UniProtKB - P63167 (DYL1_HUMAN)
Dynein light chain 1, cytoplasmic
DYNLL1
Functioni
GO - Molecular functioni
- dynein intermediate chain binding Source: GO_Central
- dynein light intermediate chain binding Source: GO_Central
- motor activity Source: UniProtKB-KW
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
- apoptotic process Source: UniProtKB-KW
- ciliary basal body-plasma membrane docking Source: Reactome
- cilium assembly Source: GO_Central
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
- G2/M transition of mitotic cell cycle Source: Reactome
- intraciliary transport involved in cilium assembly Source: Reactome
- macroautophagy Source: Reactome
- negative regulation of phosphorylation Source: UniProtKB
- neutrophil degranulation Source: Reactome
- positive regulation of ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
- regulation of G2/M transition of mitotic cell cycle Source: Reactome
- substantia nigra development Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, Motor protein |
Biological process | Apoptosis, Host-virus interaction, Transcription, Transcription regulation, Transport |
Enzyme and pathway databases
PathwayCommonsi | P63167 |
Reactomei | R-HSA-111446, Activation of BIM and translocation to mitochondria R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-1632852, Macroautophagy R-HSA-2132295, MHC class II antigen presentation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-5620924, Intraflagellar transport R-HSA-5663220, RHO GTPases Activate Formins R-HSA-6798695, Neutrophil degranulation R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic R-HSA-68877, Mitotic Prometaphase R-HSA-8854518, AURKA Activation by TPX2 R-HSA-9609690, HCMV Early Events R-HSA-9646399, Aggrephagy R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
SIGNORi | P63167 |
Names & Taxonomyi
Protein namesi | Recommended name: Dynein light chain 1, cytoplasmicAlternative name(s): 8 kDa dynein light chain Short name: DLC8 Dynein light chain LC8-type 1 Protein inhibitor of neuronal nitric oxide synthase Short name: PIN |
Gene namesi | Name:DYNLL1 Synonyms:DLC1, DNCL1, DNCLC1, HDLC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000088986.10 |
HGNCi | HGNC:15476, DYNLL1 |
MIMi | 601562, gene |
neXtProti | NX_P63167 |
Subcellular locationi
Cytoskeleton
- centrosome 1 Publication
- cytoskeleton
Nucleus
Mitochondrion
Note: Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.
Cytoskeleton
- centrosome Source: UniProtKB
- cytoplasmic dynein complex Source: GO_Central
- dynein complex Source: GO_Central
- microtubule Source: UniProtKB-KW
- mitotic spindle Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- ciliary tip Source: Reactome
- cilium Source: Reactome
- cytoplasm Source: UniProtKB
- ficolin-1-rich granule membrane Source: Reactome
- kinetochore Source: UniProtKB
- membrane Source: UniProtKB
- tertiary granule membrane Source: Reactome
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Dynein, Microtubule, Mitochondrion, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 67 | T → A: Abolishes interaction with PAK1. 1 Publication | 1 | |
Mutagenesisi | 88 | S → A: Abolishes growth factor-mediated phosphorylation. Increases BCL2L11 protein level and promotes apoptosis. 2 Publications | 1 | |
Mutagenesisi | 88 | S → E: Abolishes homodimerization. Abolishes interaction with BCL2L11 isoform 1 and isoform 2. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 8655 |
OpenTargetsi | ENSG00000088986 |
PharmGKBi | PA134972261 |
Miscellaneous databases
Pharosi | P63167, Tbio |
Polymorphism and mutation databases
BioMutai | DYNLL1 |
DMDMi | 52783578 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000195125 | 1 – 89 | Dynein light chain 1, cytoplasmicAdd BLAST | 89 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 36 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 43 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 88 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P63167 |
jPOSTi | P63167 |
MassIVEi | P63167 |
PaxDbi | P63167 |
PeptideAtlasi | P63167 |
PRIDEi | P63167 |
ProteomicsDBi | 57501 |
TopDownProteomicsi | P63167 |
PTM databases
iPTMneti | P63167 |
MetOSitei | P63167 |
PhosphoSitePlusi | P63167 |
SwissPalmi | P63167 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000088986, Expressed in anterior cingulate cortex and 249 other tissues |
ExpressionAtlasi | P63167, baseline and differential |
Genevisiblei | P63167, HS |
Organism-specific databases
HPAi | ENSG00000088986, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
Interacts with TXNDC17.
