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Protein

Endogenous retrovirus group K member 104 Pro protein

Gene

HERV-K104

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution (By similarity).By similarity

Catalytic activityi

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei26By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Endogenous retrovirus group K member 104 Pro protein
Alternative name(s):
HERV-K104 Pro protein
HERV-K_5q13.3 provirus ancestral Pro protein (EC:3.4.23.50)
Protease
Proteinase
Short name:
PR
Gene namesi
Name:HERV-K104
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

neXtProtiNX_P63124

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi52000855

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001995431 – 156Endogenous retrovirus group K member 104 Pro proteinAdd BLAST156

Post-translational modificationi

Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).By similarity

Proteomic databases

PRIDEiP63124
ProteomicsDBi57483

PTM databases

iPTMnetiP63124
PhosphoSitePlusiP63124

Interactioni

Subunit structurei

Active as a homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP63124
SMRiP63124
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 96Peptidase A2PROSITE-ProRule annotationAdd BLAST76
Domaini111 – 156G-patchPROSITE-ProRule annotationAdd BLAST46

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG063893
PhylomeDBiP63124

Family and domain databases

CDDicd05482 HIV_retropepsin_like, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR001995 Peptidase_A2_cat
IPR021109 Peptidase_aspartic_dom_sf
IPR034170 Retropepsin-like_cat_dom
IPR018061 Retropepsins
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF00077 RVP, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS50175 ASP_PROT_RETROV, 1 hit
PS50174 G_PATCH, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by ribosomal frameshifting. AlignAdd to basket
Note: This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.
Isoform 1 (identifier: P63124-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
WASQVSENRP VCKAIIQGKQ FEGLVDTEAD VSIIALNQWP KNWPKQKAVT
60 70 80 90 100
GLVGIGTASE VYQSTEILHC LGPDNQESTV QPMITSIPLN LWGQDLLQQW
110 120 130 140 150
GAEITMPAPL YSPTSQKIMT KMGYIPGKGL GKNEDGIKVP VEAKINQKRE

GIGYPF
Length:156
Mass (Da):17,121
Last modified:September 13, 2004 - v1
Checksum:iC8C3A3AF2B056761
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164612 Genomic DNA No translation available.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF164612 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliP63124
SMRiP63124
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP63124
PhosphoSitePlusiP63124

Polymorphism and mutation databases

DMDMi52000855

Proteomic databases

PRIDEiP63124
ProteomicsDBi57483

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

neXtProtiNX_P63124

Phylogenomic databases

HOVERGENiHBG063893
PhylomeDBiP63124

Family and domain databases

CDDicd05482 HIV_retropepsin_like, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR001995 Peptidase_A2_cat
IPR021109 Peptidase_aspartic_dom_sf
IPR034170 Retropepsin-like_cat_dom
IPR018061 Retropepsins
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF00077 RVP, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS50175 ASP_PROT_RETROV, 1 hit
PS50174 G_PATCH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVPK04_HUMAN
AccessioniPrimary (citable) accession number: P63124
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: June 20, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, ERV, Reference proteome, Transposable element

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Peptidase families
    Classification of peptidase families and list of entries
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Main funding by: National Institutes of Health

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