KCNJ2

Functionⁱ

Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	172	Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity		1

GO - Molecular functionⁱ

G-protein activated inward rectifier potassium channel activity Source: Reactome
identical protein binding Source: Ensembl
inward rectifier potassium channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20921230
phosphatidylinositol-4,5-bisphosphate binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 12086641
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11371347

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiac muscle cell action potential involved in contraction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11371347
cellular potassium ion homeostasis
Source: BHF-UCL
Traceable author statementⁱ
- 20086079
cellular response to mechanical stimulus Source: Ensembl
magnesium ion transport Source: Ensembl
membrane depolarization during cardiac muscle cell action potential
Source: BHF-UCL
Traceable author statementⁱ
- 20086079
membrane repolarization during action potential
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11371347
membrane repolarization during cardiac muscle cell action potential
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11371347
positive regulation of potassium ion transmembrane transport Source: Ensembl
potassium ion import
Source: BHF-UCL
Inferred from direct assayⁱ
- 11371347
potassium ion transmembrane transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 12086641
potassium ion transport
Source: UniProtKB
Inferred from direct assayⁱ
- 20921230
protein homotetramerization
Source: UniProtKB
Inferred from direct assayⁱ
- 20921230
regulation of cardiac muscle cell contraction Source: Ensembl
regulation of heart rate by cardiac conduction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15761194
regulation of membrane repolarization
Source: BHF-UCL
Inferred from direct assayⁱ
- 11371347
regulation of resting membrane potential
Source: BHF-UCL
Traceable author statementⁱ
- 20086079
regulation of skeletal muscle contraction via regulation of action potential
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11371347
relaxation of cardiac muscle
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11371347
relaxation of skeletal muscle
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11371347

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Voltage-gated channel
Biological process	Ion transport, Potassium transport, Transport
Ligand	Potassium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1296041 Activation of G protein gated Potassium channels R-HSA-1296053 Classical Kir channels R-HSA-5576886 Phase 4 - resting membrane potential R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Reactomeⁱ

R-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-1296053 Classical Kir channels
R-HSA-5576886 Phase 4 - resting membrane potential
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Protein family/group databases

TCDBⁱ	1.A.2.1.2 the inward rectifier k(+) channel (irk-c) family

TCDBⁱ

1.A.2.1.2 the inward rectifier k(+) channel (irk-c) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Inward rectifier potassium channel 2 Alternative name(s): Cardiac inward rectifier potassium channel Inward rectifier K(+) channel Kir2.1 Short name: IRK-1 Short name: hIRK1 Potassium channel, inwardly rectifying subfamily J member 2
Gene namesⁱ	Name:KCNJ2 Synonyms:IRK1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000123700.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6263 KCNJ2
MIMⁱ	600681 gene
neXtProtⁱ	NX_P63252

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	2 – 81	CytoplasmicBy similarityAdd BLAST	80
Transmembraneⁱ	82 – 106	Helical; Name=M1By similarityAdd BLAST	25
Topological domainⁱ	107 – 128	ExtracellularBy similarityAdd BLAST	22
Intramembraneⁱ	129 – 140	Helical; Pore-forming; Name=H5By similarityAdd BLAST	12
Intramembraneⁱ	141 – 147	Pore-formingBy similarity	7
Topological domainⁱ	148 – 156	ExtracellularBy similarity	9
Transmembraneⁱ	157 – 178	Helical; Name=M2By similarityAdd BLAST	22
Topological domainⁱ	179 – 427	CytoplasmicBy similarityAdd BLAST	249

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Long QT syndrome 7 (LQT7)5 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. Long QT syndrome type 7 manifests itself as a clinical triad consisting of potassium-sensitive periodic paralysis, ventricular ectopy and dysmorphic features.

Short QT syndrome 3 (SQT3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA heart disorder characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. It causes syncope and sudden death. SQT3 has a unique ECG phenotype characterized by asymmetrical T waves.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_023842	172	D → N in SQT3; gain of function. 1 PublicationCorresponds to variant dbSNP:rs104894584EnsemblClinVar.		1

Atrial fibrillation, familial, 9 (ATFB9)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_065863	93	V → I in ATFB9; has a gain-of-function effect on the channels. 1 PublicationCorresponds to variant dbSNP:rs147750704EnsemblClinVar.		1

Keywords - Diseaseⁱ

Atrial fibrillation, Disease mutation, Long QT syndrome, Short QT syndrome

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3759
GeneReviewsⁱ	KCNJ2
MalaCards human disease database More...MalaCardsⁱ	KCNJ2
MIMⁱ	170390 phenotype 609622 phenotype 613980 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000123700
Orphanetⁱ	37553 Cardiodysrhythmic potassium-sensitive periodic paralysis 334 Familial atrial fibrillation 51083 Familial short QT syndrome
PharmGKBⁱ	PA214

