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Protein

Cysteine-rich protein 1

Gene

Crip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.

GO - Molecular functioni

  • AT DNA binding Source: UniProtKB
  • DNA binding, bending Source: UniProtKB
  • peptide binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich protein 1
Short name:
CRP-1
Alternative name(s):
Cysteine-rich intestinal protein
Short name:
CRIP
Gene namesi
Name:Crip1
Synonyms:Crip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:88501 Crip1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757081 – 77Cysteine-rich protein 1Add BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei22N6-acetyllysineCombined sources1
Modified residuei68Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiP63254
MaxQBiP63254
PaxDbiP63254
PeptideAtlasiP63254
PRIDEiP63254

PTM databases

iPTMnetiP63254
PhosphoSitePlusiP63254

Expressioni

Gene expression databases

BgeeiENSMUSG00000006360 Expressed in 270 organ(s), highest expression level in jejunum
CleanExiMM_CRIP1
ExpressionAtlasiP63254 baseline and differential
GenevisibleiP63254 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006523

Structurei

3D structure databases

ProteinModelPortaliP63254
SMRiP63254
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 63LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 70Gly-rich9

Keywords - Domaini

LIM domain

Phylogenomic databases

eggNOGiENOG410ITI6 Eukaryota
ENOG4111U5J LUCA
GeneTreeiENSGT00550000074548
HOGENOMiHOG000264233
HOVERGENiHBG051118
InParanoidiP63254
PhylomeDBiP63254

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P63254-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKCPKCDKE VYFAERVTSL GKDWHRPCLK CEKCGKTLTS GGHAEHEGKP
60 70
YCNHPCYSAM FGPKGFGRGG AESHTFK
Length:77
Mass (Da):8,550
Last modified:January 23, 2007 - v2
Checksum:iBBE8E17A19352EC1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JEK2A0A0G2JEK2_MOUSE
Cysteine-rich protein 1
Crip1 mCG_15414
128Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13018 mRNA Translation: AAA37458.1
AF450245 Genomic DNA Translation: AAM97585.1
AK003075 mRNA Translation: BAB22550.1
AK008269 mRNA Translation: BAB25566.1
AK012068 mRNA Translation: BAB28006.1
AK168305 mRNA Translation: BAE40246.1
BC031922 mRNA Translation: AAH31922.1
CCDSiCCDS26205.1
RefSeqiNP_031789.1, NM_007763.3
UniGeneiMm.272368

Genome annotation databases

EnsembliENSMUST00000006523; ENSMUSP00000006523; ENSMUSG00000006360
ENSMUST00000200553; ENSMUSP00000143680; ENSMUSG00000006360
GeneIDi12925
KEGGimmu:12925
UCSCiuc007pfz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13018 mRNA Translation: AAA37458.1
AF450245 Genomic DNA Translation: AAM97585.1
AK003075 mRNA Translation: BAB22550.1
AK008269 mRNA Translation: BAB25566.1
AK012068 mRNA Translation: BAB28006.1
AK168305 mRNA Translation: BAE40246.1
BC031922 mRNA Translation: AAH31922.1
CCDSiCCDS26205.1
RefSeqiNP_031789.1, NM_007763.3
UniGeneiMm.272368

3D structure databases

ProteinModelPortaliP63254
SMRiP63254
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006523

PTM databases

iPTMnetiP63254
PhosphoSitePlusiP63254

Proteomic databases

EPDiP63254
MaxQBiP63254
PaxDbiP63254
PeptideAtlasiP63254
PRIDEiP63254

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006523; ENSMUSP00000006523; ENSMUSG00000006360
ENSMUST00000200553; ENSMUSP00000143680; ENSMUSG00000006360
GeneIDi12925
KEGGimmu:12925
UCSCiuc007pfz.1 mouse

Organism-specific databases

CTDi1396
MGIiMGI:88501 Crip1

Phylogenomic databases

eggNOGiENOG410ITI6 Eukaryota
ENOG4111U5J LUCA
GeneTreeiENSGT00550000074548
HOGENOMiHOG000264233
HOVERGENiHBG051118
InParanoidiP63254
PhylomeDBiP63254

Miscellaneous databases

PROiPR:P63254
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006360 Expressed in 270 organ(s), highest expression level in jejunum
CleanExiMM_CRIP1
ExpressionAtlasiP63254 baseline and differential
GenevisibleiP63254 MM

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRIP1_MOUSE
AccessioniPrimary (citable) accession number: P63254
Secondary accession number(s): P04006, Q3THF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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