UniProtKB - P63151 (2ABA_HUMAN)

BLAST

>sp|P63151|2ABA_HUMAN Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1
MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQE
NKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIK
LWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHI
NSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCN
TFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYM
MTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTG
SYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKIL
HTAWHPKENIIAVATTNNLYIFQDKVN

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History
Entry version 152 (07 Nov 2018)
Sequence version 1 (27 Sep 2004)
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Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

Gene

PPP2R2A

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

GO - Molecular functionⁱ

protein-containing complex binding Source: Ensembl
protein phosphatase 2A binding Source: Ensembl
protein phosphatase regulator activity
Source: UniProtKB
Traceable author statementⁱ
- 1849734
protein serine/threonine phosphatase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 1849734
tau protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

G2/M transition of mitotic cell cycle Source: Reactome
mitotic cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
peptidyl-serine dephosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein dephosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 1849734
response to morphine Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2995383 Initiation of Nuclear Envelope Reformation R-HSA-69231 Cyclin D associated events in G1 R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SignaLinkⁱ	P63151
SIGNORⁱ	P63151

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform Alternative name(s): PP2A subunit B isoform B55-alpha PP2A subunit B isoform PR55-alpha PP2A subunit B isoform R2-alpha PP2A subunit B isoform alpha
Gene namesⁱ	Name:PPP2R2A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000221914.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9304 PPP2R2A
MIMⁱ	604941 gene
neXtProtⁱ	NX_P63151

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5520
Open Targets More...OpenTargetsⁱ	ENSG00000221914
PharmGKBⁱ	PA33668

Chemistry databases

ChEMBLⁱ	CHEMBL4284

ChEMBLⁱ

CHEMBL4284

Polymorphism and mutation databases

BioMutaⁱ	PPP2R2A
DMDMⁱ	52783535

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000071415	2 – 447	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformAdd BLAST		446

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P63151
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P63151
PaxDbⁱ	P63151
PeptideAtlas More...PeptideAtlasⁱ	P63151
PRIDEⁱ	P63151

PTM databases

iPTMnetⁱ	P63151
PhosphoSitePlusⁱ	P63151
SwissPalmⁱ	P63151

Expressionⁱ

Tissue specificityⁱ

Expressed in all tissues examined.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000221914 Expressed in 236 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_PPP2R2A
ExpressionAtlasⁱ	P63151 baseline and differential
Genevisibleⁱ	P63151 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB079289 HPA042122 HPA042770

HPAⁱ

CAB079289
HPA042122
HPA042770

Interactionⁱ

Subunit structureⁱ

Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TP53 (PubMed:17245430). Interacts with IER5 (PubMed:25816751). Interacts with MFHAS1; the interaction is direct (PubMed:28609714). Interacts with FAM122A (PubMed:27588481).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PPP2R1A	P30153	17	EBI-1048931,EBI-302388
PPP2R1B	P30154	5	EBI-1048931,EBI-357094

GO - Molecular functionⁱ

protein phosphatase 2A binding Source: Ensembl
tau protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111512, 111 interactors
CORUMⁱ	P63151
Database of interacting proteins More...DIPⁱ	DIP-29398N
IntActⁱ	P63151, 65 interactors
Molecular INTeraction database More...MINTⁱ	P63151
STRINGⁱ	9606.ENSP00000325074

