UniProtKB - P63313 (TYB10_HUMAN)
Protein
Thymosin beta-10
Gene
TMSB10
Organism
Homo sapiens (Human)
Status
Functioni
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity
GO - Molecular functioni
- actin monomer binding Source: GO_Central
GO - Biological processi
- actin filament organization Source: InterPro
- regulation of cell migration Source: GO_Central
- sequestering of actin monomers Source: GO_Central
Keywordsi
Molecular function | Actin-binding |
Enzyme and pathway databases
PathwayCommonsi | P63313 |
Names & Taxonomyi
Protein namesi | Recommended name: Thymosin beta-10 |
Gene namesi | Name:TMSB10 Synonyms:PTMB10, THYB10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11879, TMSB10 |
MIMi | 188399, gene |
neXtProti | NX_P63313 |
VEuPathDBi | HostDB:ENSG00000034510.5 |
Subcellular locationi
Cytoskeleton
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 9168 |
OpenTargetsi | ENSG00000034510 |
PharmGKBi | PA36580 |
Miscellaneous databases
Pharosi | P63313, Tbio |
Genetic variation databases
BioMutai | TMSB10 |
DMDMi | 54039778 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000045931 | 2 – 44 | Thymosin beta-10Add BLAST | 43 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 4 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 12 | PhosphoserineCombined sources | 1 | |
Modified residuei | 15 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 21 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 23 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 34 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 39 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 41 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P63313 |
jPOSTi | P63313 |
MassIVEi | P63313 |
PaxDbi | P63313 |
PeptideAtlasi | P63313 |
PRIDEi | P63313 |
ProteomicsDBi | 57519 |
TopDownProteomicsi | P63313 |
PTM databases
iPTMneti | P63313 |
MetOSitei | P63313 |
PhosphoSitePlusi | P63313 |
Expressioni
Developmental stagei
Found to decrease dramatically after birth.1 Publication
Gene expression databases
Bgeei | ENSG00000034510, Expressed in forebrain and 243 other tissues |
Genevisiblei | P63313, HS |
Organism-specific databases
HPAi | ENSG00000034510, Tissue enhanced (blood) |
Interactioni
Binary interactionsi
Hide detailsP63313
With | #Exp. | IntAct |
---|---|---|
ALAS1 [P13196] | 6 | EBI-2688673,EBI-3905054 |
KRTAP9-2 [Q9BYQ4] | 3 | EBI-2688673,EBI-1044640 |
POT1 [Q9NUX5] | 2 | EBI-2688673,EBI-752420 |
GO - Molecular functioni
- actin monomer binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114609, 21 interactors |
IntActi | P63313, 19 interactors |
STRINGi | 9606.ENSP00000233143 |
Family & Domainsi
Sequence similaritiesi
Belongs to the thymosin beta family.Curated
Phylogenomic databases
eggNOGi | KOG4794, Eukaryota |
GeneTreei | ENSGT00940000163007 |
HOGENOMi | CLU_208046_0_1_1 |
InParanoidi | P63313 |
OrthoDBi | 1632292at2759 |
PhylomeDBi | P63313 |
Family and domain databases
Gene3Di | 1.20.5.520, 1 hit |
InterProi | View protein in InterPro IPR001152, Beta-thymosin IPR038386, Beta-thymosin_sf |
PANTHERi | PTHR12021, PTHR12021, 1 hit |
Pfami | View protein in Pfam PF01290, Thymosin, 1 hit |
PIRSFi | PIRSF001828, Thymosin_beta, 1 hit |
SMARTi | View protein in SMART SM00152, THY, 1 hit |
PROSITEi | View protein in PROSITE PS00500, THYMOSIN_B4, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Sequence cautioni
