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Entry version 162 (18 Sep 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Eukaryotic translation initiation factor 5A-1

Gene

EIF5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionElongation factor, RNA-binding
Biological processmRNA transport, Protein biosynthesis, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204626 Hypusine synthesis from eIF5A-lysine

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5A-1
Short name:
eIF-5A-1
Short name:
eIF-5A1
Alternative name(s):
Eukaryotic initiation factor 5A isoform 1
Short name:
eIF-5A
Rev-binding factor
eIF-4D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF5A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3300 EIF5A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600187 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P63241

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Mature eIF5A-1 may be used as an in situ diagnostic marker for aberrant proliferation in intraepithelial neoplasia of the vulva.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi47K → A or R: Abolishes acetylation. 2 Publications1
Mutagenesisi47K → D: Causes total inactivation of eIF5A in supporting yeast growth. 2 Publications1
Mutagenesisi49G → A: Causes total inactivation of eIF5A in supporting yeast growth. 1 Publication1
Mutagenesisi50K → A: Decreases significantly the acetylation at position K-47 and causes total inactivation of eIF5A in supporting yeast growth. 3 Publications1
Mutagenesisi50K → I, D or R: Causes total inactivation of eIF5A in supporting yeast growth. 3 Publications1
Mutagenesisi52G → A: Causes total inactivation of eIF5A in supporting yeast growth. 1 Publication1
Mutagenesisi55K → A: Causes total inactivation of eIF5A in supporting yeast growth. 1 Publication1
Mutagenesisi81V → G: Leads to temperature sensitivity when expressed in yeast cells. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1984

Open Targets

More...
OpenTargetsi
ENSG00000132507

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27726

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105862

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EIF5A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
54037409

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001424512 – 154Eukaryotic translation initiation factor 5A-1Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei47N6-acetyllysine1 Publication1
Modified residuei50Hypusine1 Publication1
Modified residuei121N6-acetyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated. Deacetylated by SIRT2.3 Publications
eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

Keywords - PTMi

Acetylation, Hypusine

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P63241

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P63241

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P63241

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P63241

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P63241

PeptideAtlas

More...
PeptideAtlasi
P63241

PRoteomics IDEntifications database

More...
PRIDEi
P63241

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57510 [P63241-1]
57511 [P63241-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P63241-1 [P63241-1]
P63241-2 [P63241-2]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P63241

USC-OGP 2-DE database

More...
OGPi
P63241

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P63241

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P63241

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P63241

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P63241

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132507 Expressed in 218 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P63241 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P63241 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005042
HPA061298

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DHPS, with SDCBP and DOHH.

Interacts with HIV-1 protein Rev.

Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108299, 79 interactors

Protein interaction database and analysis system

More...
IntActi
P63241, 45 interactors

Molecular INTeraction database

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MINTi
P63241

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000336702

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P63241

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P63241

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 90DOHH-bindingAdd BLAST71

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eIF-5A family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3271 Eukaryota
COG0231 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003738

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P63241

KEGG Orthology (KO)

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KOi
K03263

Identification of Orthologs from Complete Genome Data

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OMAi
EDTHFET

Database of Orthologous Groups

More...
OrthoDBi
1370513at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P63241

TreeFam database of animal gene trees

More...
TreeFami
TF101534

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.30.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001884 IF5A-like
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf

The PANTHER Classification System

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PANTHERi
PTHR11673 PTHR11673, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01287 eIF-5a, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF003025 eIF5A, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01376 eIF-5a, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00037 eIF_5A, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00302 IF5A_HYPUSINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P63241-1) [UniParc]FASTAAdd to basket
Also known as: B, C, D

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK
60 70 80 90 100
HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS
110 120 130 140 150
LLQDSGEVRE DLRLPEGDLG KEIEQKYDCG EEILITVLSA MTEEAAVAIK

AMAK
Length:154
Mass (Da):16,832
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07EF043C7DEA3091
GO
Isoform 2 (identifier: P63241-2) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MA → MCGTGGTDSKTRRPPHRASFLKRLESKPLKMA