Chemistry databases

BindingDBⁱ

P63151

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	13 – 16	Combined sources	4
Beta strandⁱ	21 – 23	Combined sources	3
Helixⁱ	27 – 29	Combined sources	3
Beta strandⁱ	30 – 36	Combined sources	7
Beta strandⁱ	38 – 47	Combined sources	10
Beta strandⁱ	50 – 57	Combined sources	8
Beta strandⁱ	71 – 78	Combined sources	8
Beta strandⁱ	83 – 85	Combined sources	3
Helixⁱ	86 – 88	Combined sources	3
Beta strandⁱ	90 – 92	Combined sources	3
Beta strandⁱ	98 – 101	Combined sources	4
Beta strandⁱ	106 – 114	Combined sources	9
Beta strandⁱ	119 – 132	Combined sources	14
Beta strandⁱ	156 – 172	Combined sources	17
Beta strandⁱ	182 – 185	Combined sources	4
Beta strandⁱ	189 – 195	Combined sources	7
Beta strandⁱ	197 – 204	Combined sources	8
Beta strandⁱ	207 – 216	Combined sources	10
Helixⁱ	222 – 224	Combined sources	3
Beta strandⁱ	229 – 234	Combined sources	6
Beta strandⁱ	241 – 246	Combined sources	6
Beta strandⁱ	251 – 255	Combined sources	5
Turnⁱ	256 – 258	Combined sources	3
Beta strandⁱ	260 – 262	Combined sources	3
Beta strandⁱ	267 – 269	Combined sources	3
Helixⁱ	280 – 284	Combined sources	5
Beta strandⁱ	288 – 293	Combined sources	6
Beta strandⁱ	297 – 312	Combined sources	16
Beta strandⁱ	323 – 325	Combined sources	3
Helixⁱ	327 – 329	Combined sources	3
Turnⁱ	330 – 332	Combined sources	3
Helixⁱ	333 – 338	Combined sources	6
Helixⁱ	341 – 343	Combined sources	3
Beta strandⁱ	348 – 350	Combined sources	3
Beta strandⁱ	354 – 360	Combined sources	7
Beta strandⁱ	365 – 370	Combined sources	6
Turnⁱ	371 – 373	Combined sources	3
Beta strandⁱ	376 – 380	Combined sources	5
Helixⁱ	410 – 412	Combined sources	3
Beta strandⁱ	421 – 424	Combined sources	4
Beta strandⁱ	426 – 434	Combined sources	9
Beta strandⁱ	439 – 443	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P63151
SMRⁱ	P63151
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P63151

EvolutionaryTraceⁱ

P63151

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	26 – 65	WD 1Add BLAST	40
Repeatⁱ	91 – 132	WD 2Add BLAST	42
Repeatⁱ	175 – 213	WD 3Add BLAST	39
Repeatⁱ	224 – 264	WD 4Add BLAST	41
Repeatⁱ	283 – 321	WD 5Add BLAST	39
Repeatⁱ	338 – 379	WD 6Add BLAST	42
Repeatⁱ	414 – 446	WD 7Add BLAST	33

Sequence similaritiesⁱ

Belongs to the phosphatase 2A regulatory subunit B family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG1354 Eukaryota COG5170 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006311
HOGENOMⁱ	HOG000089745
HOVERGENⁱ	HBG000012
InParanoidⁱ	P63151
KEGG Orthology (KO) More...KOⁱ	K04354
OMAⁱ	PGGCTSL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09BB
PhylomeDBⁱ	P63151
TreeFamⁱ	TF105553

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000009 PP2A_PR55 IPR018067 PP2A_PR55_CS IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR11871 PTHR11871, 1 hit
PIRSFⁱ	PIRSF037309 PP2A_PR55, 1 hit
PRINTSⁱ	PR00600 PP2APR55
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS01024 PR55_1, 1 hit PS01025 PR55_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P63151-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG 
        60         70         80         90        100
RVVIFQQEQE NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR 
       110        120        130        140        150
WLPQKNAAQF LLSTNDKTIK LWKISERDKR PEGYNLKEED GRYRDPTTVT 
       160        170        180        190        200
TLRVPVFRPM DLMVEASPRR IFANAHTYHI NSISINSDYE TYLSADDLRI 
       210        220        230        240        250
NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN TFVYSSSKGT 
       260        270        280        290        300
IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM 
       310        320        330        340        350
MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW 
       360        370        380        390        400
NGSDSVVMTG SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS 
       410        420        430        440 
GKRKKDEISV DSLDFNKKIL HTAWHPKENI IAVATTNNLY IFQDKVN

Length:447

Mass (Da):51,692

Last modified:September 27, 2004 - v1

Checksum:ⁱF4D407FF7ADA4ED6

Isoform 2 (identifier: P63151-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-2: MA → MFPKFSLRSMFH

