UniProtKB - P63165 (SUMO1_HUMAN)
Small ubiquitin-related modifier 1
SUMO1
Functioni
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394).
Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).
7 PublicationsGO - Molecular functioni
- enzyme binding Source: CAFA
- potassium channel regulator activity Source: UniProtKB
- protein tag Source: GO_Central
- RNA binding Source: UniProtKB
- small protein activating enzyme binding Source: CAFA
- transcription factor binding Source: AgBase
- ubiquitin-like protein ligase binding Source: GO_Central
- ubiquitin protein ligase binding Source: UniProtKB
- ubiquitin-specific protease binding Source: UniProtKB
GO - Biological processi
- cellular response to cadmium ion Source: UniProtKB
- cellular response to heat Source: UniProtKB
- DNA repair Source: ProtInc
- negative regulation of action potential Source: UniProtKB
- negative regulation of delayed rectifier potassium channel activity Source: UniProtKB
- negative regulation of DNA binding Source: CAFA
- negative regulation of DNA-binding transcription factor activity Source: UniProtKB
- negative regulation of protein import into nucleus Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: GO_Central
- negative regulation of transcription by transcription factor localization Source: UniProtKB
- PML body organization Source: Ensembl
- positive regulation of ATPase-coupled calcium transmembrane transporter activity Source: Ensembl
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- positive regulation of protein-containing complex assembly Source: BHF-UCL
- protein localization to nuclear pore Source: Ensembl
- protein stabilization Source: UniProtKB
- protein sumoylation Source: UniProtKB
- regulation of cardiac muscle cell contraction Source: Ensembl
- regulation of protein localization Source: UniProtKB
- roof of mouth development Source: UniProtKB
Keywordsi
Biological process | Host-virus interaction, Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | P63165 |
Reactomei | R-HSA-3065676, SUMO is conjugated to E1 (UBA2:SAE1) R-HSA-3065678, SUMO is transferred from E1 to E2 (UBE2I, UBC9) R-HSA-3065679, SUMO is proteolytically processed R-HSA-3108214, SUMOylation of DNA damage response and repair proteins R-HSA-3108232, SUMO E3 ligases SUMOylate target proteins R-HSA-3232118, SUMOylation of transcription factors R-HSA-3232142, SUMOylation of ubiquitinylation proteins R-HSA-3899300, SUMOylation of transcription cofactors R-HSA-4085377, SUMOylation of SUMOylation proteins R-HSA-4090294, SUMOylation of intracellular receptors R-HSA-4551638, SUMOylation of chromatin organization proteins R-HSA-4570464, SUMOylation of RNA binding proteins R-HSA-4615885, SUMOylation of DNA replication proteins R-HSA-4655427, SUMOylation of DNA methylation proteins R-HSA-4755510, SUMOylation of immune response proteins R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693571, Nonhomologous End-Joining (NHEJ) R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-5696395, Formation of Incision Complex in GG-NER R-HSA-69473, G2/M DNA damage checkpoint R-HSA-877312, Regulation of IFNG signaling R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation R-HSA-9683610, Maturation of nucleoprotein R-HSA-9694631, Maturation of nucleoprotein |
SignaLinki | P63165 |
SIGNORi | P63165 |
Protein family/group databases
MoonDBi | P63165, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Small ubiquitin-related modifier 1Short name: SUMO-1 Alternative name(s): GAP-modifying protein 1 Short name: GMP1 SMT3 homolog 3 Sentrin Ubiquitin-homology domain protein PIC1 Ubiquitin-like protein SMT3C Short name: Smt3C Ubiquitin-like protein UBL1 |
Gene namesi | Name:SUMO1 Synonyms:SMT3C, SMT3H3, UBL1 ORF Names:OK/SW-cl.43 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12502, SUMO1 |
MIMi | 601912, gene |
neXtProti | NX_P63165 |
VEuPathDBi | HostDB:ENSG00000116030 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Nucleus
- Nucleus membrane 2 Publications
- Nucleus speckle By similarity
- PML body 3 Publications
- Nucleus 2 Publications
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Note: Recruited by BCL11A into the nuclear body (By similarity). In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body (PubMed:24651376).By similarity1 Publication
Cytosol
- cytosol Source: Reactome
Nucleus
- nuclear body Source: UniProtKB
- nuclear envelope Source: Reactome
- nuclear membrane Source: HPA
- nuclear pore Source: ProtInc
- nuclear speck Source: UniProtKB-SubCell
- nuclear stress granule Source: UniProtKB
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- PML body Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- XY body Source: Ensembl
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Non-syndromic orofacial cleft 10 (OFC10)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 36 | F → A: Abolishes binding to PIAS2. 1 Publication | 1 | |
Mutagenesisi | 97 | G → A: Abolishes sumoylation of ZBED1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7341 |
MalaCardsi | SUMO1 |
MIMi | 613705, phenotype |
OpenTargetsi | ENSG00000116030 |
Orphaneti | 99798, Oligodontia |
PharmGKBi | PA37149 |
Miscellaneous databases
Pharosi | P63165, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2146296 |
Genetic variation databases
BioMutai | SUMO1 |
DMDMi | 52783799 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000035939 | 2 – 97 | Small ubiquitin-related modifier 1Add BLAST | 96 | |
PropeptideiPRO_0000035940 | 98 – 101 | 1 Publication | 4 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources1 Publication | 1 | |
Modified residuei | 2 | PhosphoserineCombined sources1 Publication | 1 | |
Cross-linki | 7 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate | ||
Cross-linki | 7 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 9 | PhosphoserineCombined sources | 1 | |
Cross-linki | 16 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 17 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 23 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 25 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) | ||
Modified residuei | 32 | PhosphoserineCombined sources | 1 | |
Cross-linki | 37 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 39 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 45 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 46 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 97 | Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)1 Publication |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P63165 |
jPOSTi | P63165 |
MassIVEi | P63165 |
MaxQBi | P63165 |
PaxDbi | P63165 |
PeptideAtlasi | P63165 |
PRIDEi | P63165 |
ProteomicsDBi | 2128 57500 [P63165-1] |
TopDownProteomicsi | P63165-1 [P63165-1] |
PTM databases
iPTMneti | P63165 |
MetOSitei | P63165 |
PhosphoSitePlusi | P63165 |
Expressioni
Gene expression databases
Bgeei | ENSG00000116030, Expressed in caudate nucleus and 217 other tissues |
ExpressionAtlasi | P63165, baseline and differential |
Genevisiblei | P63165, HS |
Organism-specific databases
HPAi | ENSG00000116030, Low tissue specificity |
Interactioni
Subunit structurei
Covalently attached to KCNB1; UBE2I increases cross-linking with KCNB1 and PIAS1 decreases cross-links with KCNB1 (PubMed:19223394, PubMed:15931224).
Interacts with SAE2, RANBP2, PIAS1 and PIAS2 (PubMed:10961991, PubMed:15608651, PubMed:15660128, PubMed:16204249, PubMed:15931224).
Interacts with PRKN (PubMed:16955485). Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG (PubMed:10961991, PubMed:15931224, PubMed:15959518, PubMed:17099698).
Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52 (PubMed:10961991, PubMed:12565818).
Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25 (PubMed:18538659).
Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains) (PubMed:23086935).
Interacts with BHLHE40/DEC1 (PubMed:21829689).
Interacts with RWDD3 (PubMed:17956732).
Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3 (PubMed:12924945, PubMed:17956732).
Interacts with MTA1 (PubMed:21965678).
Interacts with SENP2 (PubMed:15296745).
Interacts with HINT1 (By similarity).
By similarity17 Publications(Microbial infection) Interacts with Epstein-barr virus BGLF4.
1 Publication(Microbial infection) Interacts (via N-terminus) with Tula hantavirus nucleoprotein.
1 Publication(Microbial infection) Interacts (via N-terminus) with Hantaan hantavirus nucleoprotein.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 36 | Interaction with PIAS2 | 1 |
Binary interactionsi
P63165
GO - Molecular functioni
- enzyme binding Source: CAFA
- small protein activating enzyme binding Source: CAFA
- transcription factor binding Source: AgBase
- ubiquitin-like protein ligase binding Source: GO_Central
- ubiquitin protein ligase binding Source: UniProtKB
- ubiquitin-specific protease binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113188, 251 interactors |
CORUMi | P63165 |
DIPi | DIP-29080N |
IntActi | P63165, 190 interactors |
MINTi | P63165 |
STRINGi | 9606.ENSP00000376077 |
Chemistry databases
BindingDBi | P63165 |
Miscellaneous databases
RNActi | P63165, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P63165 |
BMRBi | P63165 |
SMRi | P63165 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P63165 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 97 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 16 – 25 | (Microbial infection) Interaction with Tula hantavirus1 Publication | 10 | |
Regioni | 37 – 40 | (Microbial infection) Interaction with Tula hantavirus1 Publication | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1769, Eukaryota |
GeneTreei | ENSGT00940000154319 |
HOGENOMi | CLU_148322_0_0_1 |
InParanoidi | P63165 |
OMAi | TIECHIE |
PhylomeDBi | P63165 |
TreeFami | TF315116 |
Family and domain databases
CDDi | cd16114, Ubl_SUMO1, 1 hit |
DisProti | DP02294 |
IDEALi | IID00378 |
InterProi | View protein in InterPro IPR022617, Rad60/SUMO-like_dom IPR046332, SUMO1_Ubl IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF11976, Rad60-SLD, 1 hit |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDQEAKPST EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES
60 70 80 90 100
YCQRQGVPMN SLRFLFEGQR IADNHTPKEL GMEEEDVIEV YQEQTGGHST
V
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB8ZZN6 | B8ZZN6_HUMAN | Small ubiquitin-related modifier 1 | SUMO1 | 146 | Annotation score: | ||
B8ZZJ0 | B8ZZJ0_HUMAN | Small ubiquitin-related modifier 1 | SUMO1 | 58 | Annotation score: | ||
B9A032 | B9A032_HUMAN | Small ubiquitin-related modifier 1 | SUMO1 | 77 | Annotation score: | ||
B8ZZ67 | B8ZZ67_HUMAN | SMT3 suppressor of mif two 3 homolo... | SUMO1 hCG_1776791 | 62 | Annotation score: | ||
F8WBI1 | F8WBI1_HUMAN | Small ubiquitin-related modifier 1 | SUMO1 | 73 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 75 | H → N in AAH66306 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046756 | 4 – 28 | Missing in isoform 2. CuratedAdd BLAST | 25 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99586 mRNA Translation: CAA67898.1 U61397 mRNA Translation: AAB40388.1 U38784 mRNA Translation: AAC50733.1 U67122 mRNA Translation: AAC50996.1 