UniProtKB - P63252 (KCNJ2_HUMAN)
Inward rectifier potassium channel 2
KCNJ2
Functioni
Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 172 | Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity | 1 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- inward rectifier potassium channel activity Source: UniProtKB
- phosphatidylinositol-4,5-bisphosphate binding Source: BHF-UCL
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization Source: BHF-UCL
GO - Biological processi
- cardiac muscle cell action potential involved in contraction Source: BHF-UCL
- cellular potassium ion homeostasis Source: BHF-UCL
- cellular response to mechanical stimulus Source: Ensembl
- magnesium ion transport Source: Ensembl
- membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
- membrane repolarization during action potential Source: BHF-UCL
- membrane repolarization during cardiac muscle cell action potential Source: BHF-UCL
- positive regulation of potassium ion transmembrane transport Source: Ensembl
- potassium ion import across plasma membrane Source: BHF-UCL
- potassium ion transmembrane transport Source: BHF-UCL
- potassium ion transport Source: UniProtKB
- protein homotetramerization Source: UniProtKB
- regulation of cardiac muscle cell contraction Source: Ensembl
- regulation of heart rate by cardiac conduction Source: BHF-UCL
- regulation of ion transmembrane transport Source: GO_Central
- regulation of membrane repolarization Source: BHF-UCL
- regulation of resting membrane potential Source: BHF-UCL
- regulation of skeletal muscle contraction via regulation of action potential Source: BHF-UCL
- relaxation of cardiac muscle Source: BHF-UCL
- relaxation of skeletal muscle Source: BHF-UCL
Keywordsi
Molecular function | Ion channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
PathwayCommonsi | P63252 |
Reactomei | R-HSA-1296041, Activation of G protein gated Potassium channels R-HSA-1296053, Classical Kir channels R-HSA-5576886, Phase 4 - resting membrane potential R-HSA-9729555, Sensory perception of sour taste R-HSA-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
SignaLinki | P63252 |
Protein family/group databases
TCDBi | 1.A.2.1.2, the inward rectifier k(+) channel (irk-c) family |
Names & Taxonomyi
Protein namesi | Recommended name: Inward rectifier potassium channel 2Alternative name(s): Cardiac inward rectifier potassium channel Inward rectifier K(+) channel Kir2.1 Short name: IRK-1 Short name: hIRK1 Potassium channel, inwardly rectifying subfamily J member 2 |
Gene namesi | Name:KCNJ2 Synonyms:IRK1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6263, KCNJ2 |
MIMi | 600681, gene |
neXtProti | NX_P63252 |
VEuPathDBi | HostDB:ENSG00000123700 |
Subcellular locationi
Other locations
- Membrane ; Multi-pass membrane protein
- Membrane ; Lipid-anchor 1 Publication
Endoplasmic reticulum
- rough endoplasmic reticulum Source: Ensembl
- smooth endoplasmic reticulum Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: Ensembl
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
- T-tubule Source: Ensembl
- voltage-gated potassium channel complex Source: BHF-UCL
Other locations
- dendritic spine Source: Ensembl
- intercalated disc Source: Ensembl
- intrinsic component of membrane Source: UniProtKB
- neuronal cell body Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 81 | CytoplasmicBy similarityAdd BLAST | 80 | |
Transmembranei | 82 – 106 | Helical; Name=M1By similarityAdd BLAST | 25 | |
Topological domaini | 107 – 128 | ExtracellularBy similarityAdd BLAST | 22 | |
Intramembranei | 129 – 140 | Helical; Pore-forming; Name=H5By similarityAdd BLAST | 12 | |
Intramembranei | 141 – 147 | Pore-formingBy similarity | 7 | |
Topological domaini | 148 – 156 | ExtracellularBy similarity | 9 | |
Transmembranei | 157 – 178 | Helical; Name=M2By similarityAdd BLAST | 22 | |
