UniProtKB - P63244 (RACK1_HUMAN)
Receptor of activated protein C kinase 1
RACK1
Functioni
GO - Molecular functioni
- BH3 domain binding Source: UniProtKB
- cadherin binding Source: BHF-UCL
- cyclin binding Source: UniProtKB
- cysteine-type endopeptidase activator activity involved in apoptotic process Source: UniProtKB
- enzyme binding Source: BHF-UCL
- ion channel inhibitor activity Source: UniProtKB
- molecular adaptor activity Source: BHF-UCL
- protein homodimerization activity Source: ParkinsonsUK-UCL
- protein kinase C binding Source: UniProtKB
- protein phosphatase binding Source: UniProtKB
- protein tyrosine kinase inhibitor activity Source: UniProtKB
- receptor tyrosine kinase binding Source: UniProtKB
- ribosome binding Source: UniProtKB
- RNA binding Source: UniProtKB
- SH2 domain binding Source: UniProtKB
- signaling adaptor activity Source: ParkinsonsUK-UCL
- signaling receptor binding Source: UniProtKB
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- cell cycle Source: UniProtKB-KW
- cellular response to glucose stimulus Source: ParkinsonsUK-UCL
- cellular response to growth factor stimulus Source: UniProtKB
- gastrulation Source: UniProtKB-KW
- negative regulation of cell growth Source: UniProtKB
- negative regulation of endoplasmic reticulum unfolded protein response Source: ParkinsonsUK-UCL
- negative regulation of gene expression Source: UniProtKB
- negative regulation of hydrogen peroxide-induced neuron death Source: ParkinsonsUK-UCL
- negative regulation of peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
- negative regulation of phagocytosis Source: UniProtKB
- negative regulation of protein binding Source: UniProtKB
- negative regulation of protein kinase B signaling Source: UniProtKB
- negative regulation of smoothened signaling pathway Source: FlyBase
- negative regulation of translation Source: UniProtKB
- negative regulation of Wnt signaling pathway Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of ceramide biosynthetic process Source: Reactome
- positive regulation of cyclic-nucleotide phosphodiesterase activity Source: BHF-UCL
- positive regulation of gastrulation Source: UniProtKB
- positive regulation of Golgi to plasma membrane protein transport Source: UniProtKB
- positive regulation of GTPase activity Source: UniProtKB
- positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
- positive regulation of mitochondrial depolarization Source: UniProtKB
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- positive regulation of protein-containing complex assembly Source: UniProtKB
- positive regulation of protein phosphorylation Source: UniProtKB
- protein ubiquitination Source: UniProtKB
- regulation of cell cycle Source: UniProtKB
- regulation of cell division Source: UniProtKB
- regulation of establishment of cell polarity Source: UniProtKB
- regulation of protein localization Source: UniProtKB
- regulation of tumor necrosis factor-mediated signaling pathway Source: Reactome
- rescue of stalled ribosome Source: UniProtKB
- rhythmic process Source: UniProtKB-KW
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, Ribonucleoprotein, Ribosomal protein |
Biological process | Apoptosis, Biological rhythms, Cell cycle, Gastrulation, Growth regulation, Host-virus interaction, Translation regulation |
Enzyme and pathway databases
PathwayCommonsi | P63244 |
Reactomei | R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5626978, TNFR1-mediated ceramide production |
SignaLinki | P63244 |
SIGNORi | P63244 |
Protein family/group databases
TCDBi | 8.A.92.1.4, the g-protein AlphaBetaGama complex (gpc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor of activated protein C kinase 1Alternative name(s): Cell proliferation-inducing gene 21 protein Guanine nucleotide-binding protein subunit beta-2-like 1 Guanine nucleotide-binding protein subunit beta-like protein 12.3 Human lung cancer oncogene 7 protein Short name: HLC-7 Receptor for activated C kinase Small ribosomal subunit protein RACK11 Publication Cleaved into the following chain: Alternative name(s): Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed |
Gene namesi | ORF Names:HLC7, PIG21 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4399, RACK1 |
MIMi | 176981, gene |
neXtProti | NX_P63244 |
VEuPathDBi | HostDB:ENSG00000204628.11 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Plasma membrane
- Cell membrane 2 Publications; Peripheral membrane protein
Other locations
- Cytoplasm 6 Publications
- perinuclear region 2 Publications
- Perikaryon By similarity
- dendrite By similarity
- phagocytic cup 1 Publication
Note: Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333). Also associated with the membrane in oncogene-transformed cells (PubMed:11884618). PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310).By similarity4 Publications
