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Entry version 115 (12 Aug 2020)
Sequence version 1 (11 Oct 2004)
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Protein

Glutamate/gamma-aminobutyrate antiporter

Gene

gadC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in glutaminase-dependent acid resistance (PubMed:8682809, PubMed:30498489). Exchanges extracellular glutamate (Glu) for intracellular gamma-aminobutyric acid (GABA) under acidic conditions (PubMed:22407317, PubMed:23589309). The protonation states of substrates are crucial for transport. Selectively transports Glu with no net charge and GABA with a positive charge (PubMed:23589309). Also efficiently transports glutamine and, to a smaller extent, methionine and leucine (PubMed:22407317). When the extracellular pH drops below 2.5, can import L-glutamine and export either glutamate or GABA (PubMed:30498489). The ability to survive the extremely acidic conditions of the stomach is essential for successful colonization of the host by commensal and pathogenic bacteria (PubMed:8682809, PubMed:30498489).2 Publications4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Shows pH-dependent activity (PubMed:22407317, PubMed:23589309). The Glu/GABA transport activity is robust at pH 4.5 and rapidly decreases with increasing pH, with no detectable activity at pH 6.5 or above (PubMed:22407317, PubMed:23589309). The Glu analog L-trans-pyrrolidine-2,4-dicarboxylic acid (L-PDC) blocks the uptake of glutamate by selective inhibition (PubMed:12855178).3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=146.6 µM for L-glutamate (at pH 5)1 Publication
  2. KM=85.3 µM for L-glutamate (at pH 5.5)1 Publication
  3. KM=92 µM for L-glutamate (at pH 6)1 Publication
  4. KM=203.3 µM for L-glutamine (at pH 5.5)1 Publication
  5. KM=202.4 µM for GABA (at pH 5.5)1 Publication
  1. Vmax=666 nmol/min/mg enzyme with L-glutamate as substrate (at pH 5)1 Publication
  2. Vmax=112 nmol/min/mg enzyme with L-glutamate as substrate (at pH 5.5)1 Publication
  3. Vmax=14.8 nmol/min/mg enzyme with L-glutamate as substrate (at pH 6)1 Publication
  4. Vmax=280 nmol/min/mg enzyme with L-glutamine as substrate (at pH 5.5)1 Publication
  5. Vmax=88.4 nmol/min/mg enzyme with GABA as substrate (at pH 5.5)1 Publication

pH dependencei

Inactive at pH 6.5 or above.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Antiport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:XASA-MONOMER
ECOL316407:JW1487-MONOMER
MetaCyc:XASA-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamate/gamma-aminobutyrate antiporterCurated
Short name:
Glu/GABA antiporter1 Publication
Alternative name(s):
Extreme acid sensitivity protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gadC1 Publication
Synonyms:acsA, xasA1 Publication
Ordered Locus Names:b1492, JW1487
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13Cytoplasmic1 PublicationAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 36Helical1 PublicationAdd BLAST23
Topological domaini37 – 40Periplasmic1 Publication4
Transmembranei41 – 64Helical1 PublicationAdd BLAST24
Topological domaini65 – 85Cytoplasmic1 PublicationAdd BLAST21
Transmembranei86 – 112Helical1 PublicationAdd BLAST27
Topological domaini113 – 126Periplasmic1 PublicationAdd BLAST14
Transmembranei127 – 147Helical1 PublicationAdd BLAST21
Topological domaini148 – 151Cytoplasmic1 Publication4
Transmembranei152 – 180Helical1 PublicationAdd BLAST29
Topological domaini181 – 201Periplasmic1 PublicationAdd BLAST21
Transmembranei202 – 225Helical1 PublicationAdd BLAST24
Topological domaini226 – 229Cytoplasmic1 Publication4
Transmembranei230 – 259Helical1 PublicationAdd BLAST30
Topological domaini260 – 288Periplasmic1 PublicationAdd BLAST29
Transmembranei289 – 322Helical1 PublicationAdd BLAST34
Topological domaini323 – 337Cytoplasmic1 PublicationAdd BLAST15
Transmembranei338 – 359Helical1 PublicationAdd BLAST22
Topological domaini360 – 362Periplasmic1 Publication3
Transmembranei363 – 396Helical1 PublicationAdd BLAST34
Topological domaini397 – 409Cytoplasmic1 PublicationAdd BLAST13
Transmembranei410 – 430Helical1 PublicationAdd BLAST21
Topological domaini431 – 443Periplasmic1 PublicationAdd BLAST13
Transmembranei444 – 467Helical1 PublicationAdd BLAST24
Topological domaini468 – 511Cytoplasmic2 PublicationsAdd BLAST44

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant shows a 10-fold decrease in resistance with glutamate.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi25M → A: 25% decrease in substrate transport. 1 Publication1
Mutagenesisi30Y → A: At least 90% decrease in substrate transport. 1 Publication1
Mutagenesisi212L → A: 70% decrease in substrate transport. 1 Publication1
Mutagenesisi218E → A: At least 90% decrease in substrate transport. 1 Publication1
Mutagenesisi304E → A: At least 90% decrease in substrate transport. 1 Publication1
Mutagenesisi308W → A: At least 90% decrease in substrate transport. 1 Publication1
Mutagenesisi378Y → A: At least 90% decrease in substrate transport. 1 Publication1
Mutagenesisi382Y → A: At least 90% decrease in substrate transport. 1 Publication1
Mutagenesisi471 – 511Missing : Shifts the pH-dependent substrate transport towards higher pH values. Transports Gln, but not Glu, at pH 7.0 or higher. 2 PublicationsAdd BLAST41
Mutagenesisi491H → A: Allows substrate transport at pH 6.5. 1 Publication1
Mutagenesisi497R → A: Allows substrate transport at pH 6.5. 1 Publication1
Mutagenesisi499R → A: Allows substrate transport at pH 6.5. 1 Publication1
Mutagenesisi502H → A: Allows substrate transport at pH 6.5. 1 Publication1
Mutagenesisi503Y → A: Allows substrate transport at pH 6.5. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002130401 – 511Glutamate/gamma-aminobutyrate antiporterAdd BLAST511

