UniProtKB - P63317 (TNNC1_PIG)
Protein
Troponin C, slow skeletal and cardiac muscles
Gene
TNNC1
Organism
Sus scrofa (Pig)
Status
Functioni
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Miscellaneous
Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 65 – 76 | 1Add BLAST | 12 | |
Calcium bindingi | 105 – 116 | 2Add BLAST | 12 | |
Calcium bindingi | 141 – 152 | 3Add BLAST | 12 |
GO - Molecular functioni
- actin filament binding Source: GO_Central
- calcium-dependent protein binding Source: GO_Central
- calcium ion binding Source: AgBase
GO - Biological processi
- regulation of muscle contraction Source: GO_Central
- skeletal muscle contraction Source: GO_Central
Keywordsi
Molecular function | Muscle protein |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-SSC-390522, Striated Muscle Contraction |
Names & Taxonomyi
Protein namesi | Recommended name: Troponin C, slow skeletal and cardiac musclesShort name: TN-C |
Gene namesi | Name:TNNC1 Synonyms:TNNC |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:94282, TNNC1 |
Subcellular locationi
Cytoskeleton
- troponin complex Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073699 | 1 – 161 | Troponin C, slow skeletal and cardiac musclesAdd BLAST | 161 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine1 Publication | 1 | |
Modified residuei | 98 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | P63317 |
PeptideAtlasi | P63317 |
PRIDEi | P63317 |
PTM databases
iPTMneti | P63317 |
Expressioni
Gene expression databases
Bgeei | ENSSSCG00000011441, Expressed in heart and 23 other tissues |
ExpressionAtlasi | P63317, baseline and differential |
Genevisiblei | P63317, SS |
Interactioni
GO - Molecular functioni
- actin filament binding Source: GO_Central
- calcium-dependent protein binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000012193 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 51 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 52 – 87 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 92 – 127 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 128 – 161 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the troponin C family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0027, Eukaryota |
GeneTreei | ENSGT00940000153541 |
HOGENOMi | CLU_061288_2_5_1 |
InParanoidi | P63317 |
OMAi | QKSEFRA |
OrthoDBi | 1386217at2759 |
TreeFami | TF318191 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P63317-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDDIYKAAVE QLTEEQKNEF KAAFDIFVLG AEDGCISTKE LGKVMRMLGQ
60 70 80 90 100
NPTPEELQEM IDEVDEDGSG TVDFDEFLVM MVRCMKDDSK GKSEEELSDL
110 120 130 140 150
FRMFDKNADG YIDLEELKIM LQATGETITE DDIEELMKDG DKNNDGRIDY
160
DEFLEFMKGV E
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A287AIU7 | A0A287AIU7_PIG | Troponin C, slow skeletal and cardi... | TNNC1 | 184 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY958072 Genomic DNA Translation: AAY33022.1 |
PIRi | JU0035 |
RefSeqi | NP_001123715.1, NM_001130243.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY958072 Genomic DNA Translation: AAY33022.1 |
PIRi | JU0035 |
RefSeqi | NP_001123715.1, NM_001130243.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LJ6 | model | - | A | 1-161 | [»] | |
BMRBi | P63317 | |||||
SMRi | P63317 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000012193 |
PTM databases
iPTMneti | P63317 |
Proteomic databases
PaxDbi | P63317 |
PeptideAtlasi | P63317 |
PRIDEi | P63317 |
Genome annotation databases
Organism-specific databases
CTDi | 7134 |
VGNCi | VGNC:94282, TNNC1 |
Phylogenomic databases
eggNOGi | KOG0027, Eukaryota |
GeneTreei | ENSGT00940000153541 |
HOGENOMi | CLU_061288_2_5_1 |
InParanoidi | P63317 |
OMAi | QKSEFRA |
OrthoDBi | 1386217at2759 |
TreeFami | TF318191 |
Enzyme and pathway databases
Reactomei | R-SSC-390522, Striated Muscle Contraction |
Gene expression databases
Bgeei | ENSSSCG00000011441, Expressed in heart and 23 other tissues |
ExpressionAtlasi | P63317, baseline and differential |
Genevisiblei | P63317, SS |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TNNC1_PIG | |
Accessioni | P63317Primary (citable) accession number: P63317 Secondary accession number(s): O14800 Q4G1M5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | August 13, 1987 | |
Last modified: | December 2, 2020 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families