SUMO1

Functionⁱ

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).7 Publications

GO - Molecular functionⁱ

enzyme binding
Source: CAFA
Inferred from physical interactionⁱ
- 11889051
- 15959518
glucocorticoid receptor binding
Source: CAFA
Inferred from physical interactionⁱ
- 17081986
potassium channel regulator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19223394
protein binding, bridging
Source: CAFA
Inferred from mutant phenotypeⁱ
- 17081986
protein C-terminus binding
Source: CAFA
Inferred from direct assayⁱ
- 15959518
protein tag
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
small protein activating enzyme binding
Source: CAFA
Inferred from physical interactionⁱ
- 15660128
SUMO transferase activity
Source: Reactome
Inferred from experimentⁱ
- 19744555
- 20209145
transcription corepressor binding
Source: CAFA
Inferred from physical interactionⁱ
- 17081986
transcription factor binding Source: AgBase
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18408734

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to cadmium ion
Source: UniProtKB
Inferred from direct assayⁱ
- 11514557
cellular response to heat
Source: UniProtKB
Inferred from direct assayⁱ
- 11514557
DNA repair
Source: ProtInc
Traceable author statementⁱ
- 8812453
double-strand break repair via nonhomologous end joining Source: Reactome
negative regulation of action potential
Source: UniProtKB
Inferred from direct assayⁱ
- 19223394
negative regulation of delayed rectifier potassium channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19223394
negative regulation of DNA binding
Source: CAFA
Inferred from direct assayⁱ
- 16626738
negative regulation of DNA-binding transcription factor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12072434
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 15572661
negative regulation of transcription by RNA polymerase II Source: Reactome
PML body organization Source: Ensembl
positive regulation of calcium-transporting ATPase activity Source: Ensembl
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 18408734
positive regulation of protein complex assembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 18579533
protein localization to nuclear pore Source: Ensembl
protein stabilization
Source: UniProtKB
Inferred from direct assayⁱ
- 21968017
protein sumoylation
Source: UniProtKB
Inferred from direct assayⁱ
regulation of cardiac muscle cell contraction Source: Ensembl
regulation of interferon-gamma-mediated signaling pathway Source: Reactome
regulation of protein localization
Source: UniProtKB
Traceable author statementⁱ
- 15637059
roof of mouth development Source: UniProtKB
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Host-virus interaction, Ubl conjugation pathway

Biological process

Host-virus interaction, Ubl conjugation pathway

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000116030-MONOMER
Reactomeⁱ	R-HSA-3065676 SUMO is conjugated to E1 (UBA2:SAE1) R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) R-HSA-3065679 SUMO is proteolytically processed R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-3232118 SUMOylation of transcription factors R-HSA-3232142 SUMOylation of ubiquitinylation proteins R-HSA-3899300 SUMOylation of transcription cofactors R-HSA-4085377 SUMOylation of SUMOylation proteins R-HSA-4090294 SUMOylation of intracellular receptors R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-4570464 SUMOylation of RNA binding proteins R-HSA-4615885 SUMOylation of DNA replication proteins R-HSA-4655427 SUMOylation of DNA methylation proteins R-HSA-4755510 SUMOylation of immune response proteins R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693571 Nonhomologous End-Joining (NHEJ) R-HSA-5693607 Processing of DNA double-strand break ends R-HSA-5696395 Formation of Incision Complex in GG-NER R-HSA-69473 G2/M DNA damage checkpoint R-HSA-877312 Regulation of IFNG signaling R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
SignaLinkⁱ	P63165
SIGNORⁱ	P63165

Protein family/group databases

MoonDBⁱ	P63165 Predicted

MoonDBⁱ

P63165 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Small ubiquitin-related modifier 1 Short name: SUMO-1 Alternative name(s): GAP-modifying protein 1 Short name: GMP1 SMT3 homolog 3 Sentrin Ubiquitin-homology domain protein PIC1 Ubiquitin-like protein SMT3C Short name: Smt3C Ubiquitin-like protein UBL1
Gene namesⁱ	Name:SUMO1 Synonyms:SMT3C, SMT3H3, UBL1 ORF Names:OK/SW-cl.43
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116030.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12502 SUMO1
MIMⁱ	601912 gene
neXtProtⁱ	NX_P63165

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Non-syndromic orofacial cleft 10 (OFC10)1 Publication

The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays.

Disease descriptionA birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	36	F → A: Abolishes binding to PIAS2. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7341
MalaCards human disease database More...MalaCardsⁱ	SUMO1
MIMⁱ	613705 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000116030
Orphanetⁱ	99798 Oligodontia
PharmGKBⁱ	PA37149

Chemistry databases

ChEMBLⁱ	CHEMBL2146296

ChEMBLⁱ

CHEMBL2146296

Polymorphism and mutation databases

BioMutaⁱ	SUMO1
DMDMⁱ	52783799

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000035939	2 – 97	Small ubiquitin-related modifier 1Add BLAST	96
PropeptideⁱPRO_0000035940	98 – 101	1 Publication	4

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources1 Publication	1
Modified residueⁱ	2	PhosphoserineCombined sources1 Publication	1
Cross-linkⁱ	7	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
Cross-linkⁱ	7	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	9	PhosphoserineCombined sources	1
Cross-linkⁱ	16	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	17	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	23	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	25	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
Modified residueⁱ	32	PhosphoserineCombined sources	1
Cross-linkⁱ	37	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	39	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	45	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	46	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	97	Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Post-translational modificationⁱ

Cleavage of precursor form by SENP1 or SENP2 is necessary for function.1 Publication

Polymeric SUMO1 chains undergo polyubiquitination by RNF4.

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P63165
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P63165
PaxDbⁱ	P63165
PeptideAtlas More...PeptideAtlasⁱ	P63165
PRIDEⁱ	P63165
ProteomicsDBⁱ	12703 57500
TopDownProteomicsⁱ	P63165-1 [P63165-1]

PTM databases

iPTMnetⁱ	P63165
PhosphoSitePlusⁱ	P63165

Miscellaneous databases

PMAP-CutDBⁱ	P63165

PMAP-CutDBⁱ

P63165

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000116030 Expressed in 202 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_SUMO1
ExpressionAtlasⁱ	P63165 baseline and differential
Genevisibleⁱ	P63165 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004269 HPA056956

HPAⁱ

CAB004269
HPA056956

Interactionⁱ

Subunit structureⁱ

Covalently attached to KCNB1; UBE2I increases cross-linking with KCNB1 and PIAS1 decreases cross-links with KCNB1 (PubMed:19223394). Interacts with SAE2, RANBP2, PIAS1 and PIAS2. Interacts with PRKN. Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52. Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains). Interacts with BHLHE40/DEC1. Interacts with RWDD3. Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3. Interacts with MTA1.17 Publications

(Microbial infection) Interacts with Epstein-barr virus BGLF4.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	36	Interaction with PIAS2		1