Cytosol
- cytosol Source: UniProtKB
- cytosolic small ribosomal subunit Source: GO_Central
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- phagocytic cup Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- dendrite Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- IRE1-RACK1-PP2A complex Source: ParkinsonsUK-UCL
- midbody Source: UniProtKB
- neuronal cell body Source: UniProtKB
- perikaryon Source: UniProtKB-SubCell
- perinuclear region of cytoplasm Source: UniProtKB
- small ribosomal subunit Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 36 – 38 | RDK → DDE in DEmut; abolishes association with the ribosome and ability to initiate the ribosome quality control (RQC). 1 Publication | 3 | |
Mutagenesisi | 52 | Y → F: No effect on binding to SRC. Abolishes binding to PTK2/FAK1 and reduces cell adhesion and foci formation. 3 Publications | 1 | |
Mutagenesisi | 57 | R → A: Decreased binding to PTK2/FAK1; when associated with A-60. 1 Publication | 1 | |
Mutagenesisi | 60 | R → A: Decreased binding to PTK2/FAK1; when associated with A-57. 1 Publication | 1 | |
Mutagenesisi | 127 | K → A: Decreased binding to PTK2/FAK1; when associated with A-130. 1 Publication | 1 | |
Mutagenesisi | 130 | K → A: Decreased binding to PTK2/FAK1; when associated with A-127. 1 Publication | 1 | |
Mutagenesisi | 140 | Y → F: No effect on binding to SRC. 2 Publications | 1 | |
Mutagenesisi | 194 | Y → F: No effect on binding to SRC. 2 Publications | 1 | |
Mutagenesisi | 228 | Y → F: No effect on binding to SRC. Does not abolish phosphorylation by SRC. Abolishes phosphorylation by SRC; when associated with F-246 and F-302. 2 Publications | 1 | |
Mutagenesisi | 246 | Y → F: Abolishes binding to SRC. Does not abolish phosphorylation by SRC. Abolishes phosphorylation by SRC; when associated with F-228 and F-302. 2 Publications | 1 | |
Mutagenesisi | 276 – 279 | STSS → EEEE: Enhanced translation of mRNAs containing poly-A leaders. 1 Publication | 4 | |
Mutagenesisi | 278 | S → E: Enhanced translation of mRNAs containing poly-A leaders. 1 Publication | 1 | |
Mutagenesisi | 302 | Y → F: No effect on binding to SRC. Abolishes phosphorylation by SRC; when associated with F-228 and F-246. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 10399 |
OpenTargetsi | ENSG00000204628 |
PharmGKBi | PA28779 |
Miscellaneous databases
Pharosi | P63244, Tbio |
Chemistry databases
DrugBanki | DB09130, Copper |
Genetic variation databases
BioMutai | RACK1 |
DMDMi | 54037168 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000424480 | 1 – 317 | Receptor of activated protein C kinase 1Add BLAST | 317 | |
Initiator methioninei | Removed; alternateCombined sources1 Publication | |||
ChainiPRO_0000127731 | 2 – 317 | Receptor of activated protein C kinase 1, N-terminally processedAdd BLAST | 316 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 2 | N-acetylthreonine; in Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processedCombined sources1 Publication | 1 | |
Modified residuei | 6 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 10 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 52 | Phosphotyrosine; by ABL11 Publication | 1 | |
Modified residuei | 96 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 130 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 183 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 228 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 276 | Phosphoserine; by viral VacV B1 kinaseCombined sources1 Publication | 1 | |
Modified residuei | 277 | Phosphothreonine; by viral VacV B1 kinase1 Publication | 1 | |
Modified residuei | 278 | Phosphoserine; by viral VacV B1 kinase1 Publication | 1 | |
Modified residuei | 279 | Phosphoserine; by viral VacV B1 kinase1 Publication | 1 | |
Modified residuei | 316 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-379 CPTAC-380 |
EPDi | P63244 |
jPOSTi | P63244 |
MassIVEi | P63244 |
MaxQBi | P63244 |
PaxDbi | P63244 |
PeptideAtlasi | P63244 |
PRIDEi | P63244 |
ProteomicsDBi | 57512 |
TopDownProteomicsi | P63244 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00848226 P63244 |
PTM databases
iPTMneti | P63244 |
MetOSitei | P63244 |
PhosphoSitePlusi | P63244 |
SwissPalmi | P63244 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000204628, Expressed in female gonad and 257 other tissues |
ExpressionAtlasi | P63244, baseline and differential |
Genevisiblei | P63244, HS |
Organism-specific databases
HPAi | ENSG00000204628, Low tissue specificity |
Interactioni
Subunit structurei
Monomer; also forms homodimers and homooligomers (PubMed:20529362, PubMed:15140893).
