Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei596For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:SAV2154
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353802 – 601Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST600

Proteomic databases

PaxDbiP64227

2D gel databases

World-2DPAGEi0002:P64227

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi158878.SAV2154

Structurei

3D structure databases

ProteinModelPortaliP64227
SMRiP64227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2UniRule annotationAdd BLAST217
Domaini284 – 423SIS 1UniRule annotationAdd BLAST140
Domaini453 – 591SIS 2UniRule annotationAdd BLAST139

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
PhylomeDBiP64227

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P64227-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIVGYIGY DNAKELLLKG LEKLEYRGYD SAGIAVVNDD NTTVFKEKGR
60 70 80 90 100
IAELRKVADS SDFDGPVGIG HTRWATHGVP NHENSHPHQS SNGRFTLVHN
110 120 130 140 150
GVIENYEELK GEYLQGVSFI SETDTEVIVQ LVEYFSNQGL STEEAFTKVV
160 170 180 190 200
SLLHGSYALG LLDAEDKDTI YVAKNKSPLL LGVGEGFNVI ASDALAMLQV
210 220 230 240 250
TSEYKEIHDH EIVIVKKDEV IIKDADGNVV ERDSYIAEID ASDAEKGVYA
260 270 280 290 300
HYMLKEIHEQ PAVMRRIIQE YQDAEGNLKI DQDIINDVKE ADRIYVIAAG
310 320 330 340 350
TSYHAGLVGK EFLEKWAGVP TEVHVASEFV YNMPLLSEKP LFVYISQSGE
360 370 380 390 400
TADSRAVLVE TNKLGHKSLT ITNVAGSTLS READHTLLLH AGPEIAVAST
410 420 430 440 450
KAYTAQIAVL SILSQIVAKE HGREADIDLL RELAKVTTAI EAIVDDAPIM
460 470 480 490 500
EQIATDFLET TRNAFFIGRT IDYNVSLEGA LKLKEISYIQ AEGFAGGELK
510 520 530 540 550
HGTIALIEDG TPVVALATQE NVNLSIRGNV KEVVARGAHP CIISMEGLEK
560 570 580 590 600
EGDTYVIPHV HELLTPLVSV VALQLISYYA ALHRDLDVDK PRNLAKSVTV

E
Length:601
Mass (Da):65,835
Last modified:January 23, 2007 - v2
Checksum:iC2A7B4AE4E829F0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB58316.1
RefSeqiWP_000334463.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB58316; BAB58316; SAV2154
KEGGisav:SAV2154

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB58316.1
RefSeqiWP_000334463.1, NC_002758.2

3D structure databases

ProteinModelPortaliP64227
SMRiP64227
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV2154

2D gel databases

World-2DPAGEi0002:P64227

Proteomic databases

PaxDbiP64227

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58316; BAB58316; SAV2154
KEGGisav:SAV2154

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
PhylomeDBiP64227

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGLMS_STAAM
AccessioniPrimary (citable) accession number: P64227
Secondary accession number(s): Q99SA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again