Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dynein light chain Tctex-type 1

Gene

DYNLT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein.
Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity). Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (PubMed:27502274).By similarity1 Publication
(Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site.1 Publication

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • motor activity Source: UniProtKB-KW
  • protein C-terminus binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Cytoplasmic inwards viral transport, Host-virus interaction, Microtubular inwards viral transport, Mitosis, Neurogenesis, Transport, Virus entry into host cell

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain Tctex-type 1
Alternative name(s):
Protein CW-1
T-complex testis-specific protein 1 homolog
Gene namesi
Name:DYNLT1
Synonyms:TCTEL1, TCTEX-1, TCTEX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146425.10
HGNCiHGNC:11697 DYNLT1
MIMi601554 gene
neXtProtiNX_P63172

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Golgi apparatus, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi6993
OpenTargetsiENSG00000146425
PharmGKBiPA36416

Polymorphism and mutation databases

BioMutaiDYNLT1
DMDMi52783582

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951521 – 113Dynein light chain Tctex-type 1Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Post-translational modificationi

Phosphorylated by BMPR2; the phosphorylation is abolished by BMPR2 mutations in exon 12 which lead to truncated forms of BMPR2 and which are linked to primary pulmonary hypertension (PPH1) [MIMi:178600]. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP63172
PaxDbiP63172
PeptideAtlasiP63172
PRIDEiP63172
ProteomicsDBi57502
TopDownProteomicsiP63172

PTM databases

iPTMnetiP63172
PhosphoSitePlusiP63172

Expressioni

Tissue specificityi

Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000146425 Expressed in 233 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_DYNLT1
GenevisibleiP63172 HS

Organism-specific databases

HPAiHPA046559

Interactioni

Subunit structurei

Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2. Interacts with RHO. Interacts with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2. Interacts with BMPR2. Interacts with GNB1; the interaction occurs in presence of guanine nucleotide-binding protein G(T) subunit gamma; the interaction diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the interactions occur in presence of guanine nucleotide-binding protein G(T) subunit gamma (By similarity). Interacts with ACVR2B and ARHGEF2.By similarityCurated6 Publications
(Microbial infection) Interacts with human papillomavirus 16 L2 protein; this interaction is essential for virus intracellular transport during entry.1 Publication
(Microbial infection) Interacts with Mason-Pfizer monkey virus protein Gag.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112853, 112 interactors
CORUMiP63172
DIPiDIP-35251N
IntActiP63172, 51 interactors
STRINGi9606.ENSP00000356056

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP63172
SMRiP63172
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 113Interaction with GNB1By similarityAdd BLAST73

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4081 Eukaryota
ENOG4111NHR LUCA
GeneTreeiENSGT00390000013998
HOGENOMiHOG000255148
HOVERGENiHBG001217
InParanoidiP63172
KOiK10420
OMAiCYWDNAT
OrthoDBiEOG091G0Y5N
PhylomeDBiP63172
TreeFamiTF313904

Family and domain databases

Gene3Di3.30.1140.40, 1 hit
InterProiView protein in InterPro
IPR005334 Tctex
IPR038586 Tctex-1-like_sf
PANTHERiPTHR21255 PTHR21255, 1 hit
PfamiView protein in Pfam
PF03645 Tctex-1, 1 hit

Sequencei

Sequence statusi: Complete.

P63172-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDYQAAEET AFVVDEVSNI VKEAIESAIG GNAYQHSKVN QWTTNVVEQT
60 70 80 90 100
LSQLTKLGKP FKYIVTCVIM QKNGAGLHTA SSCFWDSSTD GSCTVRWENK
110
TMYCIVSAFG LSI
Length:113
Mass (Da):12,452
Last modified:September 27, 2004 - v1
Checksum:iA6BAD1D0744D1AA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56255 mRNA Translation: AAB03318.1
D50663 mRNA Translation: BAA09317.1
EU862237 mRNA Translation: ACF74976.1
AK315601 mRNA Translation: BAG37971.1
CR456931 mRNA Translation: CAG33212.1
AL591025 Genomic DNA No translation available.
AL589931 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47657.1
BC029412 mRNA Translation: AAH29412.1
BC105588 mRNA Translation: AAI05589.1
CCDSiCCDS5257.1
RefSeqiNP_006510.1, NM_006519.3
UniGeneiHs.445999

Genome annotation databases

EnsembliENST00000367089; ENSP00000356056; ENSG00000146425
GeneIDi6993
KEGGihsa:6993
UCSCiuc003qrn.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56255 mRNA Translation: AAB03318.1
D50663 mRNA Translation: BAA09317.1
EU862237 mRNA Translation: ACF74976.1
AK315601 mRNA Translation: BAG37971.1
CR456931 mRNA Translation: CAG33212.1
AL591025 Genomic DNA No translation available.
AL589931 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47657.1
BC029412 mRNA Translation: AAH29412.1
BC105588 mRNA Translation: AAI05589.1
CCDSiCCDS5257.1
RefSeqiNP_006510.1, NM_006519.3
UniGeneiHs.445999

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JPWNMR-A/B1-113[»]
ProteinModelPortaliP63172
SMRiP63172
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112853, 112 interactors
CORUMiP63172
DIPiDIP-35251N
IntActiP63172, 51 interactors
STRINGi9606.ENSP00000356056

PTM databases

iPTMnetiP63172
PhosphoSitePlusiP63172

Polymorphism and mutation databases

BioMutaiDYNLT1
DMDMi52783582

Proteomic databases

EPDiP63172
PaxDbiP63172
PeptideAtlasiP63172
PRIDEiP63172
ProteomicsDBi57502
TopDownProteomicsiP63172

Protocols and materials databases

DNASUi6993
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367089; ENSP00000356056; ENSG00000146425
GeneIDi6993
KEGGihsa:6993
UCSCiuc003qrn.3 human

Organism-specific databases

CTDi6993
DisGeNETi6993
EuPathDBiHostDB:ENSG00000146425.10
GeneCardsiDYNLT1
HGNCiHGNC:11697 DYNLT1
HPAiHPA046559
MIMi601554 gene
neXtProtiNX_P63172
OpenTargetsiENSG00000146425
PharmGKBiPA36416
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4081 Eukaryota
ENOG4111NHR LUCA
GeneTreeiENSGT00390000013998
HOGENOMiHOG000255148
HOVERGENiHBG001217
InParanoidiP63172
KOiK10420
OMAiCYWDNAT
OrthoDBiEOG091G0Y5N
PhylomeDBiP63172
TreeFamiTF313904

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiDYNLT1 human
GeneWikiiDYNLT1
GenomeRNAii6993
PROiPR:P63172
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146425 Expressed in 233 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_DYNLT1
GenevisibleiP63172 HS

Family and domain databases

Gene3Di3.30.1140.40, 1 hit
InterProiView protein in InterPro
IPR005334 Tctex
IPR038586 Tctex-1-like_sf
PANTHERiPTHR21255 PTHR21255, 1 hit
PfamiView protein in Pfam
PF03645 Tctex-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDYLT1_HUMAN
AccessioniPrimary (citable) accession number: P63172
Secondary accession number(s): Q15763, Q5VTU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again