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Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Gene

PPP2R2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

GO - Molecular functioni

  • protein-containing complex binding Source: Ensembl
  • protein phosphatase 2A binding Source: Ensembl
  • protein phosphatase regulator activity Source: UniProtKB
  • protein serine/threonine phosphatase activity Source: UniProtKB
  • tau protein binding Source: Ensembl

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2995383 Initiation of Nuclear Envelope Reformation
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SignaLinkiP63151
SIGNORiP63151

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Alternative name(s):
PP2A subunit B isoform B55-alpha
PP2A subunit B isoform PR55-alpha
PP2A subunit B isoform R2-alpha
PP2A subunit B isoform alpha
Gene namesi
Name:PPP2R2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000221914.8
HGNCiHGNC:9304 PPP2R2A
MIMi604941 gene
neXtProtiNX_P63151

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi5520
OpenTargetsiENSG00000221914
PharmGKBiPA33668

Chemistry databases

ChEMBLiCHEMBL4284

Polymorphism and mutation databases

BioMutaiPPP2R2A
DMDMi52783535

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000714152 – 447Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP63151
MaxQBiP63151
PaxDbiP63151
PeptideAtlasiP63151
PRIDEiP63151

PTM databases

iPTMnetiP63151
PhosphoSitePlusiP63151
SwissPalmiP63151

Expressioni

Tissue specificityi

Expressed in all tissues examined.1 Publication

Gene expression databases

BgeeiENSG00000221914 Expressed in 236 organ(s), highest expression level in corpus callosum
CleanExiHS_PPP2R2A
ExpressionAtlasiP63151 baseline and differential
GenevisibleiP63151 HS

Organism-specific databases

HPAiCAB079289
HPA042122
HPA042770

Interactioni

Subunit structurei

Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TP53 (PubMed:17245430). Interacts with IER5 (PubMed:25816751). Interacts with MFHAS1; the interaction is direct (PubMed:28609714). Interacts with FAM122A (PubMed:27588481).By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111512, 111 interactors
CORUMiP63151
DIPiDIP-29398N
IntActiP63151, 65 interactors
MINTiP63151
STRINGi9606.ENSP00000325074

Chemistry databases

BindingDBiP63151

Structurei

Secondary structure

1447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP63151
SMRiP63151
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63151

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati26 – 65WD 1Add BLAST40
Repeati91 – 132WD 2Add BLAST42
Repeati175 – 213WD 3Add BLAST39
Repeati224 – 264WD 4Add BLAST41
Repeati283 – 321WD 5Add BLAST39
Repeati338 – 379WD 6Add BLAST42
Repeati414 – 446WD 7Add BLAST33

Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1354 Eukaryota
COG5170 LUCA
GeneTreeiENSGT00390000006311
HOGENOMiHOG000089745
HOVERGENiHBG000012
InParanoidiP63151
KOiK04354
OMAiPGGCTSL
OrthoDBiEOG091G09BB
PhylomeDBiP63151
TreeFamiTF105553

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11871 PTHR11871, 1 hit
PIRSFiPIRSF037309 PP2A_PR55, 1 hit
PRINTSiPR00600 PP2APR55
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P63151-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG
60 70 80 90 100
RVVIFQQEQE NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR
110 120 130 140 150
WLPQKNAAQF LLSTNDKTIK LWKISERDKR PEGYNLKEED GRYRDPTTVT
160 170 180 190 200
TLRVPVFRPM DLMVEASPRR IFANAHTYHI NSISINSDYE TYLSADDLRI
210 220 230 240 250
NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN TFVYSSSKGT
260 270 280 290 300
IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM
310 320 330 340 350
MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW
360 370 380 390 400
NGSDSVVMTG SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS
410 420 430 440
GKRKKDEISV DSLDFNKKIL HTAWHPKENI IAVATTNNLY IFQDKVN
Length:447
Mass (Da):51,692
Last modified:September 27, 2004 - v1
Checksum:iF4D407FF7ADA4ED6
GO
Isoform 2 (identifier: P63151-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MA → MFPKFSLRSMFH

