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Protein

Thymosin beta-10

Gene

TMSB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-10
Gene namesi
Name:TMSB10
Synonyms:PTMB10, THYB10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000034510.5
HGNCiHGNC:11879 TMSB10
MIMi188399 gene
neXtProtiNX_P63313

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi9168
OpenTargetsiENSG00000034510
PharmGKBiPA36580

Polymorphism and mutation databases

BioMutaiTMSB10
DMDMi54039778

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000459312 – 44Thymosin beta-10Add BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei4N6-acetyllysineCombined sources1
Modified residuei12PhosphoserineCombined sources1
Modified residuei15N6-acetyllysineCombined sources1
Modified residuei21PhosphothreonineBy similarity1
Modified residuei23PhosphothreonineCombined sources1
Modified residuei34PhosphothreonineCombined sources1
Modified residuei39N6-acetyllysineCombined sources1
Modified residuei41PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP63313
PaxDbiP63313
PeptideAtlasiP63313
PRIDEiP63313
ProteomicsDBi57519
TopDownProteomicsiP63313

PTM databases

iPTMnetiP63313
PhosphoSitePlusiP63313

Expressioni

Developmental stagei

Found to decrease dramatically after birth.1 Publication

Gene expression databases

BgeeiENSG00000034510
CleanExiHS_TMSB10
GenevisibleiP63313 HS

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114609, 15 interactors
IntActiP63313, 12 interactors
STRINGi9606.ENSP00000233143

Structurei

3D structure databases

ProteinModelPortaliP63313
SMRiP63313
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiKOG4794 Eukaryota
ENOG410Y3I4 LUCA
GeneTreeiENSGT00390000007040
HOVERGENiHBG012534
InParanoidiP63313
KOiK13785
OrthoDBiEOG091G1AVI
PhylomeDBiP63313

Family and domain databases

Gene3Di1.20.5.520, 1 hit
InterProiView protein in InterPro
IPR001152 Beta-thymosin
IPR038386 Beta-thymosin_sf
PANTHERiPTHR12021 PTHR12021, 1 hit
PfamiView protein in Pfam
PF01290 Thymosin, 1 hit
PIRSFiPIRSF001828 Thymosin_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005116 Thymosin_b4, 1 hit
SMARTiView protein in SMART
SM00152 THY, 1 hit
PROSITEiView protein in PROSITE
PS00500 THYMOSIN_B4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MADKPDMGEI ASFDKAKLKK TETQEKNTLP TKETIEQEKR SEIS
Length:44
Mass (Da):5,026
Last modified:January 23, 2007 - v2
Checksum:i5485277C275A1C70
GO

Sequence cautioni

The sequence AAA36746 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC41691 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0523047M → R. Corresponds to variant dbSNP:rs1804515Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20259 mRNA Translation: AAA36744.1
M92381 mRNA Translation: AAC41691.1 Different initiation.
S54005 mRNA Translation: AAB25225.1
M92383 Genomic DNA Translation: AAA36746.1 Different initiation.
AY453400 mRNA Translation: AAS47517.1
AK311952 mRNA Translation: BAG34892.1
AC022210 Genomic DNA Translation: AAY24191.1
BC016025 mRNA Translation: AAH16025.1
BC016731 mRNA Translation: AAH16731.1
CCDSiCCDS1970.1
PIRiA27704
RefSeqiNP_066926.1, NM_021103.3
UniGeneiHs.446574
Hs.612032

Genome annotation databases

EnsembliENST00000233143; ENSP00000233143; ENSG00000034510
GeneIDi9168
KEGGihsa:9168
UCSCiuc002sow.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTYB10_HUMAN
AccessioniPrimary (citable) accession number: P63313
Secondary accession number(s): P13472, Q596K9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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