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Protein

S-phase kinase-associated protein 1

Gene

SKP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • beta-catenin binding Source: ParkinsonsUK-UCL
  • cullin family protein binding Source: ParkinsonsUK-UCL
  • protein domain specific binding Source: CAFA
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Ubl conjugation pathway

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:ENSG00000113558-MONOMER

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1170546 Prolactin receptor signaling
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-202424 Downstream TCR signaling
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-400253 Circadian Clock
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69231 Cyclin D associated events in G1
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8951664 Neddylation
R-HSA-9020702 Interleukin-1 signaling
R-HSA-917937 Iron uptake and transport
R-HSA-9604323 Negative regulation of NOTCH4 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

SIGNOR Signaling Network Open Resource

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SIGNORi
P63208

UniPathway: a resource for the exploration and annotation of metabolic pathways

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UniPathwayi
UPA00143

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P63208 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
S-phase kinase-associated protein 1
Alternative name(s):
Cyclin-A/CDK2-associated protein p19
Short name:
p19A
Organ of Corti protein 2
Short name:
OCP-2
Organ of Corti protein II
Short name:
OCP-II
RNA polymerase II elongation factor-like protein
SIII
Transcription elongation factor B polypeptide 1-like
p19skp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SKP1
Synonyms:EMC19, OCP2, SKP1A, TCEB1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000113558.18

Human Gene Nomenclature Database

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HGNCi
HGNC:10899 SKP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601434 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P63208

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
6500

Open Targets

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OpenTargetsi
ENSG00000113558

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162403424

Chemistry databases

Drug and drug target database

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DrugBanki
DB06980 (2S)-2-(1H-indol-3-yl)hexanoic acid
DB06981 (2S)-2-(1H-indol-3-yl)pentanoic acid
DB06982 (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
DB07950 1H-INDOL-3-YLACETIC ACID
DB01750 Naphthalen-1-Yl-Acetic Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SKP1

Domain mapping of disease mutations (DMDM)

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DMDMi
52783797

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001872512 – 163S-phase kinase-associated protein 1Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei131PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes autophagy-mediated degradation in the liver in a time-dependent manner.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P63208

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P63208

MaxQB - The MaxQuant DataBase

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MaxQBi
P63208

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P63208

PeptideAtlas

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PeptideAtlasi
P63208

PRoteomics IDEntifications database

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PRIDEi
P63208

ProteomicsDB human proteome resource

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ProteomicsDBi
57504
57505 [P63208-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P63208-1 [P63208-1]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P63208

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P63208

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P63208

SwissPalm database of S-palmitoylation events

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SwissPalmi
P63208

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000113558 Expressed in 234 organ(s), highest expression level in anterior cingulate cortex

CleanEx database of gene expression profiles

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CleanExi
HS_SKP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P63208 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P63208 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB012982
HPA053745
HPA058134