Note: No experimental confirmation available.
Show »
Length:457
Mass (Da):53,000
Checksum:i242C50314171EDDE
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFR9E5RFR9_HUMAN
Serine/threonine-protein phosphatas...
PPP2R2A
197Annotation score:
E5RIY1E5RIY1_HUMAN
Serine/threonine-protein phosphatas...
PPP2R2A
132Annotation score:
A0A1W2PQI2A0A1W2PQI2_HUMAN
Serine/threonine-protein phosphatas...
PPP2R2A
105Annotation score:
E5RHQ2E5RHQ2_HUMAN
Serine/threonine-protein phosphatas...
PPP2R2A
33Annotation score:
E5RJV2E5RJV2_HUMAN
Serine/threonine-protein phosphatas...
PPP2R2A
51Annotation score:
E5RJV1E5RJV1_HUMAN
Serine/threonine-protein phosphatas...
PPP2R2A
14Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0431001 – 2MA → MFPKFSLRSMFH in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64929 mRNA Translation: AAA36490.1
AK303981 mRNA Translation: BAG64899.1
AK314823 mRNA Translation: BAG37345.1
AC022911 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63578.1
BC041071 mRNA Translation: AAH41071.1
CCDSiCCDS34867.1 [P63151-1]
CCDS55213.1 [P63151-2]
PIRiA38351
RefSeqiNP_001171062.1, NM_001177591.1 [P63151-2]
NP_002708.1, NM_002717.3 [P63151-1]
UniGeneiHs.146339

Genome annotation databases

EnsembliENST00000315985; ENSP00000325074; ENSG00000221914 [P63151-2]
ENST00000380737; ENSP00000370113; ENSG00000221914 [P63151-1]
GeneIDi5520
KEGGihsa:5520
UCSCiuc003xeu.4 human [P63151-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64929 mRNA Translation: AAA36490.1
AK303981 mRNA Translation: BAG64899.1
AK314823 mRNA Translation: BAG37345.1
AC022911 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63578.1
BC041071 mRNA Translation: AAH41071.1
CCDSiCCDS34867.1 [P63151-1]
CCDS55213.1 [P63151-2]
PIRiA38351
RefSeqiNP_001171062.1, NM_001177591.1 [P63151-2]
NP_002708.1, NM_002717.3 [P63151-1]
UniGeneiHs.146339

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DW8X-ray2.85B/E1-447[»]
ProteinModelPortaliP63151
SMRiP63151
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111512, 111 interactors
CORUMiP63151
DIPiDIP-29398N
IntActiP63151, 65 interactors
MINTiP63151
STRINGi9606.ENSP00000325074

Chemistry databases

BindingDBiP63151
ChEMBLiCHEMBL4284

PTM databases

iPTMnetiP63151
PhosphoSitePlusiP63151
SwissPalmiP63151

Polymorphism and mutation databases

BioMutaiPPP2R2A
DMDMi52783535

Proteomic databases

EPDiP63151
MaxQBiP63151
PaxDbiP63151
PeptideAtlasiP63151
PRIDEiP63151

Protocols and materials databases

DNASUi5520
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315985; ENSP00000325074; ENSG00000221914 [P63151-2]
ENST00000380737; ENSP00000370113; ENSG00000221914 [P63151-1]
GeneIDi5520
KEGGihsa:5520
UCSCiuc003xeu.4 human [P63151-1]

Organism-specific databases

CTDi5520
DisGeNETi5520
EuPathDBiHostDB:ENSG00000221914.8
GeneCardsiPPP2R2A
HGNCiHGNC:9304 PPP2R2A
HPAiCAB079289
HPA042122
HPA042770
MIMi604941 gene
neXtProtiNX_P63151
OpenTargetsiENSG00000221914
PharmGKBiPA33668
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1354 Eukaryota
COG5170 LUCA
GeneTreeiENSGT00390000006311
HOGENOMiHOG000089745
HOVERGENiHBG000012
InParanoidiP63151
KOiK04354
OMAiPGGCTSL
OrthoDBiEOG091G09BB
PhylomeDBiP63151
TreeFamiTF105553

Enzyme and pathway databases

ReactomeiR-HSA-2995383 Initiation of Nuclear Envelope Reformation
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SignaLinkiP63151
SIGNORiP63151

Miscellaneous databases

ChiTaRSiPPP2R2A human
EvolutionaryTraceiP63151
GeneWikiiPPP2R2A
GenomeRNAii5520
PROiPR:P63151
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000221914 Expressed in 236 organ(s), highest expression level in corpus callosum
CleanExiHS_PPP2R2A
ExpressionAtlasiP63151 baseline and differential
GenevisibleiP63151 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000009 PP2A_PR55
IPR018067 PP2A_PR55_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11871 PTHR11871, 1 hit
PIRSFiPIRSF037309 PP2A_PR55, 1 hit
PRINTSiPR00600 PP2APR55
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS01024 PR55_1, 1 hit
PS01025 PR55_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei2ABA_HUMAN
AccessioniPrimary (citable) accession number: P63151
Secondary accession number(s): B2RBU8
, B4E1T7, P50409, Q00007
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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