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Protein

Endogenous retrovirus group K member 19 Pro protein

Gene

ERVK-19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.

Catalytic activityi

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei26PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Endogenous retrovirus group K member 19 Pro protein
Alternative name(s):
HERV-K(C19) Pro protein
HERV-K_19q12 provirus ancestral Pro protein (EC:3.4.23.50)
Protease
Proteinase
Short name:
PR
Gene namesi
Name:ERVK-19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:39026 ERVK-19
neXtProtiNX_P63120

Pathology & Biotechi

Organism-specific databases

DisGeNETi100862685

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001995381 – 156Endogenous retrovirus group K member 19 Pro proteinAdd BLAST156

Post-translational modificationi

Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).By similarity

Keywords - PTMi

Autocatalytic cleavage

Proteomic databases

PRIDEiP63120
ProteomicsDBi57479

PTM databases

iPTMnetiP63120
PhosphoSitePlusiP63120

Interactioni

Subunit structurei

Active as a homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP63120
SMRiP63120
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 96Peptidase A2PROSITE-ProRule annotationAdd BLAST76
Domaini111 – 156G-patchPROSITE-ProRule annotationAdd BLAST46

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG063893
PhylomeDBiP63120

Family and domain databases

CDDicd05482 HIV_retropepsin_like, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR001969 Aspartic_peptidase_AS
IPR000467 G_patch_dom
IPR001995 Peptidase_A2_cat
IPR021109 Peptidase_aspartic_dom_sf
IPR034170 Retropepsin-like_cat_dom
IPR018061 Retropepsins
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF00077 RVP, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS50175 ASP_PROT_RETROV, 1 hit
PS00141 ASP_PROTEASE, 1 hit
PS50174 G_PATCH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry describes 1 isoform i produced by ribosomal frameshifting. AlignAdd to basket
Note: This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P63120-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
WASQVSENRP VCKAIIQGKQ FEGLVDTGAD VSIIALNQWP KNWPKQKAVT
60 70 80 90 100
GLVGIGTASE VYQSTEILHC LGPDNQESTV QPMITSIPLN LWGRDLLQQW
110 120 130 140 150
GAEITMPAPL YSPTSQKIMT KMGYILGKGL GKNEDGIKIP VEAKINQKRE

GIGYPF
Length:156
Mass (Da):17,107
Last modified:September 13, 2004 - v1
Checksum:i6D7D1ECF2B057AC3
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O71037ENK19_HUMAN
Endogenous retrovirus group K membe...
ERVK-19
699Annotation score:
Q9WJR5POK19_HUMAN
Endogenous retrovirus group K membe...
ERVK-19
959Annotation score:
Q9YNA8GAK19_HUMAN
Endogenous retrovirus group K membe...
ERVK-19
666Annotation score:
P61572REC19_HUMAN
Endogenous retrovirus group K membe...
ERVK-19
105Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126L → P (PubMed:15057824).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17833 Genomic DNA No translation available.
AC112702 Genomic DNA No translation available.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17833 Genomic DNA No translation available.
AC112702 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliP63120
SMRiP63120
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP63120
PhosphoSitePlusiP63120

Proteomic databases

PRIDEiP63120
ProteomicsDBi57479

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi100862685
GeneCardsiERVK-19
HGNCiHGNC:39026 ERVK-19
neXtProtiNX_P63120
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG063893
PhylomeDBiP63120

Family and domain databases

CDDicd05482 HIV_retropepsin_like, 1 hit
Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR001969 Aspartic_peptidase_AS
IPR000467 G_patch_dom
IPR001995 Peptidase_A2_cat
IPR021109 Peptidase_aspartic_dom_sf
IPR034170 Retropepsin-like_cat_dom
IPR018061 Retropepsins
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF00077 RVP, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS50175 ASP_PROT_RETROV, 1 hit
PS00141 ASP_PROTEASE, 1 hit
PS50174 G_PATCH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVPK19_HUMAN
AccessioniPrimary (citable) accession number: P63120
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: November 7, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, ERV, Reference proteome, Transposable element

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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