TNNC1

Functionⁱ

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Miscellaneous

Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.

Regions

Feature key	Position(s)	DescriptionActions	Length
Calcium bindingⁱ	65 – 76	1Add BLAST	12
Calcium bindingⁱ	105 – 116	2Add BLAST	12
Calcium bindingⁱ	141 – 152	3Add BLAST	12

GO - Molecular functionⁱ

actin filament binding Source: BHF-UCL
calcium-dependent protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 7957210
calcium ion binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 12840750
- 18092822
protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18092822
troponin I binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18092822
troponin T binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15542288
- 8205619

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiac muscle contraction
Source: CAFA
Inferred from direct assayⁱ
- 25771144
diaphragm contraction Source: Ensembl
muscle filament sliding Source: Reactome
regulation of ATPase activity Source: BHF-UCL
regulation of muscle contraction
Source: BHF-UCL
Inferred from direct assayⁱ
- 18092822
regulation of muscle filament sliding speed Source: BHF-UCL
response to metal ion Source: Ensembl
skeletal muscle contraction Source: GO_Central
transition between fast and slow fiber Source: Ensembl
ventricular cardiac muscle tissue morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15542288

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Muscle protein
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390522 Striated Muscle Contraction

Reactomeⁱ

R-HSA-390522 Striated Muscle Contraction

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Troponin C, slow skeletal and cardiac muscles Short name: TN-C
Gene namesⁱ	Name:TNNC1 Synonyms:TNNC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000114854.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11943 TNNC1
MIMⁱ	191040 gene
neXtProtⁱ	NX_P63316

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Cardiomyopathy, dilated 1Z (CMD1Z)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_043988	159	G → R in CMD1Z. 1 Publication		1

Cardiomyopathy, familial hypertrophic 13 (CMH13)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Keywords - Diseaseⁱ

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7134
GeneReviewsⁱ	TNNC1
MalaCards human disease database More...MalaCardsⁱ	TNNC1
MIMⁱ	611879 phenotype 613243 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000114854
Orphanetⁱ	154 Familial isolated dilated cardiomyopathy 155 Familial isolated hypertrophic cardiomyopathy
PharmGKBⁱ	PA36632

Chemistry databases

ChEMBLⁱ	CHEMBL2095202
Drug and drug target database More...DrugBankⁱ	DB01375 Aluminium monostearate DB01244 Bepridil DB01373 Calcium DB01023 Felodipine DB00922 Levosimendan DB04513 N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide DB00831 Trifluoperazine

Polymorphism and mutation databases

BioMutaⁱ	TNNC1
DMDMⁱ	54042075

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000073697	1 – 161	Troponin C, slow skeletal and cardiac musclesAdd BLAST		161

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionine1 Publication		1
Modified residueⁱ	98	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P63316
PaxDbⁱ	P63316
PeptideAtlas More...PeptideAtlasⁱ	P63316
PRIDEⁱ	P63316
ProteomicsDBⁱ	57520

PTM databases

iPTMnetⁱ	P63316
PhosphoSitePlusⁱ	P63316

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000114854
CleanExⁱ	HS_TNNC1
ExpressionAtlasⁱ	P63316 baseline and differential
Genevisibleⁱ	P63316 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002450 HPA044848 HPA056897

HPAⁱ

CAB002450
HPA044848
HPA056897

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TNNI1	P19237	3	EBI-3906339,EBI-746692

With

Entry

#Exp.

IntAct

Notes

TNNI1

P19237

3

EBI-3906339,EBI-746692

GO - Molecular functionⁱ

actin filament binding Source: BHF-UCL
calcium-dependent protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 7957210
protein homodimerization activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18092822
troponin I binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18092822
troponin T binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15542288
- 8205619

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112988, 23 interactors
ComplexPortalⁱ	CPX-3280 Cardiac Troponin complex
IntActⁱ	P63316, 8 interactors
STRINGⁱ	9606.ENSP00000232975

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 9	Combined sources	7
Helixⁱ	14 – 25	Combined sources	12
Turnⁱ	30 – 32	Combined sources	3
Beta strandⁱ	35 – 37	Combined sources	3
Helixⁱ	38 – 47	Combined sources	10
Beta strandⁱ	51 – 53	Combined sources	3
Helixⁱ	54 – 64	Combined sources	11
Beta strandⁱ	66 – 68	Combined sources	3
Beta strandⁱ	71 – 73	Combined sources	3
Helixⁱ	74 – 85	Combined sources	12
Helixⁱ	86 – 89	Combined sources	4
Beta strandⁱ	90 – 92	Combined sources	3
Helixⁱ	94 – 104	Combined sources	11
Beta strandⁱ	106 – 108	Combined sources	3
Beta strandⁱ	109 – 112	Combined sources	4
Helixⁱ	114 – 123	Combined sources	10
Beta strandⁱ	124 – 126	Combined sources	3
Helixⁱ	130 – 140	Combined sources	11
Beta strandⁱ	144 – 149	Combined sources	6
Helixⁱ	150 – 157	Combined sources	8
Turnⁱ	158 – 160	Combined sources	3

