UniProtKB - P63908 (ADD_MYCBO)
Protein
Adenosine deaminase
Gene
add
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Functioni
Catalytic activityi
- EC:3.5.4.4UniRule annotation
Cofactori
Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 19 | Zinc; catalyticUniRule annotation | 1 | |
Metal bindingi | 21 | Zinc; catalyticUniRule annotation | 1 | |
Binding sitei | 21 | SubstrateUniRule annotation | 1 | |
Binding sitei | 23 | SubstrateUniRule annotation | 1 | |
Binding sitei | 181 | Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 208 | Zinc; catalyticUniRule annotation | 1 | |
Active sitei | 211 | Proton donorUniRule annotation | 1 | |
Sitei | 232 | Important for catalytic activityUniRule annotation | 1 | |
Metal bindingi | 300 | Zinc; catalyticUniRule annotation | 1 |
GO - Molecular functioni
- adenosine deaminase activity Source: UniProtKB-UniRule
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- nucleotide metabolic process Source: UniProtKB-KW
- purine ribonucleoside monophosphate biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Hydrolase |
Biological process | Nucleotide metabolism |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | MBOV233413:G1GT4-3510-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Adenosine deaminaseUniRule annotation (EC:3.5.4.4UniRule annotation)Alternative name(s): Adenosine aminohydrolaseUniRule annotation |
Gene namesi | Name:addUniRule annotation Ordered Locus Names:BQ2027_MB3342C |
Organismi | Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) |
Taxonomic identifieri | 233413 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000194375 | 1 – 365 | Adenosine deaminaseAdd BLAST | 365 |
Proteomic databases
PRIDEi | P63908 |
Structurei
3D structure databases
ProteinModelPortali | P63908 |
SMRi | P63908 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000218816 |
OMAi | QWCGADR |
Family and domain databases
HAMAPi | MF_00540 A_deaminase, 1 hit |
InterProi | View protein in InterPro IPR001365 A/AMP_deaminase_dom IPR028893 A_deaminase IPR006330 Ado/ade_deaminase IPR032466 Metal_Hydrolase |
Pfami | View protein in Pfam PF00962 A_deaminase, 1 hit |
SUPFAMi | SSF51556 SSF51556, 1 hit |
TIGRFAMsi | TIGR01430 aden_deam, 1 hit |
i Sequence
Sequence statusi: Complete.
P63908-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAAPTLQTI RLAPKALLHD HLDGGLRPAT VLDIAGQVGY DDLPATDVDA
60 70 80 90 100
LASWFRTQSH SGSLERYLEP FSHTVAVMQT PEALYRVAFE CAQDLAADSV
110 120 130 140 150
VYAEVRFAPE LHISCGLSFD DVVDTVLTGF AAGEKACAAD GQPITVRCLV
160 170 180 190 200
TAMRHAAMSR EIAELAIRFR DKGVVGFDIA GAEAGHPPTR HLDAFEYMRD
210 220 230 240 250
HNARFTIHAG EAFGLPSIHE AIAFCGADRL GHGVRIVDDI DVDADGGFQL
260 270 280 290 300
GRLAAILRDK RIPLELCPSS NVQTGAVASI AEHPFDLLAR ARFRVTVNTD
310 320 330 340 350
NRLMSDTSMS LEMHRLVEAF GYGWSDLARF TVNAMKSAFI PFDQRLAIID
360
EVIKPRFAAL MGHSE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LT708304 Genomic DNA Translation: SIU01971.1 |
RefSeqi | NP_856987.1, NC_002945.3 WP_003417259.1, NC_002945.4 |
Genome annotation databases
EnsemblBacteriai | CDO44614; CDO44614; Mb3342c |
PATRICi | fig|233413.5.peg.3673 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LT708304 Genomic DNA Translation: SIU01971.1 |
RefSeqi | NP_856987.1, NC_002945.3 WP_003417259.1, NC_002945.4 |
3D structure databases
ProteinModelPortali | P63908 |
SMRi | P63908 |
ModBasei | Search... |
MobiDBi | Search... |
Proteomic databases
PRIDEi | P63908 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
EnsemblBacteriai | CDO44614; CDO44614; Mb3342c |
PATRICi | fig|233413.5.peg.3673 |
Phylogenomic databases
HOGENOMi | HOG000218816 |
OMAi | QWCGADR |
Enzyme and pathway databases
BioCyci | MBOV233413:G1GT4-3510-MONOMER |
Family and domain databases
HAMAPi | MF_00540 A_deaminase, 1 hit |
InterProi | View protein in InterPro IPR001365 A/AMP_deaminase_dom IPR028893 A_deaminase IPR006330 Ado/ade_deaminase IPR032466 Metal_Hydrolase |
Pfami | View protein in Pfam PF00962 A_deaminase, 1 hit |
SUPFAMi | SSF51556 SSF51556, 1 hit |
TIGRFAMsi | TIGR01430 aden_deam, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | ADD_MYCBO | |
Accessioni | P63908Primary (citable) accession number: P63908 Secondary accession number(s): A0A1R3Y3S4, O53365, X2BN49 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | December 5, 2018 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteomeDocuments
- SIMILARITY comments
Index of protein domains and families