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UniProtKB - P64804 (PDUO_MYCBO)
Protein
Corrinoid adenosyltransferase
Gene
BQ2027_MB1347C
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Functioni
Catalytic activityi
- 2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphateEC:2.5.1.17
- 2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphateEC:2.5.1.17
: adenosylcobalamin biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide. This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide, the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 28 | ATPBy similarity | 1 | |
Binding sitei | 163 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 18 | ATPBy similarity | 9 | |
Nucleotide bindingi | 137 – 142 | ATPBy similarity | 6 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cob(I)yrinic acid a,c-diamide adenosyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- cobalamin biosynthetic process Source: UniProtKB-UniPathway
- porphyrin-containing compound biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Transferase |
Biological process | Cobalamin biosynthesis, Porphyrin biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00148;UER00233 |
Names & Taxonomyi
Protein namesi | Recommended name: Corrinoid adenosyltransferase (EC:2.5.1.17)Alternative name(s): Cob(II)alamin adenosyltransferase Cob(II)yrinic acid a,c-diamide adenosyltransferase Cobinamide/cobalamin adenosyltransferase |
Gene namesi | Ordered Locus Names:BQ2027_MB1347C |
Organismi | Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) |
Taxonomic identifieri | 233413 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000103799 | 1 – 193 | Corrinoid adenosyltransferaseAdd BLAST | 193 |
Family & Domainsi
Sequence similaritiesi
Belongs to the Cob(I)alamin adenosyltransferase family.Curated
Phylogenomic databases
OMAi | HQACTVV |
Family and domain databases
Gene3Di | 1.20.1200.10, 1 hit |
InterProi | View protein in InterPro IPR016030, CblAdoTrfase-like IPR036451, CblAdoTrfase-like_sf IPR029499, PduO-typ |
PANTHERi | PTHR12213, PTHR12213, 1 hit |
Pfami | View protein in Pfam PF01923, Cob_adeno_trans, 1 hit |
SUPFAMi | SSF89028, SSF89028, 1 hit |
TIGRFAMsi | TIGR00636, PduO_Nterm, 1 hit |
i Sequence
Sequence statusi: Complete.
P64804-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVHLTRIYT RTGDDGTTGL SDMSRVAKTD ARLVAYADCD EANAAIGAAL
60 70 80 90 100
ALGHPDTQIT DVLRQIQNDL FDAGADLSTP IVENPKHPPL RIAQSYIDRL
110 120 130 140 150
EGWCDAYNAG LPALKSFVLP GGSPLSALLH VARTVVRRAE RSAWAAVDAH
160 170 180 190
PEGVSVLPAK YLNRLSDLLF ILSRVANPDG DVLWRPGGDR TAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LT708304 Genomic DNA Translation: SIT99950.1 |
RefSeqi | NP_855001.1, NC_002945.3 WP_003406839.1, NC_002945.4 |
Genome annotation databases
EnsemblBacteriai | SIT99950; SIT99950; BQ2027_MB1347C |
GeneIDi | 45425287 |
PATRICi | fig|233413.5.peg.1476 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LT708304 Genomic DNA Translation: SIT99950.1 |
RefSeqi | NP_855001.1, NC_002945.3 WP_003406839.1, NC_002945.4 |
3D structure databases
AlphaFoldDBi | P64804 |
SMRi | P64804 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | SIT99950; SIT99950; BQ2027_MB1347C |
GeneIDi | 45425287 |
PATRICi | fig|233413.5.peg.1476 |
Phylogenomic databases
OMAi | HQACTVV |
Enzyme and pathway databases
UniPathwayi | UPA00148;UER00233 |
Family and domain databases
Gene3Di | 1.20.1200.10, 1 hit |
InterProi | View protein in InterPro IPR016030, CblAdoTrfase-like IPR036451, CblAdoTrfase-like_sf IPR029499, PduO-typ |
PANTHERi | PTHR12213, PTHR12213, 1 hit |
Pfami | View protein in Pfam PF01923, Cob_adeno_trans, 1 hit |
SUPFAMi | SSF89028, SSF89028, 1 hit |
TIGRFAMsi | TIGR00636, PduO_Nterm, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PDUO_MYCBO | |
Accessioni | P64804Primary (citable) accession number: P64804 Secondary accession number(s): A0A1R3XY13, Q10622, X2BHJ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | May 25, 2022 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families