DYNLL1

Functionⁱ

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.

Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.

Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.

Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

GO - Molecular functionⁱ

dynein intermediate chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
dynein light intermediate chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
enzyme binding Source: Ensembl
motor activity Source: UniProtKB-KW
nitric-oxide synthase regulator activity Source: Ensembl
protein C-terminus binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
scaffold protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
apoptotic process Source: UniProtKB-KW
ciliary basal body-plasma membrane docking Source: Reactome
ER to Golgi vesicle-mediated transport Source: Reactome
G2/M transition of mitotic cell cycle Source: Reactome
intraciliary retrograde transport Source: Ensembl
intraciliary transport involved in cilium assembly Source: Reactome
macroautophagy Source: Reactome
motile cilium assembly Source: Ensembl
negative regulation of phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 18579519
neutrophil degranulation Source: Reactome
positive regulation of ATP-dependent microtubule motor activity, plus-end-directed
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
positive regulation of non-motile cilium assembly Source: Ensembl
regulation of G2/M transition of mitotic cell cycle Source: Reactome
spermatid development Source: Ensembl
substantia nigra development
Source: UniProtKB
Inferred from high throughput expression patternⁱ
- 22926577
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Motor protein
Biological process	Apoptosis, Host-virus interaction, Transcription, Transcription regulation, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111446 Activation of BIM and translocation to mitochondria R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-1632852 Macroautophagy R-HSA-2132295 MHC class II antigen presentation R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-5620924 Intraflagellar transport R-HSA-5663220 RHO GTPases Activate Formins R-HSA-6798695 Neutrophil degranulation R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic R-HSA-68877 Mitotic Prometaphase R-HSA-8854518 AURKA Activation by TPX2
SIGNORⁱ	P63167

Reactomeⁱ

R-HSA-111446 Activation of BIM and translocation to mitochondria
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-1632852 Macroautophagy
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5620924 Intraflagellar transport
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6798695 Neutrophil degranulation
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877 Mitotic Prometaphase
R-HSA-8854518 AURKA Activation by TPX2

SIGNORⁱ

P63167

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dynein light chain 1, cytoplasmic Alternative name(s): 8 kDa dynein light chain Short name: DLC8 Dynein light chain LC8-type 1 Protein inhibitor of neuronal nitric oxide synthase Short name: PIN
Gene namesⁱ	Name:DYNLL1 Synonyms:DLC1, DNCL1, DNCLC1, HDLC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000088986.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15476 DYNLL1
MIMⁱ	601562 gene
neXtProtⁱ	NX_P63167

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Dynein, Microtubule, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	67	T → A: Abolishes interaction with PAK1. 1 Publication	1
Mutagenesisⁱ	88	S → A: Abolishes growth factor-mediated phosphorylation. Increases BCL2L11 protein level and promotes apoptosis. 2 Publications	1
Mutagenesisⁱ	88	S → E: Abolishes homodimerization. Abolishes interaction with BCL2L11 isoform 1 and isoform 2. 2 Publications	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8655
Open Targets More...OpenTargetsⁱ	ENSG00000088986
PharmGKBⁱ	PA134972261

Polymorphism and mutation databases

BioMutaⁱ	DYNLL1
DMDMⁱ	52783578

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000195125	1 – 89	Dynein light chain 1, cytoplasmicAdd BLAST		89

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	36	N6-acetyllysineCombined sources	1
Cross-linkⁱ	43	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	88	Phosphoserine1 Publication	1

Post-translational modificationⁱ

Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P63167
PaxDbⁱ	P63167
PeptideAtlas More...PeptideAtlasⁱ	P63167
PRIDEⁱ	P63167
ProteomicsDBⁱ	57501
TopDownProteomicsⁱ	P63167

PTM databases

iPTMnetⁱ	P63167
PhosphoSitePlusⁱ	P63167
SwissPalmⁱ	P63167

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.1 Publication

Inductionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000088986 Expressed in 238 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_DLC1 HS_DYNLL1
ExpressionAtlasⁱ	P63167 baseline and differential
Genevisibleⁱ	P63167 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039954

HPAⁱ

HPA039954

Interactionⁱ

Subunit structureⁱ

Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The WWC1-DYNLL1 interaction is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2L11 isoform 1 and isoform 2. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at 'Ser-944'). Interacts with BICD2 (By similarity). Interacts with BCAS1 (By similarity).By similarity11 Publications

(Microbial infection) Interacts with human spumaretrovirus Gag protein; this interaction is critical for intracellular microtubule-dependent viral genome transport toward the centrosome.1 Publication