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXw2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7 (PubMed:28727686). Interacts with CEP68 (PubMed:25503564). Interacts with NOTCH2 (PubMed:29149593).15 Publications
(Microbial infection) Interacts with vaccinia virus protein C9L.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q6TVJ22EBI-307497,EBI-15718764From Orf virus (strain Goat/Texas/SA00/2000).
Q6TVJ42EBI-307497,EBI-15718558From Orf virus (strain Goat/Texas/SA00/2000).
Q6TVJ72EBI-307497,EBI-15718586From Orf virus (strain Goat/Texas/SA00/2000).
Q6TVW25EBI-307497,EBI-15718527From Orf virus (strain Goat/Texas/SA00/2000).
ANKRD36BP1Q96IX93EBI-307486,EBI-744859
APIPQ96GX93EBI-307486,EBI-359248
BTRCQ9Y2979EBI-307486,EBI-307461
CCNFP410026EBI-307497,EBI-1207574
CDKN1AP389363EBI-307486,EBI-375077
CTNNB1P352223EBI-307486,EBI-491549
CUL1Q1361610EBI-307486,EBI-359390
FBXL12Q9NXK86EBI-307486,EBI-719790
FBXL14Q8N1E63EBI-307486,EBI-6425532
FBXL2Q9UKC95EBI-307486,EBI-724253
FBXL20Q96IG23EBI-307486,EBI-8835647
Fbxl21Q8BFZ43EBI-307486,EBI-6898235From Mus musculus.
Fbxl3Q8C4V43EBI-307486,EBI-1266589From Mus musculus.
FBXL5Q9UKA110EBI-307486,EBI-2692340
FBXL8Q96CD012EBI-307486,EBI-2321097
FBXO11Q86XK26EBI-307486,EBI-1047804
FBXO17Q96EF610EBI-307486,EBI-2510157
FBXO2Q9UK228EBI-307486,EBI-4287196
Fbxo2Q80UW24EBI-307497,EBI-2314714From Mus musculus.
FBXO22Q8NEZ54EBI-307486,EBI-2510137
FBXO25Q8TCJ0-33EBI-307486,EBI-6262578
FBXO27Q8NI294EBI-307486,EBI-6425694
FBXO28Q9NVF77EBI-307486,EBI-740282
FBXO3Q9UK997EBI-307486,EBI-2509901
FBXO33Q7Z6M22EBI-307486,EBI-8555452
FBXO4Q9UKT57EBI-307486,EBI-960409
FBXO44Q9H4M35EBI-307486,EBI-2322644
FBXO46Q6PJ614EBI-307486,EBI-2322982
FBXO48Q5FWF74EBI-307486,EBI-11961122
FBXO6Q9NRD13EBI-307486,EBI-3938499
FBXO7Q9Y3I17EBI-307486,EBI-1161222
FBXO9Q9UK972EBI-307486,EBI-2869927
FBXW11Q9UKB17EBI-307486,EBI-355189
FBXW2Q9UKT84EBI-307486,EBI-914727
FBXW4P577752EBI-307486,EBI-2372268
FBXW5Q969U64EBI-307486,EBI-741068
FBXW5Q969U6-13EBI-307497,EBI-16031873
FBXW7Q969H05EBI-307486,EBI-359574
FBXW8Q8N3Y12EBI-307486,EBI-914770
FBXW9Q5XUX14EBI-307486,EBI-2322729
KCTD9Q7L2733EBI-307486,EBI-4397613
KDM2AQ9Y2K72EBI-307486,EBI-765758
KDM2BQ8NHM52EBI-307486,EBI-3955564
LMO2P257913EBI-307486,EBI-739696
MED21Q135035EBI-307497,EBI-394678
MYCQ149012EBI-307486,EBI-7982457
PPP1CAP621363EBI-307486,EBI-357253
SKP2Q1330914EBI-307486,EBI-456291
SKP2Q13309-17EBI-307497,EBI-15490084
SUGT1Q9Y2Z0-22EBI-307486,EBI-10768076
TTC21AA0A0B4J1Y23EBI-307486,EBI-10220701
TTC9CQ8N5M46EBI-307486,EBI-2851213

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112391, 288 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P63208

Database of interacting proteins

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DIPi
DIP-31606N

Protein interaction database and analysis system

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IntActi
P63208, 179 interactors

Molecular INTeraction database

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MINTi
P63208

STRING: functional protein association networks

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STRINGi
9606.ENSP00000231487

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FQVX-ray2.80B/D/F/H/J/L/N/P1-163[»]
1FS1X-ray1.80B/D1-147[»]
1FS2X-ray2.90B/D1-147[»]
1LDKX-ray3.10D2-140[»]
1P22X-ray2.95B1-163[»]
2ASSX-ray3.00A2-160[»]
2ASTX-ray2.30A2-160[»]
2E31X-ray2.40B1-163[»]
2E32X-ray3.52B/D1-163[»]
2OVPX-ray2.90A1-163[»]
2OVQX-ray2.60A1-163[»]
2OVRX-ray2.50A1-163[»]
3L2OX-ray2.80A1-69[»]
A82-163[»]
3WSOX-ray2.60B1-163[»]
4I6JX-ray2.70C1-163[»]
5IBKX-ray2.50A/D1-69[»]
A/D82-163[»]
5JH5X-ray2.55B2-163[»]
5K35X-ray2.85B1-163[»]
5V4BX-ray2.60A1-163[»]
5VZTX-ray2.70A/C1-163[»]
5VZUX-ray2.70A/C1-163[»]
5XYLNMR-A1-163[»]
6BVAX-ray2.66C/D1-163[»]
6BYHX-ray2.61A/B/G1-163[»]
6C16X-ray3.27A/B1-163[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P63208

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P63208

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P63208

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni104 – 163Interaction with the F-box domain of F-box proteinsBy similarityAdd BLAST60

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SKP1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1724 Eukaryota
COG5201 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012652

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000172184

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057008

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P63208

KEGG Orthology (KO)

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KOi
K03094

Identification of Orthologs from Complete Genome Data

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OMAi
ENKWCEE

Database of Orthologous Groups

More...
OrthoDBi
1412723at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P63208

