Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cysteine-rich protein 1

Gene

Crip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.

GO - Molecular functioni

  • AT DNA binding Source: UniProtKB
  • DNA binding, bending Source: UniProtKB
  • peptide binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • cellular response to antibiotic Source: UniProtKB
  • cellular response to UV-B Source: UniProtKB
  • immune response Source: Ensembl
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: UniProtKB
  • prostate gland stromal morphogenesis Source: Ensembl
  • regulation of gene expression Source: Ensembl
  • response to organic substance Source: Ensembl
  • response to zinc ion Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 1
Short name:
CRP-1
Alternative name(s):
Cysteine-rich intestinal protein
Short name:
CRIP
Gene namesi
Name:Crip1
Synonyms:Crip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1597237 Crip1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000757092 – 77Cysteine-rich protein 1Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei22N6-acetyllysineBy similarity1
Modified residuei68Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiP63255
PRIDEiP63255

PTM databases

iPTMnetiP63255
PhosphoSitePlusiP63255

Expressioni

Developmental stagei

The concentration in intestinal tissues undergoes an abrupt increase during the animal's transition from suckling to weaning.

Gene expression databases

BgeeiENSRNOG00000027990
GenevisibleiP63255 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006835

Structurei

Secondary structure

177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni5 – 7Combined sources3
Beta strandi8 – 10Combined sources3
Helixi13 – 15Combined sources3
Beta strandi16 – 19Combined sources4
Beta strandi22 – 25Combined sources4
Turni26 – 28Combined sources3
Turni32 – 34Combined sources3
Beta strandi43 – 46Combined sources4
Beta strandi49 – 52Combined sources4
Turni53 – 55Combined sources3
Helixi56 – 60Combined sources5
Beta strandi71 – 73Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IMLNMR-A2-77[»]
ProteinModelPortaliP63255
SMRiP63255
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63255

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 63LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 70Gly-rich9

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiENOG410ITI6 Eukaryota
ENOG4111U5J LUCA
GeneTreeiENSGT00550000074548
HOGENOMiHOG000264233
HOVERGENiHBG051118
InParanoidiP63255
OMAiYCNNPCY
OrthoDBiEOG091G11RX
PhylomeDBiP63255

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKCPKCDKE VYFAERVTSL GKDWHRPCLK CEKCGKTLTS GGHAEHEGKP
60 70
YCNHPCYSAM FGPKGFGRGG AESHTFK
Length:77
Mass (Da):8,550
Last modified:January 23, 2007 - v2
Checksum:iBBE8E17A19352EC1
GO

Sequence databases

PIRiA03270 GYRTI
RefSeqiNP_001128405.1, NM_001134933.2
NP_001231796.1, NM_001244867.1
UniGeneiRn.8405

Genome annotation databases

EnsembliENSRNOT00000006835; ENSRNOP00000006835; ENSRNOG00000027990
GeneIDi691657
KEGGirno:691657

Similar proteinsi

Entry informationi

Entry nameiCRIP1_RAT
AccessioniPrimary (citable) accession number: P63255
Secondary accession number(s): P04006
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health