(Microbial infection) Interacts with ebolavirus protein VP35; this interaction stabilizes VP35 N-terminal oligomerization domain and enhances viral RNA synthesis.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AMOTL2	Q9Y2J4-4	3	EBI-349105,EBI-10187270
CCDC36	Q8IYA8	5	EBI-349105,EBI-8638439
DNAL4	O96015	4	EBI-349105,EBI-742362
FAM117B	Q6P1L5	6	EBI-349105,EBI-3893327
GPHN	Q9NQX3	2	EBI-349105,EBI-2371891
IQUB	Q8NA54	3	EBI-349105,EBI-10220600
KANK2	Q63ZY3	5	EBI-349105,EBI-2556193
MYZAP	P0CAP1	6	EBI-349105,EBI-7929343
NEK9	Q8TD19	4	EBI-349105,EBI-1044009
RACK1	P63244	6	EBI-349105,EBI-296739
SMCP	P49901	4	EBI-349105,EBI-750494

GO - Molecular functionⁱ

dynein intermediate chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
dynein light intermediate chain binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
enzyme binding Source: Ensembl
protein C-terminus binding Source: Ensembl
protein domain specific binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein homodimerization activity Source: Ensembl
scaffold protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114206, 231 interactors
CORUMⁱ	P63167
Database of interacting proteins More...DIPⁱ	DIP-33150N
IntActⁱ	P63167, 194 interactors
Molecular INTeraction database More...MINTⁱ	P63167
STRINGⁱ	9606.ENSP00000242577

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	6 – 13	Combined sources	8
Helixⁱ	15 – 31	Combined sources	17
Beta strandⁱ	32 – 34	Combined sources	3
Helixⁱ	35 – 50	Combined sources	16
Beta strandⁱ	54 – 69	Combined sources	16
Beta strandⁱ	73 – 78	Combined sources	6
Beta strandⁱ	81 – 87	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P63167
SMRⁱ	P63167
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P63167

EvolutionaryTraceⁱ

P63167

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	67 – 89	Interaction with ESR11 PublicationAdd BLAST		23

Sequence similaritiesⁱ

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3430 Eukaryota ENOG4111NK2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000378
HOVERGENⁱ	HBG002133
InParanoidⁱ	P63167
KEGG Orthology (KO) More...KOⁱ	K10418
OMAⁱ	QAIMSDR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G15JY
PhylomeDBⁱ	P63167
TreeFamⁱ	TF300264

Family and domain databases

Gene3Dⁱ	3.30.740.10, 1 hit
InterProⁱ	View protein in InterPro IPR037177 DLC_sf IPR019763 Dynein_light_1/2_CS IPR001372 Dynein_light_chain_typ-1/2
PANTHERⁱ	PTHR11886 PTHR11886, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01221 Dynein_light, 1 hit
SMARTⁱ	View protein in SMART SM01375 Dynein_light, 1 hit
SUPFAMⁱ	SSF54648 SSF54648, 1 hit
PROSITEⁱ	View protein in PROSITE PS01239 DYNEIN_LIGHT_1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P63167-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY 
        60         70         80 
NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG

Length:89

Mass (Da):10,366

Last modified:September 27, 2004 - v1

Checksum:ⁱF5E7647D092BEB3A

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VXL2	F8VXL2_HUMAN	Dynein light chain Dynein light chain	DYNLL1	47	Annotation score:
F8VXI7	F8VXI7_HUMAN	Dynein light chain Dynein light chain	DYNLL1	42	Annotation score:
F8VRV5	F8VRV5_HUMAN	Dynein light chain Dynein light chain	DYNLL1	67	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U32944 mRNA Translation: AAB04149.1 CR407672 mRNA Translation: CAG28600.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9200.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001032583.1, NM_001037494.1 NP_001032584.1, NM_001037495.1 NP_003737.1, NM_003746.2
UniGeneⁱ	Hs.5120

Genome annotation databases

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P63167	Dynein light chain 1, cytoplasmic		BOVIN		89	UniRef100_P63167
Dynein light chain 1, cytoplasmic		MACFA		89
Dynein light chain 1, cytoplasmic		MOUSE		89
Dynein light chain 1, cytoplasmic		RABIT		89
Dynein light chain 1, cytoplasmic	)	RAT		89
+67

Protein	Similar proteins		Species	Score	Length	Source
P63167	Dynein light chain 1, cytoplasmic		BOVIN		89	UniRef90_P63167
Dynein light chain 1, cytoplasmic		MACFA		89
Dynein light chain 1, cytoplasmic		MOUSE		89
Dynein light chain 1, cytoplasmic		RABIT		89
Dynein light chain 1, cytoplasmic	)	RAT		89
+67

Protein	Similar proteins		Species	Score	Length	Source
P63167	Dynein light chain 1, cytoplasmic		BOVIN		89	UniRef50_P63167
Dynein light chain 1, cytoplasmic		MACFA		89
Dynein light chain 1, cytoplasmic		MOUSE		89
Dynein light chain 1, cytoplasmic		RABIT		89
Dynein light chain 1, cytoplasmic	)	RAT		89
+141

