8DPC1, Q97Q41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | September 18, 2019 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - PATHWAY comments
Index of metabolic and biosynthesis pathways