Interacts with WWC1 and ESR1. The WWC1-DYNLL1 interaction is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin.
Interacts with BCL2L11 isoform 1 and isoform 2.
Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis.
Interacts with PAK1; the interaction requires dimeric DYNLL1.
Interacts with MYZAP.
Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2.
Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN.
Interacts with NEK9 (not phosphorylated at 'Ser-944').
Interacts with BICD2 (By similarity).
Interacts with BCAS1 (By similarity).
Interacts with Basson/BSN.
Interacts with HDAC6 (PubMed:31505170).
Interacts with TPPP (PubMed:31505170).
By similarity13 Publications(Microbial infection) Interacts with human spumaretrovirus Gag protein; this interaction is critical for intracellular microtubule-dependent viral genome transport toward the centrosome.
1 Publication(Microbial infection) Interacts with ebolavirus protein VP35; this interaction stabilizes VP35 N-terminal oligomerization domain and enhances viral RNA synthesis.
1 PublicationBinary interactionsi
Hide detailsP63167
GO - Molecular functioni
- dynein intermediate chain binding Source: GO_Central
- dynein light intermediate chain binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114206, 302 interactors |
CORUMi | P63167 |
DIPi | DIP-33150N |
IntActi | P63167, 211 interactors |
MINTi | P63167 |
STRINGi | 9606.ENSP00000376297 |
Miscellaneous databases
RNActi | P63167, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P63167 |
SMRi | P63167 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P63167 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 67 – 89 | Interaction with ESR11 PublicationAdd BLAST | 23 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3430, Eukaryota |
GeneTreei | ENSGT00390000000378 |
HOGENOMi | CLU_070944_4_0_1 |
InParanoidi | P63167 |
OMAi | FVTHEKH |
OrthoDBi | 1520814at2759 |
PhylomeDBi | P63167 |
TreeFami | TF300264 |
Family and domain databases
Gene3Di | 3.30.740.10, 1 hit |
InterProi | View protein in InterPro IPR037177, DLC_sf IPR019763, Dynein_light_1/2_CS IPR001372, Dynein_light_chain_typ-1/2 |
PANTHERi | PTHR11886, PTHR11886, 1 hit |
Pfami | View protein in Pfam PF01221, Dynein_light, 1 hit |
SMARTi | View protein in SMART SM01375, Dynein_light, 1 hit |
SUPFAMi | SSF54648, SSF54648, 1 hit |
PROSITEi | View protein in PROSITE PS01239, DYNEIN_LIGHT_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY
60 70 80
NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VXI7 | F8VXI7_HUMAN | Dynein light chain | DYNLL1 | 42 | Annotation score: | ||
F8VXL2 | F8VXL2_HUMAN | Dynein light chain | DYNLL1 | 47 | Annotation score: | ||
F8VRV5 | F8VRV5_HUMAN | Dynein light chain | DYNLL1 | 67 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U32944 mRNA Translation: AAB04149.1 CR407672 mRNA Translation: CAG28600.1 |
CCDSi | CCDS9200.1 |
RefSeqi | NP_001032583.1, NM_001037494.1 NP_001032584.1, NM_001037495.1 NP_003737.1, NM_003746.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U32944 mRNA Translation: AAB04149.1 CR407672 mRNA Translation: CAG28600.1 |
CCDSi | CCDS9200.1 |
RefSeqi | NP_001032583.1, NM_001037494.1 NP_001032584.1, NM_001037495.1 NP_003737.1, NM_003746.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CMI | X-ray | 2.50 | A/B | 5-89 | [»] | |
3ZKE | X-ray | 2.20 | A/C/E/G/I/K | 1-89 | [»] | |
3ZKF | X-ray | 2.60 | A/C/E/G/I/K | 1-89 | [»] | |