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	G2XKQ0	3	EBI-80140,EBI-10175576
	Q59GP6	3	EBI-80140,EBI-10243413
AR	P10275	7	EBI-80140,EBI-608057
ATF2	P15336	5	EBI-80140,EBI-1170906
AXIN1	A0A0S2Z4M1	6	EBI-80140,EBI-16429430
AXIN1	O15169	3	EBI-80140,EBI-710484
BRCA1	P38398	3	EBI-80140,EBI-349905
C18orf25	Q96B23	5	EBI-80140,EBI-742108
CARD9	Q9H257	3	EBI-80140,EBI-751319
DAXX	Q9UER7	7	EBI-80140,EBI-77321
DEUP1	Q05D60	3	EBI-80140,EBI-748597
DNMT3B	Q9UBC3	4	EBI-80140,EBI-80125
DTX2	Q86UW9	3	EBI-80140,EBI-740376
EDARADD	Q8WWZ3	5	EBI-80140,EBI-2949647
EIF4E	P06730	5	EBI-80140,EBI-73440
ELK1	P19419	5	EBI-80140,EBI-726632
ELK1	P19419-1	2	EBI-80140,EBI-15799641
ETV6	A0A0S2Z3N6	3	EBI-80140,EBI-16434659
FAM118B	Q9BPY3	3	EBI-80140,EBI-726822
FBF1	Q8TES7-6	3	EBI-80140,EBI-10244131
FLJ13057	Q53SE7	3	EBI-80140,EBI-10172181
FSBP	O95073	3	EBI-80140,EBI-1059030
HGS	O14964	3	EBI-80140,EBI-740220
HIF1A	Q16665	4	EBI-80140,EBI-447269
HNRNPC	P07910	5	EBI-80140,EBI-357966
HSF1	Q00613	2	EBI-80140,EBI-719620
IKBKG	Q9Y6K9	3	EBI-80140,EBI-81279
IRF1	P10914	2	EBI-80140,EBI-1055781
KCNK1	O00180	3	EBI-80140,EBI-3914675
MAPK1IP1L	Q8NDC0	3	EBI-80140,EBI-741424
MBD1	Q9UIS9	3	EBI-80140,EBI-867196
MEF2A	Q02078-1	3	EBI-80140,EBI-15799584
MYB	P10242	3	EBI-80140,EBI-298355
NFKB2	Q00653	2	EBI-80140,EBI-307326
NPM1	P06748-1	3	EBI-80140,EBI-354150
PARP1	P09874	2	EBI-80140,EBI-355676
PIAS2	O75928	6	EBI-80140,EBI-348555
PML	P29590	6	EBI-80140,EBI-295890
PML	P29590-9	2	EBI-80140,EBI-6861318
PRDM1	O75626-2	2	EBI-80140,EBI-7839538
Prdm1	Q60636	3	EBI-80140,EBI-7000804	From Mus musculus.
PSIP1	O75475	4	EBI-80140,EBI-1801773
RAD54L2	Q9Y4B4	5	EBI-80140,EBI-948156
RANGAP1	P46060	13	EBI-80140,EBI-396091
RARA	P10276	5	EBI-80140,EBI-413374
RHOXF2	Q9BQY4	3	EBI-80140,EBI-372094
RWDD3	Q9Y3V2	2	EBI-80140,EBI-1549885
SART1	O43290	2	EBI-80140,EBI-607761
SATB1	Q01826	2	EBI-80140,EBI-743747
SENP1	Q9P0U3	8	EBI-80140,EBI-2822935
SENP2	Q9HC62	2	EBI-80140,EBI-714881
SOX10	P56693	2	EBI-80140,EBI-1167533
SOX2	P48431	3	EBI-80140,EBI-6124081
SP100	P23497	6	EBI-80140,EBI-751145
TANK	Q92844	8	EBI-80140,EBI-356349
TFCP2	Q12800	3	EBI-80140,EBI-717422
TP53	P04637	3	EBI-80140,EBI-366083
TP53BP1	Q12888	2	EBI-80140,EBI-396540
TP53BP1	Q12888-1	2	EBI-80140,EBI-8022649
TRAF4	Q9BUZ4	3	EBI-80140,EBI-3650647
UBA2	Q9UBT2	7	EBI-80140,EBI-718569
UBE2I	P63279	9	EBI-80140,EBI-80168
UBE2I	Q7KZS0	5	EBI-80140,EBI-10180829
USPL1	Q5W0Q7	5	EBI-80140,EBI-2513899
ZBTB26	Q9HCK0	5	EBI-80140,EBI-3918996
ZBTB6	Q15916	3	EBI-80140,EBI-7227791
ZCCHC12	Q6PEW1	6	EBI-80140,EBI-748373
ZMYM5	Q9UJ78	3	EBI-80140,EBI-7228860

With

Entry

#Exp.

