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Entry version 157 (10 Apr 2019)
Sequence version 1 (27 Sep 2004)
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Protein

Small nuclear ribonucleoprotein-associated protein N

Gene

SNRPN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in tissue-specific alternative RNA processing events.

Miscellaneous

Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF.
Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. N bears Sm epitopes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • response to hormone Source: Ensembl
  • RNA splicing Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P63162

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small nuclear ribonucleoprotein-associated protein N
Short name:
snRNP-N
Alternative name(s):
Sm protein D
Short name:
Sm-D
Sm protein N
Short name:
Sm-N
Short name:
SmN
Tissue-specific-splicing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNRPN
Synonyms:HCERN3, SMN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000128739.21

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11164 SNRPN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
182279 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P63162

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6638
8926

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SNRPN

MalaCards human disease database

More...
MalaCardsi
SNRPN

Open Targets

More...
OpenTargetsi
ENSG00000128739

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
411515 Angelman syndrome due to imprinting defect in 15q11-q13
177910 Prader-Willi syndrome due to imprinting mutation
98754 Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
177901 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
177904 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
177907 Prader-Willi syndrome due to translocation

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36005

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SNRPN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
52783794

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001255231 – 240Small nuclear ribonucleoprotein-associated protein NAdd BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei108Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei108Dimethylated arginine; alternateBy similarity1
Modified residuei108Omega-N-methylarginine; alternateBy similarity1
Modified residuei112Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei112Dimethylated arginine; alternateBy similarity1
Modified residuei112Omega-N-methylarginine; alternateBy similarity1
Modified residuei147Omega-N-methylarginineBy similarity1
Modified residuei172Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P63162

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P63162

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P63162

PeptideAtlas

More...
PeptideAtlasi
P63162

PRoteomics IDEntifications database

More...
PRIDEi
P63162

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57499

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P63162

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P63162

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P63162

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and lymphoblasts.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128739 Expressed in 232 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P63162 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P63162 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003482
HPA067842

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TDRD3.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112522, 121 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P63162

Protein interaction database and analysis system

More...
IntActi
P63162, 12 interactors

Molecular INTeraction database

More...
MINTi
P63162

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000382972

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MF9NMR-B219-225[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P63162

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P63162

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati175 – 1817
Repeati191 – 1966
Repeati216 – 2216
Repeati222 – 2287
Repeati230 – 2367

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni175 – 236Repeat-rich regionAdd BLAST62

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the snRNP SmB/SmN family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3168 Eukaryota
COG1958 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158222

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000188899

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG001019

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P63162

KEGG Orthology (KO)

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KOi
K11100

Identification of Orthologs from Complete Genome Data

More...
OMAi
FAPQRPG

Database of Orthologous Groups

More...
OrthoDBi
1630470at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P63162

TreeFam database of animal gene trees

More...
TreeFami
TF314232

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR017131 snRNP-assoc_SmB/SmN

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01423 LSM, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037187 snRNP_SmB/SmN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00651 Sm, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50182 SSF50182, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P63162-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK
60 70 80 90 100
IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA
110 120 130 140 150
AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV
160 170 180 190 200
AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG
210 220 230 240
PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP
Length:240
Mass (Da):24,614
Last modified:September 27, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A176D043561474C
GO
Isoform 2 (identifier: P63162-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MMDSQ

Note: No experimental confirmation available.
Show »
Length:244
Mass (Da):25,076
Checksum:i3571C3010653A837
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QLE5J3QLE5_HUMAN
Small nuclear ribonucleoprotein-ass...
SNRPN
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRY3J3KRY3_HUMAN
Small nuclear ribonucleoprotein-ass...
SNRPN
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43 – 44Missing (PubMed:8363612).Curated2
Sequence conflicti75E → Q (PubMed:8363612).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0564881M → MMDSQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X15892 mRNA Translation: CAA33901.1
J04615 mRNA Translation: AAA36617.1
U41303 mRNA Translation: AAA98969.1
AF400432 mRNA Translation: AAK92481.1
AK123119 mRNA Translation: BAG53873.1
CR450350 mRNA Translation: CAG29346.1
AC090602 Genomic DNA No translation available.
AC090983 Genomic DNA No translation available.
AC124312 Genomic DNA No translation available.
BC000611 mRNA Translation: AAH00611.1
BC003180 mRNA Translation: AAH03180.1
BC024777 mRNA Translation: AAH24777.1
BC025178 mRNA Translation: AAH25178.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10017.1 [P63162-1]

Protein sequence database of the Protein Information Resource

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PIRi
A33270

NCBI Reference Sequences

More...
RefSeqi
NP_003088.1, NM_003097.4 [P63162-1]
NP_005669.2, NM_005678.4
NP_073716.1, NM_022805.3 [P63162-1]
NP_073717.1, NM_022806.3 [P63162-1]
NP_073718.1, NM_022807.3 [P63162-1]
NP_073719.1, NM_022808.3 [P63162-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.564847

