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Entry version 147 (12 Aug 2020)
Sequence version 1 (27 Sep 2004)
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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

Gene

GNG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G-protein beta-subunit binding Source: GO_Central
  • GTPase activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P63215

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296041, Activation of G protein gated Potassium channels
R-HSA-163359, Glucagon signaling in metabolic regulation
R-HSA-202040, G-protein activation
R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170, ADP signalling through P2Y purinoceptor 12
R-HSA-392451, G beta:gamma signalling through PI3Kgamma
R-HSA-392851, Prostacyclin signalling through prostacyclin receptor
R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398, Ca2+ pathway
R-HSA-416476, G alpha (q) signalling events
R-HSA-416482, G alpha (12/13) signalling events
R-HSA-418217, G beta:gamma signalling through PLC beta
R-HSA-418555, G alpha (s) signalling events
R-HSA-418592, ADP signalling through P2Y purinoceptor 1
R-HSA-418594, G alpha (i) signalling events
R-HSA-418597, G alpha (z) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-428930, Thromboxane signalling through TP receptor
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657, Presynaptic function of Kainate receptors
R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8964315, G beta:gamma signalling through BTK
R-HSA-8964616, G beta:gamma signalling through CDC42
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P63215

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GNG3
Synonyms:GNGT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162188.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4405, GNG3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608941, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P63215

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2785

Open Targets

More...
OpenTargetsi
ENSG00000162188

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28785

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P63215, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GNG3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
52783596

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000126171 – 72Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3Add BLAST72
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001261873 – 75Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei5PhosphothreonineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei10PhosphothreonineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei72Cysteine methyl esterBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi72S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P63215

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P63215

PeptideAtlas

More...
PeptideAtlasi
P63215

PRoteomics IDEntifications database

More...
PRIDEi
P63215

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57507

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P63215

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P63215

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162188, Expressed in right frontal lobe and 151 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P63215, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000162188, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Interacts with SCN8A (PubMed:26900580).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
109047, 16 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P63215

Protein interaction database and analysis system

More...
IntActi
P63215, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000294117

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P63215, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P63215

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4119, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00990000203647

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_168377_0_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P63215

KEGG Orthology (KO)

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KOi
K04540

Identification of Orthologs from Complete Genome Data

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OMAi
PVNSNMS

Database of Orthologous Groups

More...
OrthoDBi
1581168at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P63215

TreeFam database of animal gene trees

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TreeFami
TF319909

Family and domain databases

Conserved Domains Database

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CDDi
cd00068, GGL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.260.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015898, G-protein_gamma-like_dom
IPR036284, GGL_sf
IPR001770, Gprotein-gamma

The PANTHER Classification System

More...
PANTHERi
PTHR13809, PTHR13809, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00631, G-gamma, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00321, GPROTEING

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00224, GGL, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48670, SSF48670, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50058, G_PROTEIN_GAMMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P63215-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGETPVNST MSIGQARKMV EQLKIEASLC RIKVSKAAAD LMTYCDAHAC
60 70
EDPLITPVPT SENPFREKKF FCALL
Length:75
Mass (Da):8,305
Last modified:September 27, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35CC03965FE69A9D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF092129 mRNA Translation: AAD40371.1
AF188177 Genomic DNA Translation: AAF04567.1
AF087900 mRNA Translation: AAP97199.1
AF493871 mRNA Translation: AAM12585.1
AK311933 mRNA Translation: BAG34874.1
CH471076 Genomic DNA Translation: EAW74082.1
BC015563 mRNA Translation: AAH15563.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8032.1

NCBI Reference Sequences

More...
RefSeqi
NP_036334.1, NM_012202.4
XP_006718563.1, XM_006718500.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000294117; ENSP00000294117; ENSG00000162188

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2785

UCSC genome browser

More...
UCSCi
uc001nuv.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092129 mRNA Translation: AAD40371.1
AF188177 Genomic DNA Translation: AAF04567.1
AF087900 mRNA Translation: AAP97199.1
AF493871 mRNA Translation: AAM12585.1
AK311933 mRNA Translation: BAG34874.1
CH471076 Genomic DNA Translation: EAW74082.1
BC015563 mRNA Translation: AAH15563.1
CCDSiCCDS8032.1
RefSeqiNP_036334.1, NM_012202.4
XP_006718563.1, XM_006718500.2

3D structure databases

SMRiP63215
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109047, 16 interactors
CORUMiP63215
IntActiP63215, 16 interactors
STRINGi9606.ENSP00000294117

PTM databases

iPTMnetiP63215
PhosphoSitePlusiP63215

Polymorphism and mutation databases

BioMutaiGNG3
DMDMi52783596

Proteomic databases

MassIVEiP63215
PaxDbiP63215
PeptideAtlasiP63215
PRIDEiP63215
ProteomicsDBi57507

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28689, 86 antibodies

The DNASU plasmid repository

More...
DNASUi
2785

Genome annotation databases

EnsembliENST00000294117; ENSP00000294117; ENSG00000162188
GeneIDi2785
KEGGihsa:2785
UCSCiuc001nuv.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2785
DisGeNETi2785
EuPathDBiHostDB:ENSG00000162188.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GNG3
HGNCiHGNC:4405, GNG3
HPAiENSG00000162188, Tissue enriched (brain)
MIMi608941, gene
neXtProtiNX_P63215
OpenTargetsiENSG00000162188
PharmGKBiPA28785

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4119, Eukaryota
GeneTreeiENSGT00990000203647
HOGENOMiCLU_168377_0_1_1
InParanoidiP63215
KOiK04540
OMAiPVNSNMS
OrthoDBi1581168at2759
PhylomeDBiP63215
TreeFamiTF319909

Enzyme and pathway databases

PathwayCommonsiP63215
ReactomeiR-HSA-1296041, Activation of G protein gated Potassium channels
R-HSA-163359, Glucagon signaling in metabolic regulation
R-HSA-202040, G-protein activation
R-HSA-381676, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170, ADP signalling through P2Y purinoceptor 12
R-HSA-392451, G beta:gamma signalling through PI3Kgamma
R-HSA-392851, Prostacyclin signalling through prostacyclin receptor
R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398, Ca2+ pathway
R-HSA-416476, G alpha (q) signalling events
R-HSA-416482, G alpha (12/13) signalling events
R-HSA-418217, G beta:gamma signalling through PLC beta
R-HSA-418555, G alpha (s) signalling events
R-HSA-418592, ADP signalling through P2Y purinoceptor 1
R-HSA-418594, G alpha (i) signalling events
R-HSA-418597, G alpha (z) signalling events
R-HSA-420092, Glucagon-type ligand receptors
R-HSA-428930, Thromboxane signalling through TP receptor
R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657, Presynaptic function of Kainate receptors
R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-8964315, G beta:gamma signalling through BTK
R-HSA-8964616, G beta:gamma signalling through CDC42
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production
R-HSA-997272, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SIGNORiP63215

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
2785, 23 hits in 868 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GNG3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2785
PharosiP63215, Tdark

Protein Ontology

More...
PROi
PR:P63215
RNActiP63215, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162188, Expressed in right frontal lobe and 151 other tissues
GenevisibleiP63215, HS

Family and domain databases

CDDicd00068, GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898, G-protein_gamma-like_dom
IPR036284, GGL_sf
IPR001770, Gprotein-gamma
PANTHERiPTHR13809, PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631, G-gamma, 1 hit
PRINTSiPR00321, GPROTEING
SMARTiView protein in SMART
SM00224, GGL, 1 hit
SUPFAMiSSF48670, SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058, G_PROTEIN_GAMMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGBG3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63215
Secondary accession number(s): B2R4S7, P29798, Q61014
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: August 12, 2020
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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