Interacts with CPNE3 (PubMed:20010870). May interact with ABCB4 (PubMed:19674157).
Component of the small (40S) ribosomal subunit (By similarity).
Interacts with the 80S ribosome (PubMed:23636399). Binds SLC9A3R1.
Forms a ternary complex with TRIM63 and PRKCE.
Interacts with HABP4, KRT1 and OTUB1.
Interacts with SRC (via SH2 domain); the interaction is enhanced by tyrosine phosphorylation of RACK1. Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and PRKCA.
Interacts with AR.
Interacts with IGF1R but not with INSR.
Interacts with ADAM12.
Interacts with CLEC1B (via N-terminal region) and with HIF1A; the interaction promotes their degradation.
Interacts with RHOA; this enhances RHOA activation and promotes cell migration.
Interacts with CHRM2; the interaction regulates CHRM2 internalization.
Interacts with TRPM6 (via kinase domain).
Interacts with PTK2/FAK1; required for PTK2/FAK1 phosphorylation and dephosphorylation.
Interacts with FLT1.
Interacts with TBXA2R isoform 2.
Interacts with HRAS.
Interacts with LARP4B.
Interacts with LARP4 (PubMed:21098120).
Interacts with PKD2L1.
By similarity28 Publications(Microbial infection) Interacts with Y.pseudotuberculosis yopK.
1 Publication(Microbial infection) Interacts with Y.pseudotuberculosis yopK.
Interacts with a number of viral proteins including Epstein-Barr virus BZLF1 and HIV-1 Nef; interaction with Nef increases Nef phosphorylation by PKC.
2 PublicationsBinary interactionsi
Hide detailsP63244
GO - Molecular functioni
- BH3 domain binding Source: UniProtKB
- cadherin binding Source: BHF-UCL
- cyclin binding Source: UniProtKB
- enzyme binding Source: BHF-UCL
- protein homodimerization activity Source: ParkinsonsUK-UCL
- protein kinase C binding Source: UniProtKB
- protein phosphatase binding Source: UniProtKB
- receptor tyrosine kinase binding Source: UniProtKB
- SH2 domain binding Source: UniProtKB
- signaling receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115671, 323 interactors |
CORUMi | P63244 |
DIPi | DIP-46736N |
IntActi | P63244, 132 interactors |
MINTi | P63244 |
STRINGi | 9606.ENSP00000426909 |
Miscellaneous databases
RNActi | P63244, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P63244 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 13 – 44 | WD 1Add BLAST | 32 | |
Repeati | 61 – 91 | WD 2Add BLAST | 31 | |
Repeati | 103 – 133 | WD 3Add BLAST | 31 | |
Repeati | 146 – 178 | WD 4Add BLAST | 33 | |
Repeati | 190 – 220 | WD 5Add BLAST | 31 | |
Repeati | 231 – 260 | WD 6Add BLAST | 30 | |
Repeati | 281 – 311 | WD 7Add BLAST | 31 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0279, Eukaryota |
GeneTreei | ENSGT00940000154461 |
InParanoidi | P63244 |
OMAi | CKAMLWD |
OrthoDBi | 805365at2759 |
PhylomeDBi | P63244 |
TreeFami | TF300600 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 7 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 4 hits PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET
60 70 80 90 100
NYGIPQRALR GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR
110 120 130 140 150
FVGHTKDVLS VAFSSDNRQI VSGSRDKTIK LWNTLGVCKY TVQDESHSEW