« Hide

        10         20         30         40         50
MFPKFSLRSM FHGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG 
        60         70         80         90        100
ELLATGDKGG RVVIFQQEQE NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL 
       110        120        130        140        150
EIEEKINKIR WLPQKNAAQF LLSTNDKTIK LWKISERDKR PEGYNLKEED 
       160        170        180        190        200
GRYRDPTTVT TLRVPVFRPM DLMVEASPRR IFANAHTYHI NSISINSDYE 
       210        220        230        240        250
TYLSADDLRI NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN 
       260        270        280        290        300
TFVYSSSKGT IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD 
       310        320        330        340        350
VKFSHSGRYM MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND 
       360        370        380        390        400
CIFDKFECCW NGSDSVVMTG SYNNFFRMFD RNTKRDITLE ASRENNKPRT 
       410        420        430        440        450
VLKPRKVCAS GKRKKDEISV DSLDFNKKIL HTAWHPKENI IAVATTNNLY 

IFQDKVN

Note: No experimental confirmation available.

Show »

Length:457

Mass (Da):53,000

Checksum:ⁱ242C50314171EDDE

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E5RFR9	E5RFR9_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	PPP2R2A	197	Annotation score:
E5RIY1	E5RIY1_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	PPP2R2A	132	Annotation score:
A0A1W2PQI2	A0A1W2PQI2_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	PPP2R2A	105	Annotation score:
E5RHQ2	E5RHQ2_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	PPP2R2A	33	Annotation score:
E5RJV2	E5RJV2_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	PPP2R2A	51	Annotation score:
E5RJV1	E5RJV1_HUMAN	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	PPP2R2A	14	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043100	1 – 2	MA → MFPKFSLRSMFH in isoform 2. 1 Publication		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M64929 mRNA Translation: AAA36490.1 AK303981 mRNA Translation: BAG64899.1 AK314823 mRNA Translation: BAG37345.1 AC022911 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63578.1 BC041071 mRNA Translation: AAH41071.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34867.1 [P63151-1] CCDS55213.1 [P63151-2]
PIRⁱ	A38351
NCBI Reference Sequences More...RefSeqⁱ	NP_001171062.1, NM_001177591.1 [P63151-2] NP_002708.1, NM_002717.3 [P63151-1]
UniGeneⁱ	Hs.146339

Genome annotation databases

Ensemblⁱ	ENST00000315985; ENSP00000325074; ENSG00000221914 [P63151-2] ENST00000380737; ENSP00000370113; ENSG00000221914 [P63151-1]
GeneIDⁱ	5520
KEGGⁱ	hsa:5520
UCSC genome browser More...UCSCⁱ	uc003xeu.4 human [P63151-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
P63151	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (Fragment)		PIG		426	UniRef100_P63151
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform		MACFA		447
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform		MOUSE		447
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform		RABIT		447
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B		TURTR		288
+48
P63151-2	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B		MACMU		457	UniRef100_G7N0R1
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B		PANTR		457
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B		MACFA		457
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B		SAIBB		457
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B		CALJA		457
+11

Protein	Similar proteins		Species	Score	Length	Source
P63151	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (Fragment)		PIG		426	UniRef90_P63151
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform		MACFA		447
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform		MOUSE		447
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform		RABIT		447
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform		DANRE		447
+133
P63151-2	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B		BOVIN		457	UniRef90_F1MG56
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B		FELCA		457
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B		LIPVE		457
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B		PIG		457
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B		LOXAF		491
+125

Protein	Similar proteins		Species	Score	Length	Source
P63151	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform		RAT		443	UniRef50_P36877
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform		PIG		443
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform		XENTR		443
Serine/threonine-protein phosphatase 2A regulatory subunit sur-6		CAEEL		495
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform		XENLA		468
+2107
P63151-2	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform		HUMAN		443	UniRef50_Q00005
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform		BOVIN		443
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (Fragment)		RABIT		413
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform		MACFA		443
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform		MOUSE		443
+490

