UniProtKB - P63137 (GBRB2_MOUSE)
Gamma-aminobutyric acid receptor subunit beta-2
Gabrb2
Functioni
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 224 | AgonistBy similarity | 1 |
GO - Molecular functioni
- chloride channel activity Source: UniProtKB
- GABA-A receptor activity Source: UniProtKB
- GABA-gated chloride ion channel activity Source: Ensembl
- inhibitory extracellular ligand-gated ion channel activity Source: MGI
- neurotransmitter receptor activity Source: GO_Central
- transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: SynGO
GO - Biological processi
- cellular response to histamine Source: UniProtKB
- chemical synaptic transmission Source: GO_Central
- chloride transmembrane transport Source: UniProtKB
- cochlea development Source: DFLAT
- gamma-aminobutyric acid signaling pathway Source: MGI
- inhibitory synapse assembly Source: UniProtKB
- inner ear receptor cell development Source: DFLAT
- innervation Source: DFLAT
- ion transmembrane transport Source: GO_Central
- negative regulation of neuron apoptotic process Source: DFLAT
- negative regulation of neuron death Source: DFLAT
- nervous system process Source: GO_Central
- neuron development Source: DFLAT
- regulation of membrane potential Source: GO_Central
- regulation of neuron apoptotic process Source: DFLAT
- sensory perception of sound Source: DFLAT
- signal transduction Source: GO_Central
- synaptic transmission, GABAergic Source: MGI
Keywordsi
Molecular function | Chloride channel, Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Enzyme and pathway databases
Reactomei | R-MMU-977443, GABA receptor activation |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-aminobutyric acid receptor subunit beta-2Alternative name(s): GABA(A) receptor subunit beta-2 |
Gene namesi | Name:Gabrb2 Synonyms:Gabrb-2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95620, Gabrb2 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Other locations
- Cytoplasmic vesicle By similarity
Cytosol
- cytosol Source: MGI
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- integral component of postsynaptic specialization membrane Source: SynGO
- plasma membrane Source: MGI
Other locations
- chloride channel complex Source: UniProtKB-KW
- cytoplasmic vesicle Source: UniProtKB-KW
- GABA receptor complex Source: MGI
- GABA-A receptor complex Source: UniProtKB
- GABA-ergic synapse Source: SynGO
- membrane Source: MGI
- neuron projection Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 244 | ExtracellularCuratedAdd BLAST | 219 | |
Transmembranei | 245 – 266 | HelicalCuratedAdd BLAST | 22 | |
Transmembranei | 270 – 292 | HelicalCuratedAdd BLAST | 23 | |
Transmembranei | 304 – 326 | HelicalCuratedAdd BLAST | 23 | |
Topological domaini | 327 – 489 | CytoplasmicCuratedAdd BLAST | 163 | |
Transmembranei | 490 – 511 | HelicalCuratedAdd BLAST | 22 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | By similarityAdd BLAST | 25 | |
ChainiPRO_0000000460 | 26 – 512 | Gamma-aminobutyric acid receptor subunit beta-2Add BLAST | 487 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 104 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 160 ↔ 174 | By similarity | ||
Glycosylationi | 173 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 441 | PhosphotyrosineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | P63137 |
PeptideAtlasi | P63137 |
PRIDEi | P63137 |
PTM databases
GlyConnecti | 2325, 6 N-Linked glycans (1 site) |
GlyGeni | P63137, 3 sites |
iPTMneti | P63137 |
PhosphoSitePlusi | P63137 |
SwissPalmi | P63137 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000007653, Expressed in lateral geniculate body and 193 other tissues |
Genevisiblei | P63137, MM |
Interactioni
Subunit structurei
Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (By similarity).
Interacts with UBQLN1 (By similarity).
Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (PubMed:20400944). May interact with KIF21B (By similarity).
Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 199803, 3 interactors |
ComplexPortali | CPX-2979, GABA-A receptor, alpha-1/beta-2/gamma-2 CPX-2987, GABA-A receptor, alpha-6/beta-2/delta CPX-2988, GABA-A receptor, alpha-4/beta-2/delta |
STRINGi | 10090.ENSMUSP00000007797 |
Miscellaneous databases
RNActi | P63137, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 119 – 121 | Agonist bindingBy similarity | 3 | |
Regioni | 179 – 181 | Agonist bindingBy similarity | 3 | |
Regioni | 289 – 310 | Allosteric effector bindingBy similarityAdd BLAST | 22 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3643, Eukaryota |
GeneTreei | ENSGT00940000154245 |
HOGENOMi | CLU_010920_1_4_1 |
InParanoidi | P63137 |
OMAi | RMDPNKM |
OrthoDBi | 480926at2759 |
PhylomeDBi | P63137 |