3D structure databases

ProteinModelPortalⁱ	P63316
SMRⁱ	P63316
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P63316

EvolutionaryTraceⁱ

P63316

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	16 – 51	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	52 – 87	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	92 – 127	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	128 – 161	EF-hand 4PROSITE-ProRule annotationAdd BLAST	34

Sequence similaritiesⁱ

Belongs to the troponin C family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0027 Eukaryota COG5126 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118901
HOGENOMⁱ	HOG000233018
HOVERGENⁱ	HBG012180
InParanoidⁱ	P63316
KEGG Orthology (KO) More...KOⁱ	K05865
OMAⁱ	MNDIYKA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QHM
PhylomeDBⁱ	P63316
TreeFamⁱ	TF318191

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051 EFh, 2 hits
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 1 hit PF13833 EF-hand_8, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 4 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 3 hits PS50222 EF_HAND_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P63316-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDDIYKAAVE QLTEEQKNEF KAAFDIFVLG AEDGCISTKE LGKVMRMLGQ 
        60         70         80         90        100
NPTPEELQEM IDEVDEDGSG TVDFDEFLVM MVRCMKDDSK GKSEEELSDL 
       110        120        130        140        150
FRMFDKNADG YIDLDELKIM LQATGETITE DDIEELMKDG DKNNDGRIDY 
       160 
DEFLEFMKGV E

Length:161

Mass (Da):18,403

Last modified:October 11, 2004 - v1

Checksum:ⁱ34DCCC46D503A312

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	96	Missing in AAB91994 (Ref. 4) Curated		1
Sequence conflictⁱ	115	D → E AA sequence (PubMed:3951483).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_063070	8	A → V in CMH13; increases calcium sensitivity of the myofilaments. 2 PublicationsCorresponds to variant dbSNP:rs267607125EnsemblClinVar.	1
Natural variantⁱVAR_019776	29	L → Q in CMH13; impairs protein kinase A dependent signaling from cardiac troponin I to troponin C. 2 PublicationsCorresponds to variant dbSNP:rs267607123EnsemblClinVar.	1
Natural variantⁱVAR_063071	84	C → Y in CMH13; increases calcium sensitivity of the myofilaments. 2 PublicationsCorresponds to variant dbSNP:rs267607126EnsemblClinVar.	1
Natural variantⁱVAR_063072	134	E → D in CMH13; no changes in calcium sensitivity of the myofilaments. 2 PublicationsCorresponds to variant dbSNP:rs397516847EnsemblClinVar.	1
Natural variantⁱVAR_063073	145	D → E in CMH13; increases calcium sensitivity of the myofilaments. 2 PublicationsCorresponds to variant dbSNP:rs267607124EnsemblClinVar.	1
Natural variantⁱVAR_043988	159	G → R in CMD1Z. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X07897 mRNA Translation: CAA30736.1 M37984 Genomic DNA Translation: AAA36772.1 AF020769 mRNA Translation: AAB91994.1 BC030244 mRNA Translation: AAH30244.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2857.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003271.1, NM_003280.2
UniGeneⁱ	Hs.118845

Genome annotation databases

Ensemblⁱ	ENST00000232975; ENSP00000232975; ENSG00000114854
GeneIDⁱ	7134
KEGGⁱ	hsa:7134

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length
P63316	Troponin C, slow skeletal and cardiac muscles		RABIT		161
TNNC1 protein		HUMAN		161
TNNC1 isoform 1		PANTR		161
TNNC1 isoform 1		PONAB		161
Troponin C1, slow skeletal and cardiac type		PANPA		161
+4

Protein	Similar proteins		Species	Score	Length
P63316	Troponin C, slow skeletal and cardiac muscles		RABIT		161
TNNC1 protein		HUMAN		161
TNNC1 isoform 1		PANTR		161
TNNC1 isoform 1		PONAB		161
Troponin C1, slow skeletal and cardiac type		PANPA		161
+193

Protein	Similar proteins		Species	Score	Length
P63316	Troponin C, slow skeletal and cardiac muscles		RABIT		161
TNNC1 protein		HUMAN		161
TNNC1 isoform 1		PANTR		161
TNNC1 isoform 1		PONAB		161
Troponin C1, slow skeletal and cardiac type		PANPA		161
+434

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X07897 mRNA Translation: CAA30736.1 M37984 Genomic DNA Translation: AAA36772.1 AF020769 mRNA Translation: AAB91994.1 BC030244 mRNA Translation: AAH30244.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2857.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003271.1, NM_003280.2
UniGeneⁱ	Hs.118845

