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Protein

40S ribosomal protein S21

Gene

RPS21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S21
Alternative name(s):
Small ribosomal subunit protein eS211 Publication
Gene namesi
Name:RPS21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000171858.17
HGNCiHGNC:10409 RPS21
MIMi180477 gene
neXtProtiNX_P63220

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi6227
OpenTargetsiENSG00000171858
PharmGKBiPA34812

Polymorphism and mutation databases

BioMutaiRPS21
DMDMi52783792

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001947301 – 8340S ribosomal protein S21Add BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Cross-linki41Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei81N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP63220
PaxDbiP63220
PeptideAtlasiP63220
PRIDEiP63220
ProteomicsDBi57509
TopDownProteomicsiP63220

PTM databases

iPTMnetiP63220
PhosphoSitePlusiP63220
SwissPalmiP63220

Miscellaneous databases

PMAP-CutDBiP63220

Expressioni

Gene expression databases

BgeeiENSG00000171858 Expressed in 238 organ(s), highest expression level in thyroid gland
CleanExiHS_RPS21
ExpressionAtlasiP63220 baseline and differential
GenevisibleiP63220 HS

Organism-specific databases

HPAiHPA003371

Interactioni

Subunit structurei

Component of the 40S small ribosomal subunit.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112141, 118 interactors
CORUMiP63220
IntActiP63220, 14 interactors
MINTiP63220
STRINGi9606.ENSP00000345957

Structurei

3D structure databases

ProteinModelPortaliP63220
SMRiP63220
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3486 Eukaryota
ENOG4112266 LUCA
GeneTreeiENSGT00390000017515
HOGENOMiHOG000183557
InParanoidiP63220
KOiK02971
OMAiCPRKCSA
PhylomeDBiP63220
TreeFamiTF300167

Family and domain databases

Gene3Di3.30.1230.20, 1 hit
InterProiView protein in InterPro
IPR001931 Ribosomal_S21e
IPR018279 Ribosomal_S21e_CS
IPR038579 Ribosomal_S21e_sf
PANTHERiPTHR10442 PTHR10442, 1 hit
PfamiView protein in Pfam
PF01249 Ribosomal_S21e, 1 hit
PIRSFiPIRSF002148 Ribosomal_S21e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006584 Ribosomal_S21e, 1 hit
PROSITEiView protein in PROSITE
PS00996 RIBOSOMAL_S21E, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P63220-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQNDAGEFVD LYVPRKCSAS NRIIGAKDHA SIQMNVAEVD KVTGRFNGQF
60 70 80
KTYAICGAIR RMGESDDSIL RLAKADGIVS KNF
Length:83
Mass (Da):9,111
Last modified:September 27, 2004 - v1
Checksum:i6794AC1292A06BD3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8WVC2Q8WVC2_HUMAN
40S ribosomal protein S21
RPS21
81Annotation score:
Q9BYK1Q9BYK1_HUMAN
40S ribosomal protein S21
RPS21 hCG_41768
90Annotation score:
Q9BYK2Q9BYK2_HUMAN
40S ribosomal protein S21
RPS21 hCG_41768
66Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04483 mRNA Translation: AAA99893.1
AJ250907 Genomic DNA Translation: CAB83213.1
AB061843 Genomic DNA Translation: BAB79481.1
AL121832 Genomic DNA No translation available.
AB007157 Genomic DNA Translation: BAA25821.1
CCDSiCCDS13497.1
PIRiS34108
RefSeqiNP_001015.1, NM_001024.3
UniGeneiHs.190968

Genome annotation databases

EnsembliENST00000343986; ENSP00000345957; ENSG00000171858
GeneIDi6227
KEGGihsa:6227

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04483 mRNA Translation: AAA99893.1
AJ250907 Genomic DNA Translation: CAB83213.1
AB061843 Genomic DNA Translation: BAB79481.1
AL121832 Genomic DNA No translation available.
AB007157 Genomic DNA Translation: BAA25821.1
CCDSiCCDS13497.1
PIRiS34108
RefSeqiNP_001015.1, NM_001024.3
UniGeneiHs.190968

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SV1-83[»]
4V6Xelectron microscopy5.00AV1-83[»]
5A2Qelectron microscopy3.90V1-83[»]
5AJ0electron microscopy3.50BV1-83[»]
5FLXelectron microscopy3.90V1-83[»]
5LKSelectron microscopy3.60SV1-83[»]
5OA3electron microscopy4.30V1-83[»]
5T2Celectron microscopy3.60AC1-83[»]
5VYCX-ray6.00V1/V2/V3/V4/V5/V61-83[»]
6EK0electron microscopy2.90SV1-83[»]
6G18electron microscopy3.60V1-83[»]
6G4Selectron microscopy4.00V1-83[»]
6G51electron microscopy4.10V1-83[»]
6G53electron microscopy4.50V1-83[»]
6G5Helectron microscopy3.60V1-83[»]
6G5Ielectron microscopy3.50V1-83[»]
ProteinModelPortaliP63220
SMRiP63220
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112141, 118 interactors
CORUMiP63220
IntActiP63220, 14 interactors
MINTiP63220
STRINGi9606.ENSP00000345957

PTM databases

iPTMnetiP63220
PhosphoSitePlusiP63220
SwissPalmiP63220

Polymorphism and mutation databases

BioMutaiRPS21
DMDMi52783792

Proteomic databases

EPDiP63220
PaxDbiP63220
PeptideAtlasiP63220
PRIDEiP63220
ProteomicsDBi57509
TopDownProteomicsiP63220

Protocols and materials databases

DNASUi6227
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343986; ENSP00000345957; ENSG00000171858
GeneIDi6227
KEGGihsa:6227

Organism-specific databases

CTDi6227
DisGeNETi6227
EuPathDBiHostDB:ENSG00000171858.17
GeneCardsiRPS21
HGNCiHGNC:10409 RPS21
HPAiHPA003371
MIMi180477 gene
neXtProtiNX_P63220
OpenTargetsiENSG00000171858
PharmGKBiPA34812
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3486 Eukaryota
ENOG4112266 LUCA
GeneTreeiENSGT00390000017515
HOGENOMiHOG000183557
InParanoidiP63220
KOiK02971
OMAiCPRKCSA
PhylomeDBiP63220
TreeFamiTF300167

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSiRPS21 human
GeneWikiiRPS21
GenomeRNAii6227
PMAP-CutDBiP63220
PROiPR:P63220
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171858 Expressed in 238 organ(s), highest expression level in thyroid gland
CleanExiHS_RPS21
ExpressionAtlasiP63220 baseline and differential
GenevisibleiP63220 HS

Family and domain databases

Gene3Di3.30.1230.20, 1 hit
InterProiView protein in InterPro
IPR001931 Ribosomal_S21e
IPR018279 Ribosomal_S21e_CS
IPR038579 Ribosomal_S21e_sf
PANTHERiPTHR10442 PTHR10442, 1 hit
PfamiView protein in Pfam
PF01249 Ribosomal_S21e, 1 hit
PIRSFiPIRSF002148 Ribosomal_S21e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006584 Ribosomal_S21e, 1 hit
PROSITEiView protein in PROSITE
PS00996 RIBOSOMAL_S21E, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRS21_HUMAN
AccessioniPrimary (citable) accession number: P63220
Secondary accession number(s): P35265
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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