Chemistry databases

ChEMBLⁱ	CHEMBL1914276

ChEMBLⁱ

CHEMBL1914276

Polymorphism and mutation databases

BioMutaⁱ	KCNJ2
DMDMⁱ	54037433

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000154923	2 – 427	Inward rectifier potassium channel 2Add BLAST		426

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	2	N-myristoyl glycine1 Publication		1
Modified residueⁱ	76	S-nitrosocysteine1 Publication		1

Post-translational modificationⁱ

S-nitrosylation increases the open probability and inward rectifying currents.1 Publication

Keywords - PTMⁱ

Lipoprotein, Myristate, S-nitrosylation

Proteomic databases

PaxDbⁱ	P63252
PeptideAtlas More...PeptideAtlasⁱ	P63252
PRIDEⁱ	P63252
ProteomicsDBⁱ	57513

PTM databases

iPTMnetⁱ	P63252
PhosphoSitePlusⁱ	P63252

Expressionⁱ

Tissue specificityⁱ

Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.

Gene expression databases

Bgeeⁱ	ENSG00000123700 Expressed in 210 organ(s), highest expression level in globus pallidus
CleanExⁱ	HS_KCNJ2
Genevisibleⁱ	P63252 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA029109

HPAⁱ

HPA029109

Interactionⁱ

Subunit structureⁱ

Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity).By similarity

GO - Molecular functionⁱ

identical protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109961, 3 interactors
ComplexPortalⁱ	CPX-3071 Inward rectifier potassium channel 2 complex
IntActⁱ	P63252, 7 interactors
STRINGⁱ	9606.ENSP00000243457

Chemistry databases

BindingDBⁱ

P63252

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P63252
SMRⁱ	P63252
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	142 – 147	Selectivity filterBy similarity		6
Motifⁱ	425 – 427	PDZ-bindingSequence analysis		3

Sequence similaritiesⁱ

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3827 Eukaryota ENOG410XQ62 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118842
HOGENOMⁱ	HOG000237325
HOVERGENⁱ	HBG006178
InParanoidⁱ	P63252
KEGG Orthology (KO) More...KOⁱ	K04996
OMAⁱ	VFSHNAT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08HC
PhylomeDBⁱ	P63252
TreeFamⁱ	TF313676

Family and domain databases

Gene3Dⁱ	2.60.40.1400, 2 hits
InterProⁱ	View protein in InterPro IPR014756 Ig_E-set IPR016449 K_chnl_inward-rec_Kir IPR003271 K_chnl_inward-rec_Kir2.1 IPR013518 K_chnl_inward-rec_Kir_cyto IPR013673 K_chnl_inward-rec_Kir_N
PANTHERⁱ	PTHR11767 PTHR11767, 1 hit PTHR11767:SF43 PTHR11767:SF43, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01007 IRK, 1 hit PF08466 IRK_N, 1 hit
PIRSFⁱ	PIRSF005465 GIRK_kir, 1 hit
PRINTSⁱ	PR01324 KIR21CHANNEL PR01320 KIRCHANNEL
SUPFAMⁱ	SSF81296 SSF81296, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P63252-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK 
        60         70         80         90        100
DGHCNVQFIN VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL AFVLSWLFFG 
       110        120        130        140        150
CVFWLIALLH GDLDASKEGK ACVSEVNSFT AAFLFSIETQ TTIGYGFRCV 
       160        170        180        190        200
TDECPIAVFM VVFQSIVGCI IDAFIIGAVM AKMAKPKKRN ETLVFSHNAV 
       210        220        230        240        250
IAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG EYIPLDQIDI 
       260        270        280        290        300
NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDIDNA DFEIVVILEG 
       310        320        330        340        350
MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKHYYKVD YSRFHKTYEV 
       360        370        380        390        400
PNTPLCSARD LAEKKYILSN ANSFCYENEV ALTSKEEDDS ENGVPESTST 
       410        420 
DTPPDIDLHN QASVPLEPRP LRRESEI