TreeFami | TF315453 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR002289, GABAAb_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01160, GABAARBETA PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWRVRKRGYF GIWSFPLIIA AVCAQSVNDP SNMSLVKETV DRLLKGYDIR
60 70 80 90 100
LRPDFGGPPV AVGMNIDIAS IDMVSEVNMD YTLTMYFQQA WRDKRLSYNV
110 120 130 140 150
IPLNLTLDNR VADQLWVPDT YFLNDKKSFV HGVTVKNRMI RLHPDGTVLY
160 170 180 190 200
GLRITTTAAC MMDLRRYPLD EQNCTLEIES YGYTTDDIEF YWRGDDNAVT
210 220 230 240 250
GVTKIELPQF SIVDYKLITK KVVFSTGSYP RLSLSFKLKR NIGYFILQTY
260 270 280 290 300
MPSILITILS WVSFWINYDA SAARVALGIT TVLTMTTINT HLRETLPKIP
310 320 330 340 350
YVKAIDMYLM GCFVFVFMAL LEYALVNYIF FGRGPQRQKK AAEKAANANN
360 370 380 390 400
EKMRLDVNKM FYKDIKQNGT QYRSLWDPTG DLSPTRRTTN YDFSLYTMDP
410 420 430 440 450
HENILLSTLE IKNEMATSEA VMGLGDPRST MLAYDASSIQ YRKAGLPRHS
460 470 480 490 500
FGRNALERHV AQKKSRLRRR ASQLKITIPD LTDVNAIDRW SRIFFPVVFS
510
FFNIVYWLYY VN
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038829 | 360 – 397 | Missing in isoform 2. 3 PublicationsAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14419 mRNA Translation: AAA79974.1 GU086167 mRNA Translation: ACY69098.1 AK090279 mRNA Translation: BAC41155.1 AL627444 Genomic DNA No translation available. AL645964 Genomic DNA No translation available. CH466609 Genomic DNA Translation: EDL32344.1 BC145973 mRNA Translation: AAI45974.1 BC145975 mRNA Translation: AAI45976.1 |
CCDSi | CCDS24555.1 [P63137-2] CCDS88146.1 [P63137-1] |
PIRi | S53531 |
RefSeqi | NP_001334243.1, NM_001347314.1 [P63137-1] NP_032096.1, NM_008070.3 [P63137-2] XP_011247028.1, XM_011248726.1 XP_017169750.1, XM_017314261.1 |
Genome annotation databases
Ensembli | ENSMUST00000007797; ENSMUSP00000007797; ENSMUSG00000007653 [P63137-2] ENSMUST00000192403; ENSMUSP00000141868; ENSMUSG00000007653 [P63137-1] |
GeneIDi | 14401 |
KEGGi | mmu:14401 |
UCSCi | uc007imi.1, mouse [P63137-2] uc011xte.1, mouse [P63137-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14419 mRNA Translation: AAA79974.1 GU086167 mRNA Translation: ACY69098.1 AK090279 mRNA Translation: BAC41155.1 AL627444 Genomic DNA No translation available. AL645964 Genomic DNA No translation available. CH466609 Genomic DNA Translation: EDL32344.1 BC145973 mRNA Translation: AAI45974.1 BC145975 mRNA Translation: AAI45976.1 |
CCDSi | CCDS24555.1 [P63137-2] CCDS88146.1 [P63137-1] |
PIRi | S53531 |
RefSeqi | NP_001334243.1, NM_001347314.1 [P63137-1] NP_032096.1, NM_008070.3 [P63137-2] XP_011247028.1, XM_011248726.1 XP_017169750.1, XM_017314261.1 |
3D structure databases
SMRi | P63137 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199803, 3 interactors |
ComplexPortali | CPX-2979, GABA-A receptor, alpha-1/beta-2/gamma-2 CPX-2987, GABA-A receptor, alpha-6/beta-2/delta CPX-2988, GABA-A receptor, alpha-4/beta-2/delta |
STRINGi | 10090.ENSMUSP00000007797 |
Chemistry databases
ChEMBLi | CHEMBL4296059 |
PTM databases
GlyConnecti | 2325, 6 N-Linked glycans (1 site) |
GlyGeni | P63137, 3 sites |
iPTMneti | P63137 |
PhosphoSitePlusi | P63137 |
SwissPalmi | P63137 |
Proteomic databases
MaxQBi | P63137 |
PeptideAtlasi | P63137 |
PRIDEi | P63137 |
Protocols and materials databases
Antibodypediai | 4534, 323 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000007797; ENSMUSP00000007797; ENSMUSG00000007653 [P63137-2] ENSMUST00000192403; ENSMUSP00000141868; ENSMUSG00000007653 [P63137-1] |
GeneIDi | 14401 |
KEGGi | mmu:14401 |
UCSCi | uc007imi.1, mouse [P63137-2] uc011xte.1, mouse [P63137-1] |
Organism-specific databases
CTDi | 2561 |
MGIi | MGI:95620, Gabrb2 |
Phylogenomic databases
eggNOGi | KOG3643, Eukaryota |
GeneTreei | ENSGT00940000154245 |
HOGENOMi | CLU_010920_1_4_1 |
InParanoidi | P63137 |
OMAi | RMDPNKM |
OrthoDBi | 480926at2759 |
PhylomeDBi | P63137 |
TreeFami | TF315453 |
Enzyme and pathway databases
Reactomei | R-MMU-977443, GABA receptor activation |
Miscellaneous databases
BioGRID-ORCSi | 14401, 1 hit in 17 CRISPR screens |
ChiTaRSi | Gabrb2, mouse |
PROi | PR:P63137 |
RNActi | P63137, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000007653, Expressed in lateral geniculate body and 193 other tissues |
Genevisiblei | P63137, MM |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006028, GABAA/Glycine_rcpt IPR002289, GABAAb_rcpt IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01160, GABAARBETA PR00253, GABAARECEPTR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GBRB2_MOUSE | |
Accessioni | P63137Primary (citable) accession number: P63137 Secondary accession number(s): A6H6R7, D1LYT3, P15432 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2004 |
Last sequence update: | March 23, 2010 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families