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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Gene

GNG2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • G-protein beta-subunit binding Source: UniProtKB
  • GTPase activity Source: MGI

GO - Biological processi

  • adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
  • cell proliferation Source: Ensembl
  • cellular response to catecholamine stimulus Source: BHF-UCL
  • cellular response to prostaglandin E stimulus Source: BHF-UCL
  • G-protein coupled receptor signaling pathway Source: MGI

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-BTA-1296041 Activation of G protein gated Potassium channels
R-BTA-163359 Glucagon signaling in metabolic regulation
R-BTA-202040 G-protein activation
R-BTA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-BTA-392170 ADP signalling through P2Y purinoceptor 12
R-BTA-392451 G beta:gamma signalling through PI3Kgamma
R-BTA-392851 Prostacyclin signalling through prostacyclin receptor
R-BTA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-BTA-4086398 Ca2+ pathway
R-BTA-416476 G alpha (q) signalling events
R-BTA-416482 G alpha (12/13) signalling events
R-BTA-418217 G beta:gamma signalling through PLC beta
R-BTA-418555 G alpha (s) signalling events
R-BTA-418592 ADP signalling through P2Y purinoceptor 1
R-BTA-418594 G alpha (i) signalling events
R-BTA-418597 G alpha (z) signalling events
R-BTA-420092 Glucagon-type ligand receptors
R-BTA-428930 Thromboxane signalling through TP receptor
R-BTA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-BTA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-BTA-500657 Presynaptic function of Kainate receptors
R-BTA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-BTA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Alternative name(s):
G gamma-I
Gene namesi
Name:GNG2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:29465 GNG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000126092 – 68Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Add BLAST67
PropeptideiPRO_000001261069 – 71Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei68Cysteine methyl ester1 Publication1
Lipidationi68S-geranylgeranyl cysteine3 Publications1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP63212
PeptideAtlasiP63212
PRIDEiP63212

PTM databases

iPTMnetiP63212

Expressioni

Tissue specificityi

Adrenal gland and brain.

Gene expression databases

BgeeiENSBTAG00000003043

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma (PubMed:8521505). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GNB1P628716EBI-1036424,EBI-357141

GO - Molecular functioni

Protein-protein interaction databases

CORUMiP63212
DIPiDIP-586N
IntActiP63212, 5 interactors
STRINGi9913.ENSBTAP00000003959

Structurei

Secondary structure

171
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 23Combined sources15
Helixi30 – 43Combined sources14
Helixi45 – 47Combined sources3
Turni49 – 51Combined sources3
Helixi56 – 58Combined sources3
Turni60 – 63Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GG2X-ray2.40G1-71[»]
1GP2X-ray2.30G1-71[»]
1OMWX-ray2.50G1-68[»]
1XHMX-ray2.70B1-71[»]
2BCJX-ray3.06G1-71[»]
3AH8X-ray2.90G1-71[»]
3CIKX-ray2.75G1-68[»]
3KRWX-ray2.90G1-68[»]
3KRXX-ray3.10G1-68[»]
3PSCX-ray2.67G1-68[»]
3PVUX-ray2.48G1-68[»]
3PVWX-ray2.49G1-68[»]
3SN6X-ray3.20G1-68[»]
3UZSX-ray4.52G1-67[»]
3V5WX-ray2.07G1-71[»]
4MK0X-ray2.40G6-64[»]
4PNKX-ray2.56G1-71[»]
5TDHX-ray3.00G/K1-68[»]
5VAIelectron microscopy4.10G1-68[»]
5WG3X-ray2.90G1-71[»]
5WG4X-ray2.31G1-71[»]
5WG5X-ray3.10G1-71[»]
6C2YX-ray2.74G1-71[»]
ProteinModelPortaliP63212
SMRiP63212
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63212

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00760000119218
HOVERGENiHBG014983
InParanoidiP63212
KOiK07826
OMAiETSEMAS
OrthoDBiEOG091G17J0
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63212-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL
60 70
LTPVPASENP FREKKFFCAI L
Length:71
Mass (Da):7,850
Last modified:January 23, 2007 - v2
Checksum:iEDB74E4135E7A37A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05071 mRNA Translation: AAA30541.1
M37183 mRNA Translation: AAA30555.1
BC112789 mRNA Translation: AAI12790.1
PIRiB34228 RGBOG2
RefSeqiNP_776497.1, NM_174072.4
XP_005211711.1, XM_005211654.3
XP_010807541.1, XM_010809239.2
UniGeneiBt.4586
Bt.90717

Genome annotation databases

EnsembliENSBTAT00000003959; ENSBTAP00000003959; ENSBTAG00000003043
GeneIDi281203
KEGGibta:281203

Similar proteinsi

Entry informationi

Entry nameiGBG2_BOVIN
AccessioniPrimary (citable) accession number: P63212
Secondary accession number(s): P16874
, Q2KI31, Q61013, Q9TS47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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