Topological domaini | 179 – 427 | CytoplasmicBy similarityAdd BLAST | 249 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Long QT syndrome 7 (LQT7)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065861 | 54 | C → F in LQT7; there is loss of function when the mutant is expressed alone and a dominant-negative effect when expressed with wild-type channels; channel trafficking and assembly are not affected. 1 PublicationCorresponds to variant dbSNP:rs199473650EnsemblClinVar. | 1 | |
Natural variantiVAR_017851 | 67 | R → W in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894580EnsemblClinVar. | 1 | |
Natural variantiVAR_017852 | 71 | D → V in LQT7; loss of function mutation acting in a dominant-negative manner. 1 PublicationCorresponds to variant dbSNP:rs104894575EnsemblClinVar. | 1 | |
Natural variantiVAR_065862 | 75 | T → R in LQT7; loss of function mutation acting in a dominant-negative manner. 1 PublicationCorresponds to variant dbSNP:rs104894585EnsemblClinVar. | 1 | |
Natural variantiVAR_017853 | 95 – 98 | Missing in LQT7. 1 Publication | 4 | |
Natural variantiVAR_017854 | 186 | P → L in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894581EnsemblClinVar. | 1 | |
Natural variantiVAR_017855 | 216 | N → H in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894583EnsemblClinVar. | 1 | |
Natural variantiVAR_017856 | 218 | R → W in LQT7; loss of function and dominant-negative effect in current. 1 PublicationCorresponds to variant dbSNP:rs104894578EnsemblClinVar. | 1 | |
Natural variantiVAR_017857 | 300 | G → V in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894579EnsemblClinVar. | 1 | |
Natural variantiVAR_017858 | 302 | V → M in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894582EnsemblClinVar. | 1 | |
Natural variantiVAR_065864 | 305 | T → P in LQT7; there is loss of function when the mutant is expressed alone and a dominant-negative effect when expressed with wild-type channels; channel trafficking and assembly are not affected. 1 PublicationCorresponds to variant dbSNP:rs199473387EnsemblClinVar. | 1 | |
Natural variantiVAR_017859 | 314 – 315 | Missing in LQT7. | 2 |
Short QT syndrome 3 (SQT3)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023842 | 172 | D → N in SQT3; gain of function. 1 PublicationCorresponds to variant dbSNP:rs104894584EnsemblClinVar. | 1 |
Atrial fibrillation, familial, 9 (ATFB9)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065863 | 93 | V → I in ATFB9; has a gain-of-function effect on the channels. 1 PublicationCorresponds to variant dbSNP:rs147750704EnsemblClinVar. | 1 |
Keywords - Diseasei
Atrial fibrillation, Disease variant, Long QT syndrome, Short QT syndromeOrganism-specific databases
DisGeNETi | 3759 |
GeneReviewsi | KCNJ2 |
MalaCardsi | KCNJ2 |
MIMi | 170390, phenotype 609622, phenotype 613980, phenotype |
OpenTargetsi | ENSG00000123700 |
Orphaneti | 37553, Andersen-Tawil syndrome 334, Familial atrial fibrillation 51083, Familial short QT syndrome |
PharmGKBi | PA214 |
Miscellaneous databases
Pharosi | P63252, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1914276 |
DrugBanki | DB01136, Carvedilol DB04855, Dronedarone DB01110, Miconazole DB00243, Ranolazine |
Genetic variation databases
BioMutai | KCNJ2 |
DMDMi | 54037433 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000154923 | 2 – 427 | Inward rectifier potassium channel 2Add BLAST | 426 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine1 Publication | 1 | |
Modified residuei | 76 | S-nitrosocysteine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Lipoprotein, Myristate, S-nitrosylationProteomic databases
jPOSTi | P63252 |
MassIVEi | P63252 |
PaxDbi | P63252 |
PeptideAtlasi | P63252 |
PRIDEi | P63252 |
ProteomicsDBi | 57513 |
PTM databases
GlyGeni | P63252, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P63252 |
PhosphoSitePlusi | P63252 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000123700, Expressed in globus pallidus and 227 other tissues |
Genevisiblei | P63252, HS |
Organism-specific databases
HPAi | ENSG00000123700, Tissue enhanced (brain, parathyroid gland) |
Interactioni
Subunit structurei
Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity).
