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Entry version 146 (18 Sep 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Eukaryotic translation initiation factor 5A-1

Gene

Eif5a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionElongation factor, RNA-binding
Biological processmRNA transport, Protein biosynthesis, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-204626 Hypusine synthesis from eIF5A-lysine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5A-1
Short name:
eIF-5A-1
Short name:
eIF-5A1
Alternative name(s):
Eukaryotic initiation factor 5A isoform 1
Short name:
eIF-5A
eIF-4D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Eif5a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:106248 Eif5a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001424522 – 154Eukaryotic translation initiation factor 5A-1Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei47N6-acetyllysineBy similarity1
Modified residuei50HypusineBy similarity1
Modified residuei121N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated. Deacetylated by SIRT2 (By similarity).By similarity
eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

Keywords - PTMi

Acetylation, Hypusine

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P63242

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P63242

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P63242

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P63242

PeptideAtlas

More...
PeptideAtlasi
P63242

PRoteomics IDEntifications database

More...
PRIDEi
P63242

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P63242

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
P63242

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P63242

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P63242

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P63242

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P63242

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000078812 Expressed in 268 organ(s), highest expression level in forelimb bud

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P63242 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P63242 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DHPS, with SDCBP and DOHH.

Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
234898, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P63242, 7 interactors

Molecular INTeraction database

More...
MINTi
P63242

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000047008

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P63242

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 19Nuclear localization regulationAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eIF-5A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3271 Eukaryota
COG0231 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003738

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000106270

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P63242

KEGG Orthology (KO)

More...
KOi
K03263

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDTHFET

Database of Orthologous Groups

More...
OrthoDBi
1370513at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P63242

TreeFam database of animal gene trees

More...
TreeFami
TF101534

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001884 IF5A-like
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11673 PTHR11673, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01287 eIF-5a, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF003025 eIF5A, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01376 eIF-5a, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00037 eIF_5A, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00302 IF5A_HYPUSINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P63242-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK
60 70 80 90 100
HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS
110 120 130 140 150
LLQDSGEVRE DLRLPEGDLG KEIEQKYDCG EEILITVLSA MTEEAAVAIK

AMAK
Length:154
Mass (Da):16,832
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07EF043C7DEA3091
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQM0A0A0A0MQM0_MOUSE
Eukaryotic translation initiation f...
Eif5a
149Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QPS8J3QPS8_MOUSE
Eukaryotic translation initiation f...
Eif5a
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAI35154 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8E → Y in BAB27641 (PubMed:16141072).Curated1
Sequence conflicti16A → S in BAB27641 (PubMed:16141072).Curated1
Sequence conflicti139S → F in BAB27641 (PubMed:16141072).Curated1
Sequence conflicti143E → K in BAB27641 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY129323 mRNA Translation: AAN17521.1
AY129324 mRNA Translation: AAN17527.1
AY129325 mRNA Translation: AAN17528.1
AY129326 mRNA Translation: AAN17532.1
AY129327 mRNA Translation: AAN17534.1
AY129328 mRNA Translation: AAN17535.1
AY129329 mRNA Translation: AAN17539.1
AK011306 mRNA Translation: BAB27532.1
AK011470 mRNA Translation: BAB27641.1
AK149705 mRNA Translation: BAE29039.1
AL596185 Genomic DNA Translation: CAI35153.1
AL596185 Genomic DNA Translation: CAI35154.1 Sequence problems.
BC003889 mRNA Translation: AAH03889.1
BC008093 mRNA Translation: AAH08093.1
BC024899 mRNA Translation: AAH24899.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24923.1

NCBI Reference Sequences

More...
RefSeqi
NP_001160061.1, NM_001166589.1
NP_001160062.1, NM_001166590.1
NP_001160063.1, NM_001166591.1
NP_001160064.1, NM_001166592.1
NP_001160065.1, NM_001166593.1
NP_001160066.1, NM_001166594.1
NP_001160067.1, NM_001166595.1
NP_001160068.1, NM_001166596.1
NP_853613.1, NM_181582.4
XP_011247360.1, XM_011249058.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000043419; ENSMUSP00000047008; ENSMUSG00000078812
ENSMUST00000070996; ENSMUSP00000067077; ENSMUSG00000078812
ENSMUST00000071026; ENSMUSP00000068651; ENSMUSG00000078812
ENSMUST00000108607; ENSMUSP00000104247; ENSMUSG00000078812
ENSMUST00000108608; ENSMUSP00000104248; ENSMUSG00000078812
ENSMUST00000108609; ENSMUSP00000104249; ENSMUSG00000078812
ENSMUST00000108610; ENSMUSP00000104250; ENSMUSG00000078812
ENSMUST00000108611; ENSMUSP00000104251; ENSMUSG00000078812
ENSMUST00000108612; ENSMUSP00000104252; ENSMUSG00000078812
ENSMUST00000108613; ENSMUSP00000104253; ENSMUSG00000078812
ENSMUST00000164359; ENSMUSP00000132717; ENSMUSG00000078812

