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Protein

Guanine nucleotide-binding protein G(T) subunit gamma-T1

Gene

GNGT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • GTPase activity Source: ProtInc

GO - Biological processi

  • cardiac muscle cell apoptotic process Source: GO_Central
  • cellular response to hypoxia Source: GO_Central
  • eye photoreceptor cell development Source: GO_Central
  • phototransduction Source: GO_Central
  • protein localization Source: GO_Central
  • rhodopsin mediated signaling pathway Source: Reactome
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-202040 G-protein activation
R-HSA-2485179 Activation of the phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-381753 Olfactory Signaling Pathway
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SIGNORiP63211

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Alternative name(s):
Transducin gamma chain
Gene namesi
Name:GNGT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000127928.12
HGNCiHGNC:4411 GNGT1
MIMi189970 gene
neXtProtiNX_P63211

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127928
PharmGKBiPA28790

Polymorphism and mutation databases

BioMutaiGNGT1
DMDMi52783592

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126051 – 71Guanine nucleotide-binding protein G(T) subunit gamma-T1Add BLAST71
PropeptideiPRO_000001260672 – 74Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71Cysteine methyl esterBy similarity1
Lipidationi71S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP63211
PeptideAtlasiP63211
PRIDEiP63211
ProteomicsDBi57506

PTM databases

iPTMnetiP63211
PhosphoSitePlusiP63211

Expressioni

Tissue specificityi

Retinal rod outer segment.

Gene expression databases

BgeeiENSG00000127928 Expressed in 59 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_GNGT1
ExpressionAtlasiP63211 baseline and differential
GenevisibleiP63211 HS

Organism-specific databases

HPAiHPA042721

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF277Q8WWA63EBI-10220715,EBI-10192794

Protein-protein interaction databases

BioGridi109054, 6 interactors
CORUMiP63211
DIPiDIP-471N
IntActiP63211, 6 interactors
STRINGi9606.ENSP00000248572

Structurei

3D structure databases

ProteinModelPortaliP63211
SMRiP63211
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000063397
HOVERGENiHBG014983
InParanoidiP63211
KOiK04548
OMAiTSKCCEE
OrthoDBiEOG091G17J0
PhylomeDBiP63211
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P63211-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVINIEDLT EKDKLKMEVD QLKKEVTLER MLVSKCCEEV RDYVEERSGE
60 70
DPLVKGIPED KNPFKELKGG CVIS
Length:74
Mass (Da):8,496
Last modified:January 23, 2007 - v2
Checksum:iB12B42BE00DB1C05
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JGI9C9JGI9_HUMAN
Guanine nucleotide binding protein ...
GNGT1 hCG_19199
46Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03394950E → K. Corresponds to variant dbSNP:rs17243826Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62027 mRNA Translation: AAB26896.1
S62026 Genomic DNA Translation: AAD13931.1
U41492 Genomic DNA Translation: AAB92386.1
U41493 Genomic DNA Translation: AAB92387.1
AF493869 mRNA Translation: AAM12583.1
CR456912 mRNA Translation: CAG33193.1
AC002076 Genomic DNA Translation: AAS02021.1
CH236949 Genomic DNA Translation: EAL24139.1
CH471091 Genomic DNA Translation: EAW76806.1
BC029367 mRNA Translation: AAH29367.1
CCDSiCCDS5633.1
PIRiI62760
RefSeqiNP_001316355.1, NM_001329426.1
NP_068774.1, NM_021955.4
UniGeneiHs.732212

Genome annotation databases

EnsembliENST00000248572; ENSP00000248572; ENSG00000127928
ENST00000429473; ENSP00000388777; ENSG00000127928
GeneIDi2792
KEGGihsa:2792
UCSCiuc003unc.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62027 mRNA Translation: AAB26896.1
S62026 Genomic DNA Translation: AAD13931.1
U41492 Genomic DNA Translation: AAB92386.1
U41493 Genomic DNA Translation: AAB92387.1
AF493869 mRNA Translation: AAM12583.1
CR456912 mRNA Translation: CAG33193.1
AC002076 Genomic DNA Translation: AAS02021.1
CH236949 Genomic DNA Translation: EAL24139.1
CH471091 Genomic DNA Translation: EAW76806.1
BC029367 mRNA Translation: AAH29367.1
CCDSiCCDS5633.1
PIRiI62760
RefSeqiNP_001316355.1, NM_001329426.1
NP_068774.1, NM_021955.4
UniGeneiHs.732212

3D structure databases

ProteinModelPortaliP63211
SMRiP63211
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109054, 6 interactors
CORUMiP63211
DIPiDIP-471N
IntActiP63211, 6 interactors
STRINGi9606.ENSP00000248572

PTM databases

iPTMnetiP63211
PhosphoSitePlusiP63211

Polymorphism and mutation databases

BioMutaiGNGT1
DMDMi52783592

Proteomic databases

PaxDbiP63211
PeptideAtlasiP63211
PRIDEiP63211
ProteomicsDBi57506

Protocols and materials databases

DNASUi2792
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248572; ENSP00000248572; ENSG00000127928
ENST00000429473; ENSP00000388777; ENSG00000127928
GeneIDi2792
KEGGihsa:2792
UCSCiuc003unc.2 human

Organism-specific databases

CTDi2792
EuPathDBiHostDB:ENSG00000127928.12
GeneCardsiGNGT1
HGNCiHGNC:4411 GNGT1
HPAiHPA042721
MIMi189970 gene
neXtProtiNX_P63211
OpenTargetsiENSG00000127928
PharmGKBiPA28790
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000063397
HOVERGENiHBG014983
InParanoidiP63211
KOiK04548
OMAiTSKCCEE
OrthoDBiEOG091G17J0
PhylomeDBiP63211
TreeFamiTF319909

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-202040 G-protein activation
R-HSA-2485179 Activation of the phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-381753 Olfactory Signaling Pathway
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SIGNORiP63211

Miscellaneous databases

ChiTaRSiGNGT1 human
GeneWikiiGNGT1
GenomeRNAii2792
PROiPR:P63211
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127928 Expressed in 59 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_GNGT1
ExpressionAtlasiP63211 baseline and differential
GenevisibleiP63211 HS

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBG1_HUMAN
AccessioniPrimary (citable) accession number: P63211
Secondary accession number(s): A4D1H2
, O43835, Q08447, Q16026, Q6LCP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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