Show »
Length:184
Mass (Da):20,170
Checksum:i9E2A400E66540B74
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L397I3L397_HUMAN
Eukaryotic translation initiation f...
EIF5A
146Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L504I3L504_HUMAN
Eukaryotic translation initiation f...
EIF5A
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36R → W in AAD14095 (PubMed:7545941).Curated1
Sequence conflicti45T → A in AAD14095 (PubMed:7545941).Curated1
Sequence conflicti85K → R in AAD14095 (PubMed:7545941).Curated1
Sequence conflicti109R → P in AAD14095 (PubMed:7545941).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0220201 – 2MA → MCGTGGTDSKTRRPPHRASF LKRLESKPLKMA in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M23419 mRNA Translation: AAA58453.1
S72024 Genomic DNA Translation: AAD14095.1
U17969 Genomic DNA Translation: AAA86989.1
AY129319 mRNA Translation: AAN17514.1
AY129320 mRNA Translation: AAN17515.1
AY129321 mRNA Translation: AAN17516.1
AY129322 mRNA Translation: AAN17518.1
AK292615 mRNA Translation: BAF85304.1
CH471108 Genomic DNA Translation: EAW90219.1
CH471108 Genomic DNA Translation: EAW90220.1
CH471108 Genomic DNA Translation: EAW90221.1
CH471108 Genomic DNA Translation: EAW90222.1
BC000751 mRNA Translation: AAH00751.1
BC001832 mRNA Translation: AAH01832.1
BC030160 mRNA Translation: AAH30160.1
BC080196 mRNA Translation: AAH80196.1
BC085015 mRNA Translation: AAH85015.1
BC107779 mRNA Translation: AAI07780.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11099.1 [P63241-1]
CCDS45601.1 [P63241-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
B31486 FIHUA

NCBI Reference Sequences

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RefSeqi
NP_001137232.1, NM_001143760.1 [P63241-2]
NP_001137233.1, NM_001143761.1 [P63241-1]
NP_001137234.1, NM_001143762.1 [P63241-1]
NP_001961.1, NM_001970.4 [P63241-1]
XP_005256566.1, XM_005256509.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000336452; ENSP00000336702; ENSG00000132507 [P63241-2]
ENST00000336458; ENSP00000336776; ENSG00000132507 [P63241-1]
ENST00000416016; ENSP00000396073; ENSG00000132507 [P63241-1]
ENST00000419711; ENSP00000390677; ENSG00000132507 [P63241-1]
ENST00000571955; ENSP00000458269; ENSG00000132507 [P63241-1]
ENST00000573542; ENSP00000459611; ENSG00000132507 [P63241-1]
ENST00000576930; ENSP00000459196; ENSG00000132507 [P63241-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1984

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1984

UCSC genome browser

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UCSCi
uc002gfr.3 human [P63241-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23419 mRNA Translation: AAA58453.1
S72024 Genomic DNA Translation: AAD14095.1
U17969 Genomic DNA Translation: AAA86989.1
AY129319 mRNA Translation: AAN17514.1
AY129320 mRNA Translation: AAN17515.1
AY129321 mRNA Translation: AAN17516.1
AY129322 mRNA Translation: AAN17518.1
AK292615 mRNA Translation: BAF85304.1
CH471108 Genomic DNA Translation: EAW90219.1
CH471108 Genomic DNA Translation: EAW90220.1
CH471108 Genomic DNA Translation: EAW90221.1
CH471108 Genomic DNA Translation: EAW90222.1
BC000751 mRNA Translation: AAH00751.1
BC001832 mRNA Translation: AAH01832.1
BC030160 mRNA Translation: AAH30160.1
BC080196 mRNA Translation: AAH80196.1
BC085015 mRNA Translation: AAH85015.1
BC107779 mRNA Translation: AAI07780.1
CCDSiCCDS11099.1 [P63241-1]
CCDS45601.1 [P63241-2]
PIRiB31486 FIHUA
RefSeqiNP_001137232.1, NM_001143760.1 [P63241-2]
NP_001137233.1, NM_001143761.1 [P63241-1]
NP_001137234.1, NM_001143762.1 [P63241-1]
NP_001961.1, NM_001970.4 [P63241-1]
XP_005256566.1, XM_005256509.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FH4model-A1-154[»]
3CPFX-ray2.50A/B15-151[»]
5DLQX-ray3.20E/F15-154[»]
SMRiP63241
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108299, 79 interactors
IntActiP63241, 45 interactors
MINTiP63241
STRINGi9606.ENSP00000336702

