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Protein

Small nuclear ribonucleoprotein-associated protein N

Gene

SNRPN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in tissue-specific alternative RNA processing events.

Miscellaneous

Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.
Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. N bears Sm epitopes.

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • response to hormone Source: Ensembl
  • RNA splicing Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
SIGNORiP63162

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein-associated protein N
Short name:
snRNP-N
Alternative name(s):
Sm protein D
Short name:
Sm-D
Sm protein N
Short name:
Sm-N
Short name:
SmN
Tissue-specific-splicing protein
Gene namesi
Name:SNRPN
Synonyms:HCERN3, SMN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000128739.21
HGNCiHGNC:11164 SNRPN
MIMi182279 gene
neXtProtiNX_P63162

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6638
8926
GeneReviewsiSNRPN
MalaCardsiSNRPN
OpenTargetsiENSG00000128739
Orphaneti411515 Angelman syndrome due to imprinting defect in 15q11-q13
177910 Prader-Willi syndrome due to imprinting mutation
98754 Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
177901 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
177904 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
177907 Prader-Willi syndrome due to translocation
PharmGKBiPA36005

Polymorphism and mutation databases

BioMutaiSNRPN
DMDMi52783794

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255231 – 240Small nuclear ribonucleoprotein-associated protein NAdd BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei108Dimethylated arginine; alternateBy similarity1
Modified residuei108Omega-N-methylarginine; alternateBy similarity1
Modified residuei112Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei112Dimethylated arginine; alternateBy similarity1
Modified residuei112Omega-N-methylarginine; alternateBy similarity1
Modified residuei147Omega-N-methylarginineBy similarity1
Modified residuei172Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiP63162
PaxDbiP63162
PeptideAtlasiP63162
PRIDEiP63162
ProteomicsDBi57499

PTM databases

iPTMnetiP63162
PhosphoSitePlusiP63162
SwissPalmiP63162

Expressioni

Tissue specificityi

Expressed in brain and lymphoblasts.1 Publication

Gene expression databases

BgeeiENSG00000128739 Expressed in 232 organ(s), highest expression level in cerebellum
CleanExiHS_SNRPN
ExpressionAtlasiP63162 baseline and differential
GenevisibleiP63162 HS

Organism-specific databases

HPAiHPA003482
HPA067842

Interactioni

Subunit structurei

Interacts with TDRD3.1 Publication

Protein-protein interaction databases

BioGridi112522, 117 interactors
CORUMiP63162
IntActiP63162, 12 interactors
MINTiP63162
STRINGi9606.ENSP00000306223

Structurei

3D structure databases

ProteinModelPortaliP63162
SMRiP63162
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati175 – 1817
Repeati191 – 1966
Repeati216 – 2216
Repeati222 – 2287
Repeati230 – 2367

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni175 – 236Repeat-rich regionAdd BLAST62

Sequence similaritiesi

Belongs to the snRNP SmB/SmN family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3168 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00670000098029
HOGENOMiHOG000188899
HOVERGENiHBG001019
InParanoidiP63162
KOiK11100
OMAiFAPQRPG
OrthoDBiEOG091G0Y7H
PhylomeDBiP63162
TreeFamiTF314232

Family and domain databases

InterProiView protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR017131 snRNP-assoc_SmB/SmN
PfamiView protein in Pfam
PF01423 LSM, 1 hit
PIRSFiPIRSF037187 snRNP_SmB/SmN, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P63162-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK
60 70 80 90 100
IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA
110 120 130 140 150
AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV
160 170 180 190 200
AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG
210 220 230 240
PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP
Length:240
Mass (Da):24,614
Last modified:September 27, 2004 - v1
Checksum:i9A176D043561474C
GO
Isoform 2 (identifier: P63162-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMDSQ

Note: No experimental confirmation available.
Show »
Length:244
Mass (Da):25,076
Checksum:i3571C3010653A837
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QLE5J3QLE5_HUMAN
Small nuclear ribonucleoprotein-ass...
SNRPN
169Annotation score:
J3KRY3J3KRY3_HUMAN
Small nuclear ribonucleoprotein-ass...
SNRPN
59Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43 – 44Missing (PubMed:8363612).Curated2
Sequence conflicti75E → Q (PubMed:8363612).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0564881M → MMDSQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15892 mRNA Translation: CAA33901.1
J04615 mRNA Translation: AAA36617.1
U41303 mRNA Translation: AAA98969.1
AF400432 mRNA Translation: AAK92481.1
AK123119 mRNA Translation: BAG53873.1
CR450350 mRNA Translation: CAG29346.1
AC090602 Genomic DNA No translation available.
AC090983 Genomic DNA No translation available.
AC124312 Genomic DNA No translation available.
BC000611 mRNA Translation: AAH00611.1
BC003180 mRNA Translation: AAH03180.1
BC024777 mRNA Translation: AAH24777.1
BC025178 mRNA Translation: AAH25178.1
CCDSiCCDS10017.1 [P63162-1]
PIRiA33270
RefSeqiNP_003088.1, NM_003097.4 [P63162-1]
NP_005669.2, NM_005678.4
NP_073716.1, NM_022805.3 [P63162-1]
NP_073717.1, NM_022806.3 [P63162-1]
NP_073718.1, NM_022807.3 [P63162-1]
NP_073719.1, NM_022808.3 [P63162-1]
UniGeneiHs.564847

