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Entry version 118 (07 Oct 2020)
Sequence version 1 (27 Sep 2004)
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Protein

Low affinity potassium transport system protein kup

Gene

kup

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the low-affinity transport of potassium into the cell, with the probable concomitant uptake of protons (symport system). Can also transport cesium.3 Publications

Miscellaneous

Kup is probably the major potassium uptake system upon hyper-osmotic stress at a low pH.
Uptake is inhibited by protonophores such as CCCP.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Potassium transport, Symport, Transport
LigandPotassium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:KUP-MONOMER
MetaCyc:KUP-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.72.1.1, the k(+) uptake permease (kup) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Low affinity potassium transport system protein kup
Alternative name(s):
Kup system potassium uptake protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kup
Synonyms:trkD
Ordered Locus Names:b3747, JW5609
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8CytoplasmicSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 48PeriplasmicSequence analysisAdd BLAST19
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 102CytoplasmicSequence analysisAdd BLAST33
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 136PeriplasmicSequence analysisAdd BLAST13
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 164CytoplasmicSequence analysis7
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 212PeriplasmicSequence analysisAdd BLAST27
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 246CytoplasmicSequence analysisAdd BLAST13
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 275PeriplasmicSequence analysis8
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 336CytoplasmicSequence analysisAdd BLAST40
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 362PeriplasmicSequence analysis5
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 395CytoplasmicSequence analysisAdd BLAST12
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 418PeriplasmicSequence analysis2
Transmembranei419 – 439HelicalSequence analysisAdd BLAST21
Topological domaini440 – 622CytoplasmicSequence analysisAdd BLAST183

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002090111 – 622Low affinity potassium transport system protein kupAdd BLAST622

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P63183

PRoteomics IDEntifications database

More...
PRIDEi
P63183

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4263467, 29 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b3747

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3158, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008142_4_2_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P63183

KEGG Orthology (KO)

More...
KOi
K03549

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P63183

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01522, Kup, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003855, K+_transporter
IPR023051, K+_uptake_low_affin

The PANTHER Classification System

More...
PANTHERi
PTHR30540, PTHR30540, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02705, K_trans, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00794, kup, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P63183-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTDNKQSLP AITLAAIGVV YGDIGTSPLY TLRECLSGQF GFGVERDAVF
60 70 80 90 100
GFLSLIFWLL IFVVSIKYLT FVMRADNAGE GGILTLMSLA GRNTSARTTS
110 120 130 140 150
MLVIMGLIGG SFFYGEVVIT PAISVMSAIE GLEIVAPQLD TWIVPLSIIV
160 170 180 190 200
LTLLFMIQKH GTAMVGKLFA PIMLTWFLIL AGLGLRSIIA NPEVLHALNP
210 220 230 240 250
MWAVHFFLEY KTVSFIALGA VVLSITGVEA LYADMGHFGK FPIRLAWFTV
260 270 280 290 300
VLPSLTLNYF GQGALLLKNP EAIKNPFFLL APDWALIPLL IIAALATVIA
310 320 330 340 350
SQAVISGVFS LTRQAVRLGY LSPMRIIHTS EMESGQIYIP FVNWMLYVAV
360 370 380 390 400
VIVIVSFEHS SNLAAAYGIA VTGTMVLTSI LSTTVARQNW HWNKYFVALI
410 420 430 440 450
LIAFLCVDIP LFTANLDKLL SGGWLPLSLG TVMFIVMTTW KSERFRLLRR
460 470 480 490 500
MHEHGNSLEA MIASLEKSPP VRVPGTAVYM SRAINVIPFA LMHNLKHNKV
510 520 530 540 550
LHERVILLTL RTEDAPYVHN VRRVQIEQLS PTFWRVVASY GWRETPNVEE
560 570 580 590 600
VFHRCGLEGL SCRMMETSFF MSHESLILGK RPWYLRLRGK LYLLLQRNAL
610 620
RAPDQFEIPP NRVIELGTQV EI
Length:622
Mass (Da):69,294
Last modified:September 27, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE556791ABF9B8D25
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA62100 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X68551 Genomic DNA Translation: CAA48555.1
L10328 Genomic DNA Translation: AAA62100.1 Frameshift.
U00096 Genomic DNA Translation: AAT48204.1
AP009048 Genomic DNA Translation: BAE77541.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A49345

NCBI Reference Sequences

More...
RefSeqi
WP_000102319.1, NZ_STEB01000015.1
YP_026244.1, NC_000913.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAT48204; AAT48204; b3747
BAE77541; BAE77541; BAE77541

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
49586988
948255

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5609
eco:b3747

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.2953

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68551 Genomic DNA Translation: CAA48555.1
L10328 Genomic DNA Translation: AAA62100.1 Frameshift.
U00096 Genomic DNA Translation: AAT48204.1
AP009048 Genomic DNA Translation: BAE77541.1
PIRiA49345
RefSeqiWP_000102319.1, NZ_STEB01000015.1
YP_026244.1, NC_000913.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4263467, 29 interactors
STRINGi511145.b3747

Protein family/group databases

TCDBi2.A.72.1.1, the k(+) uptake permease (kup) family

Proteomic databases

PaxDbiP63183
PRIDEiP63183

Genome annotation databases

EnsemblBacteriaiAAT48204; AAT48204; b3747
BAE77541; BAE77541; BAE77541
GeneIDi49586988
948255
KEGGiecj:JW5609
eco:b3747
PATRICifig|1411691.4.peg.2953

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1503

Phylogenomic databases

eggNOGiCOG3158, Bacteria
HOGENOMiCLU_008142_4_2_6
InParanoidiP63183
KOiK03549
PhylomeDBiP63183

Enzyme and pathway databases

BioCyciEcoCyc:KUP-MONOMER
MetaCyc:KUP-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P63183

Family and domain databases

HAMAPiMF_01522, Kup, 1 hit
InterProiView protein in InterPro
IPR003855, K+_transporter
IPR023051, K+_uptake_low_affin
PANTHERiPTHR30540, PTHR30540, 1 hit
PfamiView protein in Pfam
PF02705, K_trans, 1 hit
TIGRFAMsiTIGR00794, kup, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKUP_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63183
Secondary accession number(s): P30016, P76748, Q2M865
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: October 7, 2020
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
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