TMSB10

Functionⁱ

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

GO - Molecular functionⁱ

actin monomer binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament organization Source: InterPro
regulation of cell migration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequestering of actin monomers
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding

Molecular function

Actin-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thymosin beta-10
Gene namesⁱ	Name:TMSB10 Synonyms:PTMB10, THYB10
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000034510.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11879 TMSB10
MIMⁱ	188399 gene
neXtProtⁱ	NX_P63313

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9168
Open Targets More...OpenTargetsⁱ	ENSG00000034510
PharmGKBⁱ	PA36580

Polymorphism and mutation databases

BioMutaⁱ	TMSB10
DMDMⁱ	54039778

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000045931	2 – 44	Thymosin beta-10Add BLAST		43

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	4	N6-acetyllysineCombined sources	1
Modified residueⁱ	12	PhosphoserineCombined sources	1
Modified residueⁱ	15	N6-acetyllysineCombined sources	1
Modified residueⁱ	21	PhosphothreonineBy similarity	1
Modified residueⁱ	23	PhosphothreonineCombined sources	1
Modified residueⁱ	34	PhosphothreonineCombined sources	1
Modified residueⁱ	39	N6-acetyllysineCombined sources	1
Modified residueⁱ	41	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P63313
PaxDbⁱ	P63313
PeptideAtlas More...PeptideAtlasⁱ	P63313
PRIDEⁱ	P63313
ProteomicsDBⁱ	57519
TopDownProteomicsⁱ	P63313

PTM databases

iPTMnetⁱ	P63313
PhosphoSitePlusⁱ	P63313

Expressionⁱ

Developmental stageⁱ

Found to decrease dramatically after birth.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000034510 Expressed in 231 organ(s), highest expression level in forebrain
CleanExⁱ	HS_TMSB10
Genevisibleⁱ	P63313 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ALAS1	P13196	5	EBI-2688673,EBI-3905054
KRTAP9-2	Q9BYQ4	3	EBI-2688673,EBI-1044640
POT1	Q9NUX5	2	EBI-2688673,EBI-752420

GO - Molecular functionⁱ

actin monomer binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114609, 15 interactors
IntActⁱ	P63313, 12 interactors
STRINGⁱ	9606.ENSP00000233143

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P63313
SMRⁱ	P63313
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4794 Eukaryota ENOG410Y3I4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007040
HOVERGENⁱ	HBG012534
InParanoidⁱ	P63313
KEGG Orthology (KO) More...KOⁱ	K13785
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1AVI
PhylomeDBⁱ	P63313

Family and domain databases

Gene3Dⁱ	1.20.5.520, 1 hit
InterProⁱ	View protein in InterPro IPR001152 Beta-thymosin IPR038386 Beta-thymosin_sf
PANTHERⁱ	PTHR12021 PTHR12021, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01290 Thymosin, 1 hit
PIRSFⁱ	PIRSF001828 Thymosin_beta, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD005116 Thymosin_b4, 1 hit
SMARTⁱ	View protein in SMART SM00152 THY, 1 hit
PROSITEⁱ	View protein in PROSITE PS00500 THYMOSIN_B4, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P63313-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40 
MADKPDMGEI ASFDKAKLKK TETQEKNTLP TKETIEQEKR SEIS

Length:44

Mass (Da):5,026

Last modified:January 23, 2007 - v2

Checksum:ⁱ5485277C275A1C70

GO

Sequence cautionⁱ

The sequence AAA36746 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAC41691 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052304	7	M → R. Corresponds to variant dbSNP:rs1804515Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M20259 mRNA Translation: AAA36744.1 M92381 mRNA Translation: AAC41691.1 Different initiation. S54005 mRNA Translation: AAB25225.1 M92383 Genomic DNA Translation: AAA36746.1 Different initiation. AY453400 mRNA Translation: AAS47517.1 AK311952 mRNA Translation: BAG34892.1 AC022210 Genomic DNA Translation: AAY24191.1 BC016025 mRNA Translation: AAH16025.1 BC016731 mRNA Translation: AAH16731.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1970.1
PIRⁱ	A27704
NCBI Reference Sequences More...RefSeqⁱ	NP_066926.1, NM_021103.3
UniGeneⁱ	Hs.446574 Hs.612032

Genome annotation databases

Ensemblⁱ	ENST00000233143; ENSP00000233143; ENSG00000034510
GeneIDⁱ	9168
KEGGⁱ	hsa:9168
UCSC genome browser More...UCSCⁱ	uc002sow.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P63313	Thymosin beta-10		HORSE		44	UniRef100_P63313
Thymosin beta-10		MOUSE		44
Thymosin beta-10		RAT		44
Thymosin, beta 10, isoform CRA_a (Fragment)		HUMAN		169
Thymosin beta		MACMU		44
+33