Length:427

Mass (Da):48,288

Last modified:October 11, 2004 - v1

Checksum:ⁱAB37CAD4B99B4050

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	330	L → F in AAC39555 (PubMed:9490857).Curated		1
Sequence conflictⁱ	340	D → E in AAC39555 (PubMed:9490857).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_065861	54	C → F in LQT7; there is loss of function when the mutant is expressed alone and a dominant-negative effect when expressed with wild-type channels; channel trafficking and assembly are not affected. 1 PublicationCorresponds to variant dbSNP:rs199473650EnsemblClinVar.	1
Natural variantⁱVAR_017851	67	R → W in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894580EnsemblClinVar.	1
Natural variantⁱVAR_017852	71	D → V in LQT7; loss of function mutation acting in a dominant-negative manner. 1 PublicationCorresponds to variant dbSNP:rs104894575EnsemblClinVar.	1
Natural variantⁱVAR_065862	75	T → R in LQT7; loss of function mutation acting in a dominant-negative manner. 1 PublicationCorresponds to variant dbSNP:rs104894585EnsemblClinVar.	1
Natural variantⁱVAR_065863	93	V → I in ATFB9; has a gain-of-function effect on the channels. 1 PublicationCorresponds to variant dbSNP:rs147750704EnsemblClinVar.	1
Natural variantⁱVAR_017853	95 – 98	Missing in LQT7. 1 Publication	4
Natural variantⁱVAR_023842	172	D → N in SQT3; gain of function. 1 PublicationCorresponds to variant dbSNP:rs104894584EnsemblClinVar.	1
Natural variantⁱVAR_017854	186	P → L in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894581EnsemblClinVar.	1
Natural variantⁱVAR_017855	216	N → H in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894583EnsemblClinVar.	1
Natural variantⁱVAR_017856	218	R → W in LQT7; loss of function and dominant-negative effect in current. 1 PublicationCorresponds to variant dbSNP:rs104894578EnsemblClinVar.	1
Natural variantⁱVAR_017857	300	G → V in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894579EnsemblClinVar.	1
Natural variantⁱVAR_017858	302	V → M in LQT7. 1 PublicationCorresponds to variant dbSNP:rs104894582EnsemblClinVar.	1
Natural variantⁱVAR_065864	305	T → P in LQT7; there is loss of function when the mutant is expressed alone and a dominant-negative effect when expressed with wild-type channels; channel trafficking and assembly are not affected. 1 PublicationCorresponds to variant dbSNP:rs199473387EnsemblClinVar.	1
Natural variantⁱVAR_017859	314 – 315	Missing in LQT7.	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U24055 mRNA Translation: AAB50277.1 U12507 mRNA Translation: AAC50072.1 U16861 mRNA Translation: AAA91781.1 AF153819 Genomic DNA Translation: AAF73242.1 AF153820 mRNA Translation: AAF73241.1 U22413 mRNA Translation: AAA64282.1 AF011904 mRNA Translation: AAC39555.1 AF021139 mRNA Translation: AAB88797.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11688.1
PIRⁱ	I38727
NCBI Reference Sequences More...RefSeqⁱ	NP_000882.1, NM_000891.2
UniGeneⁱ	Hs.1547

Genome annotation databases

Ensemblⁱ	ENST00000243457; ENSP00000243457; ENSG00000123700 ENST00000535240; ENSP00000441848; ENSG00000123700
GeneIDⁱ	3759
KEGGⁱ	hsa:3759
UCSC genome browser More...UCSCⁱ	uc002jir.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P63252	Inward rectifier potassium channel 2		MACMU		427	UniRef100_P63252
KCNJ2 isoform 1		PANTR		427
Potassium voltage-gated channel subfamily J member 2		MACFA		427
KCNJ2 isoform 1		PONAB		427
Uncharacterized protein		COLAP		427
+9

Protein	Similar proteins		Species	Score	Length	Source
P63252	Inward rectifier potassium channel 2		MACMU		427	UniRef90_P63252
Inward rectifier potassium channel 2	)	MOUSE		428
Inward rectifier potassium channel 2		BOVIN		427
Inward rectifier potassium channel 2		CANLF		427
Inward rectifier potassium channel 2		CHICK		427
+189

Protein	Similar proteins		Species	Score	Length	Source
P63252	Inward rectifier potassium channel 2		MACMU		427	UniRef50_P63252
Inward rectifier potassium channel 2	)	MOUSE		428
Inward rectifier potassium channel 2		RAT		427
Inward rectifier potassium channel 2		BOVIN		427
Inward rectifier potassium channel 2		RABIT		427
+740

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U24055 mRNA Translation: AAB50277.1 U12507 mRNA Translation: AAC50072.1 U16861 mRNA Translation: AAA91781.1 AF153819 Genomic DNA Translation: AAF73242.1 AF153820 mRNA Translation: AAF73241.1 U22413 mRNA Translation: AAA64282.1 AF011904 mRNA Translation: AAC39555.1 AF021139 mRNA Translation: AAB88797.1
CCDSⁱ	CCDS11688.1
PIRⁱ	I38727
RefSeqⁱ	NP_000882.1, NM_000891.2
UniGeneⁱ	Hs.1547