U72722 mRNA Translation: AAB40390.1 U83117 mRNA Translation: AAB39999.1 AB062294 mRNA Translation: BAB93477.1 BT006632 mRNA Translation: AAP35278.1 CR542147 mRNA Translation: CAG46944.1 CR542156 mRNA Translation: CAG46953.1 AK311840 mRNA Translation: BAG34782.1 AC079354 Genomic DNA Translation: AAY24035.1 CH471063 Genomic DNA Translation: EAW70304.1 CH471063 Genomic DNA Translation: EAW70307.1 BC006462 mRNA Translation: AAH06462.1 BC053528 mRNA Translation: AAH53528.1 BC066306 mRNA Translation: AAH66306.1 |
CCDSi | CCDS2352.1 [P63165-1] CCDS46493.1 [P63165-2] |
RefSeqi | NP_001005781.1, NM_001005781.1 [P63165-1] NP_001005782.1, NM_001005782.1 [P63165-2] NP_003343.1, NM_003352.4 [P63165-1] |
Genome annotation databases
Ensembli | ENST00000392244.7; ENSP00000376075.3; ENSG00000116030.17 [P63165-2] ENST00000392245.5; ENSP00000376076.1; ENSG00000116030.17 ENST00000392246.7; ENSP00000376077.2; ENSG00000116030.17 |
GeneIDi | 7341 |
KEGGi | hsa:7341 |
MANE-Selecti | ENST00000392246.7; ENSP00000376077.2; NM_003352.8; NP_003343.1 |
UCSCi | uc002uyz.2, human [P63165-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia SUMO protein entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99586 mRNA Translation: CAA67898.1 U61397 mRNA Translation: AAB40388.1 U38784 mRNA Translation: AAC50733.1 U67122 mRNA Translation: AAC50996.1 U72722 mRNA Translation: AAB40390.1 U83117 mRNA Translation: AAB39999.1 AB062294 mRNA Translation: BAB93477.1 BT006632 mRNA Translation: AAP35278.1 CR542147 mRNA Translation: CAG46944.1 CR542156 mRNA Translation: CAG46953.1 AK311840 mRNA Translation: BAG34782.1 AC079354 Genomic DNA Translation: AAY24035.1 CH471063 Genomic DNA Translation: EAW70304.1 CH471063 Genomic DNA Translation: EAW70307.1 BC006462 mRNA Translation: AAH06462.1 BC053528 mRNA Translation: AAH53528.1 BC066306 mRNA Translation: AAH66306.1 |
CCDSi | CCDS2352.1 [P63165-1] CCDS46493.1 [P63165-2] |
RefSeqi | NP_001005781.1, NM_001005781.1 [P63165-1] NP_001005782.1, NM_001005782.1 [P63165-2] NP_003343.1, NM_003352.4 [P63165-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A5R | NMR | - | A | 1-101 | [»] | |
1TGZ | X-ray | 2.80 | B | 18-97 | [»] | |
1WYW | X-ray | 2.10 | B | 1-97 | [»] | |
1Y8R | X-ray | 2.75 | C/F | 1-97 | [»] | |
1Z5S | X-ray | 3.01 | B | 18-97 | [»] | |
2ASQ | NMR | - | A | 1-97 | [»] | |
2BF8 | X-ray | 2.30 | B | 21-97 | [»] | |
2G4D | X-ray | 2.80 | B/D | 20-97 | [»] | |
2IO2 | X-ray | 2.90 | B | 18-97 | [»] | |
2IY0 | X-ray | 2.77 | B | 20-101 | [»] | |
2IY1 | X-ray | 2.46 | B/D | 20-101 | [»] | |
2KQS | NMR | - | A | 1-97 | [»] | |
2LAS | NMR | - | A | 1-101 | [»] | |
2MW5 | NMR | - | A | 1-97 | [»] | |
2N1A | NMR | - | A | 1-101 | [»] | |
2N1V | NMR | - | A | 1-97 | [»] | |
2PE6 | X-ray | 2.40 | B | 1-97 | [»] | |
2UYZ | X-ray | 1.40 | B | 20-97 | [»] | |
2VRR | X-ray | 2.22 | B | 20-97 | [»] | |
3KYC | X-ray | 2.45 | D | 1-97 | [»] | |
3KYD | X-ray | 2.61 | D | 1-94 | [»] | |