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P63235

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P63235

PRoteomics IDEntifications database

More...
PRIDEi
P63235

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By acidic conditions. Expression is regulated by a complex system involving RpoS, cAMP, CRP, EvgAS, H-NS, GadE, GadW and GadX. The level of involvement for each regulator varies depending upon the growth phase and the medium.6 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4260789, 37 interactors

Database of interacting proteins

More...
DIPi
DIP-48121N

STRING: functional protein association networks

More...
STRINGi
511145.b1492

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1511
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P63235

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a unique C-terminal C-plug that plays an important role in substrate transport. The C-plug forms a folded domain and completely blocks the path to the putative substrate-binding site. Under neutral or basic pH, the C-plug probably remains closed and prevents substrate transport (PubMed:22407317, PubMed:23589309). At acidic pH, the C-plug may be displaced, allowing influx of Glu and efflux of GABA (PubMed:23589309).2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0531, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020854_4_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P63235

KEGG Orthology (KO)

More...
KOi
K20265

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P63235

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002293, AA/rel_permease1
IPR004759, Glu_antiport

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13520, AA_permease_2, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00910, 2A0307_GadC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P63235-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSVQTGKA KQLTLLGFFA ITASMVMAVY EYPTFATSGF SLVFFLLLGG
60 70 80 90 100
ILWFIPVGLC AAEMATVDGW EEGGVFAWVS NTLGPRWGFA AISFGYLQIA
110 120 130 140 150
IGFIPMLYFV LGALSYILKW PALNEDPITK TIAALIILWA LALTQFGGTK
160 170 180 190 200
YTARIAKVGF FAGILLPAFI LIALAAIYLH SGAPVAIEMD SKTFFPDFSK
210 220 230 240 250
VGTLVVFVAF ILSYMGVEAS ATHVNEMSNP GRDYPLAMLL LMVAAICLSS
260 270 280 290 300
VGGLSIAMVI PGNEINLSAG VMQTFTVLMS HVAPEIEWTV RVISALLLLG
310 320 330 340 350
VLAEIASWIV GPSRGMYVTA QKNLLPAAFA KMNKNGVPVT LVISQLVITS
360 370 380 390 400
IALIILTNTG GGNNMSFLIA LALTVVIYLC AYFMLFIGYI VLVLKHPDLK
410 420 430 440 450
RTFNIPGGKG VKLVVAIVGL LTSIMAFIVS FLPPDNIQGD STDMYVELLV
460 470 480 490 500
VSFLVVLALP FILYAVHDRK GKANTGVTLE PINSQNAPKG HFFLHPRARS
510
PHYIVMNDKK H
Length:511
Mass (Da):55,077
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i85DF72B82816CE33
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74565.1
AP009048 Genomic DNA Translation: BAA15156.2
U13204 Genomic DNA Translation: AAB17694.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G64902

NCBI Reference Sequences

More...
RefSeqi
NP_416009.1, NC_000913.3
WP_000246019.1, NZ_STEB01000054.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74565; AAC74565; b1492
BAA15156; BAA15156; BAA15156

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
48105739
946057

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1487
eco:b1492

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.775

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74565.1
AP009048 Genomic DNA Translation: BAA15156.2
U13204 Genomic DNA Translation: AAB17694.1
PIRiG64902
RefSeqiNP_416009.1, NC_000913.3
WP_000246019.1, NZ_STEB01000054.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DJIX-ray3.19A/B1-511[»]
4DJKX-ray3.10A/B1-511[»]
SMRiP63235
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi4260789, 37 interactors
DIPiDIP-48121N
STRINGi511145.b1492

Proteomic databases

jPOSTiP63235
PaxDbiP63235
PRIDEiP63235

Genome annotation databases

EnsemblBacteriaiAAC74565; AAC74565; b1492
BAA15156; BAA15156; BAA15156
GeneIDi48105739
946057
KEGGiecj:JW1487
eco:b1492
PATRICifig|1411691.4.peg.775

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2350

Phylogenomic databases

eggNOGiCOG0531, Bacteria
HOGENOMiCLU_020854_4_0_6
InParanoidiP63235
KOiK20265
PhylomeDBiP63235

Enzyme and pathway databases

BioCyciEcoCyc:XASA-MONOMER
ECOL316407:JW1487-MONOMER
MetaCyc:XASA-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P63235

Family and domain databases

InterProiView protein in InterPro
IPR002293, AA/rel_permease1
IPR004759, Glu_antiport
PfamiView protein in Pfam
PF13520, AA_permease_2, 1 hit
TIGRFAMsiTIGR00910, 2A0307_GadC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGADC_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63235
Secondary accession number(s): P39183
, P76131, P77384, Q54152
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: August 12, 2020
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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