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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

Gene

GNG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • type 1 angiotensin receptor binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SIGNORiP63215

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Gene namesi
Name:GNG3
Synonyms:GNGT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000162188.5
HGNCiHGNC:4405 GNG3
MIMi608941 gene
neXtProtiNX_P63215

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2785
OpenTargetsiENSG00000162188
PharmGKBiPA28785

Polymorphism and mutation databases

BioMutaiGNG3
DMDMi52783596

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126171 – 72Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3Add BLAST72
PropeptideiPRO_000001261873 – 75Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5PhosphothreonineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei10PhosphothreonineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei72Cysteine methyl esterBy similarity1
Lipidationi72S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP63215
PeptideAtlasiP63215
PRIDEiP63215
ProteomicsDBi57507

PTM databases

iPTMnetiP63215
PhosphoSitePlusiP63215

Expressioni

Gene expression databases

BgeeiENSG00000162188 Expressed in 130 organ(s), highest expression level in right frontal lobe
CleanExiHS_GNG3
GenevisibleiP63215 HS

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with SCN8A (PubMed:26900580).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109047, 16 interactors
IntActiP63215, 3 interactors
STRINGi9606.ENSP00000294117

Structurei

3D structure databases

ProteinModelPortaliP63215
SMRiP63215
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOVERGENiHBG014983
InParanoidiP63215
KOiK04540
OMAiEASMCRI
OrthoDBiEOG091G17J0
PhylomeDBiP63215
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63215-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGETPVNST MSIGQARKMV EQLKIEASLC RIKVSKAAAD LMTYCDAHAC
60 70
EDPLITPVPT SENPFREKKF FCALL
Length:75
Mass (Da):8,305
Last modified:September 27, 2004 - v1
Checksum:i35CC03965FE69A9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092129 mRNA Translation: AAD40371.1
AF188177 Genomic DNA Translation: AAF04567.1
AF087900 mRNA Translation: AAP97199.1
AF493871 mRNA Translation: AAM12585.1
AK311933 mRNA Translation: BAG34874.1
CH471076 Genomic DNA Translation: EAW74082.1
BC015563 mRNA Translation: AAH15563.1
CCDSiCCDS8032.1
RefSeqiNP_036334.1, NM_012202.4
XP_006718563.1, XM_006718500.2
UniGeneiHs.179915
Hs.740581

Genome annotation databases

EnsembliENST00000294117; ENSP00000294117; ENSG00000162188
GeneIDi2785
KEGGihsa:2785
UCSCiuc001nuv.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092129 mRNA Translation: AAD40371.1
AF188177 Genomic DNA Translation: AAF04567.1
AF087900 mRNA Translation: AAP97199.1
AF493871 mRNA Translation: AAM12585.1
AK311933 mRNA Translation: BAG34874.1
CH471076 Genomic DNA Translation: EAW74082.1
BC015563 mRNA Translation: AAH15563.1
CCDSiCCDS8032.1
RefSeqiNP_036334.1, NM_012202.4
XP_006718563.1, XM_006718500.2
UniGeneiHs.179915
Hs.740581

3D structure databases

ProteinModelPortaliP63215
SMRiP63215
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109047, 16 interactors
IntActiP63215, 3 interactors
STRINGi9606.ENSP00000294117

PTM databases

iPTMnetiP63215
PhosphoSitePlusiP63215

Polymorphism and mutation databases

BioMutaiGNG3
DMDMi52783596

Proteomic databases

PaxDbiP63215
PeptideAtlasiP63215
PRIDEiP63215
ProteomicsDBi57507

Protocols and materials databases

DNASUi2785
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294117; ENSP00000294117; ENSG00000162188
GeneIDi2785
KEGGihsa:2785
UCSCiuc001nuv.5 human

Organism-specific databases

CTDi2785
DisGeNETi2785
EuPathDBiHostDB:ENSG00000162188.5
GeneCardsiGNG3
HGNCiHGNC:4405 GNG3
MIMi608941 gene
neXtProtiNX_P63215
OpenTargetsiENSG00000162188
PharmGKBiPA28785
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOVERGENiHBG014983
InParanoidiP63215
KOiK04540
OMAiEASMCRI
OrthoDBiEOG091G17J0
PhylomeDBiP63215
TreeFamiTF319909

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SIGNORiP63215

Miscellaneous databases

GeneWikiiGNG3
GenomeRNAii2785
PROiPR:P63215
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162188 Expressed in 130 organ(s), highest expression level in right frontal lobe
CleanExiHS_GNG3
GenevisibleiP63215 HS

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBG3_HUMAN
AccessioniPrimary (citable) accession number: P63215
Secondary accession number(s): B2R4S7, P29798, Q61014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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