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UniProtKB - P63167 (DYL1_HUMAN)

Entry version 177 (02 Jun 2021)
Sequence version 1 (27 Sep 2004)
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Protein

Dynein light chain 1, cytoplasmic

Gene

DYNLL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.

Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.

Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.

Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Motor protein
Biological processApoptosis, Host-virus interaction, Transcription, Transcription regulation, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P63167

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-111446, Activation of BIM and translocation to mitochondria
R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-1632852, Macroautophagy
R-HSA-2132295, MHC class II antigen presentation
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-5620924, Intraflagellar transport
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-6798695, Neutrophil degranulation
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877, Mitotic Prometaphase
R-HSA-8854518, AURKA Activation by TPX2
R-HSA-9609690, HCMV Early Events
R-HSA-9646399, Aggrephagy
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation

SIGNOR Signaling Network Open Resource

More...SIGNORi		P63167

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein light chain 1, cytoplasmic
Alternative name(s):
8 kDa dynein light chain
Short name:
DLC8
Dynein light chain LC8-type 1
Protein inhibitor of neuronal nitric oxide synthase
Short name:
PIN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DYNLL1
Synonyms:DLC1, DNCL1, DNCLC1, HDLC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15476, DYNLL1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601562, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P63167

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000088986.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi67T → A: Abolishes interaction with PAK1. 1 Publication1
Mutagenesisi88S → A: Abolishes growth factor-mediated phosphorylation. Increases BCL2L11 protein level and promotes apoptosis. 2 Publications1
Mutagenesisi88S → E: Abolishes homodimerization. Abolishes interaction with BCL2L11 isoform 1 and isoform 2. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		8655

Open Targets

More...OpenTargetsi		ENSG00000088986

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134972261

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P63167, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DYNLL1

Domain mapping of disease mutations (DMDM)

More...DMDMi		52783578

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001951251 – 89Dynein light chain 1, cytoplasmicAdd BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei36N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki43Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei88Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P63167

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P63167

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P63167

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P63167

PeptideAtlas

More...PeptideAtlasi		P63167

PRoteomics IDEntifications database

More...PRIDEi		P63167

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57501

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P63167

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P63167

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P63167

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P63167

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P63167

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by ATMIN, PAK1 and estrogen.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000088986, Expressed in anterior cingulate cortex and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P63167, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P63167, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000088986, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.

Interacts with TXNDC17.

Interacts with WWC1 and ESR1. The WWC1-DYNLL1 interaction is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin.

Interacts with BCL2L11 isoform 1 and isoform 2.

Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis.

Interacts with PAK1; the interaction requires dimeric DYNLL1.

Interacts with MYZAP.

Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2.

Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN.

Interacts with NEK9 (not phosphorylated at 'Ser-944').

Interacts with BICD2 (By similarity).

Interacts with BCAS1 (By similarity).

Interacts with Basson/BSN.

Interacts with HDAC6 (PubMed:31505170).

Interacts with TPPP (PubMed:31505170).

By similarity13 Publications

(Microbial infection) Interacts with human spumaretrovirus Gag protein; this interaction is critical for intracellular microtubule-dependent viral genome transport toward the centrosome.

1 Publication

(Microbial infection) Interacts with ebolavirus protein VP35; this interaction stabilizes VP35 N-terminal oligomerization domain and enhances viral RNA synthesis.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P63167
With#Exp.IntAct
AMOTL2 - isoform 4 [Q9Y2J4-4]3EBI-349105,EBI-10187270
BMF [Q96LC9]3EBI-349105,EBI-3919268
C12orf40 [Q86WS4]3EBI-349105,EBI-10286004
C14orf119 [Q9NWQ9]3EBI-349105,EBI-725606
C19orf44 - isoform 2 [Q9H6X5-2]5EBI-349105,EBI-12061599
CCDC28A [Q7Z6N9]5EBI-349105,EBI-10258115
DCTN5 [Q9BTE1]3EBI-349105,EBI-747324
DNAL4 [O96015]3EBI-349105,EBI-742362
DPPA3 [Q6W0C5]5EBI-349105,EBI-12082590
FAM117B [Q6P1L5]11EBI-349105,EBI-3893327
FAM153A [Q9UHL3]4EBI-349105,EBI-2834075
FAM53B - isoform 2 [Q14153-2]3EBI-349105,EBI-12401851
GABARAPL1 [Q9H0R8]3EBI-349105,EBI-746969
GABARAPL2 [P60520]3EBI-349105,EBI-720116
GNL3L [Q9NVN8]3EBI-349105,EBI-746682
GPHN [Q9NQX3]2EBI-349105,EBI-2371891
HMBOX1 [Q6NT76]5EBI-349105,EBI-2549423
HOMER3 [Q9NSC5]5EBI-349105,EBI-748420
HTT [P42858]10EBI-349105,EBI-466029
IHO1 [Q8IYA8]6EBI-349105,EBI-8638439
IQUB [Q8NA54]3EBI-349105,EBI-10220600
KANK2 [Q63ZY3]6EBI-349105,EBI-2556193
KLK6 [Q92876]3EBI-349105,EBI-2432309
MORN3 [Q6PF18]3EBI-349105,EBI-9675802
MYZAP [P0CAP1]6EBI-349105,EBI-7929343
NEK9 [Q8TD19]4EBI-349105,EBI-1044009
ODF3 [Q96PU9]3EBI-349105,EBI-12002088
OR7C2 [O60412]3EBI-349105,EBI-12173063
OTUD6A [Q7L8S5]5EBI-349105,EBI-11960139
PAK1 [Q13153]4EBI-349105,EBI-1307
PKIA [P61925]3EBI-349105,EBI-2682139
PKIG [Q9Y2B9]5EBI-349105,EBI-1052231
RACK1 [P63244]6EBI-349105,EBI-296739
RASGRP4 - isoform 2 [Q8TDF6-2]3EBI-349105,EBI-12816371
SEPTIN4 [O43236]5EBI-349105,EBI-1047513
SMCP [P49901]9EBI-349105,EBI-750494
THAP10 [Q9P2Z0]8EBI-349105,EBI-745404
TSNARE1 [A0AVG3]3EBI-349105,EBI-12003468
ZNF710 [Q8N1W2]4EBI-349105,EBI-18096911

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114206, 320 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5025, Cytoplasmic dynein complex, variant 1

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P63167

Database of interacting proteins

More...DIPi		DIP-33150N

Protein interaction database and analysis system

More...IntActi		P63167, 215 interactors

Molecular INTeraction database

More...MINTi		P63167

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000376297

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P63167, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P63167

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P63167

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P63167

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 89Interaction with ESR11 PublicationAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3430, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000378

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_070944_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P63167

Identification of Orthologs from Complete Genome Data

More...OMAi		FVTHEKH

Database of Orthologous Groups

More...OrthoDBi		1520814at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P63167

TreeFam database of animal gene trees

More...TreeFami		TF300264

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.740.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037177, DLC_sf
IPR019763, Dynein_light_1/2_CS
IPR001372, Dynein_light_chain_typ-1/2

The PANTHER Classification System

More...PANTHERi		PTHR11886, PTHR11886, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01221, Dynein_light, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01375, Dynein_light, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54648, SSF54648, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01239, DYNEIN_LIGHT_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P63167-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY 
        60         70         80 
NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG
Length:89
Mass (Da):10,366
Last modified:September 27, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5E7647D092BEB3A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VRV5F8VRV5_HUMAN
Dynein light chain
DYNLL1
67Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VXI7F8VXI7_HUMAN
Dynein light chain
DYNLL1
42Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VXL2F8VXL2_HUMAN
Dynein light chain
DYNLL1
47Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U32944 mRNA Translation: AAB04149.1
CR407672 mRNA Translation: CAG28600.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9200.1

NCBI Reference Sequences

More...RefSeqi		NP_001032583.1, NM_001037494.1
NP_001032584.1, NM_001037495.1
NP_003737.1, NM_003746.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000242577; ENSP00000242577; ENSG00000088986
ENST00000392508; ENSP00000376296; ENSG00000088986
ENST00000392509; ENSP00000376297; ENSG00000088986
ENST00000548342; ENSP00000447907; ENSG00000088986
ENST00000549989; ENSP00000446614; ENSG00000088986

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8655

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8655

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32944 mRNA Translation: AAB04149.1
CR407672 mRNA Translation: CAG28600.1
CCDSiCCDS9200.1
RefSeqiNP_001032583.1, NM_001037494.1
NP_001032584.1, NM_001037495.1
NP_003737.1, NM_003746.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CMIX-ray2.50A/B5-89[»]
3ZKEX-ray2.20A/C/E/G/I/K1-89[»]
3ZKFX-ray2.60A/C/E/G/I/K1-89[»]
6GZJX-ray1.98A1-89[»]
6GZLX-ray1.95A1-89[»]
6RLBelectron microscopy4.50I/J/K/L/M/N1-89[»]
6SC2electron microscopy3.90I/J/K/L/M/N1-89[»]
BMRBiP63167
SMRiP63167
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114206, 320 interactors
ComplexPortaliCPX-5025, Cytoplasmic dynein complex, variant 1
CORUMiP63167
DIPiDIP-33150N
IntActiP63167, 215 interactors
MINTiP63167
STRINGi9606.ENSP00000376297

PTM databases

iPTMnetiP63167
MetOSiteiP63167
PhosphoSitePlusiP63167
SwissPalmiP63167

Genetic variation databases

BioMutaiDYNLL1
DMDMi52783578

Proteomic databases

EPDiP63167
jPOSTiP63167
MassIVEiP63167
PaxDbiP63167
PeptideAtlasiP63167
PRIDEiP63167
ProteomicsDBi57501
TopDownProteomicsiP63167

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31481, 297 antibodies

The DNASU plasmid repository

More...DNASUi		8655

Genome annotation databases

EnsembliENST00000242577; ENSP00000242577; ENSG00000088986
ENST00000392508; ENSP00000376296; ENSG00000088986
ENST00000392509; ENSP00000376297; ENSG00000088986
ENST00000548342; ENSP00000447907; ENSG00000088986
ENST00000549989; ENSP00000446614; ENSG00000088986
GeneIDi8655
KEGGihsa:8655

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8655
DisGeNETi8655

GeneCards: human genes, protein and diseases

More...GeneCardsi		DYNLL1
HGNCiHGNC:15476, DYNLL1
HPAiENSG00000088986, Low tissue specificity
MIMi601562, gene
neXtProtiNX_P63167
OpenTargetsiENSG00000088986
PharmGKBiPA134972261
VEuPathDBiHostDB:ENSG00000088986.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3430, Eukaryota
GeneTreeiENSGT00390000000378
HOGENOMiCLU_070944_4_0_1
InParanoidiP63167
OMAiFVTHEKH
OrthoDBi1520814at2759
PhylomeDBiP63167
TreeFamiTF300264

Enzyme and pathway databases

PathwayCommonsiP63167
ReactomeiR-HSA-111446, Activation of BIM and translocation to mitochondria
R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-1632852, Macroautophagy
R-HSA-2132295, MHC class II antigen presentation
R-HSA-2467813, Separation of Sister Chromatids
R-HSA-2500257, Resolution of Sister Chromatid Cohesion
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-5620924, Intraflagellar transport
R-HSA-5663220, RHO GTPases Activate Formins
R-HSA-6798695, Neutrophil degranulation
R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877, Mitotic Prometaphase
R-HSA-8854518, AURKA Activation by TPX2
R-HSA-9609690, HCMV Early Events
R-HSA-9646399, Aggrephagy
R-HSA-9648025, EML4 and NUDC in mitotic spindle formation
SIGNORiP63167

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8655, 323 hits in 978 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DYNLL1, human
EvolutionaryTraceiP63167

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DYNLL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8655
PharosiP63167, Tbio

Protein Ontology

More...PROi		PR:P63167
RNActiP63167, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000088986, Expressed in anterior cingulate cortex and 250 other tissues
ExpressionAtlasiP63167, baseline and differential
GenevisibleiP63167, HS

Family and domain databases

Gene3Di3.30.740.10, 1 hit
InterProiView protein in InterPro
IPR037177, DLC_sf
IPR019763, Dynein_light_1/2_CS
IPR001372, Dynein_light_chain_typ-1/2
PANTHERiPTHR11886, PTHR11886, 1 hit
PfamiView protein in Pfam
PF01221, Dynein_light, 1 hit
SMARTiView protein in SMART
SM01375, Dynein_light, 1 hit
SUPFAMiSSF54648, SSF54648, 1 hit
PROSITEiView protein in PROSITE
PS01239, DYNEIN_LIGHT_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63167
Secondary accession number(s): Q15701
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: June 2, 2021
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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