160 170 180 190 200
VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA NCKLKTNHIG HTGYLNTVTV
210 220 230 240 250
SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC FSPNRYWLCA
260 270 280 290 300
ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA
310
GYTDNLVRVW QVTIGTR
Computationally mapped potential isoform sequencesi
There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6REE5 | D6REE5_HUMAN | Receptor of-activated protein C kin... | RACK1 | 321 | Annotation score: | ||
D6R9L0 | D6R9L0_HUMAN | Receptor of-activated protein C kin... | RACK1 | 300 | Annotation score: | ||
D6RFX4 | D6RFX4_HUMAN | Receptor of-activated protein C kin... | RACK1 | 194 | Annotation score: | ||
H0Y8R5 | H0Y8R5_HUMAN | Receptor of-activated protein C kin... | RACK1 | 138 | Annotation score: | ||
D6R9Z1 | D6R9Z1_HUMAN | Receptor of-activated protein C kin... | RACK1 | 236 | Annotation score: | ||
D6RAC2 | D6RAC2_HUMAN | Receptor of-activated protein C kin... | RACK1 | 269 | Annotation score: | ||
H0Y8W2 | H0Y8W2_HUMAN | Receptor of-activated protein C kin... | RACK1 | 274 | Annotation score: | ||
H0YAM7 | H0YAM7_HUMAN | Receptor of-activated protein C kin... | RACK1 | 247 | Annotation score: | ||
J3KPE3 | J3KPE3_HUMAN | Receptor of-activated protein C kin... | RACK1 | 273 | Annotation score: | ||
D6RF23 | D6RF23_HUMAN | Receptor of-activated protein C kin... | RACK1 | 101 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 70 – 111 | Missing in BAG53102 (PubMed:14702039).CuratedAdd BLAST | 42 | |
Sequence conflicti | 94 | T → TRK in AAR24619 (Ref. 3) Curated | 1 | |
Sequence conflicti | 221 | L → F in BAD96208 (Ref. 6) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M24194 mRNA Translation: AAA59626.1 AY159316 mRNA Translation: AAO21313.1 Different initiation. AY336089 mRNA Translation: AAR24619.1 Frameshift. AK095666 mRNA Translation: BAG53102.1 CR456978 mRNA Translation: CAG33259.1 CR541909 mRNA Translation: CAG46707.1 AK222488 mRNA Translation: BAD96208.1 CH471165 Genomic DNA Translation: EAW53692.1 CH471165 Genomic DNA Translation: EAW53702.1 BC000214 mRNA Translation: AAH00214.1 BC000366 mRNA Translation: AAH00366.1 BC010119 mRNA Translation: AAH10119.1 BC014256 mRNA Translation: AAH14256.1 BC014788 mRNA Translation: AAH14788.1 BC017287 mRNA Translation: AAH17287.1 BC019093 mRNA Translation: AAH19093.1 BC019362 mRNA Translation: AAH19362.1 BC021993 mRNA Translation: AAH21993.1 BC032006 mRNA Translation: AAH32006.1 |
CCDSi | CCDS34324.1 |
PIRi | B33928 |
RefSeqi | NP_006089.1, NM_006098.4 |
Genome annotation databases
Ensembli | ENST00000512805; ENSP00000426909; ENSG00000204628 |
GeneIDi | 10399 |
KEGGi | hsa:10399 |