3D structure databases

ProteinModelPortalⁱ	P63252
SMRⁱ	P63252
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109961, 3 interactors
ComplexPortalⁱ	CPX-3071 Inward rectifier potassium channel 2 complex
IntActⁱ	P63252, 7 interactors
STRINGⁱ	9606.ENSP00000243457

Chemistry databases

BindingDBⁱ	P63252
ChEMBLⁱ	CHEMBL1914276

Protein family/group databases

TCDBⁱ	1.A.2.1.2 the inward rectifier k(+) channel (irk-c) family

TCDBⁱ

1.A.2.1.2 the inward rectifier k(+) channel (irk-c) family

PTM databases

iPTMnetⁱ	P63252
PhosphoSitePlusⁱ	P63252

Polymorphism and mutation databases

BioMutaⁱ	KCNJ2
DMDMⁱ	54037433

Proteomic databases

PaxDbⁱ	P63252
PeptideAtlasⁱ	P63252
PRIDEⁱ	P63252
ProteomicsDBⁱ	57513

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3759
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000243457; ENSP00000243457; ENSG00000123700 ENST00000535240; ENSP00000441848; ENSG00000123700
GeneIDⁱ	3759
KEGGⁱ	hsa:3759
UCSCⁱ	uc002jir.4 human

Organism-specific databases

CTDⁱ	3759
DisGeNETⁱ	3759
EuPathDBⁱ	HostDB:ENSG00000123700.4
GeneCardsⁱ	KCNJ2
GeneReviewsⁱ	KCNJ2
HGNCⁱ	HGNC:6263 KCNJ2
HPAⁱ	HPA029109
MalaCardsⁱ	KCNJ2
MIMⁱ	170390 phenotype 600681 gene 609622 phenotype 613980 phenotype
neXtProtⁱ	NX_P63252
OpenTargetsⁱ	ENSG00000123700
Orphanetⁱ	37553 Cardiodysrhythmic potassium-sensitive periodic paralysis 334 Familial atrial fibrillation 51083 Familial short QT syndrome
PharmGKBⁱ	PA214
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3827 Eukaryota ENOG410XQ62 LUCA
GeneTreeⁱ	ENSGT00760000118842
HOGENOMⁱ	HOG000237325
HOVERGENⁱ	HBG006178
InParanoidⁱ	P63252
KOⁱ	K04996
OMAⁱ	VFSHNAT
OrthoDBⁱ	EOG091G08HC
PhylomeDBⁱ	P63252
TreeFamⁱ	TF313676

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1296041 Activation of G protein gated Potassium channels R-HSA-1296053 Classical Kir channels R-HSA-5576886 Phase 4 - resting membrane potential R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Reactomeⁱ

R-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-1296053 Classical Kir channels
R-HSA-5576886 Phase 4 - resting membrane potential
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

GeneWikiⁱ	Kir2.1
GenomeRNAiⁱ	3759
Protein Ontology More...PROⁱ	PR:P63252
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000123700 Expressed in 210 organ(s), highest expression level in globus pallidus
CleanExⁱ	HS_KCNJ2
Genevisibleⁱ	P63252 HS

Family and domain databases

Gene3Dⁱ	2.60.40.1400, 2 hits
InterProⁱ	View protein in InterPro IPR014756 Ig_E-set IPR016449 K_chnl_inward-rec_Kir IPR003271 K_chnl_inward-rec_Kir2.1 IPR013518 K_chnl_inward-rec_Kir_cyto IPR013673 K_chnl_inward-rec_Kir_N
PANTHERⁱ	PTHR11767 PTHR11767, 1 hit PTHR11767:SF43 PTHR11767:SF43, 1 hit
Pfamⁱ	View protein in Pfam PF01007 IRK, 1 hit PF08466 IRK_N, 1 hit
PIRSFⁱ	PIRSF005465 GIRK_kir, 1 hit
PRINTSⁱ	PR01324 KIR21CHANNEL PR01320 KIRCHANNEL
SUPFAMⁱ	SSF81296 SSF81296, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCNJ2_HUMAN
Accessionⁱ	P63252Primary (citable) accession number: P63252 Secondary accession number(s): O15110, P48049
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
	Last sequence update:	October 11, 2004
	Last modified:	September 12, 2018
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P63252 (KCNJ2_HUMAN)

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Inward rectifier potassium channel 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endoplasmic reticulum

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