Protein	Similar proteins		Species	Score	Length	Source
P63313	Thymosin beta-10		HORSE		44	UniRef90_P63313
Thymosin beta-10		MOUSE		44
Thymosin beta-10		RAT		44
Thymosin, beta 10, isoform CRA_a (Fragment)		HUMAN		169
Thymosin beta		MACMU		44
+33

Protein	Similar proteins		Species	Score	Length	Source
P63313	Thymosin beta-10		HORSE		44	UniRef50_P63313
Thymosin beta-10		MOUSE		44
Thymosin beta-10		RAT		44
Thymosin, beta 10, isoform CRA_a (Fragment)		HUMAN		169
Thymosin beta		MACMU		44
+34

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M20259 mRNA Translation: AAA36744.1 M92381 mRNA Translation: AAC41691.1 Different initiation. S54005 mRNA Translation: AAB25225.1 M92383 Genomic DNA Translation: AAA36746.1 Different initiation. AY453400 mRNA Translation: AAS47517.1 AK311952 mRNA Translation: BAG34892.1 AC022210 Genomic DNA Translation: AAY24191.1 BC016025 mRNA Translation: AAH16025.1 BC016731 mRNA Translation: AAH16731.1
CCDSⁱ	CCDS1970.1
PIRⁱ	A27704
RefSeqⁱ	NP_066926.1, NM_021103.3
UniGeneⁱ	Hs.446574 Hs.612032

3D structure databases

ProteinModelPortalⁱ	P63313
SMRⁱ	P63313
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114609, 15 interactors
IntActⁱ	P63313, 12 interactors
STRINGⁱ	9606.ENSP00000233143

PTM databases

iPTMnetⁱ	P63313
PhosphoSitePlusⁱ	P63313

Polymorphism and mutation databases

BioMutaⁱ	TMSB10
DMDMⁱ	54039778

Proteomic databases

EPDⁱ	P63313
PaxDbⁱ	P63313
PeptideAtlasⁱ	P63313
PRIDEⁱ	P63313
ProteomicsDBⁱ	57519
TopDownProteomicsⁱ	P63313

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9168
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000233143; ENSP00000233143; ENSG00000034510
GeneIDⁱ	9168
KEGGⁱ	hsa:9168
UCSCⁱ	uc002sow.2 human

Organism-specific databases

CTDⁱ	9168
DisGeNETⁱ	9168
EuPathDBⁱ	HostDB:ENSG00000034510.5
GeneCardsⁱ	TMSB10
HGNCⁱ	HGNC:11879 TMSB10
MIMⁱ	188399 gene
neXtProtⁱ	NX_P63313
OpenTargetsⁱ	ENSG00000034510
PharmGKBⁱ	PA36580
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4794 Eukaryota ENOG410Y3I4 LUCA
GeneTreeⁱ	ENSGT00390000007040
HOVERGENⁱ	HBG012534
InParanoidⁱ	P63313
KOⁱ	K13785
OrthoDBⁱ	EOG091G1AVI
PhylomeDBⁱ	P63313

Miscellaneous databases

ChiTaRSⁱ	TMSB10 human
GeneWikiⁱ	TMSB10
GenomeRNAiⁱ	9168
Protein Ontology More...PROⁱ	PR:P63313
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000034510 Expressed in 231 organ(s), highest expression level in forebrain
CleanExⁱ	HS_TMSB10
Genevisibleⁱ	P63313 HS

Family and domain databases

Gene3Dⁱ	1.20.5.520, 1 hit
InterProⁱ	View protein in InterPro IPR001152 Beta-thymosin IPR038386 Beta-thymosin_sf
PANTHERⁱ	PTHR12021 PTHR12021, 1 hit
Pfamⁱ	View protein in Pfam PF01290 Thymosin, 1 hit
PIRSFⁱ	PIRSF001828 Thymosin_beta, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD005116 Thymosin_b4, 1 hit
SMARTⁱ	View protein in SMART SM00152 THY, 1 hit
PROSITEⁱ	View protein in PROSITE PS00500 THYMOSIN_B4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TYB10_HUMAN
Accessionⁱ	P63313Primary (citable) accession number: P63313 Secondary accession number(s): P13472, Q596K9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P63313 (TYB10_HUMAN)

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Thymosin beta-10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