UniProtKB - P63163 (RSMN_MOUSE)
Protein
Small nuclear ribonucleoprotein-associated protein N
Gene
Snrpn
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in tissue-specific alternative RNA processing events.
Miscellaneous
Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- mRNA splicing, via spliceosome Source: GO_Central
- response to hormone Source: Ensembl
Keywordsi
Molecular function | Ribonucleoprotein, RNA-binding |
Enzyme and pathway databases
Reactomei | R-MMU-72163, mRNA Splicing - Major Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Small nuclear ribonucleoprotein-associated protein NShort name: snRNP-N Alternative name(s): Sm protein D Short name: Sm-D Sm protein N Short name: Sm-N Short name: SmN Tissue-specific-splicing protein |
Gene namesi | Name:Snrpn Synonyms:Smn |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98347, Snrpn |
Subcellular locationi
Nucleus
Nucleus
- catalytic step 2 spliceosome Source: GO_Central
- nucleoplasm Source: MGI
- nucleus Source: MGI
- U1 snRNP Source: MGI
- U2 snRNP Source: MGI
- U2-type prespliceosome Source: GO_Central
- U4 snRNP Source: GO_Central
- U4/U6 x U5 tri-snRNP complex Source: GO_Central
- U5 snRNP Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125524 | 1 – 240 | Small nuclear ribonucleoprotein-associated protein NAdd BLAST | 240 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 108 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 108 | Dimethylated arginine; alternateBy similarity | 1 | |
Modified residuei | 108 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 112 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 112 | Dimethylated arginine; alternateBy similarity | 1 | |
Modified residuei | 112 | Omega-N-methylarginine; alternateBy similarity | 1 | |
Modified residuei | 147 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 172 | Omega-N-methylarginineCombined sources | 1 |
Keywords - PTMi
MethylationProteomic databases
PaxDbi | P63163 |
PeptideAtlasi | P63163 |
PRIDEi | P63163 |
PTM databases
iPTMneti | P63163 |
PhosphoSitePlusi | P63163 |
SwissPalmi | P63163 |
Expressioni
Tissue specificityi
Expressed in brain and embryonic stem (ES) cells.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000102252, Expressed in dentate gyrus of hippocampal formation granule cell and 301 other tissues |
Genevisiblei | P63163, MM |
Interactioni
Subunit structurei
Interacts with TDRD3.
By similarityProtein-protein interaction databases
BioGRIDi | 203381, 3 interactors |
IntActi | P63163, 1 interactor |
STRINGi | 10090.ENSMUSP00000096003 |
Miscellaneous databases
RNActi | P63163, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 175 – 181 | 7 | ||
Repeati | 191 – 196 | 6 | ||
Repeati | 216 – 221 | 6 | ||
Repeati | 222 – 228 | 7 | ||
Repeati | 230 – 236 | 7 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 175 – 236 | Repeat-rich regionAdd BLAST | 62 |
Sequence similaritiesi
Belongs to the snRNP SmB/SmN family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3168, Eukaryota |
GeneTreei | ENSGT00940000158222 |
HOGENOMi | CLU_076902_1_0_1 |
InParanoidi | P63163 |
OMAi | FAPQRPG |
OrthoDBi | 1630470at2759 |
PhylomeDBi | P63163 |
TreeFami | TF314232 |
Family and domain databases
InterProi | View protein in InterPro IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf IPR017131, snRNP-assoc_SmB/SmN |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
PIRSFi | PIRSF037187, snRNP_SmB/SmN, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
i Sequence
Sequence statusi: Complete.
P63163-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK
60 70 80 90 100
IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA
110 120 130 140 150
AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV
160 170 180 190 200
AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG
210 220 230 240
PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62648 mRNA Translation: CAA44517.1 X63730 mRNA Translation: CAA45273.1 S62288 mRNA Translation: AAB27138.1 AK013607 mRNA Translation: BAB28927.1 BC019589 mRNA Translation: AAH19589.1 BC024880 mRNA Translation: AAH24880.1 |
CCDSi | CCDS39974.1 |
PIRi | S20068 |
RefSeqi | NP_001076430.1, NM_001082961.1 NP_001076431.1, NM_001082962.1 NP_038698.1, NM_013670.3 |
Genome annotation databases
Ensembli | ENSMUST00000059305; ENSMUSP00000055941; ENSMUSG00000102252 ENSMUST00000098402; ENSMUSP00000096003; ENSMUSG00000102252 |
GeneIDi | 20646 |
KEGGi | mmu:20646 |
UCSCi | uc009heq.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62648 mRNA Translation: CAA44517.1 X63730 mRNA Translation: CAA45273.1 S62288 mRNA Translation: AAB27138.1 AK013607 mRNA Translation: BAB28927.1 BC019589 mRNA Translation: AAH19589.1 BC024880 mRNA Translation: AAH24880.1 |
CCDSi | CCDS39974.1 |
PIRi | S20068 |
RefSeqi | NP_001076430.1, NM_001082961.1 NP_001076431.1, NM_001082962.1 NP_038698.1, NM_013670.3 |
3D structure databases
SMRi | P63163 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203381, 3 interactors |
IntActi | P63163, 1 interactor |
STRINGi | 10090.ENSMUSP00000096003 |
PTM databases
iPTMneti | P63163 |
PhosphoSitePlusi | P63163 |
SwissPalmi | P63163 |
Proteomic databases
PaxDbi | P63163 |
PeptideAtlasi | P63163 |
PRIDEi | P63163 |
Protocols and materials databases
Antibodypediai | 22280, 152 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000059305; ENSMUSP00000055941; ENSMUSG00000102252 ENSMUST00000098402; ENSMUSP00000096003; ENSMUSG00000102252 |
GeneIDi | 20646 |
KEGGi | mmu:20646 |
UCSCi | uc009heq.3, mouse |
Organism-specific databases
CTDi | 6638 |
MGIi | MGI:98347, Snrpn |
Phylogenomic databases
eggNOGi | KOG3168, Eukaryota |
GeneTreei | ENSGT00940000158222 |
HOGENOMi | CLU_076902_1_0_1 |
InParanoidi | P63163 |
OMAi | FAPQRPG |
OrthoDBi | 1630470at2759 |
PhylomeDBi | P63163 |
TreeFami | TF314232 |
Enzyme and pathway databases
Reactomei | R-MMU-72163, mRNA Splicing - Major Pathway |
Miscellaneous databases
BioGRID-ORCSi | 20646, 1 hit in 17 CRISPR screens |
ChiTaRSi | Snrpn, mouse |
PROi | PR:P63163 |
RNActi | P63163, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000102252, Expressed in dentate gyrus of hippocampal formation granule cell and 301 other tissues |
Genevisiblei | P63163, MM |
Family and domain databases
InterProi | View protein in InterPro IPR001163, LSM_dom_euk/arc IPR010920, LSM_dom_sf IPR017131, snRNP-assoc_SmB/SmN |
Pfami | View protein in Pfam PF01423, LSM, 1 hit |
PIRSFi | PIRSF037187, snRNP_SmB/SmN, 1 hit |
SMARTi | View protein in SMART SM00651, Sm, 1 hit |
SUPFAMi | SSF50182, SSF50182, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RSMN_MOUSE | |
Accessioni | P63163Primary (citable) accession number: P63163 Secondary accession number(s): P14648, P17135 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | September 27, 2004 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families