3RZW | X-ray | 2.15 | C/D | 1-97 | [»] | |
3UIP | X-ray | 2.29 | B | 18-97 | [»] | |
4WJN | X-ray | 1.50 | A | 17-97 | [»] | |
4WJO | X-ray | 1.46 | A | 17-97 | [»] | |
4WJP | X-ray | 1.70 | A/C | 17-97 | [»] | |
4WJQ | X-ray | 1.35 | A/C | 17-97 | [»] | |
5AEK | X-ray | 3.00 | B/D/F/H/J/L/N/P/R/T/V/X | 20-97 | [»] | |
5B7A | NMR | - | A | 1-97 | [»] | |
5ELJ | X-ray | 1.98 | B | 18-97 | [»] | |
5GHD | NMR | - | A | 1-97 | [»] | |
6EOP | X-ray | 2.40 | D/E/F | 61-68 | [»] | |
6EOT | X-ray | 3.50 | C/E/F/H/J/L | 61-68 | [»] | |
6J4I | NMR | - | A | 1-97 | [»] | |
6JXU | NMR | - | A | 1-101 | [»] | |
6JXV | NMR | - | A | 1-101 | [»] | |
6K5T | NMR | - | A | 21-97 | [»] | |
6TRW | X-ray | 3.00 | D/E/F | 61-75 | [»] | |
6UYO | X-ray | 1.64 | A/C | 17-97 | [»] | |
6UYP | X-ray | 1.42 | A | 17-97 | [»] | |
6UYQ | X-ray | 1.50 | A | 17-97 | [»] | |
6UYR | X-ray | 1.30 | A | 17-97 | [»] | |
6UYS | X-ray | 1.59 | A/C | 17-97 | [»] | |
6UYT | X-ray | 1.66 | A | 17-97 | [»] | |
6UYU | X-ray | 1.66 | A/C | 17-97 | [»] | |
6UYV | X-ray | 1.40 | A | 17-97 | [»] | |
6UYX | X-ray | 1.70 | A/C | 17-97 | [»] | |
6UYY | X-ray | 1.60 | A | 17-97 | [»] | |
6UYZ | X-ray | 1.40 | A/C | 17-97 | [»] | |
6V7P | X-ray | 1.40 | A/C | 17-97 | [»] | |
6V7Q | X-ray | 1.35 | A/C | 17-97 | [»] | |
6V7R | X-ray | 1.55 | A/C | 17-97 | [»] | |
6V7S | X-ray | 1.47 | A/C | 17-97 | [»] | |
6WW3 | X-ray | 2.10 | A/B | 2-7 | [»] | |
6XOG | X-ray | 1.98 | C | 1-101 | [»] | |
6XOH | X-ray | 2.23 | C | 1-101 | [»] | |
6XOI | X-ray | 2.00 | C | 1-101 | [»] | |
AlphaFoldDBi | P63165 | |||||
BMRBi | P63165 | |||||
SMRi | P63165 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113188, 251 interactors |
CORUMi | P63165 |
DIPi | DIP-29080N |
IntActi | P63165, 190 interactors |
MINTi | P63165 |
STRINGi | 9606.ENSP00000376077 |
Chemistry databases
BindingDBi | P63165 |
ChEMBLi | CHEMBL2146296 |
Protein family/group databases
MoonDBi | P63165, Predicted |
PTM databases
iPTMneti | P63165 |
MetOSitei | P63165 |
PhosphoSitePlusi | P63165 |
Genetic variation databases
BioMutai | SUMO1 |
DMDMi | 52783799 |
Proteomic databases
EPDi | P63165 |
jPOSTi | P63165 |
MassIVEi | P63165 |
MaxQBi | P63165 |
PaxDbi | P63165 |
PeptideAtlasi | P63165 |
PRIDEi | P63165 |
ProteomicsDBi | 2128 57500 [P63165-1] |
TopDownProteomicsi | P63165-1 [P63165-1] |
Protocols and materials databases
Antibodypediai | 3793, 1178 antibodies from 45 providers |
DNASUi | 7341 |
Genome annotation databases
Ensembli | ENST00000392244.7; ENSP00000376075.3; ENSG00000116030.17 [P63165-2] ENST00000392245.5; ENSP00000376076.1; ENSG00000116030.17 ENST00000392246.7; ENSP00000376077.2; ENSG00000116030.17 |
GeneIDi | 7341 |
KEGGi | hsa:7341 |
MANE-Selecti | ENST00000392246.7; ENSP00000376077.2; NM_003352.8; NP_003343.1 |
UCSCi | uc002uyz.2, human [P63165-1] |
Organism-specific databases
CTDi | 7341 |
DisGeNETi | 7341 |
GeneCardsi | SUMO1 |
HGNCi | HGNC:12502, SUMO1 |
HPAi | ENSG00000116030, Low tissue specificity |
MalaCardsi | SUMO1 |
MIMi | 601912, gene 613705, phenotype |
neXtProti | NX_P63165 |
OpenTargetsi | ENSG00000116030 |
Orphaneti | 99798, Oligodontia |
PharmGKBi | PA37149 |
VEuPathDBi | HostDB:ENSG00000116030 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1769, Eukaryota |
GeneTreei | ENSGT00940000154319 |
HOGENOMi | CLU_148322_0_0_1 |
InParanoidi | P63165 |
OMAi | TIECHIE |
PhylomeDBi | P63165 |
TreeFami | TF315116 |
Enzyme and pathway databases
PathwayCommonsi | P63165 |
Reactomei | R-HSA-3065676, SUMO is conjugated to E1 (UBA2:SAE1) R-HSA-3065678, SUMO is transferred from E1 to E2 (UBE2I, UBC9) R-HSA-3065679, SUMO is proteolytically processed R-HSA-3108214, SUMOylation of DNA damage response and repair proteins R-HSA-3108232, SUMO E3 ligases SUMOylate target proteins R-HSA-3232118, SUMOylation of transcription factors R-HSA-3232142, SUMOylation of ubiquitinylation proteins R-HSA-3899300, SUMOylation of transcription cofactors R-HSA-4085377, SUMOylation of SUMOylation proteins R-HSA-4090294, SUMOylation of intracellular receptors R-HSA-4551638, SUMOylation of chromatin organization proteins R-HSA-4570464, SUMOylation of RNA binding proteins R-HSA-4615885, SUMOylation of DNA replication proteins R-HSA-4655427, SUMOylation of DNA methylation proteins R-HSA-4755510, SUMOylation of immune response proteins R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693571, Nonhomologous End-Joining (NHEJ) R-HSA-5693607, Processing of DNA double-strand break ends R-HSA-5696395, Formation of Incision Complex in GG-NER R-HSA-69473, G2/M DNA damage checkpoint R-HSA-877312, Regulation of IFNG signaling R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation R-HSA-9683610, Maturation of nucleoprotein R-HSA-9694631, Maturation of nucleoprotein |
SignaLinki | P63165 |
SIGNORi | P63165 |
Miscellaneous databases
BioGRID-ORCSi | 7341, 46 hits in 1041 CRISPR screens |
ChiTaRSi | SUMO1, human |
EvolutionaryTracei | P63165 |
GeneWikii | Small_ubiquitin-related_modifier_1 |
GenomeRNAii | 7341 |
Pharosi | P63165, Tbio |
PROi | PR:P63165 |
RNActi | P63165, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116030, Expressed in caudate nucleus and 217 other tissues |
ExpressionAtlasi | P63165, baseline and differential |
Genevisiblei | P63165, HS |
Family and domain databases
CDDi | cd16114, Ubl_SUMO1, 1 hit |
DisProti | DP02294 |
IDEALi | IID00378 |
InterProi | View protein in InterPro IPR022617, Rad60/SUMO-like_dom IPR046332, SUMO1_Ubl IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF11976, Rad60-SLD, 1 hit |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SUMO1_HUMAN | |
Accessioni | P63165Primary (citable) accession number: P63165 Secondary accession number(s): A8MUS8 Q93068 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | September 27, 2004 | |
Last modified: | May 25, 2022 | |
This is version 197 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families