UniProtKB - P63151 (2ABA_HUMAN)
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
PPP2R2A
Functioni
GO - Molecular functioni
- protein-containing complex binding Source: Ensembl
- protein phosphatase 2A binding Source: Ensembl
- protein phosphatase regulator activity Source: UniProtKB
- tau protein binding Source: Ensembl
GO - Biological processi
- G2/M transition of mitotic cell cycle Source: Reactome
- mitotic nuclear envelope reassembly Source: Reactome
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- peptidyl-serine dephosphorylation Source: GO_Central
- protein dephosphorylation Source: UniProtKB
- response to morphine Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | P63151 |
Reactomei | R-HSA-2995383, Initiation of Nuclear Envelope (NE) Reformation R-HSA-69231, Cyclin D associated events in G1 R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | P63151 |
SIGNORi | P63151 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformAlternative name(s): PP2A subunit B isoform B55-alpha PP2A subunit B isoform PR55-alpha PP2A subunit B isoform R2-alpha PP2A subunit B isoform alpha |
Gene namesi | Name:PPP2R2A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000221914.8 |
HGNCi | HGNC:9304, PPP2R2A |
MIMi | 604941, gene |
neXtProti | NX_P63151 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleoplasm Source: Reactome
Other locations
- glutamatergic synapse Source: Ensembl
- protein phosphatase type 2A complex Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 5520 |
OpenTargetsi | ENSG00000221914 |
PharmGKBi | PA33668 |
Miscellaneous databases
Pharosi | P63151, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4284 |
DrugBanki | DB02506, 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid |
Polymorphism and mutation databases
BioMutai | PPP2R2A |
DMDMi | 52783535 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000071415 | 2 – 447 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformAdd BLAST | 446 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P63151 |
jPOSTi | P63151 |
MassIVEi | P63151 |
MaxQBi | P63151 |
PaxDbi | P63151 |
PeptideAtlasi | P63151 |
PRIDEi | P63151 |
ProteomicsDBi | 57497 57498 [P63151-2] |
PTM databases
iPTMneti | P63151 |
PhosphoSitePlusi | P63151 |
SwissPalmi | P63151 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000221914, Expressed in corpus callosum and 244 other tissues |
ExpressionAtlasi | P63151, baseline and differential |
Genevisiblei | P63151, HS |
Organism-specific databases
HPAi | ENSG00000221914, Low tissue specificity |
Interactioni
Subunit structurei
Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity).
Interacts with TP53 (PubMed:17245430).
Interacts with IER5 (PubMed:25816751).
Interacts with MFHAS1; the interaction is direct (PubMed:28609714).
Interacts with FAM122A (PubMed:27588481).
Interacts with CRTC3 (PubMed:30611118).
By similarity5 PublicationsBinary interactionsi
Hide detailsP63151
With | #Exp. | IntAct |
---|---|---|
LRRK2 [Q5S007] | 4 | EBI-1048931,EBI-5323863 |
PPP2R1A [P30153] | 17 | EBI-1048931,EBI-302388 |
PPP2R1B [P30154] | 5 | EBI-1048931,EBI-357094 |
GO - Molecular functioni
- protein phosphatase 2A binding Source: Ensembl
- tau protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 111512, 150 interactors |
CORUMi | P63151 |
DIPi | DIP-29398N |
IntActi | P63151, 84 interactors |
MINTi | P63151 |
STRINGi | 9606.ENSP00000325074 |
Chemistry databases
BindingDBi | P63151 |
Miscellaneous databases
RNActi | P63151, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P63151 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P63151 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 26 – 65 | WD 1Add BLAST | 40 | |
Repeati | 91 – 132 | WD 2Add BLAST | 42 | |
Repeati | 175 – 213 | WD 3Add BLAST | 39 | |
Repeati | 224 – 264 | WD 4Add BLAST | 41 | |
Repeati | 283 – 321 | WD 5Add BLAST | 39 | |
Repeati | 338 – 379 | WD 6Add BLAST | 42 | |
Repeati | 414 – 446 | WD 7Add BLAST | 33 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1354, Eukaryota |
GeneTreei | ENSGT00950000182864 |
HOGENOMi | CLU_021713_3_3_1 |
InParanoidi | P63151 |
OMAi | RMFDRGH |
OrthoDBi | 810409at2759 |
PhylomeDBi | P63151 |
TreeFami | TF105553 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG
60 70 80 90 100
RVVIFQQEQE NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR
110 120 130 140 150
WLPQKNAAQF LLSTNDKTIK LWKISERDKR PEGYNLKEED GRYRDPTTVT
160 170 180 190 200
TLRVPVFRPM DLMVEASPRR IFANAHTYHI NSISINSDYE TYLSADDLRI
210 220 230 240 250
NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN TFVYSSSKGT
260 270 280 290 300
IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM
310 320 330 340 350
MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW
360 370 380 390 400