By similarityBinary interactionsi
P63252
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 109961, 30 interactors |
ComplexPortali | CPX-3071, Inward rectifier potassium channel 2 complex |
IntActi | P63252, 223 interactors |
STRINGi | 9606.ENSP00000243457 |
Chemistry databases
BindingDBi | P63252 |
Miscellaneous databases
RNActi | P63252, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P63252 |
SMRi | P63252 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 384 – 427 | DisorderedSequence analysisAdd BLAST | 44 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 142 – 147 | Selectivity filterBy similarity | 6 | |
Motifi | 425 – 427 | PDZ-bindingSequence analysis | 3 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3827, Eukaryota |
GeneTreei | ENSGT01030000234586 |
HOGENOMi | CLU_022738_3_0_1 |
InParanoidi | P63252 |
OMAi | SEHHQAT |
OrthoDBi | 956263at2759 |
PhylomeDBi | P63252 |
TreeFami | TF313676 |
Family and domain databases
Gene3Di | 2.60.40.1400, 1 hit |
InterProi | View protein in InterPro IPR014756, Ig_E-set IPR041647, IRK_C IPR016449, K_chnl_inward-rec_Kir IPR003271, K_chnl_inward-rec_Kir2.1 IPR013518, K_chnl_inward-rec_Kir_cyto IPR013673, K_chnl_inward-rec_Kir_N IPR040445, Kir_TM |
PANTHERi | PTHR11767, PTHR11767, 1 hit PTHR11767:SF43, PTHR11767:SF43, 1 hit |
Pfami | View protein in Pfam PF01007, IRK, 1 hit PF17655, IRK_C, 1 hit PF08466, IRK_N, 1 hit |
PIRSFi | PIRSF005465, GIRK_kir, 1 hit |
PRINTSi | PR01324, KIR21CHANNEL PR01320, KIRCHANNEL |
SUPFAMi | SSF81296, SSF81296, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK
60 70 80 90 100
DGHCNVQFIN VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL AFVLSWLFFG
110 120 130 140 150
CVFWLIALLH GDLDASKEGK ACVSEVNSFT AAFLFSIETQ TTIGYGFRCV
160 170 180 190 200
TDECPIAVFM VVFQSIVGCI IDAFIIGAVM AKMAKPKKRN ETLVFSHNAV
210 220 230 240 250
IAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG EYIPLDQIDI
260 270 280 290 300
NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDIDNA DFEIVVILEG
310 320 330 340 350
MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKHYYKVD YSRFHKTYEV
360 370 380 390 400
PNTPLCSARD LAEKKYILSN ANSFCYENEV ALTSKEEDDS ENGVPESTST
410 420
DTPPDIDLHN QASVPLEPRP LRRESEI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 330 | L → F in AAC39555 (PubMed:9490857).Curated | 1 | |
Sequence conflicti | 340 | D → E in AAC39555 (PubMed:9490857).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065861 | 54 | C → F in LQT7; there is loss of function when the mutant is expressed alone and a dominant-negative effect when expressed with wild-type channels; channel trafficking and assembly are not affected. 1 PublicationCorresponds to variant dbSNP:rs199473650EnsemblClinVar. | 1 | |
Natural variantiVAR_017851 | 67 | R → W in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894580EnsemblClinVar. | 1 | |
Natural variantiVAR_017852 | 71 | D → V in LQT7; loss of function mutation acting in a dominant-negative manner. 1 PublicationCorresponds to variant dbSNP:rs104894575EnsemblClinVar. | 1 | |
Natural variantiVAR_065862 | 75 | T → R in LQT7; loss of function mutation acting in a dominant-negative manner. 1 PublicationCorresponds to variant dbSNP:rs104894585EnsemblClinVar. | 1 | |
Natural variantiVAR_065863 | 93 | V → I in ATFB9; has a gain-of-function effect on the channels. 1 PublicationCorresponds to variant dbSNP:rs147750704EnsemblClinVar. | 1 | |
Natural variantiVAR_017853 | 95 – 98 | Missing in LQT7. 1 Publication | 4 | |
Natural variantiVAR_023842 | 172 | D → N in SQT3; gain of function. 1 PublicationCorresponds to variant dbSNP:rs104894584EnsemblClinVar. | 1 | |
Natural variantiVAR_017854 | 186 | P → L in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894581EnsemblClinVar. | 1 | |
Natural variantiVAR_017855 | 216 | N → H in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894583EnsemblClinVar. | 1 | |
Natural variantiVAR_017856 | 218 | R → W in LQT7; loss of function and dominant-negative effect in current. 1 PublicationCorresponds to variant dbSNP:rs104894578EnsemblClinVar. | 1 | |
Natural variantiVAR_017857 | 300 | G → V in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894579EnsemblClinVar. | 1 | |
Natural variantiVAR_017858 | 302 | V → M in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894582EnsemblClinVar. | 1 | |
Natural variantiVAR_065864 | 305 | T → P in LQT7; there is loss of function when the mutant is expressed alone and a dominant-negative effect when expressed with wild-type channels; channel trafficking and assembly are not affected. 1 PublicationCorresponds to variant dbSNP:rs199473387EnsemblClinVar. | 1 | |
Natural variantiVAR_017859 | 314 – 315 | Missing in LQT7. | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24055 mRNA Translation: AAB50277.1 U12507 mRNA Translation: AAC50072.1 U16861 mRNA Translation: AAA91781.1 AF153819 Genomic DNA Translation: AAF73242.1 AF153820 mRNA Translation: AAF73241.1 U22413 mRNA Translation: AAA64282.1 AF011904 mRNA Translation: AAC39555.1 AF021139 mRNA Translation: AAB88797.1 |
CCDSi | CCDS11688.1 |
PIRi | I38727 |
RefSeqi | NP_000882.1, NM_000891.2 |
Genome annotation databases
Ensembli | ENST00000243457.4; ENSP00000243457.2; ENSG00000123700.5 ENST00000535240.1; ENSP00000441848.1; ENSG00000123700.5 |
GeneIDi | 3759 |
KEGGi | hsa:3759 |
MANE-Selecti | ENST00000243457.4; ENSP00000243457.2; NM_000891.3; NP_000882.1 |
UCSCi | uc002jir.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U24055 mRNA Translation: AAB50277.1 U12507 mRNA Translation: AAC50072.1 U16861 mRNA Translation: AAA91781.1 AF153819 Genomic DNA Translation: AAF73242.1 AF153820 mRNA Translation: AAF73241.1 U22413 mRNA Translation: AAA64282.1 AF011904 mRNA Translation: AAC39555.1 AF021139 mRNA Translation: AAB88797.1 |
CCDSi | CCDS11688.1 |
PIRi | I38727 |
RefSeqi | NP_000882.1, NM_000891.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6SPZ | X-ray | 2.08 | P/Q | 422-427 | [»] | |
AlphaFoldDBi | P63252 | |||||
SMRi | P63252 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109961, 30 interactors |
ComplexPortali | CPX-3071, Inward rectifier potassium channel 2 complex |
IntActi | P63252, 223 interactors |
STRINGi | 9606.ENSP00000243457 |
Chemistry databases
BindingDBi | P63252 |
ChEMBLi | CHEMBL1914276 |
DrugBanki | DB01136, Carvedilol DB04855, Dronedarone DB01110, Miconazole DB00243, Ranolazine |
Protein family/group databases