UCSCi | uc003mni.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M24194 mRNA Translation: AAA59626.1 AY159316 mRNA Translation: AAO21313.1 Different initiation. AY336089 mRNA Translation: AAR24619.1 Frameshift. AK095666 mRNA Translation: BAG53102.1 CR456978 mRNA Translation: CAG33259.1 CR541909 mRNA Translation: CAG46707.1 AK222488 mRNA Translation: BAD96208.1 CH471165 Genomic DNA Translation: EAW53692.1 CH471165 Genomic DNA Translation: EAW53702.1 BC000214 mRNA Translation: AAH00214.1 BC000366 mRNA Translation: AAH00366.1 BC010119 mRNA Translation: AAH10119.1 BC014256 mRNA Translation: AAH14256.1 BC014788 mRNA Translation: AAH14788.1 BC017287 mRNA Translation: AAH17287.1 BC019093 mRNA Translation: AAH19093.1 BC019362 mRNA Translation: AAH19362.1 BC021993 mRNA Translation: AAH21993.1 BC032006 mRNA Translation: AAH32006.1 |
CCDSi | CCDS34324.1 |
PIRi | B33928 |
RefSeqi | NP_006089.1, NM_006098.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4AOW | X-ray | 2.45 | A/B/C | 1-317 | [»] | |
4UG0 | electron microscopy | - | Sg | 1-317 | [»] | |
4V6X | electron microscopy | 5.00 | Ag | 1-317 | [»] | |
5A2Q | electron microscopy | 3.90 | g | 1-315 | [»] | |
5AJ0 | electron microscopy | 3.50 | Bg | 1-317 | [»] | |
5FLX | electron microscopy | 3.90 | g | 1-317 | [»] | |
5LKS | electron microscopy | 3.60 | Sg | 1-317 | [»] | |
5OA3 | electron microscopy | 4.30 | g | 1-315 | [»] | |
5T2C | electron microscopy | 3.60 | AI | 1-317 | [»] | |
5VYC | X-ray | 6.00 | g1/g2/g3/g4/g5/g6 | 1-317 | [»] | |
6EK0 | electron microscopy | 2.90 | Sg | 1-317 | [»] | |
6FEC | electron microscopy | 6.30 | m | 2-314 | [»] | |
6G18 | electron microscopy | 3.60 | g | 1-317 | [»] | |
6G51 | electron microscopy | 4.10 | g | 1-317 | [»] | |
6G53 | electron microscopy | 4.50 | g | 1-317 | [»] | |
6G5H | electron microscopy | 3.60 | g | 1-317 | [»] | |
6G5I | electron microscopy | 3.50 | g | 1-317 | [»] | |
6IP5 | electron microscopy | 3.90 | 3F | 1-317 | [»] | |
6IP6 | electron microscopy | 4.50 | 3F | 1-317 | [»] | |
6IP8 | electron microscopy | 3.90 | 3F | 1-317 | [»] | |
6OLE | electron microscopy | 3.10 | Sg | 3-314 | [»] | |
6OLF | electron microscopy | 3.90 | Sg | 3-314 | [»] | |
6OLG | electron microscopy | 3.40 | Bg | 2-315 | [»] | |
6OLI | electron microscopy | 3.50 | Sg | 3-314 | [»] | |
6OLZ | electron microscopy | 3.90 | Bg | 2-315 | [»] | |
6OM0 | electron microscopy | 3.10 | Sg | 3-314 | [»] | |
6OM7 | electron microscopy | 3.70 | Sg | 3-314 | [»] | |
6QZP | electron microscopy | 2.90 | Sg | 2-314 | [»] | |
6XA1 | electron microscopy | 2.80 | Sg | 2-314 | [»] | |
6Y0G | electron microscopy | 3.20 | Sg | 1-317 | [»] | |
6Y2L | electron microscopy | 3.00 | Sg | 1-317 | [»] | |
6Y57 | electron microscopy | 3.50 | Sg | 1-317 | [»] | |
6YBS | electron microscopy | 3.10 | c | 1-317 | [»] | |
6Z6L | electron microscopy | 3.00 | Sg | 1-317 | [»] | |
6Z6M | electron microscopy | 3.10 | Sg | 1-317 | [»] | |
6Z6N | electron microscopy | 2.90 | Sg | 1-317 | [»] | |
6ZLW | electron microscopy | 2.60 | j | 1-317 | [»] | |
6ZM7 | electron microscopy | 2.70 | Sg | 1-317 | [»] | |
6ZME | electron microscopy | 3.00 | Sg | 1-317 | [»] | |
6ZMI | electron microscopy | 2.60 | Sg | 1-317 | [»] | |
6ZMO | electron microscopy | 3.10 | Sg | 1-317 | [»] | |
6ZMT | electron microscopy | 3.00 | j | 1-317 | [»] | |
6ZMW | electron microscopy | 3.70 | c | 1-317 | [»] | |
6ZN5 | electron microscopy | 3.20 | j | 2-315 | [»] | |
6ZOJ | electron microscopy | 2.80 | g | 1-315 | [»] | |