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U32944 mRNA Translation: AAB04149.1 CR407672 mRNA Translation: CAG28600.1
CCDSⁱ	CCDS9200.1
RefSeqⁱ	NP_001032583.1, NM_001037494.1 NP_001032584.1, NM_001037495.1 NP_003737.1, NM_003746.2
UniGeneⁱ	Hs.5120

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1CMI	X-ray	2.50	A/B	5-89	[»]
	3ZKE	X-ray	2.20	A/C/E/G/I/K	1-89	[»]
	3ZKF	X-ray	2.60	A/C/E/G/I/K	1-89	[»]
ProteinModelPortalⁱ	P63167
SMRⁱ	P63167
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114206, 231 interactors
CORUMⁱ	P63167
DIPⁱ	DIP-33150N
IntActⁱ	P63167, 194 interactors
MINTⁱ	P63167
STRINGⁱ	9606.ENSP00000242577

PTM databases

iPTMnetⁱ	P63167
PhosphoSitePlusⁱ	P63167
SwissPalmⁱ	P63167

Polymorphism and mutation databases

BioMutaⁱ	DYNLL1
DMDMⁱ	52783578

Proteomic databases

EPDⁱ	P63167
PaxDbⁱ	P63167
PeptideAtlasⁱ	P63167
PRIDEⁱ	P63167
ProteomicsDBⁱ	57501
TopDownProteomicsⁱ	P63167

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8655
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000242577; ENSP00000242577; ENSG00000088986 ENST00000392508; ENSP00000376296; ENSG00000088986 ENST00000392509; ENSP00000376297; ENSG00000088986 ENST00000548342; ENSP00000447907; ENSG00000088986 ENST00000549989; ENSP00000446614; ENSG00000088986
GeneIDⁱ	8655
KEGGⁱ	hsa:8655

Organism-specific databases

CTDⁱ	8655
DisGeNETⁱ	8655
EuPathDBⁱ	HostDB:ENSG00000088986.10
GeneCardsⁱ	DYNLL1
HGNCⁱ	HGNC:15476 DYNLL1
HPAⁱ	HPA039954
MIMⁱ	601562 gene
neXtProtⁱ	NX_P63167
OpenTargetsⁱ	ENSG00000088986
PharmGKBⁱ	PA134972261
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3430 Eukaryota ENOG4111NK2 LUCA
GeneTreeⁱ	ENSGT00390000000378
HOVERGENⁱ	HBG002133
InParanoidⁱ	P63167
KOⁱ	K10418
OMAⁱ	QAIMSDR
OrthoDBⁱ	EOG091G15JY
PhylomeDBⁱ	P63167
TreeFamⁱ	TF300264

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111446 Activation of BIM and translocation to mitochondria R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-1632852 Macroautophagy R-HSA-2132295 MHC class II antigen presentation R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-5620924 Intraflagellar transport R-HSA-5663220 RHO GTPases Activate Formins R-HSA-6798695 Neutrophil degranulation R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic R-HSA-68877 Mitotic Prometaphase R-HSA-8854518 AURKA Activation by TPX2
SIGNORⁱ	P63167

Reactomeⁱ

R-HSA-111446 Activation of BIM and translocation to mitochondria
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-1632852 Macroautophagy
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5620924 Intraflagellar transport
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6798695 Neutrophil degranulation
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877 Mitotic Prometaphase
R-HSA-8854518 AURKA Activation by TPX2

SIGNORⁱ

P63167

Miscellaneous databases

ChiTaRSⁱ	DYNLL1 human
EvolutionaryTraceⁱ	P63167
GeneWikiⁱ	DYNLL1
GenomeRNAiⁱ	8655
Protein Ontology More...PROⁱ	PR:P63167
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000088986 Expressed in 238 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_DLC1 HS_DYNLL1
ExpressionAtlasⁱ	P63167 baseline and differential
Genevisibleⁱ	P63167 HS

Family and domain databases

Gene3Dⁱ	3.30.740.10, 1 hit
InterProⁱ	View protein in InterPro IPR037177 DLC_sf IPR019763 Dynein_light_1/2_CS IPR001372 Dynein_light_chain_typ-1/2
PANTHERⁱ	PTHR11886 PTHR11886, 1 hit
Pfamⁱ	View protein in Pfam PF01221 Dynein_light, 1 hit
SMARTⁱ	View protein in SMART SM01375 Dynein_light, 1 hit
SUPFAMⁱ	SSF54648 SSF54648, 1 hit
PROSITEⁱ	View protein in PROSITE PS01239 DYNEIN_LIGHT_1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DYL1_HUMAN
Accessionⁱ	P63167Primary (citable) accession number: P63167 Secondary accession number(s): Q15701
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
	Last sequence update:	September 27, 2004
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P63167 (DYL1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Dynein light chain 1, cytoplasmic

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Mitochondrion

Nucleus

Cytoskeleton

Cytosol

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