TCDBi | 1.A.2.1.2, the inward rectifier k(+) channel (irk-c) family |
PTM databases
GlyGeni | P63252, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P63252 |
PhosphoSitePlusi | P63252 |
Genetic variation databases
BioMutai | KCNJ2 |
DMDMi | 54037433 |
Proteomic databases
jPOSTi | P63252 |
MassIVEi | P63252 |
PaxDbi | P63252 |
PeptideAtlasi | P63252 |
PRIDEi | P63252 |
ProteomicsDBi | 57513 |
Protocols and materials databases
Antibodypediai | 31891, 324 antibodies from 36 providers |
DNASUi | 3759 |
Genome annotation databases
Ensembli | ENST00000243457.4; ENSP00000243457.2; ENSG00000123700.5 ENST00000535240.1; ENSP00000441848.1; ENSG00000123700.5 |
GeneIDi | 3759 |
KEGGi | hsa:3759 |
MANE-Selecti | ENST00000243457.4; ENSP00000243457.2; NM_000891.3; NP_000882.1 |
UCSCi | uc002jir.4, human |
Organism-specific databases
CTDi | 3759 |
DisGeNETi | 3759 |
GeneCardsi | KCNJ2 |
GeneReviewsi | KCNJ2 |
HGNCi | HGNC:6263, KCNJ2 |
HPAi | ENSG00000123700, Tissue enhanced (brain, parathyroid gland) |
MalaCardsi | KCNJ2 |
MIMi | 170390, phenotype 600681, gene 609622, phenotype 613980, phenotype |
neXtProti | NX_P63252 |
OpenTargetsi | ENSG00000123700 |
Orphaneti | 37553, Andersen-Tawil syndrome 334, Familial atrial fibrillation 51083, Familial short QT syndrome |
PharmGKBi | PA214 |
VEuPathDBi | HostDB:ENSG00000123700 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3827, Eukaryota |
GeneTreei | ENSGT01030000234586 |
HOGENOMi | CLU_022738_3_0_1 |
InParanoidi | P63252 |
OMAi | SEHHQAT |
OrthoDBi | 956263at2759 |
PhylomeDBi | P63252 |
TreeFami | TF313676 |
Enzyme and pathway databases
PathwayCommonsi | P63252 |
Reactomei | R-HSA-1296041, Activation of G protein gated Potassium channels R-HSA-1296053, Classical Kir channels R-HSA-5576886, Phase 4 - resting membrane potential R-HSA-9729555, Sensory perception of sour taste R-HSA-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
SignaLinki | P63252 |
Miscellaneous databases
BioGRID-ORCSi | 3759, 10 hits in 1065 CRISPR screens |
GeneWikii | Kir2.1 |
GenomeRNAii | 3759 |
Pharosi | P63252, Tchem |
PROi | PR:P63252 |
RNActi | P63252, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123700, Expressed in globus pallidus and 227 other tissues |
Genevisiblei | P63252, HS |
Family and domain databases
Gene3Di | 2.60.40.1400, 1 hit |
InterProi | View protein in InterPro IPR014756, Ig_E-set IPR041647, IRK_C IPR016449, K_chnl_inward-rec_Kir IPR003271, K_chnl_inward-rec_Kir2.1 IPR013518, K_chnl_inward-rec_Kir_cyto IPR013673, K_chnl_inward-rec_Kir_N IPR040445, Kir_TM |
PANTHERi | PTHR11767, PTHR11767, 1 hit PTHR11767:SF43, PTHR11767:SF43, 1 hit |
Pfami | View protein in Pfam PF01007, IRK, 1 hit PF17655, IRK_C, 1 hit PF08466, IRK_N, 1 hit |
PIRSFi | PIRSF005465, GIRK_kir, 1 hit |
PRINTSi | PR01324, KIR21CHANNEL PR01320, KIRCHANNEL |
SUPFAMi | SSF81296, SSF81296, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNJ2_HUMAN | |
Accessioni | P63252Primary (citable) accession number: P63252 Secondary accession number(s): O15110, P48049 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 11, 2004 | |
Last modified: | May 25, 2022 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families