IntAct

Notes

G2XKQ0

3

EBI-80140,EBI-10175576

Q59GP6

3

EBI-80140,EBI-10243413

AR

P10275

7

EBI-80140,EBI-608057

ATF2

P15336

5

EBI-80140,EBI-1170906

AXIN1

A0A0S2Z4M1

6

EBI-80140,EBI-16429430

AXIN1

3

BRCA1

3

C18orf25

5

CARD9

3

DAXX

7

DEUP1

3

DNMT3B

4

DTX2

3

EDARADD

5

EBI-80140,EBI-2949647

EIF4E

5

ELK1

5

ELK1

2

EBI-80140,EBI-15799641

ETV6

A0A0S2Z3N6

3

EBI-80140,EBI-16434659

FAM118B

Q9BPY3

3

EBI-80140,EBI-726822

FBF1

Q8TES7-6

3

EBI-80140,EBI-10244131

FLJ13057

Q53SE7

3

EBI-80140,EBI-10172181

FSBP

O95073

3

EBI-80140,EBI-1059030

HGS

3

HIF1A

4

HNRNPC

5

HSF1

2

IKBKG

3

IRF1

2

EBI-80140,EBI-1055781

KCNK1

O00180

3

EBI-80140,EBI-3914675

MAPK1IP1L

3

MBD1

3

MEF2A

3

EBI-80140,EBI-15799584

MYB

3

NFKB2

2

NPM1

3

PARP1

2

PIAS2

6

PML

6

PML

2

EBI-80140,EBI-6861318

PRDM1

O75626-2

2

EBI-80140,EBI-7839538

Prdm1

Q60636

3

EBI-80140,EBI-7000804

From Mus musculus.

PSIP1

O75475

4

EBI-80140,EBI-1801773

RAD54L2

5

RANGAP1

13

RARA

5

RHOXF2

3

RWDD3

2

EBI-80140,EBI-1549885

SART1

2

SATB1

2

SENP1

8

EBI-80140,EBI-2822935

SENP2

Q9HC62

2

EBI-80140,EBI-714881

SOX10

P56693

2

EBI-80140,EBI-1167533

SOX2

P48431

3

EBI-80140,EBI-6124081

SP100

6

TANK

8

TFCP2

3

TP53

3

TP53BP1

2

TP53BP1

2

EBI-80140,EBI-8022649

TRAF4

Q9BUZ4

3

EBI-80140,EBI-3650647

UBA2

7

UBE2I

9

UBE2I

5

EBI-80140,EBI-10180829

USPL1

Q5W0Q7

5

EBI-80140,EBI-2513899

ZBTB26

Q9HCK0

5

EBI-80140,EBI-3918996

ZBTB6

Q15916

3

EBI-80140,EBI-7227791

ZCCHC12

Q6PEW1

6

EBI-80140,EBI-748373

ZMYM5

Q9UJ78

3

EBI-80140,EBI-7228860

GO - Molecular functionⁱ

enzyme binding
Source: CAFA
Inferred from physical interactionⁱ
- 11889051
- 15959518
glucocorticoid receptor binding
Source: CAFA
Inferred from physical interactionⁱ
- 17081986
protein binding, bridging
Source: CAFA
Inferred from mutant phenotypeⁱ
- 17081986
protein C-terminus binding
Source: CAFA
Inferred from direct assayⁱ
- 15959518
small protein activating enzyme binding
Source: CAFA
Inferred from physical interactionⁱ
- 15660128
transcription corepressor binding
Source: CAFA
Inferred from physical interactionⁱ
- 17081986
transcription factor binding Source: AgBase
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18408734

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113188, 174 interactors
ComplexPortalⁱ	CPX-3042 activated SUMO1-E1 ligase complex CPX-3043 sumoylated E2 ligase complex (SUMO1)
CORUMⁱ	P63165
Database of interacting proteins More...DIPⁱ	DIP-29080N
IntActⁱ	P63165, 162 interactors
Molecular INTeraction database More...MINTⁱ	P63165
STRINGⁱ	9606.ENSP00000376076