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000346403; ENSP00000306223; ENSG00000128739 [P63162-1]
ENST00000390687; ENSP00000375105; ENSG00000128739 [P63162-1]
ENST00000400097; ENSP00000382969; ENSG00000128739 [P63162-1]
ENST00000400100; ENSP00000382972; ENSG00000128739 [P63162-1]
ENST00000554227; ENSP00000452342; ENSG00000128739 [P63162-2]
ENST00000577565; ENSP00000463458; ENSG00000128739 [P63162-1]
ENST00000642807; ENSP00000495345; ENSG00000128739 [P63162-1]
ENST00000645002; ENSP00000494831; ENSG00000128739 [P63162-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6638
8926

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6638
hsa:8926

UCSC genome browser

More...
UCSCi
uc059gty.1 human [P63162-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15892 mRNA Translation: CAA33901.1
J04615 mRNA Translation: AAA36617.1
U41303 mRNA Translation: AAA98969.1
AF400432 mRNA Translation: AAK92481.1
AK123119 mRNA Translation: BAG53873.1
CR450350 mRNA Translation: CAG29346.1
AC090602 Genomic DNA No translation available.
AC090983 Genomic DNA No translation available.
AC124312 Genomic DNA No translation available.
BC000611 mRNA Translation: AAH00611.1
BC003180 mRNA Translation: AAH03180.1
BC024777 mRNA Translation: AAH24777.1
BC025178 mRNA Translation: AAH25178.1
CCDSiCCDS10017.1 [P63162-1]
PIRiA33270
RefSeqiNP_003088.1, NM_003097.4 [P63162-1]
NP_005669.2, NM_005678.4
NP_073716.1, NM_022805.3 [P63162-1]
NP_073717.1, NM_022806.3 [P63162-1]
NP_073718.1, NM_022807.3 [P63162-1]
NP_073719.1, NM_022808.3 [P63162-1]
UniGeneiHs.564847

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MF9NMR-B219-225[»]
ProteinModelPortaliP63162
SMRiP63162
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112522, 121 interactors
CORUMiP63162
IntActiP63162, 12 interactors
MINTiP63162
STRINGi9606.ENSP00000382972

PTM databases

iPTMnetiP63162
PhosphoSitePlusiP63162
SwissPalmiP63162

Polymorphism and mutation databases

BioMutaiSNRPN
DMDMi52783794

Proteomic databases

EPDiP63162
jPOSTiP63162
PaxDbiP63162
PeptideAtlasiP63162
PRIDEiP63162
ProteomicsDBi57499

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6638
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346403; ENSP00000306223; ENSG00000128739 [P63162-1]
ENST00000390687; ENSP00000375105; ENSG00000128739 [P63162-1]
ENST00000400097; ENSP00000382969; ENSG00000128739 [P63162-1]
ENST00000400100; ENSP00000382972; ENSG00000128739 [P63162-1]
ENST00000554227; ENSP00000452342; ENSG00000128739 [P63162-2]
ENST00000577565; ENSP00000463458; ENSG00000128739 [P63162-1]
ENST00000642807; ENSP00000495345; ENSG00000128739 [P63162-1]
ENST00000645002; ENSP00000494831; ENSG00000128739 [P63162-1]
GeneIDi6638
8926
KEGGihsa:6638
hsa:8926
UCSCiuc059gty.1 human [P63162-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6638
8926
DisGeNETi6638
8926
EuPathDBiHostDB:ENSG00000128739.21

GeneCards: human genes, protein and diseases

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GeneCardsi
SNRPN
GeneReviewsiSNRPN
HGNCiHGNC:11164 SNRPN
HPAiHPA003482
HPA067842
MalaCardsiSNRPN
MIMi182279 gene
neXtProtiNX_P63162
OpenTargetsiENSG00000128739
Orphaneti411515 Angelman syndrome due to imprinting defect in 15q11-q13
177910 Prader-Willi syndrome due to imprinting mutation
98754 Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
177901 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
177904 Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
177907 Prader-Willi syndrome due to translocation
PharmGKBiPA36005

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3168 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00940000158222
HOGENOMiHOG000188899
HOVERGENiHBG001019
InParanoidiP63162
KOiK11100
OMAiFAPQRPG
OrthoDBi1630470at2759
PhylomeDBiP63162
TreeFamiTF314232

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
SIGNORiP63162

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SNRPN human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Small_nuclear_ribonucleoprotein_polypeptide_N

Protein Ontology

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PROi
PR:P63162

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128739 Expressed in 232 organ(s), highest expression level in cerebellum
ExpressionAtlasiP63162 baseline and differential
GenevisibleiP63162 HS

Family and domain databases

InterProiView protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR017131 snRNP-assoc_SmB/SmN
PfamiView protein in Pfam
PF01423 LSM, 1 hit
PIRSFiPIRSF037187 snRNP_SmB/SmN, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRSMN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63162
Secondary accession number(s): B3KVR1
, P14648, P17135, Q0D2Q5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: April 10, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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