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Protein

BarH-like 1 homeobox protein

Gene

Barhl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi178 – 237HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • midbrain development Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • neuron migration Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • sensory perception of sound Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BarH-like 1 homeobox protein
Alternative name(s):
Bar-class homeodomain protein MBH2
BarH-related homeobox protein 1
Gene namesi
Name:Barhl1
Synonyms:Bhx1, Mbh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1859288 Barhl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488271 – 327BarH-like 1 homeobox proteinAdd BLAST327

Proteomic databases

PaxDbiP63157
PRIDEiP63157

PTM databases

PhosphoSitePlusiP63157

Expressioni

Developmental stagei

Exclusively expressed in restricted domains of the developing central nervous system, in particular the diencephalon and rhombencephalon, where it is expressed in migrating cells giving rise to the cerebellar external granular layer and to specific populations of dorsal sensory interneurons of the spinal cord.1 Publication

Gene expression databases

BgeeiENSMUSG00000026805
CleanExiMM_BARHL1
GenevisibleiP63157 MM

Interactioni

Protein-protein interaction databases

BioGridi207657, 2 interactors
STRINGi10090.ENSMUSP00000053147

Structurei

3D structure databases

ProteinModelPortaliP63157
SMRiP63157
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000231533
HOVERGENiHBG050663
InParanoidiP63157
KOiK09360
OMAiSDSEYKG
OrthoDBiEOG091G13SM
PhylomeDBiP63157
TreeFamiTF316128

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P63157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGSNGFGID SILSHRAGSP ALPKGDPLLG DCRSPLELSP RSESSSDCSS
60 70 80 90 100
PASPGRDCLE TSTSRPGAAS GPGLDSHLQP GQLSAPAQSR TVTSSFLIRD
110 120 130 140 150
ILADCKPLAA CAPYSSSGQP AAPEPGGRLA AKAGEDFRDK LDKSVSSASS
160 170 180 190 200
DSEYKVKEEG DREISSSRDS PPVRLKKPRK ARTAFTDHQL AQLERSFERQ
210 220 230 240 250
KYLSVQDRME LAASLNLTDT QVKTWYQNRR TKWKRQTAVG LELLAEAGNY
260 270 280 290 300
SALQRMFPSP YFYPQSLVSN LDPGAALYLY RGPSAPPPAL QRPLVPRILI
310 320
HGLQGASEPP PPLPPLPGVL PRAAQPR
Length:327
Mass (Da):35,136
Last modified:September 27, 2004 - v1
Checksum:i4130725E55D322FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ237590 mRNA Translation: CAB92529.1
AB043980 mRNA Translation: BAB18599.1
AF264026 mRNA Translation: AAK58534.1
BC055731 mRNA Translation: AAH55731.1
CCDSiCCDS15849.1
RefSeqiNP_001157658.1, NM_001164186.1
NP_062319.1, NM_019446.4
XP_006498245.1, XM_006498182.3
XP_006498246.1, XM_006498183.2
XP_011237440.1, XM_011239138.2
UniGeneiMm.21390

Genome annotation databases

EnsembliENSMUST00000050776; ENSMUSP00000053147; ENSMUSG00000026805
ENSMUST00000113847; ENSMUSP00000109478; ENSMUSG00000026805
ENSMUST00000113849; ENSMUSP00000109480; ENSMUSG00000026805
GeneIDi54422
KEGGimmu:54422
UCSCiuc008izh.2 mouse

Similar proteinsi

Entry informationi

Entry nameiBARH1_MOUSE
AccessioniPrimary (citable) accession number: P63157
Secondary accession number(s): Q9JK26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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