6GZJ | X-ray | 1.98 | A | 1-89 | [»] | |
6GZL | X-ray | 1.95 | A | 1-89 | [»] | |
6RLB | electron microscopy | 4.50 | I/J/K/L/M/N | 1-89 | [»] | |
6SC2 | electron microscopy | 3.90 | I/J/K/L/M/N | 1-89 | [»] | |
BMRBi | P63167 | |||||
SMRi | P63167 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114206, 302 interactors |
CORUMi | P63167 |
DIPi | DIP-33150N |
IntActi | P63167, 211 interactors |
MINTi | P63167 |
STRINGi | 9606.ENSP00000376297 |
PTM databases
iPTMneti | P63167 |
MetOSitei | P63167 |
PhosphoSitePlusi | P63167 |
SwissPalmi | P63167 |
Polymorphism and mutation databases
BioMutai | DYNLL1 |
DMDMi | 52783578 |
Proteomic databases
EPDi | P63167 |
jPOSTi | P63167 |
MassIVEi | P63167 |
PaxDbi | P63167 |
PeptideAtlasi | P63167 |
PRIDEi | P63167 |
ProteomicsDBi | 57501 |
TopDownProteomicsi | P63167 |
Protocols and materials databases
Antibodypediai | 31481, 286 antibodies |
DNASUi | 8655 |
Genome annotation databases
Organism-specific databases
CTDi | 8655 |
DisGeNETi | 8655 |
EuPathDBi | HostDB:ENSG00000088986.10 |
GeneCardsi | DYNLL1 |
HGNCi | HGNC:15476, DYNLL1 |
HPAi | ENSG00000088986, Low tissue specificity |
MIMi | 601562, gene |
neXtProti | NX_P63167 |
OpenTargetsi | ENSG00000088986 |
PharmGKBi | PA134972261 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3430, Eukaryota |
GeneTreei | ENSGT00390000000378 |
HOGENOMi | CLU_070944_4_0_1 |
InParanoidi | P63167 |
OMAi | FVTHEKH |
OrthoDBi | 1520814at2759 |
PhylomeDBi | P63167 |
TreeFami | TF300264 |
Enzyme and pathway databases
PathwayCommonsi | P63167 |
Reactomei | R-HSA-111446, Activation of BIM and translocation to mitochondria R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-1632852, Macroautophagy R-HSA-2132295, MHC class II antigen presentation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-5620924, Intraflagellar transport R-HSA-5663220, RHO GTPases Activate Formins R-HSA-6798695, Neutrophil degranulation R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic R-HSA-68877, Mitotic Prometaphase R-HSA-8854518, AURKA Activation by TPX2 R-HSA-9609690, HCMV Early Events R-HSA-9646399, Aggrephagy R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
SIGNORi | P63167 |
Miscellaneous databases
BioGRID-ORCSi | 8655, 313 hits in 859 CRISPR screens |
ChiTaRSi | DYNLL1, human |
EvolutionaryTracei | P63167 |
GeneWikii | DYNLL1 |
GenomeRNAii | 8655 |
Pharosi | P63167, Tbio |
PROi | PR:P63167 |
RNActi | P63167, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000088986, Expressed in anterior cingulate cortex and 249 other tissues |
ExpressionAtlasi | P63167, baseline and differential |
Genevisiblei | P63167, HS |
Family and domain databases
Gene3Di | 3.30.740.10, 1 hit |
InterProi | View protein in InterPro IPR037177, DLC_sf IPR019763, Dynein_light_1/2_CS IPR001372, Dynein_light_chain_typ-1/2 |
PANTHERi | PTHR11886, PTHR11886, 1 hit |
Pfami | View protein in Pfam PF01221, Dynein_light, 1 hit |
SMARTi | View protein in SMART SM01375, Dynein_light, 1 hit |
SUPFAMi | SSF54648, SSF54648, 1 hit |
PROSITEi | View protein in PROSITE PS01239, DYNEIN_LIGHT_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DYL1_HUMAN | |
Accessioni | P63167Primary (citable) accession number: P63167 Secondary accession number(s): Q15701 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | September 27, 2004 | |
Last modified: | December 2, 2020 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM