Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

Gene

Gng3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-163359 Glucagon signaling in metabolic regulation
R-MMU-202040 G-protein activation
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-4086398 Ca2+ pathway
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-418217 G beta:gamma signalling through PLC beta
R-MMU-418555 G alpha (s) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-418594 G alpha (i) signalling events
R-MMU-418597 G alpha (z) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-500657 Presynaptic function of Kainate receptors
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene namesi
Name:Gng3
Synonyms:Gngt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:102704 Gng3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126191 – 72Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3Add BLAST72
PropeptideiPRO_000001262073 – 75Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphothreonineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei10PhosphothreonineCombined sources1
Modified residuei12PhosphoserineCombined sources1
Modified residuei72Cysteine methyl esterBy similarity1
Lipidationi72S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiP63216
PaxDbiP63216
PeptideAtlasiP63216
PRIDEiP63216

PTM databases

iPTMnetiP63216
PhosphoSitePlusiP63216

Expressioni

Tissue specificityi

Abundantly expressed in brain. Low levels in testis.

Gene expression databases

BgeeiENSMUSG00000071658 Expressed in 202 organ(s), highest expression level in prefrontal cortex
GenevisibleiP63216 MM

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with SCN8A.By similarity

Protein-protein interaction databases

IntActiP63216, 1 interactor
STRINGi10090.ENSMUSP00000093978

Structurei

3D structure databases

ProteinModelPortaliP63216
SMRiP63216
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOVERGENiHBG014983
InParanoidiP63216
KOiK04540
OMAiEASMCRI
OrthoDBiEOG091G17J0
PhylomeDBiP63216
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63216-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGETPVNST MSIGQARKMV EQLKIEASLC RIKVSKAAAD LMTYCDAHAC
60 70
EDPLITPVPT SENPFREKKF FCALL
Length:75
Mass (Da):8,305
Last modified:September 27, 2004 - v1
Checksum:i35CC03965FE69A9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069953 Genomic DNA Translation: AAC83941.1
AK004459 mRNA Translation: BAB23313.1
AK032646 mRNA Translation: BAC27969.1
BC029680 mRNA Translation: AAH29680.1
U38497 mRNA Translation: AAB01728.1
CCDSiCCDS29550.1
PIRiJC4340
RefSeqiNP_034446.1, NM_010316.3
UniGeneiMm.329700

Genome annotation databases

EnsembliENSMUST00000096259; ENSMUSP00000093978; ENSMUSG00000071658
GeneIDi14704
KEGGimmu:14704
UCSCiuc008gnh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069953 Genomic DNA Translation: AAC83941.1
AK004459 mRNA Translation: BAB23313.1
AK032646 mRNA Translation: BAC27969.1
BC029680 mRNA Translation: AAH29680.1
U38497 mRNA Translation: AAB01728.1
CCDSiCCDS29550.1
PIRiJC4340
RefSeqiNP_034446.1, NM_010316.3
UniGeneiMm.329700

3D structure databases

ProteinModelPortaliP63216
SMRiP63216
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP63216, 1 interactor
STRINGi10090.ENSMUSP00000093978

PTM databases

iPTMnetiP63216
PhosphoSitePlusiP63216

Proteomic databases

MaxQBiP63216
PaxDbiP63216
PeptideAtlasiP63216
PRIDEiP63216

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096259; ENSMUSP00000093978; ENSMUSG00000071658
GeneIDi14704
KEGGimmu:14704
UCSCiuc008gnh.1 mouse

Organism-specific databases

CTDi2785
MGIiMGI:102704 Gng3

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOVERGENiHBG014983
InParanoidiP63216
KOiK04540
OMAiEASMCRI
OrthoDBiEOG091G17J0
PhylomeDBiP63216
TreeFamiTF319909

Enzyme and pathway databases

ReactomeiR-MMU-1296041 Activation of G protein gated Potassium channels
R-MMU-163359 Glucagon signaling in metabolic regulation
R-MMU-202040 G-protein activation
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-4086398 Ca2+ pathway
R-MMU-416476 G alpha (q) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-418217 G beta:gamma signalling through PLC beta
R-MMU-418555 G alpha (s) signalling events
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-418594 G alpha (i) signalling events
R-MMU-418597 G alpha (z) signalling events
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-500657 Presynaptic function of Kainate receptors
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-MMU-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Miscellaneous databases

PROiPR:P63216
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071658 Expressed in 202 organ(s), highest expression level in prefrontal cortex
GenevisibleiP63216 MM

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBG3_MOUSE
AccessioniPrimary (citable) accession number: P63216
Secondary accession number(s): P29798, Q61014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again