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	2 – 6	Combined sources	5
Turnⁱ	9 – 11	Combined sources	3
Turnⁱ	16 – 18	Combined sources	3
Beta strandⁱ	22 – 27	Combined sources	6
Beta strandⁱ	29 – 31	Combined sources	3
Beta strandⁱ	33 – 38	Combined sources	6
Beta strandⁱ	40 – 42	Combined sources	3
Helixⁱ	45 – 55	Combined sources	11
Helixⁱ	59 – 61	Combined sources	3
Beta strandⁱ	62 – 66	Combined sources	5
Beta strandⁱ	69 – 71	Combined sources	3
Helixⁱ	77 – 80	Combined sources	4
Beta strandⁱ	87 – 92	Combined sources	6
Beta strandⁱ	96 – 99	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P63165
SMRⁱ	P63165
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P63165

EvolutionaryTraceⁱ

P63165

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	20 – 97	Ubiquitin-likePROSITE-ProRule annotationAdd BLAST		78

Sequence similaritiesⁱ

Belongs to the ubiquitin family. SUMO subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1769 Eukaryota COG5227 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018808
HOGENOMⁱ	HOG000207495
HOVERGENⁱ	HBG053025
InParanoidⁱ	P63165
KEGG Orthology (KO) More...KOⁱ	K12160
PhylomeDBⁱ	P63165
TreeFamⁱ	TF315116

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01763 Sumo, 1 hit
InterProⁱ	View protein in InterPro IPR022617 Rad60/SUMO-like_dom IPR033950 Sumo IPR029071 Ubiquitin-like_domsf IPR000626 Ubiquitin_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11976 Rad60-SLD, 1 hit
SMARTⁱ	View protein in SMART SM00213 UBQ, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50053 UBIQUITIN_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P63165-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDQEAKPST EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES 
        60         70         80         90        100
YCQRQGVPMN SLRFLFEGQR IADNHTPKEL GMEEEDVIEV YQEQTGGHST 

V

Length:101

Mass (Da):11,557

Last modified:September 27, 2004 - v1

Checksum:ⁱ89BE97D2D054FB33

GO

Isoform 2 (identifier: P63165-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
4-28: Missing.

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        10         20         30         40         50
MSDQDSSEIH FKVKMTTHLK KLKESYCQRQ GVPMNSLRFL FEGQRIADNH 
        60         70 
TPKELGMEEE DVIEVYQEQT GGHSTV

Note: No experimental confirmation available. Gene prediction based on EST data.

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Length:76

Mass (Da):8,799

Checksum:ⁱ709FCA25A95F9020

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B8ZZN6	B8ZZN6_HUMAN	Small ubiquitin-related modifier 1 Small ubiquitin-related modifier 1	SUMO1	146	Annotation score:
B8ZZJ0	B8ZZJ0_HUMAN	Small ubiquitin-related modifier 1 Small ubiquitin-related modifier 1	SUMO1	58	Annotation score:
B9A032	B9A032_HUMAN	Small ubiquitin-related modifier 1 Small ubiquitin-related modifier 1	SUMO1	77	Annotation score:
B8ZZ67	B8ZZ67_HUMAN	SMT3 suppressor of mif two 3 homolo... SMT3 suppressor of mif two 3 homolog 1 (Yeast), isoform CRA_b (Small ubiquitin-related modifier 1)	SUMO1 hCG_1776791	62	Annotation score:
F8WBI1	F8WBI1_HUMAN	Small ubiquitin-related modifier 1 Small ubiquitin-related modifier 1	SUMO1	73	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	75	H → N in AAH66306 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046756	4 – 28	Missing in isoform 2. CuratedAdd BLAST		25