Genome annotation databases

EnsembliENST00000346403; ENSP00000306223; ENSG00000128739 [P63162-1]
ENST00000390687; ENSP00000375105; ENSG00000128739 [P63162-1]
ENST00000400097; ENSP00000382969; ENSG00000128739 [P63162-1]
ENST00000400100; ENSP00000382972; ENSG00000128739 [P63162-1]
ENST00000554227; ENSP00000452342; ENSG00000128739 [P63162-2]
ENST00000577565; ENSP00000463458; ENSG00000128739 [P63162-1]
ENST00000642807; ENSP00000495345; ENSG00000128739 [P63162-1]
ENST00000645002; ENSP00000494831; ENSG00000128739 [P63162-1]
GeneIDi6638
8926
KEGGihsa:6638
hsa:8926
UCSCiuc059gty.1 human [P63162-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15892 mRNA Translation: CAA33901.1
J04615 mRNA Translation: AAA36617.1
U41303 mRNA Translation: AAA98969.1
AF400432 mRNA Translation: AAK92481.1
AK123119 mRNA Translation: BAG53873.1
CR450350 mRNA Translation: CAG29346.1
AC090602 Genomic DNA No translation available.
AC090983 Genomic DNA No translation available.
AC124312 Genomic DNA No translation available.
BC000611 mRNA Translation: AAH00611.1
BC003180 mRNA Translation: AAH03180.1
BC024777 mRNA Translation: AAH24777.1
BC025178 mRNA Translation: AAH25178.1
CCDSiCCDS10017.1 [P63162-1]
PIRiA33270
RefSeqiNP_003088.1, NM_003097.4 [P63162-1]
NP_005669.2, NM_005678.4
NP_073716.1, NM_022805.3 [P63162-1]
NP_073717.1, NM_022806.3 [P63162-1]
NP_073718.1, NM_022807.3 [P63162-1]
NP_073719.1, NM_022808.3 [P63162-1]
UniGeneiHs.564847

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MF9NMR-B219-225[»]
ProteinModelPortaliP63162
SMRiP63162
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112522, 117 interactors
CORUMiP63162
IntActiP63162, 12 interactors
MINTiP63162
STRINGi9606.ENSP00000306223

PTM databases

iPTMnetiP63162
PhosphoSitePlusiP63162
SwissPalmiP63162

Polymorphism and mutation databases

BioMutaiSNRPN
DMDMi52783794

Proteomic databases

EPDiP63162
PaxDbiP63162
PeptideAtlasiP63162
PRIDEiP63162
ProteomicsDBi57499

Protocols and materials databases

DNASUi6638
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346403; ENSP00000306223; ENSG00000128739 [P63162-1]
ENST00000390687; ENSP00000375105; ENSG00000128739 [P63162-1]
ENST00000400097; ENSP00000382969; ENSG00000128739 [P63162-1]
ENST00000400100; ENSP00000382972; ENSG00000128739 [P63162-1]
ENST00000554227; ENSP00000452342; ENSG00000128739 [P63162-2]
ENST00000577565; ENSP00000463458; ENSG00000128739 [P63162-1]
ENST00000642807; ENSP00000495345; ENSG00000128739 [P63162-1]
ENST00000645002; ENSP00000494831; ENSG00000128739 [P63162-1]
GeneIDi6638
8926
KEGGihsa:6638
hsa:8926
UCSCiuc059gty.1 human [P63162-1]

Organism-specific databases

CTDi6638
8926
DisGeNETi6638
8926
EuPathDBiHostDB:ENSG00000128739.21
GeneCardsiSNRPN
GeneReviewsiSNRPN
HGNCiHGNC:11164 SNRPN
HPAiHPA003482
HPA067842
MalaCardsiSNRPN
MIMi182279 gene
neXtProtiNX_P63162
OpenTargetsiENSG00000128739
Orphaneti411515 Angelman syndrome due to imprinting defect in 15q11-q13
177910 Prader-Willi syndrome due to imprinting mutation
98754 Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
177901 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
177904 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
177907 Prader-Willi syndrome due to translocation
PharmGKBiPA36005
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3168 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00670000098029
HOGENOMiHOG000188899
HOVERGENiHBG001019
InParanoidiP63162
KOiK11100
OMAiFAPQRPG
OrthoDBiEOG091G0Y7H
PhylomeDBiP63162
TreeFamiTF314232

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
SIGNORiP63162

Miscellaneous databases

ChiTaRSiSNRPN human
GeneWikiiSmall_nuclear_ribonucleoprotein_polypeptide_N
GenomeRNAii6638
PROiPR:P63162
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128739 Expressed in 232 organ(s), highest expression level in cerebellum
CleanExiHS_SNRPN
ExpressionAtlasiP63162 baseline and differential
GenevisibleiP63162 HS

Family and domain databases

InterProiView protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR017131 snRNP-assoc_SmB/SmN
PfamiView protein in Pfam
PF01423 LSM, 1 hit
PIRSFiPIRSF037187 snRNP_SmB/SmN, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRSMN_HUMAN
AccessioniPrimary (citable) accession number: P63162
Secondary accession number(s): B3KVR1
, P14648, P17135, Q0D2Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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