The sequence AAA36746 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAC41691 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052304 | 7 | M → R. Corresponds to variant dbSNP:rs1804515Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20259 mRNA Translation: AAA36744.1 M92381 mRNA Translation: AAC41691.1 Different initiation. S54005 mRNA Translation: AAB25225.1 M92383 Genomic DNA Translation: AAA36746.1 Different initiation. AY453400 mRNA Translation: AAS47517.1 AK311952 mRNA Translation: BAG34892.1 AC022210 Genomic DNA Translation: AAY24191.1 BC016025 mRNA Translation: AAH16025.1 BC016731 mRNA Translation: AAH16731.1 |
CCDSi | CCDS1970.1 |
PIRi | A27704 |
RefSeqi | NP_066926.1, NM_021103.3 |
Genome annotation databases
Ensembli | ENST00000233143; ENSP00000233143; ENSG00000034510 |
GeneIDi | 9168 |
KEGGi | hsa:9168 |
UCSCi | uc002sow.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20259 mRNA Translation: AAA36744.1 M92381 mRNA Translation: AAC41691.1 Different initiation. S54005 mRNA Translation: AAB25225.1 M92383 Genomic DNA Translation: AAA36746.1 Different initiation. AY453400 mRNA Translation: AAS47517.1 AK311952 mRNA Translation: BAG34892.1 AC022210 Genomic DNA Translation: AAY24191.1 BC016025 mRNA Translation: AAH16025.1 BC016731 mRNA Translation: AAH16731.1 |
CCDSi | CCDS1970.1 |
PIRi | A27704 |
RefSeqi | NP_066926.1, NM_021103.3 |
3D structure databases
SMRi | P63313 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114609, 21 interactors |
IntActi | P63313, 19 interactors |
STRINGi | 9606.ENSP00000233143 |
PTM databases
iPTMneti | P63313 |
MetOSitei | P63313 |
PhosphoSitePlusi | P63313 |
Genetic variation databases
BioMutai | TMSB10 |
DMDMi | 54039778 |
Proteomic databases
EPDi | P63313 |
jPOSTi | P63313 |
MassIVEi | P63313 |
PaxDbi | P63313 |
PeptideAtlasi | P63313 |
PRIDEi | P63313 |
ProteomicsDBi | 57519 |
TopDownProteomicsi | P63313 |
Protocols and materials databases
Antibodypediai | 16880, 104 antibodies |
DNASUi | 9168 |
Genome annotation databases
Ensembli | ENST00000233143; ENSP00000233143; ENSG00000034510 |
GeneIDi | 9168 |
KEGGi | hsa:9168 |
UCSCi | uc002sow.2, human |
Organism-specific databases
CTDi | 9168 |
DisGeNETi | 9168 |
GeneCardsi | TMSB10 |
HGNCi | HGNC:11879, TMSB10 |
HPAi | ENSG00000034510, Tissue enhanced (blood) |
MIMi | 188399, gene |
neXtProti | NX_P63313 |
OpenTargetsi | ENSG00000034510 |
PharmGKBi | PA36580 |
VEuPathDBi | HostDB:ENSG00000034510.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4794, Eukaryota |
GeneTreei | ENSGT00940000163007 |
HOGENOMi | CLU_208046_0_1_1 |
InParanoidi | P63313 |
OrthoDBi | 1632292at2759 |
PhylomeDBi | P63313 |
Enzyme and pathway databases
PathwayCommonsi | P63313 |
Miscellaneous databases
BioGRID-ORCSi | 9168, 228 hits in 987 CRISPR screens |
ChiTaRSi | TMSB10, human |
GeneWikii | TMSB10 |
GenomeRNAii | 9168 |
Pharosi | P63313, Tbio |
PROi | PR:P63313 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000034510, Expressed in forebrain and 243 other tissues |
Genevisiblei | P63313, HS |
Family and domain databases
Gene3Di | 1.20.5.520, 1 hit |
InterProi | View protein in InterPro IPR001152, Beta-thymosin IPR038386, Beta-thymosin_sf |
PANTHERi | PTHR12021, PTHR12021, 1 hit |
Pfami | View protein in Pfam PF01290, Thymosin, 1 hit |
PIRSFi | PIRSF001828, Thymosin_beta, 1 hit |
SMARTi | View protein in SMART SM00152, THY, 1 hit |
PROSITEi | View protein in PROSITE PS00500, THYMOSIN_B4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TYB10_HUMAN | |
Accessioni | P63313Primary (citable) accession number: P63313 Secondary accession number(s): P13472, Q596K9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families