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X99586 mRNA Translation: CAA67898.1 U61397 mRNA Translation: AAB40388.1 U38784 mRNA Translation: AAC50733.1 U67122 mRNA Translation: AAC50996.1 U72722 mRNA Translation: AAB40390.1 U83117 mRNA Translation: AAB39999.1 AB062294 mRNA Translation: BAB93477.1 BT006632 mRNA Translation: AAP35278.1 CR542147 mRNA Translation: CAG46944.1 CR542156 mRNA Translation: CAG46953.1 AK311840 mRNA Translation: BAG34782.1 AC079354 Genomic DNA Translation: AAY24035.1 CH471063 Genomic DNA Translation: EAW70304.1 CH471063 Genomic DNA Translation: EAW70307.1 BC006462 mRNA Translation: AAH06462.1 BC053528 mRNA Translation: AAH53528.1 BC066306 mRNA Translation: AAH66306.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2352.1 [P63165-1] CCDS46493.1 [P63165-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001005781.1, NM_001005781.1 [P63165-1] NP_001005782.1, NM_001005782.1 [P63165-2] NP_003343.1, NM_003352.4 [P63165-1]
UniGeneⁱ	Hs.81424

Genome annotation databases

Ensemblⁱ	ENST00000392244; ENSP00000376075; ENSG00000116030 [P63165-2] ENST00000392245; ENSP00000376076; ENSG00000116030 [P63165-1] ENST00000392246; ENSP00000376077; ENSG00000116030 [P63165-1]
GeneIDⁱ	7341
KEGGⁱ	hsa:7341
UCSC genome browser More...UCSCⁱ	uc002uyz.2 human [P63165-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P63165	Small ubiquitin-related modifier 1		BOVIN		101	UniRef100_P63165
Small ubiquitin-related modifier 1		MOUSE		101
Small ubiquitin-related modifier 1		PIG		101
Small ubiquitin-related modifier 1		PONAB		101
Small ubiquitin-related modifier 1		RAT		101
+27
P63165-2	Small ubiquitin-related modifier		PANTR		76	UniRef100_K7DGL2
Small ubiquitin-related modifier		PROCO		76
Small ubiquitin-related modifier		SAIBB		76
Small ubiquitin-related modifier		CALJA		76
Small ubiquitin-related modifier		MACMU		76
+12

Protein	Similar proteins		Species	Score	Length	Source
P63165	Small ubiquitin-related modifier 1		BOVIN		101	UniRef90_P63165
Small ubiquitin-related modifier 1		MOUSE		101
Small ubiquitin-related modifier 1		PIG		101
Small ubiquitin-related modifier 1		PONAB		101
Small ubiquitin-related modifier 1		RAT		101
+27
P63165-2	Small ubiquitin-related modifier		FELCA		76	UniRef90_M3WR50
Small ubiquitin-related modifier		ALLMI		93
Small ubiquitin-related modifier		PANTR		76
Small ubiquitin-related modifier		PROCO		76
Small ubiquitin-related modifier		SAIBB		76
+22

Protein	Similar proteins		Species	Score	Length	Source
P63165	Small ubiquitin-related modifier 1		BOVIN		101	UniRef50_P63165
Small ubiquitin-related modifier 1		MOUSE		101
Small ubiquitin-related modifier 1		PIG		101
Small ubiquitin-related modifier 1		PONAB		101
Small ubiquitin-related modifier 1		RAT		101
+31
P63165-2	Small ubiquitin-related modifier		NOMLE		88	UniRef50_A0A2I3HS90
Small ubiquitin-related modifier		MACFA		77
Small ubiquitin-related modifier		COLAP		74
Small ubiquitin-related modifier		SAIBB		88
Uncharacterized protein		FELCA		91
+34