Chemistry databases

ChEMBLiCHEMBL4105862

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiP63241
PhosphoSitePlusiP63241
SwissPalmiP63241

Polymorphism and mutation databases

BioMutaiEIF5A
DMDMi54037409

2D gel databases

DOSAC-COBS-2DPAGEiP63241
OGPiP63241

Proteomic databases

EPDiP63241
jPOSTiP63241
MassIVEiP63241
MaxQBiP63241
PaxDbiP63241
PeptideAtlasiP63241
PRIDEiP63241
ProteomicsDBi57510 [P63241-1]
57511 [P63241-2]
TopDownProteomicsiP63241-1 [P63241-1]
P63241-2 [P63241-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1984
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336452; ENSP00000336702; ENSG00000132507 [P63241-2]
ENST00000336458; ENSP00000336776; ENSG00000132507 [P63241-1]
ENST00000416016; ENSP00000396073; ENSG00000132507 [P63241-1]
ENST00000419711; ENSP00000390677; ENSG00000132507 [P63241-1]
ENST00000571955; ENSP00000458269; ENSG00000132507 [P63241-1]
ENST00000573542; ENSP00000459611; ENSG00000132507 [P63241-1]
ENST00000576930; ENSP00000459196; ENSG00000132507 [P63241-1]
GeneIDi1984
KEGGihsa:1984
UCSCiuc002gfr.3 human [P63241-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1984
DisGeNETi1984

GeneCards: human genes, protein and diseases

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GeneCardsi
EIF5A
HGNCiHGNC:3300 EIF5A
HPAiCAB005042
HPA061298
MIMi600187 gene
neXtProtiNX_P63241
OpenTargetsiENSG00000132507
PharmGKBiPA27726

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3271 Eukaryota
COG0231 LUCA
GeneTreeiENSGT00390000003738
InParanoidiP63241
KOiK03263
OMAiEDTHFET
OrthoDBi1370513at2759
PhylomeDBiP63241
TreeFamiTF101534

Enzyme and pathway databases

ReactomeiR-HSA-204626 Hypusine synthesis from eIF5A-lysine

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EIF5A human
EvolutionaryTraceiP63241

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
EIF5A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1984

Pharos

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Pharosi
P63241
PMAP-CutDBiP63241

Protein Ontology

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PROi
PR:P63241

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132507 Expressed in 218 organ(s), highest expression level in right testis
ExpressionAtlasiP63241 baseline and differential
GenevisibleiP63241 HS

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR001884 IF5A-like
IPR012340 NA-bd_OB-fold
IPR014722 Rib_L2_dom2
IPR019769 Trans_elong_IF5A_hypusine_site
IPR020189 Transl_elong_IF5A_C
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11673 PTHR11673, 1 hit
PfamiView protein in Pfam
PF01287 eIF-5a, 1 hit
PIRSFiPIRSF003025 eIF5A, 1 hit
SMARTiView protein in SMART
SM01376 eIF-5a, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00037 eIF_5A, 1 hit
PROSITEiView protein in PROSITE
PS00302 IF5A_HYPUSINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF5A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63241
Secondary accession number(s): A8K9A0
, D3DTP2, P10159, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Translation initiation factors
    List of translation initiation factor entries
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