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Entry version 129 (18 Sep 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Thymosin beta-10

Gene

TMSB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thymosin beta-10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMSB10
Synonyms:PTMB10, THYB10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11879 TMSB10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
188399 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P63313

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9168

Open Targets

More...
OpenTargetsi
ENSG00000034510

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36580

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMSB10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
54039778

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000459312 – 44Thymosin beta-10Add BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei4N6-acetyllysineCombined sources1
Modified residuei12PhosphoserineCombined sources1
Modified residuei15N6-acetyllysineCombined sources1
Modified residuei21PhosphothreonineBy similarity1
Modified residuei23PhosphothreonineCombined sources1
Modified residuei34PhosphothreonineCombined sources1
Modified residuei39N6-acetyllysineCombined sources1
Modified residuei41PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P63313

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P63313

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P63313

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P63313

PeptideAtlas

More...
PeptideAtlasi
P63313

PRoteomics IDEntifications database

More...
PRIDEi
P63313

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57519

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P63313

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P63313

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P63313

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Found to decrease dramatically after birth.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000034510 Expressed in 231 organ(s), highest expression level in forebrain

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P63313 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114609, 15 interactors

Protein interaction database and analysis system

More...
IntActi
P63313, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000233143

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P63313

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4794 Eukaryota
ENOG410Y3I4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163007

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P63313

KEGG Orthology (KO)

More...
KOi
K13785

Database of Orthologous Groups

More...
OrthoDBi
1327598at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P63313

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.520, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001152 Beta-thymosin
IPR038386 Beta-thymosin_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12021 PTHR12021, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01290 Thymosin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001828 Thymosin_beta, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00152 THY, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00500 THYMOSIN_B4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P63313-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
MADKPDMGEI ASFDKAKLKK TETQEKNTLP TKETIEQEKR SEIS
Length:44
Mass (Da):5,026
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5485277C275A1C70
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA36746 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC41691 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0523047M → R. Corresponds to variant dbSNP:rs1804515Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M20259 mRNA Translation: AAA36744.1
M92381 mRNA Translation: AAC41691.1 Different initiation.
S54005 mRNA Translation: AAB25225.1
M92383 Genomic DNA Translation: AAA36746.1 Different initiation.
AY453400 mRNA Translation: AAS47517.1
AK311952 mRNA Translation: BAG34892.1
AC022210 Genomic DNA Translation: AAY24191.1
BC016025 mRNA Translation: AAH16025.1
BC016731 mRNA Translation: AAH16731.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1970.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A27704

NCBI Reference Sequences

More...
RefSeqi
NP_066926.1, NM_021103.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000233143; ENSP00000233143; ENSG00000034510

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9168

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9168

UCSC genome browser

More...
UCSCi
uc002sow.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20259 mRNA Translation: AAA36744.1
M92381 mRNA Translation: AAC41691.1 Different initiation.
S54005 mRNA Translation: AAB25225.1
M92383 Genomic DNA Translation: AAA36746.1 Different initiation.
AY453400 mRNA Translation: AAS47517.1
AK311952 mRNA Translation: BAG34892.1
AC022210 Genomic DNA Translation: AAY24191.1
BC016025 mRNA Translation: AAH16025.1
BC016731 mRNA Translation: AAH16731.1
CCDSiCCDS1970.1
PIRiA27704
RefSeqiNP_066926.1, NM_021103.3

3D structure databases

SMRiP63313
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114609, 15 interactors
IntActiP63313, 12 interactors
STRINGi9606.ENSP00000233143

PTM databases

iPTMnetiP63313
PhosphoSitePlusiP63313

Polymorphism and mutation databases

BioMutaiTMSB10
DMDMi54039778

Proteomic databases

EPDiP63313
jPOSTiP63313
MassIVEiP63313
PaxDbiP63313
PeptideAtlasiP63313
PRIDEiP63313
ProteomicsDBi57519
TopDownProteomicsiP63313

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9168
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233143; ENSP00000233143; ENSG00000034510
GeneIDi9168
KEGGihsa:9168
UCSCiuc002sow.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9168
DisGeNETi9168

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMSB10
HGNCiHGNC:11879 TMSB10
MIMi188399 gene
neXtProtiNX_P63313
OpenTargetsiENSG00000034510
PharmGKBiPA36580

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4794 Eukaryota
ENOG410Y3I4 LUCA
GeneTreeiENSGT00940000163007
InParanoidiP63313
KOiK13785
OrthoDBi1327598at2759
PhylomeDBiP63313

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMSB10 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TMSB10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9168

Pharos

More...
Pharosi
P63313

Protein Ontology

More...
PROi
PR:P63313

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000034510 Expressed in 231 organ(s), highest expression level in forebrain
GenevisibleiP63313 HS

Family and domain databases

Gene3Di1.20.5.520, 1 hit
InterProiView protein in InterPro
IPR001152 Beta-thymosin
IPR038386 Beta-thymosin_sf
PANTHERiPTHR12021 PTHR12021, 1 hit
PfamiView protein in Pfam
PF01290 Thymosin, 1 hit
PIRSFiPIRSF001828 Thymosin_beta, 1 hit
SMARTiView protein in SMART
SM00152 THY, 1 hit
PROSITEiView protein in PROSITE
PS00500 THYMOSIN_B4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTYB10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63313
Secondary accession number(s): P13472, Q596K9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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