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1AP4	NMR	-	A	1-89	[»]
	1IH0	NMR	-	A	91-161	[»]
	1J1D	X-ray	2.61	A/D	1-161	[»]
	1J1E	X-ray	3.30	A/D	1-161	[»]
	1LXF	NMR	-	C	1-89	[»]
	1MXL	NMR	-	C	1-89	[»]
	1OZS	NMR	-	A	90-161	[»]
	1SPY	NMR	-	A	1-89	[»]
	1WRK	X-ray	2.15	A/B	1-88	[»]
	1WRL	X-ray	2.60	A/B/C/D/E/F	1-88	[»]
	2JT0	NMR	-	A	1-161	[»]
	2JT3	NMR	-	A	1-161	[»]
	2JT8	NMR	-	A	1-161	[»]
	2JTZ	NMR	-	A	1-161	[»]
	2JXL	NMR	-	A	1-89	[»]
	2KDH	NMR	-	A	91-161	[»]
	2KFX	NMR	-	T	1-89	[»]
	2KGB	NMR	-	C	1-89	[»]
	2KRD	NMR	-	C	1-89	[»]
	2L1R	NMR	-	A	1-89	[»]
	2L98	NMR	-	A	91-161	[»]
	2MKP	NMR	-	C	1-89	[»]
	2MLE	NMR	-	C	91-161	[»]
	2MLF	NMR	-	C	91-161	[»]
	2MZP	NMR	-	C	1-89	[»]
	2N79	NMR	-	C	1-89	[»]
	2N7L	NMR	-	C	1-89	[»]
	3RV5	X-ray	2.20	A/B/C/D	1-89	[»]
	3SD6	X-ray	1.37	A	1-89	[»]
	3SWB	X-ray	1.67	A	1-89	[»]
	4GJE	X-ray	1.60	A	1-89	[»]
	4GJF	X-ray	1.90	A	1-89	[»]
	4GJG	X-ray	2.00	A	1-89	[»]
	4Y99	X-ray	2.00	A	1-161	[»]
	5VLN	NMR	-	A	1-92	[»]
	5W88	NMR	-	A	1-90	[»]
	5WCL	NMR	-	A	1-92	[»]
ProteinModelPortalⁱ	P63316
SMRⁱ	P63316
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112988, 23 interactors
ComplexPortalⁱ	CPX-3280 Cardiac Troponin complex
IntActⁱ	P63316, 8 interactors
STRINGⁱ	9606.ENSP00000232975

Chemistry databases

ChEMBLⁱ	CHEMBL2095202
Drug and drug target database More...DrugBankⁱ	DB01375 Aluminium monostearate DB01244 Bepridil DB01373 Calcium DB01023 Felodipine DB00922 Levosimendan DB04513 N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide DB00831 Trifluoperazine

PTM databases

iPTMnetⁱ	P63316
PhosphoSitePlusⁱ	P63316

Polymorphism and mutation databases

BioMutaⁱ	TNNC1
DMDMⁱ	54042075

Proteomic databases

EPDⁱ	P63316
PaxDbⁱ	P63316
PeptideAtlas More...PeptideAtlasⁱ	P63316
PRIDEⁱ	P63316
ProteomicsDBⁱ	57520

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7134
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000232975; ENSP00000232975; ENSG00000114854
GeneIDⁱ	7134
KEGGⁱ	hsa:7134

Organism-specific databases

CTDⁱ	7134
DisGeNET More...DisGeNETⁱ	7134
EuPathDBⁱ	HostDB:ENSG00000114854.7
GeneCardsⁱ	TNNC1
GeneReviewsⁱ	TNNC1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11943 TNNC1
Human Protein Atlas More...HPAⁱ	CAB002450 HPA044848 HPA056897
MalaCards human disease database More...MalaCardsⁱ	TNNC1
MIMⁱ	191040 gene 611879 phenotype 613243 phenotype
neXtProtⁱ	NX_P63316
Open Targets More...OpenTargetsⁱ	ENSG00000114854
Orphanetⁱ	154 Familial isolated dilated cardiomyopathy 155 Familial isolated hypertrophic cardiomyopathy
PharmGKBⁱ	PA36632
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0027 Eukaryota COG5126 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118901
HOGENOMⁱ	HOG000233018
HOVERGENⁱ	HBG012180
InParanoidⁱ	P63316
KEGG Orthology (KO) More...KOⁱ	K05865
OMAⁱ	MNDIYKA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QHM
PhylomeDBⁱ	P63316
TreeFamⁱ	TF318191

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390522 Striated Muscle Contraction

Reactomeⁱ

R-HSA-390522 Striated Muscle Contraction

Miscellaneous databases

ChiTaRSⁱ	TNNC1 human
EvolutionaryTraceⁱ	P63316
GeneWikiⁱ	Troponin_C_type_1
GenomeRNAiⁱ	7134
Protein Ontology More...PROⁱ	PR:P63316
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000114854
CleanExⁱ	HS_TNNC1
ExpressionAtlasⁱ	P63316 baseline and differential
Genevisibleⁱ	P63316 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051 EFh, 2 hits
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 1 hit PF13833 EF-hand_8, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 4 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 3 hits PS50222 EF_HAND_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNNC1_HUMAN
Accessionⁱ	P63316Primary (citable) accession number: P63316 Secondary accession number(s): O14800, P02590, P04463
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
	Last sequence update:	October 11, 2004
	Last modified:	July 18, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P63316 (TNNC1_HUMAN)

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Troponin C, slow skeletal and cardiac muscles

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