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
276770

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:276770

UCSC genome browser

More...
UCSCi
uc007jsq.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129323 mRNA Translation: AAN17521.1
AY129324 mRNA Translation: AAN17527.1
AY129325 mRNA Translation: AAN17528.1
AY129326 mRNA Translation: AAN17532.1
AY129327 mRNA Translation: AAN17534.1
AY129328 mRNA Translation: AAN17535.1
AY129329 mRNA Translation: AAN17539.1
AK011306 mRNA Translation: BAB27532.1
AK011470 mRNA Translation: BAB27641.1
AK149705 mRNA Translation: BAE29039.1
AL596185 Genomic DNA Translation: CAI35153.1
AL596185 Genomic DNA Translation: CAI35154.1 Sequence problems.
BC003889 mRNA Translation: AAH03889.1
BC008093 mRNA Translation: AAH08093.1
BC024899 mRNA Translation: AAH24899.1
CCDSiCCDS24923.1
RefSeqiNP_001160061.1, NM_001166589.1
NP_001160062.1, NM_001166590.1
NP_001160063.1, NM_001166591.1
NP_001160064.1, NM_001166592.1
NP_001160065.1, NM_001166593.1
NP_001160066.1, NM_001166594.1
NP_001160067.1, NM_001166595.1
NP_001160068.1, NM_001166596.1
NP_853613.1, NM_181582.4
XP_011247360.1, XM_011249058.2

3D structure databases

SMRiP63242
ModBaseiSearch...

Protein-protein interaction databases

BioGridi234898, 3 interactors
IntActiP63242, 7 interactors
MINTiP63242
STRINGi10090.ENSMUSP00000047008

PTM databases

iPTMnetiP63242
PhosphoSitePlusiP63242
SwissPalmiP63242

2D gel databases

REPRODUCTION-2DPAGEiP63242
UCD-2DPAGEiP63242

Proteomic databases

EPDiP63242
jPOSTiP63242
MaxQBiP63242
PaxDbiP63242
PeptideAtlasiP63242
PRIDEiP63242
TopDownProteomicsiP63242

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043419; ENSMUSP00000047008; ENSMUSG00000078812
ENSMUST00000070996; ENSMUSP00000067077; ENSMUSG00000078812
ENSMUST00000071026; ENSMUSP00000068651; ENSMUSG00000078812
ENSMUST00000108607; ENSMUSP00000104247; ENSMUSG00000078812
ENSMUST00000108608; ENSMUSP00000104248; ENSMUSG00000078812
ENSMUST00000108609; ENSMUSP00000104249; ENSMUSG00000078812
ENSMUST00000108610; ENSMUSP00000104250; ENSMUSG00000078812
ENSMUST00000108611; ENSMUSP00000104251; ENSMUSG00000078812
ENSMUST00000108612; ENSMUSP00000104252; ENSMUSG00000078812
ENSMUST00000108613; ENSMUSP00000104253; ENSMUSG00000078812
ENSMUST00000164359; ENSMUSP00000132717; ENSMUSG00000078812
GeneIDi276770
KEGGimmu:276770
UCSCiuc007jsq.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1984
MGIiMGI:106248 Eif5a

Phylogenomic databases

eggNOGiKOG3271 Eukaryota
COG0231 LUCA
GeneTreeiENSGT00390000003738
HOGENOMiHOG000106270
InParanoidiP63242
KOiK03263
OMAiEDTHFET
OrthoDBi1370513at2759
PhylomeDBiP63242
TreeFamiTF101534

Enzyme and pathway databases

ReactomeiR-MMU-204626 Hypusine synthesis from eIF5A-lysine

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Eif5a mouse

Protein Ontology

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PROi
PR:P63242

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000078812 Expressed in 268 organ(s), highest expression level in forelimb bud
ExpressionAtlasiP63242 baseline and differential
GenevisibleiP63242 MM

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR001884 IF5A-like
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11673 PTHR11673, 1 hit
PfamiView protein in Pfam
PF01287 eIF-5a, 1 hit
PIRSFiPIRSF003025 eIF5A, 1 hit
SMARTiView protein in SMART
SM01376 eIF-5a, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00037 eIF_5A, 1 hit
PROSITEiView protein in PROSITE
PS00302 IF5A_HYPUSINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF5A1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63242
Secondary accession number(s): P10159
, Q16182, Q5NCX0, Q78NR3, Q9D0G2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Translation initiation factors
    List of translation initiation factor entries
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