NGSDSVVMTG SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS
410 420 430 440
GKRKKDEISV DSLDFNKKIL HTAWHPKENI IAVATTNNLY IFQDKVN
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A590UJJ1 | A0A590UJJ1_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2A | 288 | Annotation score: | ||
A0A590UJY3 | A0A590UJY3_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2A | 340 | Annotation score: | ||
E5RFR9 | E5RFR9_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2A | 197 | Annotation score: | ||
E5RIY1 | E5RIY1_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2A | 132 | Annotation score: | ||
E5RJV1 | E5RJV1_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2A | 14 | Annotation score: | ||
E5RJV2 | E5RJV2_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2A | 51 | Annotation score: | ||
E5RHQ2 | E5RHQ2_HUMAN | Serine/threonine-protein phosphatas... | PPP2R2A | 33 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043100 | 1 – 2 | MA → MFPKFSLRSMFH in isoform 2. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64929 mRNA Translation: AAA36490.1 AK303981 mRNA Translation: BAG64899.1 AK314823 mRNA Translation: BAG37345.1 AC022911 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63578.1 BC041071 mRNA Translation: AAH41071.1 |
CCDSi | CCDS34867.1 [P63151-1] CCDS55213.1 [P63151-2] |
PIRi | A38351 |
RefSeqi | NP_001171062.1, NM_001177591.1 [P63151-2] NP_002708.1, NM_002717.3 [P63151-1] |
Genome annotation databases
Ensembli | ENST00000315985; ENSP00000325074; ENSG00000221914 [P63151-2] ENST00000380737; ENSP00000370113; ENSG00000221914 [P63151-1] |
GeneIDi | 5520 |
KEGGi | hsa:5520 |
UCSCi | uc003xeu.4, human [P63151-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M64929 mRNA Translation: AAA36490.1 AK303981 mRNA Translation: BAG64899.1 AK314823 mRNA Translation: BAG37345.1 AC022911 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63578.1 BC041071 mRNA Translation: AAH41071.1 |
CCDSi | CCDS34867.1 [P63151-1] CCDS55213.1 [P63151-2] |
PIRi | A38351 |
RefSeqi | NP_001171062.1, NM_001177591.1 [P63151-2] NP_002708.1, NM_002717.3 [P63151-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3DW8 | X-ray | 2.85 | B/E | 1-447 | [»] | |
SMRi | P63151 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111512, 150 interactors |
CORUMi | P63151 |
DIPi | DIP-29398N |
IntActi | P63151, 84 interactors |
MINTi | P63151 |
STRINGi | 9606.ENSP00000325074 |
Chemistry databases
BindingDBi | P63151 |
ChEMBLi | CHEMBL4284 |
DrugBanki | DB02506, 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid |
PTM databases
iPTMneti | P63151 |
PhosphoSitePlusi | P63151 |
SwissPalmi | P63151 |
Polymorphism and mutation databases
BioMutai | PPP2R2A |
DMDMi | 52783535 |
Proteomic databases
EPDi | P63151 |
jPOSTi | P63151 |
MassIVEi | P63151 |
MaxQBi | P63151 |
PaxDbi | P63151 |
PeptideAtlasi | P63151 |
PRIDEi | P63151 |
ProteomicsDBi | 57497 57498 [P63151-2] |
Protocols and materials databases
Antibodypediai | 22918, 213 antibodies |
DNASUi | 5520 |
Genome annotation databases
Ensembli | ENST00000315985; ENSP00000325074; ENSG00000221914 [P63151-2] ENST00000380737; ENSP00000370113; ENSG00000221914 [P63151-1] |
GeneIDi | 5520 |
KEGGi | hsa:5520 |
UCSCi | uc003xeu.4, human [P63151-1] |
Organism-specific databases
CTDi | 5520 |
DisGeNETi | 5520 |
EuPathDBi | HostDB:ENSG00000221914.8 |
GeneCardsi | PPP2R2A |
HGNCi | HGNC:9304, PPP2R2A |
HPAi | ENSG00000221914, Low tissue specificity |
MIMi | 604941, gene |
neXtProti | NX_P63151 |
OpenTargetsi | ENSG00000221914 |
PharmGKBi | PA33668 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1354, Eukaryota |
GeneTreei | ENSGT00950000182864 |
HOGENOMi | CLU_021713_3_3_1 |
InParanoidi | P63151 |
OMAi | RMFDRGH |
OrthoDBi | 810409at2759 |
PhylomeDBi | P63151 |
TreeFami | TF105553 |
Enzyme and pathway databases
PathwayCommonsi | P63151 |
Reactomei | R-HSA-2995383, Initiation of Nuclear Envelope (NE) Reformation R-HSA-69231, Cyclin D associated events in G1 R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | P63151 |
SIGNORi | P63151 |
Miscellaneous databases
BioGRID-ORCSi | 5520, 159 hits in 853 CRISPR screens |
ChiTaRSi | PPP2R2A, human |
EvolutionaryTracei | P63151 |
GeneWikii | PPP2R2A |
GenomeRNAii | 5520 |
Pharosi | P63151, Tchem |
PROi | PR:P63151 |
RNActi | P63151, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000221914, Expressed in corpus callosum and 244 other tissues |
ExpressionAtlasi | P63151, baseline and differential |
Genevisiblei | P63151, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 2ABA_HUMAN | |
Accessioni | P63151Primary (citable) accession number: P63151 Secondary accession number(s): B2RBU8 Q00007 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2004 |
Last sequence update: | September 27, 2004 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM