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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (BMEII0235)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (BMEII0235)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00241;UER00356

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinaseUniRule annotation (EC:2.7.1.24UniRule annotation)
Alternative name(s):
Dephosphocoenzyme A kinaseUniRule annotation
Gene namesi
Name:coaEUniRule annotation
Ordered Locus Names:BMEI2057
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001729171 – 200Dephospho-CoA kinaseAdd BLAST200

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_0191

Structurei

3D structure databases

ProteinModelPortaliP63824
SMRiP63824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 200DPCKUniRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the CoaE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZQD Bacteria
COG0237 LUCA
HOGENOMiHOG000020768
KOiK00859
OMAiLVTEIWV

Family and domain databases

CDDicd02022 DPCK, 1 hit
HAMAPiMF_00376 Dephospho_CoA_kinase, 1 hit
InterProiView protein in InterPro
IPR001977 Depp_CoAkinase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01121 CoaE, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00152 TIGR00152, 1 hit
PROSITEiView protein in PROSITE
PS51219 DPCK, 1 hit

Sequencei

Sequence statusi: Complete.

P63824-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIVLGLTGSI GMGKTTAAGM FAEAGVPVYS ADDAVHRLYS GRAAPLIEAT
60 70 80 90 100
FPGTVENGIV NREKLFKAVI GQPEAIKKLE AVVHPLVREE EDAFRREAEK
110 120 130 140 150
SGAAIALVDI PLLFETGAEK RVDKVVVVSA PADIQHTRVL ARPGMTQEKL
160 170 180 190 200
KAILVRQIPD AEKRSRADFV LDTSGSFDDL RRQIAEIITG LSGKPAAATR
Length:200
Mass (Da):21,441
Last modified:October 11, 2004 - v1
Checksum:iB2CE67FF86C8430D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA Translation: AAL53238.1
PIRiAC3509
RefSeqiWP_004684536.1, NZ_GG703778.1

Genome annotation databases

EnsemblBacteriaiAAL53238; AAL53238; BMEI2057
GeneIDi29594948
KEGGibme:BMEI2057
bmel:DK63_1437
PATRICifig|224914.52.peg.1513

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA Translation: AAL53238.1
PIRiAC3509
RefSeqiWP_004684536.1, NZ_GG703778.1

3D structure databases

ProteinModelPortaliP63824
SMRiP63824
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BAWG_0191

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL53238; AAL53238; BMEI2057
GeneIDi29594948
KEGGibme:BMEI2057
bmel:DK63_1437
PATRICifig|224914.52.peg.1513

Phylogenomic databases

eggNOGiENOG4108ZQD Bacteria
COG0237 LUCA
HOGENOMiHOG000020768
KOiK00859
OMAiLVTEIWV

Enzyme and pathway databases

UniPathwayi
UPA00241;UER00356

Family and domain databases

CDDicd02022 DPCK, 1 hit
HAMAPiMF_00376 Dephospho_CoA_kinase, 1 hit
InterProiView protein in InterPro
IPR001977 Depp_CoAkinase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01121 CoaE, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00152 TIGR00152, 1 hit
PROSITEiView protein in PROSITE
PS51219 DPCK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOAE_BRUME
AccessioniPrimary (citable) accession number: P63824
Secondary accession number(s): Q8YE21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 7, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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