UniProtKB - P63360 (MSBA_SALTI)
Protein
Lipid A export ATP-binding/permease protein MsbA
Gene
msbA
Organism
Salmonella typhi
Status
Functioni
Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation
Catalytic activityi
- ATP + H(2)O + lipid A-core oligosaccharide(Side 1) = ADP + phosphate + lipid A-core oligosaccharide(Side 2).UniRule annotation EC:7.5.2.6
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 376 – 383 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled lipid transmembrane transporter activity Source: UniProtKB-UniRule
- ATP binding Source: UniProtKB-KW
Keywordsi
Molecular function | Translocase |
Biological process | Lipid transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:7.5.2.6UniRule annotation) |
Gene namesi | Name:msbAUniRule annotation Ordered Locus Names:STY0985, t1950 |
Organismi | Salmonella typhi |
Taxonomic identifieri | 90370 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 64 – 84 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 140 – 162 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 167 – 186 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 253 – 273 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 275 – 295 | HelicalUniRule annotationAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000092597 | 1 – 582 | Lipid A export ATP-binding/permease protein MsbAAdd BLAST | 582 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 220341.16502147 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 310 | ABC transmembrane type-1UniRule annotationAdd BLAST | 284 | |
Domaini | 342 – 578 | ABC transporterUniRule annotationAdd BLAST | 237 |
Domaini
In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.
Sequence similaritiesi
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105BZ1 Bacteria COG1132 LUCA |
KOi | K11085 |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR011917 ABC_transpr_lipidA IPR027417 P-loop_NTPase IPR039421 Type_I_exporter |
PANTHERi | PTHR24221 PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664 ABC_membrane, 1 hit PF00005 ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382 AAA, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit SSF90123 SSF90123, 1 hit |
TIGRFAMsi | TIGR02203 MsbA_lipidA, 1 hit |
PROSITEi | View protein in PROSITE PS50929 ABC_TM1F, 1 hit PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit PS51239 MSBA, 1 hit |
i Sequence
Sequence statusi: Complete.
P63360-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHNDKDLSTW QTFRRLWPTI APFKAGLIVA GIALILNAAS DTFMLSLLKP
60 70 80 90 100
LLDDGFGKTD RSVLLWMPLV VIGLMILRGI TSYISSYCIS WVSGKVVMTM
110 120 130 140 150
RRRLFGHMMG MPVAFFDKQS TGTLLSRITY DSEQVASSSS GALITVVREG
160 170 180 190 200
ASIIGLFIMM FYYSWQLSII LVVLAPIVSI AIRVVSKRFR SISKNMQNTM
210 220 230 240 250
GQVTTSAEQM LKGHKEVLIF GGQEVETKRF DKVSNKMRLQ GMKMVSASSI
260 270 280 290 300
SDPIIQLIAS LALAFVLYAA SFPSVMDSLT AGTITVVFSS MIALMRPLKS
310 320 330 340 350
LTNVNAQFQR GMAACQTLFA ILDSEQEKDE GKRVIDRATG DLEFRNVTFT
360 370 380 390 400
YPGREVPALR NINLKIPAGK TVALVGRSGS GKSTIASLIT RFYDIDEGHI
410 420 430 440 450
LMDGHDLREY TLASLRNQVA LVSQNVHLFN DTVANNIAYA RTEEYSREQI
460 470 480 490 500
EEAARMAYAM DFINKMDNGL DTIIGENGVL LSGGQRQRIA IARALLRDSP
510 520 530 540 550
ILILDEATSA LDTESERAIQ AALDELQKNR TSLVIAHRLS TIEQADEIVV
560 570 580
VEDGIIVERG THSELLAQHG VYAQLHKMQF GQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL513382 Genomic DNA Translation: CAD05384.1 AE014613 Genomic DNA Translation: AAO69564.1 |
RefSeqi | NP_455471.1, NC_003198.1 WP_000551246.1, NZ_UFRG01000003.1 |
Genome annotation databases
EnsemblBacteriai | AAO69564; AAO69564; t1950 CAD05384; CAD05384; CAD05384 |
GeneIDi | 1247416 |
KEGGi | stt:t1950 sty:STY0985 |
PATRICi | fig|220341.7.peg.993 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL513382 Genomic DNA Translation: CAD05384.1 AE014613 Genomic DNA Translation: AAO69564.1 |
RefSeqi | NP_455471.1, NC_003198.1 WP_000551246.1, NZ_UFRG01000003.1 |
3D structure databases
SMRi | P63360 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 220341.16502147 |
Genome annotation databases
EnsemblBacteriai | AAO69564; AAO69564; t1950 CAD05384; CAD05384; CAD05384 |
GeneIDi | 1247416 |
KEGGi | stt:t1950 sty:STY0985 |
PATRICi | fig|220341.7.peg.993 |
Phylogenomic databases
eggNOGi | ENOG4105BZ1 Bacteria COG1132 LUCA |
KOi | K11085 |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR011917 ABC_transpr_lipidA IPR027417 P-loop_NTPase IPR039421 Type_I_exporter |
PANTHERi | PTHR24221 PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664 ABC_membrane, 1 hit PF00005 ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382 AAA, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit SSF90123 SSF90123, 1 hit |
TIGRFAMsi | TIGR02203 MsbA_lipidA, 1 hit |
PROSITEi | View protein in PROSITE PS50929 ABC_TM1F, 1 hit PS00211 ABC_TRANSPORTER_1, 1 hit PS50893 ABC_TRANSPORTER_2, 1 hit PS51239 MSBA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MSBA_SALTI | |
Accessioni | P63360Primary (citable) accession number: P63360 Secondary accession number(s): Q8XFG5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | September 18, 2019 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteomeDocuments
- SIMILARITY comments
Index of protein domains and families