6ZOL | electron microscopy | 2.80 | g | 1-315 | [»] | |
6ZON | electron microscopy | 3.00 | V | 1-317 | [»] | |
6ZP4 | electron microscopy | 2.90 | V | 1-317 | [»] | |
6ZVH | electron microscopy | 2.90 | g | 2-314 | [»] | |
6ZVJ | electron microscopy | 3.80 | V | 4-312 | [»] | |
7A09 | electron microscopy | 3.50 | V | 1-317 | [»] | |
7K5I | electron microscopy | 2.90 | g | 1-317 | [»] | |
SMRi | P63244 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115671, 323 interactors |
CORUMi | P63244 |
DIPi | DIP-46736N |
IntActi | P63244, 132 interactors |
MINTi | P63244 |
STRINGi | 9606.ENSP00000426909 |
Chemistry databases
DrugBanki | DB09130, Copper |
Protein family/group databases
TCDBi | 8.A.92.1.4, the g-protein AlphaBetaGama complex (gpc) family |
PTM databases
iPTMneti | P63244 |
MetOSitei | P63244 |
PhosphoSitePlusi | P63244 |
SwissPalmi | P63244 |
Genetic variation databases
BioMutai | RACK1 |
DMDMi | 54037168 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00848226 P63244 |
Proteomic databases
CPTACi | CPTAC-379 CPTAC-380 |
EPDi | P63244 |
jPOSTi | P63244 |
MassIVEi | P63244 |
MaxQBi | P63244 |
PaxDbi | P63244 |
PeptideAtlasi | P63244 |
PRIDEi | P63244 |
ProteomicsDBi | 57512 |
TopDownProteomicsi | P63244 |
Protocols and materials databases
Antibodypediai | 3802, 435 antibodies |
DNASUi | 10399 |
Genome annotation databases
Ensembli | ENST00000512805; ENSP00000426909; ENSG00000204628 |
GeneIDi | 10399 |
KEGGi | hsa:10399 |
UCSCi | uc003mni.2, human |
Organism-specific databases
CTDi | 10399 |
DisGeNETi | 10399 |
GeneCardsi | RACK1 |
HGNCi | HGNC:4399, RACK1 |
HPAi | ENSG00000204628, Low tissue specificity |
MIMi | 176981, gene |
neXtProti | NX_P63244 |
OpenTargetsi | ENSG00000204628 |
PharmGKBi | PA28779 |
VEuPathDBi | HostDB:ENSG00000204628.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0279, Eukaryota |
GeneTreei | ENSGT00940000154461 |
InParanoidi | P63244 |
OMAi | CKAMLWD |
OrthoDBi | 805365at2759 |
PhylomeDBi | P63244 |
TreeFami | TF300600 |
Enzyme and pathway databases
PathwayCommonsi | P63244 |
Reactomei | R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5626978, TNFR1-mediated ceramide production |
SignaLinki | P63244 |
SIGNORi | P63244 |
Miscellaneous databases
BioGRID-ORCSi | 10399, 770 hits in 885 CRISPR screens |
ChiTaRSi | RACK1, human |
GeneWikii | GNB2L1 |
GenomeRNAii | 10399 |
Pharosi | P63244, Tbio |
PROi | PR:P63244 |
RNActi | P63244, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000204628, Expressed in female gonad and 257 other tissues |
ExpressionAtlasi | P63244, baseline and differential |
Genevisiblei | P63244, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 7 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 4 hits PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RACK1_HUMAN | |
Accessioni | P63244Primary (citable) accession number: P63244 Secondary accession number(s): B3KTJ0 Q6FH47 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 172 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Ribosomal proteins
Ribosomal proteins families and list of entries