Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Actin, gamma-enteric smooth muscle

Gene

Actg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Miscellaneous

In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-445355 Smooth Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Actin, gamma-enteric smooth muscle
Alternative name(s):
Alpha-actin-3
Gamma-2-actin
Smooth muscle gamma-actin
Cleaved into the following chain:
Gene namesi
Name:Actg2
Synonyms:Acta3, Actsg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:104589 Actg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00004429512 – 376Actin, gamma-enteric smooth muscle, intermediate formBy similarityAdd BLAST375
ChainiPRO_00004429523 – 376Actin, gamma-enteric smooth muscleBy similarityAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteine; in intermediate formBy similarity1
Modified residuei45Methionine (R)-sulfoxide1 Publication1
Modified residuei48Methionine (R)-sulfoxide1 Publication1

Post-translational modificationi

Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.1 Publication
Monomethylation at Lys-85 (K85me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.By similarity

Keywords - PTMi

Acetylation, Oxidation

Proteomic databases

PaxDbiP63268
PeptideAtlasiP63268
PRIDEiP63268

PTM databases

iPTMnetiP63268
PhosphoSitePlusiP63268

Expressioni

Tissue specificityi

Expressed in tissues containing smooth muscle particularly the intestines and bladder.1 Publication

Gene expression databases

BgeeiENSMUSG00000059430 Expressed in 194 organ(s), highest expression level in urinary bladder
CleanExiMM_ACTG2
ExpressionAtlasiP63268 baseline and differential
GenevisibleiP63268 MM

Interactioni

Subunit structurei

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

Protein-protein interaction databases

BioGridi197947, 1 interactor
IntActiP63268, 2 interactors
MINTiP63268
STRINGi10090.ENSMUSP00000074658

Structurei

3D structure databases

ProteinModelPortaliP63268
SMRiP63268
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00930000150927
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiP63268
KOiK12315
OMAiPXEREIV
OrthoDBiEOG091G08LD
PhylomeDBiP63268
TreeFamiTF354237

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P63268-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCEEETTALV CDNGSGLCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ
60 70 80 90 100
KDSYVGDEAQ SKRGILTLKY PIEHGIITNW DDMEKIWHHS FYNELRVAPE
110 120 130 140 150
EHPTLLTEAP LNPKANREKM TQIMFETFNV PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GIVLDSGDGV THNVPIYEGY ALPHAIMRLD LAGRDLTDYL MKILTERGYS
210 220 230 240 250
FVTTAEREIV RDIKEKLCYV ALDFENEMAT AASSSSLEKS YELPDGQVIT
260 270 280 290 300
IGNERFRCPE TLFQPSFIGM ESAGIHETTY NSIMKCDIDI RKDLYANNVL
310 320 330 340 350
SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK PEYDEAGPSI VHRKCF
Length:376
Mass (Da):41,877
Last modified:October 11, 2004 - v1
Checksum:i6EC08CD5EEAD445E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2K3D3Z2K3_MOUSE
Actin, gamma-enteric smooth muscle
Actg2
195Annotation score:
D3YZY0D3YZY0_MOUSE
Actin, gamma-enteric smooth muscle
Actg2
221Annotation score:
A0A0U1RQ96A0A0U1RQ96_MOUSE
Actin, gamma-enteric smooth muscle
Actg2
195Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26689 mRNA Translation: AAA56841.1
BC002042 mRNA Translation: AAH02042.1
CCDSiCCDS51822.1
PIRiA32788
RefSeqiNP_033740.2, NM_009610.2
UniGeneiMm.292865

Genome annotation databases

EnsembliENSMUST00000075161; ENSMUSP00000074658; ENSMUSG00000059430
ENSMUST00000121731; ENSMUSP00000113552; ENSMUSG00000059430
GeneIDi11468
KEGGimmu:11468
UCSCiuc009cnr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26689 mRNA Translation: AAA56841.1
BC002042 mRNA Translation: AAH02042.1
CCDSiCCDS51822.1
PIRiA32788
RefSeqiNP_033740.2, NM_009610.2
UniGeneiMm.292865

3D structure databases

ProteinModelPortaliP63268
SMRiP63268
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197947, 1 interactor
IntActiP63268, 2 interactors
MINTiP63268
STRINGi10090.ENSMUSP00000074658

PTM databases

iPTMnetiP63268
PhosphoSitePlusiP63268

Proteomic databases

PaxDbiP63268
PeptideAtlasiP63268
PRIDEiP63268

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075161; ENSMUSP00000074658; ENSMUSG00000059430
ENSMUST00000121731; ENSMUSP00000113552; ENSMUSG00000059430
GeneIDi11468
KEGGimmu:11468
UCSCiuc009cnr.1 mouse

Organism-specific databases

CTDi72
MGIiMGI:104589 Actg2

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00930000150927
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiP63268
KOiK12315
OMAiPXEREIV
OrthoDBiEOG091G08LD
PhylomeDBiP63268
TreeFamiTF354237

Enzyme and pathway databases

ReactomeiR-MMU-445355 Smooth Muscle Contraction

Miscellaneous databases

PROiPR:P63268
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059430 Expressed in 194 organ(s), highest expression level in urinary bladder
CleanExiMM_ACTG2
ExpressionAtlasiP63268 baseline and differential
GenevisibleiP63268 MM

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACTH_MOUSE
AccessioniPrimary (citable) accession number: P63268
Secondary accession number(s): P12718
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again