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Protein

60S ribosomal protein L38

Gene

RPL38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L38
Alternative name(s):
Large ribosomal subunit protein eL381 Publication
Gene namesi
Name:RPL38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000172809.12
HGNCiHGNC:10349 RPL38
MIMi604182 gene
neXtProtiNX_P63173

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6169
OpenTargetsiENSG00000172809
PharmGKBiPA34741

Polymorphism and mutation databases

DMDMi52783779

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002154341 – 7060S ribosomal protein L38Add BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei9N6-acetyllysine; alternateCombined sources1
Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei67N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP63173
MaxQBiP63173
PaxDbiP63173
PeptideAtlasiP63173
PRIDEiP63173
ProteomicsDBi57503
TopDownProteomicsiP63173

PTM databases

iPTMnetiP63173
PhosphoSitePlusiP63173
SwissPalmiP63173

Expressioni

Gene expression databases

BgeeiENSG00000172809
CleanExiHS_RPL38
ExpressionAtlasiP63173 baseline and differential
GenevisibleiP63173 HS

Organism-specific databases

HPAiHPA052543

Interactioni

Protein-protein interaction databases

BioGridi112088, 134 interactors
CORUMiP63173
IntActiP63173, 24 interactors
MINTiP63173
STRINGi9606.ENSP00000309830

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Lk1-70[»]
4V6Xelectron microscopy5.00Ck1-70[»]
5AJ0electron microscopy3.50Ak1-70[»]
5LKSelectron microscopy3.60Lk1-70[»]
5T2Celectron microscopy3.60e1-70[»]
6EK0electron microscopy2.90Lk1-70[»]
ProteinModelPortaliP63173
SMRiP63173
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3499 Eukaryota
ENOG4112229 LUCA
GeneTreeiENSGT00390000003718
HOGENOMiHOG000188979
HOVERGENiHBG001013
InParanoidiP63173
KOiK02923
OMAiRDIKQFI
OrthoDBiEOG091G0SPL
PhylomeDBiP63173
TreeFamiTF300215

Family and domain databases

Gene3Di3.30.720.90, 1 hit
InterProiView protein in InterPro
IPR002675 Ribosomal_L38e
IPR038464 Ribosomal_L38e_sf
PANTHERiPTHR10965 PTHR10965, 1 hit
PfamiView protein in Pfam
PF01781 Ribosomal_L38e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010361 Ribosomal_L38e, 1 hit

Sequencei

Sequence statusi: Complete.

P63173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRKIEEIKD FLLTARRKDA KSVKIKKNKD NVKFKVRCSR YLYTLVITDK
60 70
EKAEKLKQSL PPGLAVKELK
Length:70
Mass (Da):8,218
Last modified:January 23, 2007 - v2
Checksum:iFDD9A107BC98DBBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26876 mRNA Translation: CAA81488.1
AK312119 mRNA Translation: BAG35055.1
CH471099 Genomic DNA Translation: EAW89137.1
BC000603 mRNA Translation: AAH00603.1
AB007185 Genomic DNA Translation: BAA25844.1
CCDSiCCDS11696.1
PIRiS38385
RefSeqiNP_000990.1, NM_000999.3
NP_001030335.1, NM_001035258.1
UniGeneiHs.380953

Genome annotation databases

EnsembliENST00000311111; ENSP00000309830; ENSG00000172809
ENST00000439590; ENSP00000390279; ENSG00000172809
ENST00000533498; ENSP00000434243; ENSG00000172809
GeneIDi6169
KEGGihsa:6169
UCSCiuc002jjz.4 human

Similar proteinsi

Entry informationi

Entry nameiRL38_HUMAN
AccessioniPrimary (citable) accession number: P63173
Secondary accession number(s): B2R5A8, P23411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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