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

SUMO protein entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X99586 mRNA Translation: CAA67898.1 U61397 mRNA Translation: AAB40388.1 U38784 mRNA Translation: AAC50733.1 U67122 mRNA Translation: AAC50996.1 U72722 mRNA Translation: AAB40390.1 U83117 mRNA Translation: AAB39999.1 AB062294 mRNA Translation: BAB93477.1 BT006632 mRNA Translation: AAP35278.1 CR542147 mRNA Translation: CAG46944.1 CR542156 mRNA Translation: CAG46953.1 AK311840 mRNA Translation: BAG34782.1 AC079354 Genomic DNA Translation: AAY24035.1 CH471063 Genomic DNA Translation: EAW70304.1 CH471063 Genomic DNA Translation: EAW70307.1 BC006462 mRNA Translation: AAH06462.1 BC053528 mRNA Translation: AAH53528.1 BC066306 mRNA Translation: AAH66306.1
CCDSⁱ	CCDS2352.1 [P63165-1] CCDS46493.1 [P63165-2]
RefSeqⁱ	NP_001005781.1, NM_001005781.1 [P63165-1] NP_001005782.1, NM_001005782.1 [P63165-2] NP_003343.1, NM_003352.4 [P63165-1]
UniGeneⁱ	Hs.81424

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1A5R	NMR	-	A	1-101	[»]
	1TGZ	X-ray	2.80	B	18-97	[»]
	1WYW	X-ray	2.10	B	1-97	[»]
	1Y8R	X-ray	2.75	C/F	1-97	[»]
	1Z5S	X-ray	3.01	B	18-97	[»]
	2ASQ	NMR	-	A	1-97	[»]
	2BF8	X-ray	2.30	B	21-97	[»]
	2G4D	X-ray	2.80	B/D	20-97	[»]
	2IO2	X-ray	2.90	B	18-97	[»]
	2IY0	X-ray	2.77	B	20-101	[»]
	2IY1	X-ray	2.46	B/D	20-101	[»]
	2KQS	NMR	-	A	1-97	[»]
	2LAS	NMR	-	A	1-101	[»]
	2MW5	NMR	-	A	1-97	[»]
	2N1A	NMR	-	A	1-101	[»]
	2N1V	NMR	-	A	1-97	[»]
	2PE6	X-ray	2.40	B	1-97	[»]
	2UYZ	X-ray	1.40	B	20-97	[»]
	2VRR	X-ray	2.22	B	20-97	[»]
	3KYC	X-ray	2.45	D	1-97	[»]
	3KYD	X-ray	2.61	D	1-94	[»]
	3RZW	X-ray	2.15	C/D	1-97	[»]
	3UIP	X-ray	2.29	B	18-97	[»]
	4WJN	X-ray	1.50	A	17-97	[»]
	4WJO	X-ray	1.46	A	17-97	[»]
	4WJP	X-ray	1.70	A/C	17-97	[»]
	4WJQ	X-ray	1.35	A/C	17-97	[»]
	5AEK	X-ray	3.00	B/D/F/H/J/L/N/P/R/T/V/X	20-97	[»]
	5B7A	NMR	-	A	1-97	[»]
	5ELJ	X-ray	1.98	B	18-97	[»]
	5GHD	NMR	-	A	1-97	[»]
	6EOP	X-ray	2.40	D/E/F	61-68	[»]
	6EOT	X-ray	3.50	C/E/F/H/J/L	61-68	[»]
ProteinModelPortalⁱ	P63165
SMRⁱ	P63165
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113188, 174 interactors
ComplexPortalⁱ	CPX-3042 activated SUMO1-E1 ligase complex CPX-3043 sumoylated E2 ligase complex (SUMO1)
CORUMⁱ	P63165
DIPⁱ	DIP-29080N
IntActⁱ	P63165, 162 interactors
MINTⁱ	P63165
STRINGⁱ	9606.ENSP00000376076

Chemistry databases

ChEMBLⁱ	CHEMBL2146296

ChEMBLⁱ

CHEMBL2146296

Protein family/group databases

MoonDBⁱ	P63165 Predicted

MoonDBⁱ

P63165 Predicted

PTM databases

iPTMnetⁱ	P63165
PhosphoSitePlusⁱ	P63165

Polymorphism and mutation databases

BioMutaⁱ	SUMO1
DMDMⁱ	52783799

Proteomic databases

EPDⁱ	P63165
MaxQBⁱ	P63165
PaxDbⁱ	P63165
PeptideAtlasⁱ	P63165
PRIDEⁱ	P63165
ProteomicsDBⁱ	12703 57500
TopDownProteomicsⁱ	P63165-1 [P63165-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7341
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000392244; ENSP00000376075; ENSG00000116030 [P63165-2] ENST00000392245; ENSP00000376076; ENSG00000116030 [P63165-1] ENST00000392246; ENSP00000376077; ENSG00000116030 [P63165-1]
GeneIDⁱ	7341
KEGGⁱ	hsa:7341
UCSCⁱ	uc002uyz.2 human [P63165-1]