TreeFam database of animal gene trees

More...
TreeFami
TF354233

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016897 SKP1
IPR001232 SKP1-like
IPR036296 SKP1-like_dim_sf
IPR011333 SKP1/BTB/POZ_sf
IPR016072 Skp1_comp_dimer
IPR016073 Skp1_comp_POZ

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01466 Skp1, 1 hit
PF03931 Skp1_POZ, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF028729 E3_ubiquit_lig_SCF_Skp, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00512 Skp1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit
SSF81382 SSF81382, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P63208-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV
60 70 80 90 100
NAAILKKVIQ WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL
110 120 130 140 150
FELILAANYL DIKGLLDVTC KTVANMIKGK TPEEIRKTFN IKNDFTEEEE
160
AQVRKENQWC EEK
Length:163
Mass (Da):18,658
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC794D62AFB75528A
GO
Isoform 2 (identifier: P63208-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-163: RKENQWCEEK → GSTQFCL

Note: No experimental confirmation available.
Show »
Length:160
Mass (Da):18,063
Checksum:iA376AA50007A3D2D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJR5E5RJR5_HUMAN
S-phase kinase-associated protein 1
SKP1
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W8N3F8W8N3_HUMAN
S-phase kinase-associated protein 1
SKP1
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGM3E5RGM3_HUMAN
S-phase kinase-associated protein 1
SKP1
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERH2E7ERH2_HUMAN
S-phase kinase-associated protein 1
SKP1
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGM4E5RGM4_HUMAN
S-phase kinase-associated protein 1
SKP1
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHM3E5RHM3_HUMAN
S-phase kinase-associated protein 1
SKP1
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK33E5RK33_HUMAN
S-phase kinase-associated protein 1
SKP1
18Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007555154 – 163RKENQWCEEK → GSTQFCL in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U33760 mRNA Translation: AAC50241.1
Z47087 mRNA Translation: CAA87392.1
CH471062 Genomic DNA Translation: EAW62270.1
CH471062 Genomic DNA Translation: EAW62271.1
CH471062 Genomic DNA Translation: EAW62272.1
CH471062 Genomic DNA Translation: EAW62276.1
BC009839 mRNA Translation: AAH09839.1
BC020798 mRNA Translation: AAH20798.1
BC025673 mRNA Translation: AAH25673.1
BC065730 mRNA Translation: AAH65730.1
U37558 mRNA Translation: AAA79202.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4171.1
CCDS4172.1 [P63208-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
I39170

NCBI Reference Sequences

More...
RefSeqi
NP_008861.2, NM_006930.3 [P63208-2]
NP_733779.1, NM_170679.2 [P63208-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.171626

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000353411; ENSP00000231487; ENSG00000113558 [P63208-1]
ENST00000517625; ENSP00000429961; ENSG00000113558 [P63208-1]
ENST00000522552; ENSP00000429472; ENSG00000113558 [P63208-2]
ENST00000522855; ENSP00000429686; ENSG00000113558 [P63208-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6500

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6500

UCSC genome browser

More...
UCSCi
uc003kzc.5 human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33760 mRNA Translation: AAC50241.1
Z47087 mRNA Translation: CAA87392.1
CH471062 Genomic DNA Translation: EAW62270.1
CH471062 Genomic DNA Translation: EAW62271.1
CH471062 Genomic DNA Translation: EAW62272.1
CH471062 Genomic DNA Translation: EAW62276.1
BC009839 mRNA Translation: AAH09839.1
BC020798 mRNA Translation: AAH20798.1
BC025673 mRNA Translation: AAH25673.1
BC065730 mRNA Translation: AAH65730.1
U37558 mRNA Translation: AAA79202.1
CCDSiCCDS4171.1
CCDS4172.1 [P63208-2]
PIRiI39170
RefSeqiNP_008861.2, NM_006930.3 [P63208-2]
NP_733779.1, NM_170679.2 [P63208-1]
UniGeneiHs.171626

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FQVX-ray2.80B/D/F/H/J/L/N/P1-163[»]
1FS1X-ray1.80B/D1-147[»]
1FS2X-ray2.90B/D1-147[»]
1LDKX-ray3.10D2-140[»]
1P22X-ray2.95B1-163[»]
2ASSX-ray3.00A2-160[»]
2ASTX-ray2.30A2-160[»]
2E31X-ray2.40B1-163[»]
2E32X-ray3.52B/D1-163[»]
2OVPX-ray2.90A1-163[»]
2OVQX-ray2.60A1-163[»]
2OVRX-ray2.50A1-163[»]
3L2OX-ray2.80A1-69[»]
A82-163[»]
3WSOX-ray2.60B1-163[»]
4I6JX-ray2.70C1-163[»]
5IBKX-ray2.50A/D1-69[»]
A/D82-163[»]
5JH5X-ray2.55B2-163[»]
5K35X-ray2.85B1-163[»]
5V4BX-ray2.60A1-163[»]
5VZTX-ray2.70A/C1-163[»]
5VZUX-ray2.70A/C1-163[»]
5XYLNMR-A1-163[»]
6BVAX-ray2.66C/D1-163[»]
6BYHX-ray2.61A/B/G1-163[»]
6C16X-ray3.27A/B1-163[»]
ProteinModelPortaliP63208
SMRiP63208
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112391, 288 interactors
CORUMiP63208
DIPiDIP-31606N
IntActiP63208, 179 interactors
MINTiP63208
STRINGi9606.ENSP00000231487

Chemistry databases

DrugBankiDB06980 (2S)-2-(1H-indol-3-yl)hexanoic acid
DB06981 (2S)-2-(1H-indol-3-yl)pentanoic acid
DB06982 (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
DB07950 1H-INDOL-3-YLACETIC ACID
DB01750 Naphthalen-1-Yl-Acetic Acid

Protein family/group databases

MoonDBiP63208 Predicted

PTM databases

iPTMnetiP63208
PhosphoSitePlusiP63208
SwissPalmiP63208

Polymorphism and mutation databases

BioMutaiSKP1
DMDMi52783797

2D gel databases

SWISS-2DPAGEiP63208

Proteomic databases

EPDiP63208
jPOSTiP63208
MaxQBiP63208
PaxDbiP63208
PeptideAtlasiP63208
PRIDEiP63208
ProteomicsDBi57504
57505 [P63208-2]
TopDownProteomicsiP63208-1 [P63208-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6500
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353411; ENSP00000231487; ENSG00000113558 [P63208-1]
ENST00000517625; ENSP00000429961; ENSG00000113558 [P63208-1]
ENST00000522552; ENSP00000429472; ENSG00000113558 [P63208-2]
ENST00000522855; ENSP00000429686; ENSG00000113558 [P63208-1]
GeneIDi6500
KEGGihsa:6500
UCSCiuc003kzc.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6500
DisGeNETi6500
EuPathDBiHostDB:ENSG00000113558.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SKP1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0129723
HGNCiHGNC:10899 SKP1
HPAiCAB012982
HPA053745
HPA058134
MIMi601434 gene
neXtProtiNX_P63208
OpenTargetsiENSG00000113558
PharmGKBiPA162403424

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1724 Eukaryota
COG5201 LUCA
GeneTreeiENSGT00390000012652
HOGENOMiHOG000172184
HOVERGENiHBG057008
InParanoidiP63208
KOiK03094
OMAiENKWCEE
OrthoDBi1412723at2759
PhylomeDBiP63208
TreeFamiTF354233

Enzyme and pathway databases

UniPathwayi
UPA00143

BioCyciMetaCyc:ENSG00000113558-MONOMER
ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1170546 Prolactin receptor signaling
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-202424 Downstream TCR signaling
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-400253 Circadian Clock
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69231 Cyclin D associated events in G1
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8951664 Neddylation
R-HSA-9020702 Interleukin-1 signaling
R-HSA-917937 Iron uptake and transport
R-HSA-9604323 Negative regulation of NOTCH4 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiP63208

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SKP1 human
EvolutionaryTraceiP63208

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SKP1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6500

Protein Ontology

More...
PROi
PR:P63208

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113558 Expressed in 234 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_SKP1
ExpressionAtlasiP63208 baseline and differential
GenevisibleiP63208 HS

Family and domain databases

InterProiView protein in InterPro
IPR016897 SKP1
IPR001232 SKP1-like
IPR036296 SKP1-like_dim_sf
IPR011333 SKP1/BTB/POZ_sf
IPR016072 Skp1_comp_dimer
IPR016073 Skp1_comp_POZ
PfamiView protein in Pfam
PF01466 Skp1, 1 hit
PF03931 Skp1_POZ, 1 hit
PIRSFiPIRSF028729 E3_ubiquit_lig_SCF_Skp, 1 hit
SMARTiView protein in SMART
SM00512 Skp1, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
SSF81382 SSF81382, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63208
Secondary accession number(s): D3DQ97
, D3DQ98, P34991, Q8TAY2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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