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M64929 mRNA Translation: AAA36490.1 AK303981 mRNA Translation: BAG64899.1 AK314823 mRNA Translation: BAG37345.1 AC022911 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63578.1 BC041071 mRNA Translation: AAH41071.1
CCDSⁱ	CCDS34867.1 [P63151-1] CCDS55213.1 [P63151-2]
PIRⁱ	A38351
RefSeqⁱ	NP_001171062.1, NM_001177591.1 [P63151-2] NP_002708.1, NM_002717.3 [P63151-1]
UniGeneⁱ	Hs.146339

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3DW8	X-ray	2.85	B/E	1-447	[»]
ProteinModelPortalⁱ	P63151
SMRⁱ	P63151
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111512, 111 interactors
CORUMⁱ	P63151
DIPⁱ	DIP-29398N
IntActⁱ	P63151, 65 interactors
MINTⁱ	P63151
STRINGⁱ	9606.ENSP00000325074

Chemistry databases

BindingDBⁱ	P63151
ChEMBLⁱ	CHEMBL4284

PTM databases

iPTMnetⁱ	P63151
PhosphoSitePlusⁱ	P63151
SwissPalmⁱ	P63151

Polymorphism and mutation databases

BioMutaⁱ	PPP2R2A
DMDMⁱ	52783535

Proteomic databases

EPDⁱ	P63151
MaxQBⁱ	P63151
PaxDbⁱ	P63151
PeptideAtlasⁱ	P63151
PRIDEⁱ	P63151

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5520
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000315985; ENSP00000325074; ENSG00000221914 [P63151-2] ENST00000380737; ENSP00000370113; ENSG00000221914 [P63151-1]
GeneIDⁱ	5520
KEGGⁱ	hsa:5520
UCSCⁱ	uc003xeu.4 human [P63151-1]

Organism-specific databases

CTDⁱ	5520
DisGeNETⁱ	5520
EuPathDBⁱ	HostDB:ENSG00000221914.8
GeneCardsⁱ	PPP2R2A
HGNCⁱ	HGNC:9304 PPP2R2A
HPAⁱ	CAB079289 HPA042122 HPA042770
MIMⁱ	604941 gene
neXtProtⁱ	NX_P63151
OpenTargetsⁱ	ENSG00000221914
PharmGKBⁱ	PA33668
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1354 Eukaryota COG5170 LUCA
GeneTreeⁱ	ENSGT00390000006311
HOGENOMⁱ	HOG000089745
HOVERGENⁱ	HBG000012
InParanoidⁱ	P63151
KOⁱ	K04354
OMAⁱ	PGGCTSL
OrthoDBⁱ	EOG091G09BB
PhylomeDBⁱ	P63151
TreeFamⁱ	TF105553

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2995383 Initiation of Nuclear Envelope Reformation R-HSA-69231 Cyclin D associated events in G1 R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SignaLinkⁱ	P63151
SIGNORⁱ	P63151

Miscellaneous databases

ChiTaRSⁱ	PPP2R2A human
EvolutionaryTraceⁱ	P63151
GeneWikiⁱ	PPP2R2A
GenomeRNAiⁱ	5520
Protein Ontology More...PROⁱ	PR:P63151
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000221914 Expressed in 236 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_PPP2R2A
ExpressionAtlasⁱ	P63151 baseline and differential
Genevisibleⁱ	P63151 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000009 PP2A_PR55 IPR018067 PP2A_PR55_CS IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR036322 WD40_repeat_dom_sf
PANTHERⁱ	PTHR11871 PTHR11871, 1 hit
PIRSFⁱ	PIRSF037309 PP2A_PR55, 1 hit
PRINTSⁱ	PR00600 PP2APR55
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS01024 PR55_1, 1 hit PS01025 PR55_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	2ABA_HUMAN
Accessionⁱ	P63151Primary (citable) accession number: P63151 Secondary accession number(s): B2RBU8 , B4E1T7, P50409, Q00007
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
	Last sequence update:	September 27, 2004
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniProtKB - P63151 (2ABA_HUMAN)

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Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

PPP2R2A

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