Organism-specific databases

CTDⁱ	7341
DisGeNETⁱ	7341
EuPathDBⁱ	HostDB:ENSG00000116030.16
GeneCardsⁱ	SUMO1
HGNCⁱ	HGNC:12502 SUMO1
HPAⁱ	CAB004269 HPA056956
MalaCardsⁱ	SUMO1
MIMⁱ	601912 gene 613705 phenotype
neXtProtⁱ	NX_P63165
OpenTargetsⁱ	ENSG00000116030
Orphanetⁱ	99798 Oligodontia
PharmGKBⁱ	PA37149
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1769 Eukaryota COG5227 LUCA
GeneTreeⁱ	ENSGT00390000018808
HOGENOMⁱ	HOG000207495
HOVERGENⁱ	HBG053025
InParanoidⁱ	P63165
KOⁱ	K12160
PhylomeDBⁱ	P63165
TreeFamⁱ	TF315116

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000116030-MONOMER
Reactomeⁱ	R-HSA-3065676 SUMO is conjugated to E1 (UBA2:SAE1) R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) R-HSA-3065679 SUMO is proteolytically processed R-HSA-3108214 SUMOylation of DNA damage response and repair proteins R-HSA-3232118 SUMOylation of transcription factors R-HSA-3232142 SUMOylation of ubiquitinylation proteins R-HSA-3899300 SUMOylation of transcription cofactors R-HSA-4085377 SUMOylation of SUMOylation proteins R-HSA-4090294 SUMOylation of intracellular receptors R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-4570464 SUMOylation of RNA binding proteins R-HSA-4615885 SUMOylation of DNA replication proteins R-HSA-4655427 SUMOylation of DNA methylation proteins R-HSA-4755510 SUMOylation of immune response proteins R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-5693571 Nonhomologous End-Joining (NHEJ) R-HSA-5693607 Processing of DNA double-strand break ends R-HSA-5696395 Formation of Incision Complex in GG-NER R-HSA-69473 G2/M DNA damage checkpoint R-HSA-877312 Regulation of IFNG signaling R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
SignaLinkⁱ	P63165
SIGNORⁱ	P63165

Miscellaneous databases

ChiTaRSⁱ	SUMO1 human
EvolutionaryTraceⁱ	P63165
GeneWikiⁱ	Small_ubiquitin-related_modifier_1
GenomeRNAiⁱ	7341
PMAP-CutDBⁱ	P63165
Protein Ontology More...PROⁱ	PR:P63165
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116030 Expressed in 202 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_SUMO1
ExpressionAtlasⁱ	P63165 baseline and differential
Genevisibleⁱ	P63165 HS

Family and domain databases

CDDⁱ	cd01763 Sumo, 1 hit
InterProⁱ	View protein in InterPro IPR022617 Rad60/SUMO-like_dom IPR033950 Sumo IPR029071 Ubiquitin-like_domsf IPR000626 Ubiquitin_dom
Pfamⁱ	View protein in Pfam PF11976 Rad60-SLD, 1 hit
SMARTⁱ	View protein in SMART SM00213 UBQ, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50053 UBIQUITIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SUMO1_HUMAN
Accessionⁱ	P63165Primary (citable) accession number: P63165 Secondary accession number(s): A8MUS8 , B2R4I5, P55856, Q6FGG0, Q6NZ62, Q93068
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
	Last sequence update:	September 27, 2004
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniRef

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Supporting data

UniProtKB - P63165 (SUMO1_HUMAN)

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Small ubiquitin-related modifier 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Plasma membrane

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