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UniProtKB - P63463 (AZOR_SALTI)
Protein
FMN-dependent NADH:quinone oxidoreductase
Gene
azoR
Organism
Salmonella typhi
Status
Functioni
Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.
UniRule annotationAlso exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
UniRule annotationCatalytic activityi
- anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD+ = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H+ + 2 NADHUniRule annotationEC:1.7.1.17UniRule annotation
Cofactori
FMNUniRule annotationNote: Binds 1 FMN per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 10 | FMNUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 16 – 18 | FMNUniRule annotation | 3 | |
Nucleotide bindingi | 96 – 99 | FMNUniRule annotation | 4 | |
Nucleotide bindingi | 140 – 143 | FMNUniRule annotation | 4 |
GO - Molecular functioni
- electron transfer activity Source: UniProtKB-UniRule
- FMN binding Source: UniProtKB-UniRule
- oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor Source: UniProtKB-UniRule
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Flavoprotein, FMN, NAD |
Names & Taxonomyi
Protein namesi | Recommended name: FMN-dependent NADH:quinone oxidoreductaseUniRule annotation (EC:1.6.5.-UniRule annotation)Alternative name(s): Azo-dye reductaseUniRule annotation FMN-dependent NADH-azo compound oxidoreductaseUniRule annotation FMN-dependent NADH-azoreductaseUniRule annotation (EC:1.7.1.17UniRule annotation) |
Gene namesi | Name:azoRUniRule annotation Ordered Locus Names:STY1427, t1545 |
Organismi | Salmonella typhi |
Taxonomic identifieri | 90370 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000166315 | 2 – 201 | FMN-dependent NADH:quinone oxidoreductaseAdd BLAST | 200 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 220341.16502540 |
Family & Domainsi
Sequence similaritiesi
Belongs to the azoreductase type 1 family.UniRule annotation
Phylogenomic databases
eggNOGi | COG1182, Bacteria |
HOGENOMi | CLU_088964_0_0_6 |
OMAi | AGITFKY |
Family and domain databases
Gene3Di | 3.40.50.360, 1 hit |
HAMAPi | MF_01216, Azoreductase_type1, 1 hit |
InterProi | View protein in InterPro IPR003680, Flavodoxin_fold IPR029039, Flavoprotein-like_sf IPR023048, NADH:quinone_OxRdtase_FMN_depd |
Pfami | View protein in Pfam PF02525, Flavodoxin_2, 1 hit |
SUPFAMi | SSF52218, SSF52218, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P63463-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKVLVLKSS ILAGYSQSGQ LTDYFIEQWR EKHVADEITV RDLAANPVPV
60 70 80 90 100
LDGELVGAMR PGDAPLTPRQ QDALALSDEL IAELKAHDVI VIAAPMYNFN
110 120 130 140 150
IPTQLKNYFD LIARAGITFR YTEKGPEGLV TGKRAVVLSS RGGIHKDTPT
160 170 180 190 200
DLIAPYLKVF LGFIGITDVN FVFAEGIAYG PEVAAKAQAD AKAAIDSVVA
A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL513382 Genomic DNA Translation: CAD01689.1 AE014613 Genomic DNA Translation: AAO69178.1 |
RefSeqi | NP_455862.1, NC_003198.1 WP_000048924.1, NZ_WSUR01000020.1 |
Genome annotation databases
EnsemblBacteriai | AAO69178; AAO69178; t1545 |
KEGGi | stt:t1545 sty:STY1427 |
PATRICi | fig|220341.7.peg.1437 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL513382 Genomic DNA Translation: CAD01689.1 AE014613 Genomic DNA Translation: AAO69178.1 |
RefSeqi | NP_455862.1, NC_003198.1 WP_000048924.1, NZ_WSUR01000020.1 |
3D structure databases
AlphaFoldDBi | P63463 |
SMRi | P63463 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 220341.16502540 |
Genome annotation databases
EnsemblBacteriai | AAO69178; AAO69178; t1545 |
KEGGi | stt:t1545 sty:STY1427 |
PATRICi | fig|220341.7.peg.1437 |
Phylogenomic databases
eggNOGi | COG1182, Bacteria |
HOGENOMi | CLU_088964_0_0_6 |
OMAi | AGITFKY |
Family and domain databases
Gene3Di | 3.40.50.360, 1 hit |
HAMAPi | MF_01216, Azoreductase_type1, 1 hit |
InterProi | View protein in InterPro IPR003680, Flavodoxin_fold IPR029039, Flavoprotein-like_sf IPR023048, NADH:quinone_OxRdtase_FMN_depd |
Pfami | View protein in Pfam PF02525, Flavodoxin_2, 1 hit |
SUPFAMi | SSF52218, SSF52218, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AZOR_SALTI | |
Accessioni | P63463Primary (citable) accession number: P63463 Secondary accession number(s): Q8XFP4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 95 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |