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UniProtKB - P63455 (KASA_MYCBO)
Protein
3-oxoacyl-[acyl-carrier-protein] synthase 1
Gene
kasA
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Functioni
Part of the mycobacterial fatty acid elongation system FAS-II, which is involved in mycolic acid biosynthesis. Catalyzes the elongation of long chain acyl-ACP substrates by the addition of two carbons from malonyl-ACP to an acyl acceptor. Involved in the initial extension of the mycolate chain and forms monounsaturated fatty acids that averaged 40 carbons in length.
By similarityCatalytic activityi
- an ultra-long-chain mono-unsaturated fatty acyl-[ACP] + H+ + malonyl-[ACP] = a 3-oxo-ultra-long-chain mono-unsaturated fatty acyl-[ACP] + CO2 + holo-[ACP]By similarityEC:2.3.1.293By similarityThis reaction proceeds in the forwardBy similarity direction.
: mycolic acid biosynthesis Pathwayi
This protein is involved in the pathway mycolic acid biosynthesis, which is part of Lipid metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway mycolic acid biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 171 | By similarity | 1 | |
Binding sitei | 311 | SubstrateBy similarity | 1 | |
Binding sitei | 345 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- acyltransferase activity Source: UniProtKB-KW
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00915 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC:2.3.1.293By similarity)Alternative name(s): Beta-ketoacyl-ACP synthase 1 Short name: KAS 1 |
Gene namesi | Name:kasA Ordered Locus Names:BQ2027_MB2269 |
Organismi | Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) |
Taxonomic identifieri | 233413 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180329 | 1 – 416 | 3-oxoacyl-[acyl-carrier-protein] synthase 1Add BLAST | 416 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
OMAi | YAYLSMQ |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR000794, Beta-ketoacyl_synthase IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
i Sequence
Sequence statusi: Complete.
P63455-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQPSTANGG FPSVVVTAVT ATTSISPDIE STWKGLLAGE SGIHALEDEF
60 70 80 90 100
VTKWDLAVKI GGHLKDPVDS HMGRLDMRRM SYVQRMGKLL GGQLWESAGS
110 120 130 140 150
PEVDPDRFAV VVGTGLGGAE RIVESYDLMN AGGPRKVSPL AVQMIMPNGA
160 170 180 190 200
AAVIGLQLGA RAGVMTPVSA CSSGSEAIAH AWRQIVMGDA DVAVCGGVEG
210 220 230 240 250
PIEALPIAAF SMMRAMSTRN DEPERASRPF DKDRDGFVFG EAGALMLIET
260 270 280 290 300
EEHAKARGAK PLARLLGAGI TSDAFHMVAP AADGVRAGRA MTRSLELAGL
310 320 330 340 350
SPADIDHVNA HGTATPIGDA AEANAIRVAG CDQAAVYAPK SALGHSIGAV
360 370 380 390 400
GALESVLTVL TLRDGVIPPT LNYETPDPEI DLDVVAGEPR YGDYRYAVNN
410
SFGFGGHNVA LAFGRY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LT708304 Genomic DNA Translation: SIU00880.1 |
RefSeqi | NP_855918.1, NC_002945.3 WP_003411571.1, NC_002945.4 |
Genome annotation databases
EnsemblBacteriai | SIU00880; SIU00880; BQ2027_MB2269 |
GeneIDi | 45426225 |
PATRICi | fig|233413.5.peg.2490 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LT708304 Genomic DNA Translation: SIU00880.1 |
RefSeqi | NP_855918.1, NC_002945.3 WP_003411571.1, NC_002945.4 |
3D structure databases
SMRi | P63455 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | SIU00880; SIU00880; BQ2027_MB2269 |
GeneIDi | 45426225 |
PATRICi | fig|233413.5.peg.2490 |
Phylogenomic databases
OMAi | YAYLSMQ |
Enzyme and pathway databases
UniPathwayi | UPA00915 |
Family and domain databases
CDDi | cd00834, KAS_I_II, 1 hit |
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR000794, Beta-ketoacyl_synthase IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR020841, PKS_Beta-ketoAc_synthase_dom IPR016039, Thiolase-like |
PANTHERi | PTHR11712, PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KASA_MYCBO | |
Accessioni | P63455Primary (citable) accession number: P63455 Secondary accession number(s): A0A1R3Y0P3, Q10524, X2BKI6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | February 23, 2022 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families